Warning: require_once(): It is not safe to rely on the system's timezone settings. You are *required* to use the date.timezone setting or the date_default_timezone_set() function. In case you used any of those methods and you are still getting this warning, you most likely misspelled the timezone identifier. We selected the timezone 'UTC' for now, but please set date.timezone to select your timezone. in /home/gkatak/public_html/4adj/ngs/.excel/excel_reader2.php on line 916

Deprecated: Assigning the return value of new by reference is deprecated in /home/gkatak/public_html/4adj/ngs/.excel/excel_reader2.php on line 916
  A B C D E F G H I J K L M N O P Q R S T U V W X Y Z AA AB AC AD AE AF AG AH AI AJ AK AL AM AN AO AP AQ AR AS AT AU AV AW AX AY AZ BA BB BC BD BE
1 ID STUDY PNUMBER sample_id_to_use Case_First_row_INCOMPLETE TP53&PIK3CA YES/NO Gene_Symbol_merged mut non-synonymous YES/NO common SNP YES/NO nonMUTnonSNP Chr__merged Chr__Band_merged location__intron_exon__merged pos_merged Amplicon_ID_merged Amplicon_Start_merged Amplicon_Stop_merged Amplicon_GC_content_merged ampEVAL_cat10_TUMOR_merged ampEVAL_cat10_BLOOD_merged type_merged ref_merged length_merged genotype_merged maf_merged gene_merged location_merged function_merged codon_merged exon_merged protein_merged coding coding_merged sift_merged polyphen_merged cosmic_merged dbsnp_merged pfam_merged phylop_merged sampleIDOriginal_T1 Run_ID_Common_T1 Reads_T1 sample_description_T1 TCC_T1 Mapped_Reads_T1 On_Target_T1 Mean_Depth_T1 Uniformity_T1 barcode_T1 pvalue_T1 coverage_T1 ref_coverage_T1 var1_coverage_T1 freqVAR1_T1 freqVAR1_T1_CAT Age_cat_years_at_50 MenopDiagn
2 16879 HE10/97 207 97_395   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 in5-ex6 7578210 AMPL4392179183 7578209 7578382 58.3 1 2 SNV T 1 T/C   TP53 exonic synonymous CGG 6 WT 639A>G c.639A>G NA   45513:249885:45753 rs1800372 PF08563:PF07710:PF00870 -0,16 97_395 PRO-30-20141121_HE1097_T2_ 660 tumor 65 637232 84.51 1420 84.12 IonXpress_048   550 369 181 0.33 30 - 40 <=50 Premenopausal
3 16881 HE10/97 207 97_395   YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC|GGC 4 p.Pro72Arg|p.Pro72Gly 215C>G|215C>G c.215C>G|c.215C>G NA | 45985:250061 rs1042522 PF08563:PF07710:PF00870 1,36 97_395 PRO-30-20141121_HE1097_T2_ 1083 tumor 65 637232 84.51 1420 84.12 IonXpress_048   1005 257 748 0.74 70 - 80 <=50 Premenopausal
4 16882 HE10/97 207 97_395   YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579473 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense GCC|GGC 4 p.Pro72Ala|p.Pro72Gly 214C>G|214C>G c.214C>G|c.214C>G NA 0.0|0.011 45335:44018   PF08563:PF07710:PF00870 0,1 97_395 PRO-30-20141121_HE1097_T2_ 1083 tumor 65 637232 84.51 1420 84.12 IonXpress_048 3.0E-5 1013 927 86 0.08 <10 <=50 Premenopausal
5 16907 HE10/97 784 97_396   YES TP53 YES NO other chr17 17p13.1 in6-ex7-in7 7577570 AMPL4981177402 7577472 7577638 53.4 2 3 SNV C 1 C/T   TP53 exonic missense ATA 7 p.Met237Ile 711G>A c.711G>A NA   99646:99647:99648:10834:45673:44415:11063:1189385:1189384:45862:1189386:301404:301403:301402:1640834:1640835   PF08563:PF07710:PF00870 1,31 97_396c PRO-30-20141121_HE1097_T2_ 1796 tumor 90 1053439 81.66 2183 84.26 IonXpress_049   1684 1321 363 0.22 20 - 30 <=50 Premenopausal
6 16908 HE10/97 784 97_396   YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   45985:250061 rs1042522 PF08563:PF07710:PF00870 1,36 97_396c PRO-30-20141121_HE1097_T2_ 628 tumor 90 1053439 81.66 2183 84.26 IonXpress_049   567 270 297 0.52 50 - 60 <=50 Premenopausal
7 16909 HE10/97 784 97_396   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 in3-ex4 7579579 AMPL6795075395 7579475 7579618 52 2 3 SNV C 1 C/T   TP53 exonic synonymous CCA 4 WT 108G>A c.108G>A NA   53250 rs1800370 PF08563:PF07710:PF00870 -1,05 97_396c PRO-30-20141121_HE1097_T2_ 2379 tumor 90 1053439 81.66 2183 84.26 IonXpress_049   1995 1623 372 0.19 10 - 20 <=50 Premenopausal
8 16928 HE10/97 2864 97_398   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 in8-ex9-in9 7576841 AMPL1516620128 7576812 7576978 50 1 2 SNV A 1 A/G   TP53 intronic             NA     rs1800899 PF08563:PF07710:PF00870 -1,12 97_398b PRO-30-20141121_HE1097_T2_ 487 tumor 85 437855 80.04 909.6 85.86 IonXpress_050   457 126 331 0.72 70 - 80 >50 Premenopausal
9 16929 HE10/97 2864 97_398   YES TP53 YES NO other chr17 17p13.1 in4-ex5 7578496 AMPL6326144323 7578407 7578581 61.7 1 3 SNV A 1 A/T   TP53 exonic missense CAG 5 p.Leu145Gln 434T>A c.434T>A NA   1679515:1679516:87861:1679514:45161:1679517:1679518:128671:43899:128673:45351:128672:44880:128675:128674:44137   PF08563:PF07710:PF00870 2,21 97_398b PRO-30-20141121_HE1097_T2_ 757 tumor 85 437855 80.04 909.6 85.86 IonXpress_050   726 378 348 0.48 40 - 50 >50 Premenopausal
10 16930 HE10/97 2864 97_398   YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   45985:250061 rs1042522 PF08563:PF07710:PF00870 1,36 97_398b PRO-30-20141121_HE1097_T2_ 384 tumor 85 437855 80.04 909.6 85.86 IonXpress_050   357 272 85 0.24 20 - 30 >50 Premenopausal
11 16931 HE10/97 2864 97_398   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 in3-ex4 7579579 AMPL6795075395 7579475 7579618 52 2 3 SNV C 1 C/T   TP53 exonic synonymous CCA 4 WT 108G>A c.108G>A NA   53250 rs1800370 PF08563:PF07710:PF00870 -1,05 97_398b PRO-30-20141121_HE1097_T2_ 1958 tumor 85 437855 80.04 909.6 85.86 IonXpress_050   1872 511 1361 0.73 70 - 80 >50 Premenopausal
12 16955 HE10/97 1350 97_400   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 ex6-in6 7578210 AMPL4574207192 7578114 7578273 53.5 1 1 SNV T 1 T/C   TP53 exonic synonymous CGG 6 WT 639A>G c.639A>G NA   45513:249885:45753 rs1800372 PF08563:PF07710:PF00870 -0,16 97_400a PRO-30-20141121_HE1097_T2_ 225 tumor 90 600135 82.63 1227 70.71 IonXpress_051   210 54 156 0.74 70 - 80 <=50 Premenopausal
13 16956 HE10/97 1350 97_400   YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   45985:250061 rs1042522 PF08563:PF07710:PF00870 1,36 97_400a PRO-30-20141121_HE1097_T2_ 177 tumor 90 600135 82.63 1227 70.71 IonXpress_051   164 41 123 0.75 70 - 80 <=50 Premenopausal
14 16973 HE10/97 2549 97_401   YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   45985:250061 rs1042522 PF08563:PF07710:PF00870 1,36 97_401a PRO-30-20141121_HE1097_T2_ 657 tumor 70 233545 87.46 548.7 52.76 IonXpress_052   624 282 342 0.55 50 - 60 >50 Postmenopausal
15 16998 HE10/97 4457 97_403   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 ex7-in7 7577407 AMPL3426752792 7577372 7577532 61 2 3 SNV A 1 A/C   TP53 intronic             NA     rs12951053 PF08563:PF07710:PF00870 -1,68 97_403a PRO-30-20141121_HE1097_T2_ 1422 tumor 82,5 589397 88.33 1344 83.55 IonXpress_053   1355 846 509 0.38 30 - 40 <=50 Premenopausal
16 16999 HE10/97 4457 97_403   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 ex7-in7 7577427 AMPL3426752792 7577372 7577532 61 2 3 SNV G 1 G/A   TP53 intronic             NA     rs12947788 PF08563:PF07710:PF00870 0,16 97_403a PRO-30-20141121_HE1097_T2_ 1422 tumor 82,5 589397 88.33 1344 83.55 IonXpress_053   1375 868 507 0.37 30 - 40 <=50 Premenopausal
17 17000 HE10/97 4457 97_403   YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   45985:250061 rs1042522 PF08563:PF07710:PF00870 1,36 97_403a PRO-30-20141121_HE1097_T2_ 390 tumor 82,5 589397 88.33 1344 83.55 IonXpress_053   377 73 304 0.81 80 - 90 <=50 Premenopausal
18 17001 HE10/97 4457 97_403   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 in3-ex4 7579579 AMPL6795075395 7579475 7579618 52 2 3 SNV C 1 C/T   TP53 exonic synonymous CCA 4 WT 108G>A c.108G>A NA   53250 rs1800370 PF08563:PF07710:PF00870 -1,05 97_403a PRO-30-20141121_HE1097_T2_ 1228 tumor 82,5 589397 88.33 1344 83.55 IonXpress_053   1180 1068 112 0.09 <10 <=50 Premenopausal
19 17021 HE10/97 5043 97_404   YES PIK3CA NO NO nonMUTnonSNP chr03 3q26.3 off target 115118900 AMPL6795279620 115118832 115118979 44.9 2 1 SNV C 1 C/T                   NA     rs9821873   -2,3 97_404a PRO-30-20141121_HE1097_T2_ 844 tumor 85 396695 74.09 744.9 84.56 IonXpress_055   815 575 240 0.29 20 - 30 >50 Postmenopausal
20 17033 HE10/97 5043 97_404   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 ex7-in7 7577407 AMPL3426752792 7577372 7577532 61 2 3 SNV A 1 A/C   TP53 intronic             NA     rs12951053 PF08563:PF07710:PF00870 -1,68 97_404a PRO-30-20141121_HE1097_T2_ 747 tumor 85 396695 74.09 744.9 84.56 IonXpress_055   668 458 210 0.31 30 - 40 >50 Postmenopausal
21 17034 HE10/97 5043 97_404   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 ex7-in7 7577427 AMPL3426752792 7577372 7577532 61 2 3 SNV G 1 G/A   TP53 intronic             NA     rs12947788 PF08563:PF07710:PF00870 0,16 97_404a PRO-30-20141121_HE1097_T2_ 747 tumor 85 396695 74.09 744.9 84.56 IonXpress_055   677 469 208 0.31 30 - 40 >50 Postmenopausal
22 17035 HE10/97 5043 97_404   YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   45985:250061 rs1042522 PF08563:PF07710:PF00870 1,36 97_404a PRO-30-20141121_HE1097_T2_ 294 tumor 85 396695 74.09 744.9 84.56 IonXpress_055   270 109 161 0.6 60 - 70 >50 Postmenopausal
23 17065 HE10/97 2722 97_405   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 ex7-in7 7577407 AMPL3426752792 7577372 7577532 61 2 3 SNV A 1 A/C   TP53 intronic             NA     rs12951053 PF08563:PF07710:PF00870 -1,68 97_405c PRO-30-20141121_HE1097_T2_ 559 tumor 55 269776 72.33 487 86.12 IonXpress_056   532 456 76 0.14 10 - 20 <=50 Premenopausal
24 17066 HE10/97 2722 97_405   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 ex7-in7 7577427 AMPL3426752792 7577372 7577532 61 2 3 SNV G 1 G/A   TP53 intronic             NA     rs12947788 PF08563:PF07710:PF00870 0,16 97_405c PRO-30-20141121_HE1097_T2_ 559 tumor 55 269776 72.33 487 86.12 IonXpress_056   542 466 76 0.14 10 - 20 <=50 Premenopausal
25 17067 HE10/97 2722 97_405   YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   45985:250061 rs1042522 PF08563:PF07710:PF00870 1,36 97_405c PRO-30-20141121_HE1097_T2_ 166 tumor 55 269776 72.33 487 86.12 IonXpress_056   157 61 96 0.61 60 - 70 <=50 Premenopausal
26 17093 HE10/97 2557 97_407   YES PIK3CA YES NO other chr03 3q26.3 ex21 178952085 AMPL392292511 178952020 178952194 36.3 3 2 SNV A 1 A/G   PIK3CA exonic missense CGT 21 p.His1047Arg 3140A>G c.3140A>G NA 926 94987:94986:776:775:249874 rs121913279 PF00613:PF02192:PF00792:PF00454:PF00794 2,33 97_407 PRO-30-20141121_HE1097_T2_ 769 tumor 80 496939 75.34 932.9 86.16 IonXpress_057   522 440 82 0.16 10 - 20 <=50 Premenopausal
27 17105 HE10/97 2557 97_407   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 ex6-in6 7578146 AMPL4574207192 7578114 7578273 53.5 1 1 SNV T 1 T/C   TP53 intronic             NA   45453 rs34949160 PF08563:PF07710:PF00870 -0,3 97_407 PRO-30-20141121_HE1097_T2_ 365 tumor 80 496939 75.34 932.9 86.16 IonXpress_057   287 214 73 0.25 20 - 30 <=50 Premenopausal
28 17106 HE10/97 2557 97_407   YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   45985:250061 rs1042522 PF08563:PF07710:PF00870 1,36 97_407 PRO-30-20141121_HE1097_T2_ 289 tumor 80 496939 75.34 932.9 86.16 IonXpress_057   255 94 161 0.63 60 - 70 <=50 Premenopausal
29 17128 HE10/97 357 97_408   YES PIK3CA NO NO nonMUTnonSNP chr03 3q26.3 in1 178866408 AMPL4347527835 178866384 178866543 78.2     SNV C 1 C/T   PIK3CA intronic             NA     rs2699887 PF00613:PF02192:PF00792:PF00454:PF00794 -0,07 97_408a PRO-30-20141121_HE1097_T2_ 202 tumor 50 1763354 89.17 4014 82.72 IonXpress_058   221 131 90 0.41 40 - 50 <=50 Premenopausal
30 17129 HE10/97 357 97_408   YES PIK3CA NO NO nonMUTnonSNP chr03 3q26.3 in3 178917762 AMPL2705185935 178917726 178917900 29.9 2 1 SNV,INDEL CTTTTT 2 CTTTTC/CTTT   PIK3CA intronic             NA     rs11409397 PF00613:PF02192:PF00792:PF00454:PF00794 -0.84,0.17,0.18,0.18,0.18,0.26 97_408a PRO-30-20141121_HE1097_T2_ 1768 tumor 50 1763354 89.17 4014 82.72 IonXpress_058   690   49 0.07 <10 <=50 Premenopausal
31 17141 HE10/97 357 97_408   YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   45985:250061 rs1042522 PF08563:PF07710:PF00870 1,36 97_408a PRO-30-20141121_HE1097_T2_ 716 tumor 50 1763354 89.17 4014 82.72 IonXpress_058   656 335 321 0.49 40 - 50 <=50 Premenopausal
32 17142 HE10/97 1382 97_409 1 NO   NO NO                                                                                             >50 Postmenopausal
33 17204 HE10/97 3715 97_410   YES PIK3CA NO NO nonMUTnonSNP chr03 3q26.3 off target 115118856 AMPL6795277223 115118748 115118874 48.8 3 3 SNV C 1 C/T                   NA         -0,59 97_410b PRO-30-20141121_HE1097_T2_ 4708 tumor 80 693435 76.3 1280 59.87 IonXpress_061   477 424 53 0.11 10 - 20 >50 Postmenopausal
34 17206 HE10/97 3715 97_410   YES PIK3CA NO NO nonMUTnonSNP chr03 3q26.3 off target 115118900 AMPL6795279620 115118832 115118979 44.9 2 1 SNV C 1 C/T                   NA     rs9821873   -2,3 97_410b PRO-30-20141121_HE1097_T2_ 834 tumor 80 693435 76.3 1280 59.87 IonXpress_061   661 338 323 0.49 40 - 50 >50 Postmenopausal
35 17218 HE10/97 3715 97_410   YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   45985:250061 rs1042522 PF08563:PF07710:PF00870 1,36 97_410b   189 tumor                     0.85 80 - 90 >50 Postmenopausal
36 17244 HE10/97 5032 97_411   YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   45985:250061 rs1042522 PF08563:PF07710:PF00870 1,36 97_411c PRO-30-20141121_HE1097_T2_ 354 tumor 90 1205640 76.08 2364 82.85 IonXpress_063   322 255 67 0.21 20 - 30 <=50 Premenopausal
37 17262 HE10/97 2714 97_413   YES PIK3CA NO NO nonMUTnonSNP chr03 3q26.3 in1 178866408 AMPL4347527835 178866384 178866543 78.2     SNV C 1 C/T   PIK3CA intronic             NA     rs2699887 PF00613:PF02192:PF00792:PF00454:PF00794 -0,07 97_413 PRO-30-20141121_HE1097_T2_ 153 tumor 90 1789185 77.34 3553 84.72 IonXpress_064   187 55 132 0.71 70 - 80 >50 Premenopausal
38 17263 HE10/97 2714 97_413   YES PIK3CA YES NO other chr03 3q26.3 ex 10 178936082 AMPL393459515 178935994 178936131 38.6 3 2 SNV G 1 G/A   PIK3CA exonic missense AAA 10 p.Glu542Lys 1624G>A c.1624G>A NA 998 125369:760:326157:17442:1659153:1659152 rs121913273 PF00613:PF02192:PF00792:PF00454:PF00794 2,72 97_413 PRO-30-20141121_HE1097_T2_ 6459 tumor 90 1789185 77.34 3553 84.72 IonXpress_064   1996 1144 852 0.43 40 - 50 >50 Premenopausal
39 17271 HE10/97 2714 97_413   YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   45985:250061 rs1042522 PF08563:PF07710:PF00870 1,36 97_413 PRO-30-20141121_HE1097_T2_ 925 tumor 90 1789185 77.34 3553 84.72 IonXpress_064   879 132 747 0.85 80 - 90 >50 Premenopausal
40 17293 HE10/97 5848 97_414   YES PIK3CA NO NO nonMUTnonSNP chr03 3q26.3 in1 178866408 AMPL4347527835 178866384 178866543 78.2     SNV C 1 C/T   PIK3CA intronic             NA     rs2699887 PF00613:PF02192:PF00792:PF00454:PF00794 -0,07 97_414a   352 tumor                     0.79 70 - 80 >50 Premenopausal
41 17299 HE10/97 5848 97_414   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 in8-ex9-in9 7576841 AMPL1516620128 7576812 7576978 50 1 2 SNV A 1 A/G   TP53 intronic             NA     rs1800899 PF08563:PF07710:PF00870 -1,12 97_414a   1313 tumor                     0.1 10 - 20 >50 Premenopausal
42 17300 HE10/97 5848 97_414   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 ex7-in7 7577407 AMPL3426752792 7577372 7577532 61 2 3 SNV A 1 A/C   TP53 intronic             NA     rs12951053 PF08563:PF07710:PF00870 -1,68 97_414a   4316 tumor                     0.33 30 - 40 >50 Premenopausal
43 17301 HE10/97 5848 97_414   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 ex7-in7 7577427 AMPL3426752792 7577372 7577532 61 2 3 SNV G 1 G/A   TP53 intronic             NA     rs12947788 PF08563:PF07710:PF00870 0,16 97_414a   4316 tumor                     0.31 30 - 40 >50 Premenopausal
44 17302 HE10/97 5848 97_414   YES TP53 YES NO other chr17 17p13.1 in6-ex7-in7 7577557 AMPL4981177402 7577472 7577638 53.4 2 3 SNV A 1 A/G   TP53 exonic missense CGC 7 p.Cys242Arg 724T>C c.724T>C   1 11738:45912:437499:342678:342679:437498:342677:1386619:44135:6530:44657:45788:45889:437500:1386621:1386620:44935   PF08563:PF07710:PF00870 2,07 97_414a   2124 tumor                     0.08 <10 >50 Premenopausal
45 17303 HE10/97 5848 97_414   YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   45985:250061 rs1042522 PF08563:PF07710:PF00870 1,36 97_414a   997 tumor                     0.54 50 - 60 >50 Premenopausal
46 17316 HE10/97 521 97_415   YES TP53 YES NO other chr17 17p13.1 in6-ex7-in7 7577557 AMPL4981177402 7577472 7577638 53.4 2 3 SNV A 1 A/G   TP53 exonic missense CGC 7 p.Cys242Arg 724T>C c.724T>C   1 11738:45912:437499:342678:342679:437498:342677:1386619:44135:6530:44657:45788:45889:437500:1386621:1386620:44935   PF08563:PF07710:PF00870 2,07 97_415 PRO-30-20141121_HE1097_T2_ 353 tumor 87,5 400528 78.42 816.2 59.33 IonXpress_067   304 180 124 0.41 40 - 50 >50 Postmenopausal
47 17318 HE10/97 521 97_415   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 in3-ex4 7579579 AMPL6795075395 7579475 7579618 52 2 3 SNV C 1 C/T   TP53 exonic synonymous CCA 4 WT 108G>A c.108G>A NA   53250 rs1800370 PF08563:PF07710:PF00870 -1,05 97_415 PRO-30-20141121_HE1097_T2_ 3026 tumor 87,5 400528 78.42 816.2 59.33 IonXpress_067   1988 622 1366 0.69 60 - 70 >50 Postmenopausal
48 17319 HE10/97 4534 97_416 1 YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 in3-ex4 7579579 AMPL6795075395 7579475 7579618 52 2 3 SNV C 1 C/T   TP53 exonic synonymous CCA 4 WT 108G>A c.108G>A NA   53250 rs1800370 PF08563:PF07710:PF00870 -1,05 97_416 PRO-30-20141121_HE1097_T2_ 541 tumor 70 102141 79.08 210.4 54.8 IonXpress_068   525 209 316 0.6 60 - 70 <=50 Premenopausal
49 17351 HE10/97 166 97_417   YES PIK3CA YES NO other chr03 3q26.3 ex21 178952085 AMPL1497305257 178951918 178952092 38.1 3 3 SNV A 1 A/T   PIK3CA exonic missense CTT 21 p.His1047Leu 3140A>T c.3140A>T NA 957 94987:94986:776:775:249874 rs121913279 PF00613:PF02192:PF00792:PF00454:PF00794 2,33 97_417 PRO-30-20141121_HE1097_T2_ 2461 tumor 85 1247960 84.1 2621 61.07 IonXpress_069   313 201 112 0.36 30 - 40 <=50 Premenopausal
50 17364 HE10/97 166 97_417   YES TP53 YES NO other chr17 17p13.1 in6-ex7-in7 7577548 AMPL4981177402 7577472 7577638 53.4 2 3 SNV C 1 C/T   TP53 exonic missense AGC 7 p.Gly245Ser 733G>A c.733G>A   1 1646855:45398:1610835:1610836:131039:121035:121036:1610837:10957:121037:1640833:6932:131040:562652:562653:11081:131042:131041:562651 rs28934575 PF08563:PF07710:PF00870 2,56 97_417 PRO-30-20141121_HE1097_T2_ 880 tumor 85 1247960 84.1 2621 61.07 IonXpress_069 1.0E-5 742 320 422 0.57 50 - 60 <=50 Premenopausal
51 17365 HE10/97 166 97_417   YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   45985:250061 rs1042522 PF08563:PF07710:PF00870 1,36 97_417 PRO-30-20141121_HE1097_T2_ 139 tumor 85 1247960 84.1 2621 61.07 IonXpress_069   113 25 88 0.78 70 - 80 <=50 Premenopausal
52 17386 HE10/97 893 97_419   YES PIK3CA NO NO nonMUTnonSNP chr03 3q26.3 in1 178866408 AMPL4347527835 178866384 178866543 78.2     SNV C 1 C/T   PIK3CA intronic             NA     rs2699887 PF00613:PF02192:PF00792:PF00454:PF00794 -0,07 97_419 PRO-30-20141121_HE1097_T2_ 509 tumor 47,5 1727710 71.88 3127 53.4 IonXpress_070   363 155 208 0.57 50 - 60 <=50 Premenopausal
53 17400 HE10/97 893 97_419   YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   45985:250061 rs1042522 PF08563:PF07710:PF00870 1,36 97_419 PRO-30-20141121_HE1097_T2_ 152 tumor 47,5 1727710 71.88 3127 53.4 IonXpress_070   102 51 51 0.5 50 - 60 <=50 Premenopausal
54 17425 HE10/97 5877 97_420   YES PIK3CA YES NO other chr03 3q26.3 ex21 178952085 AMPL1497305257 178951918 178952092 38.1 3 3 SNV A 1 A/T   PIK3CA exonic missense CTT 21 p.His1047Leu 3140A>T c.3140A>T NA 957 94987:94986:776:775:249874 rs121913279 PF00613:PF02192:PF00792:PF00454:PF00794 2,33 97_420 PRO-30-20141121_HE1097_T2_ 1161 tumor 77,5 871016 81.1 1823 82.74 IonXpress_071   650 582 68 0.1 10 - 20 <=50 Premenopausal
55 17439 HE10/97 5877 97_420   YES TP53 YES NO other chr17 17p13.1 in6-ex7-in7 7577548 AMPL4981177402 7577472 7577638 53.4 2 3 SNV C 1 C/T   TP53 exonic missense AGC 7 p.Gly245Ser 733G>A c.733G>A   1 1646855:45398:1610835:1610836:131039:121035:121036:1610837:10957:121037:1640833:6932:131040:562652:562653:11081:131042:131041:562651 rs28934575 PF08563:PF07710:PF00870 2,56 97_420 PRO-30-20141121_HE1097_T2_ 1662 tumor 77,5 871016 81.1 1823 82.74 IonXpress_071   1491 1299 192 0.13 10 - 20 <=50 Premenopausal
56 17440 HE10/97 5877 97_420   YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   45985:250061 rs1042522 PF08563:PF07710:PF00870 1,36 97_420 PRO-30-20141121_HE1097_T2_ 460 tumor 77,5 871016 81.1 1823 82.74 IonXpress_071   434 231 203 0.47 40 - 50 <=50 Premenopausal
57 17463 HE10/97 5042 97_421   YES TP53 YES NO other chr17 17p13.1 in8-ex9-in9 7576855 AMPL1516620128 7576812 7576978 50 1 2 SNV G 1 G/A   TP53 exonic nonsense TAG 9 p.Gln331* 991C>T c.991C>T NA   289612:44875:1649348:11354   PF08563:PF07710:PF00870 0,56 97_421 PRO-30-20141121_HE1097_T2_ 1458 tumor 90 1095630 84.82 2409 85.11 IonXpress_072   1298 1059 239 0.18 10 - 20 >50 Postmenopausal
58 17464 HE10/97 5042 97_421   YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   45985:250061 rs1042522 PF08563:PF07710:PF00870 1,36 97_421 PRO-30-20141121_HE1097_T2_ 953 tumor 90 1095630 84.82 2409 85.11 IonXpress_072   901 134 767 0.85 80 - 90 >50 Postmenopausal
59 17481 HE10/97 4652 97_422   YES PIK3CA YES NO other chr03 3q26.3 ex21 178952085 AMPL392292511 178952020 178952194 36.3 3 2 SNV A 1 A/G   PIK3CA exonic missense CGT 21 p.His1047Arg 3140A>G c.3140A>G NA 926 94987:94986:776:775:249874 rs121913279 PF00613:PF02192:PF00792:PF00454:PF00794 2,33 97_422 PRO-30-20141121_HE1097_T2_ 1130 tumor 55 398166 85.08 885.9 85.68 IonXpress_073   643 550 93 0.14 10 - 20 >50 Postmenopausal
60 17488 HE10/97 4652 97_422   YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   45985:250061 rs1042522 PF08563:PF07710:PF00870 1,36 97_422 PRO-30-20141121_HE1097_T2_ 501 tumor 55 398166 85.08 885.9 85.68 IonXpress_073   463 223 240 0.52 50 - 60 >50 Postmenopausal
61 17511 HE10/97 1362 97_423   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 in8-ex9-in9 7576841 AMPL1516620128 7576812 7576978 50 1 2 SNV A 1 A/G   TP53 intronic             NA     rs1800899 PF08563:PF07710:PF00870 -1,12 97_423 PRO-30-20141121_HE1097_T2_ 524 tumor 72,5 297653 81.22 622.8 80.56 IonXpress_074   477 420 57 0.12 10 - 20 <=50 Premenopausal
62 17512 HE10/97 1362 97_423   YES TP53 YES NO other chr17 17p13.1 in8-ex9-in9 7576885 AMPL1516620128 7576812 7576978 50 1 2 SNV T 1 T/A   TP53 exonic nonsense TAA 9 p.Lys321* 961A>T c.961A>T NA   44720   PF08563:PF07710:PF00870 2,03 97_423 PRO-30-20141121_HE1097_T2_ 524 tumor 72,5 297653 81.22 622.8 80.56 IonXpress_074   485 422 63 0.13 10 - 20 <=50 Premenopausal
63 17513 HE10/97 1362 97_423   YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   45985:250061 rs1042522 PF08563:PF07710:PF00870 1,36 97_423 PRO-30-20141121_HE1097_T2_ 306 tumor 72,5 297653 81.22 622.8 80.56 IonXpress_074   280 61 219 0.78 70 - 80 <=50 Premenopausal
64 17514 HE10/97 1362 97_423   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 in3-ex4 7579579 AMPL6795075395 7579475 7579618 52 2 3 SNV C 1 C/T   TP53 exonic synonymous CCA 4 WT 108G>A c.108G>A NA   53250 rs1800370 PF08563:PF07710:PF00870 -1,05 97_423 PRO-30-20141121_HE1097_T2_ 867 tumor 72,5 297653 81.22 622.8 80.56 IonXpress_074   816 681 135 0.17 10 - 20 <=50 Premenopausal
65 17515 HE10/97 2740 97_424 1 NO   NO NO                                                                                             <=50 Premenopausal
66 17540 HE10/97 200 97_429   YES PIK3CA NO NO nonMUTnonSNP chr03 3q26.3 off target 115118900 AMPL6795279620 115118832 115118979 44.9 2 1 SNV C 1 C/T                   NA     rs9821873   -2,3 97_429a PRO-30-20141121_HE1097_T2_ 177 tumor 75 64780 84.69 142.7 79.48 IonXpress_076   168 121 47 0.28 20 - 30 <=50 Premenopausal
67 17541 HE10/97 200 97_429   YES PIK3CA YES NO other chr03 3q26.3 ex 10 178936092 AMPL393459515 178935994 178936131 38.6 3 2 SNV A 1 A/G   PIK3CA exonic missense GGG 10 p.Glu545Gly 1634A>G c.1634A>G NA 1 764:12458:27155:125371:297145 rs121913274 PF00613:PF02192:PF00792:PF00454:PF00794 2,2 97_429a PRO-30-20141121_HE1097_T2_ 332 tumor 75 64780 84.69 142.7 79.48 IonXpress_076   299 239 60 0.2 20 - 30 <=50 Premenopausal
68 17547 HE10/97 200 97_429   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 ex7-in7 7577407 AMPL3426752792 7577372 7577532 61 2 3 SNV A 1 A/C   TP53 intronic             NA     rs12951053 PF08563:PF07710:PF00870 -1,68 97_429a PRO-30-20141121_HE1097_T2_ 356 tumor 75 64780 84.69 142.7 79.48 IonXpress_076   337 236 101 0.3 30 - 40 <=50 Premenopausal
69 17548 HE10/97 200 97_429   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 ex7-in7 7577427 AMPL3426752792 7577372 7577532 61 2 3 SNV G 1 G/A   TP53 intronic             NA     rs12947788 PF08563:PF07710:PF00870 0,16 97_429a PRO-30-20141121_HE1097_T2_ 356 tumor 75 64780 84.69 142.7 79.48 IonXpress_076   343 238 105 0.31 30 - 40 <=50 Premenopausal
70 17550 HE10/97 1373 97_431 1 NO   NO NO                                                                                             >50 Postmenopausal
71 17571 HE10/97 1368 97_433 1 NO   NO NO                                                                                             <=50 Premenopausal
72 17585 HE10/97 4797 97_435   YES PIK3CA NO NO nonMUTnonSNP chr03 3q26.3 ex1-in1 178866330 AMPL394912449 178866301 178866447 77.7     SNV C 1 C/T   PIK3CA utr_5     1       NA     rs149946088 PF00613:PF02192:PF00792:PF00454:PF00794 1,68 97_435b1 PRO-30-20141121_HE1097_T2_ 179 tumor 65 1539150 81.53 3170 81.59 IonXpress_079   162 50 112 0.69 60 - 70 <=50 Premenopausal
73 17586 HE10/97 4797 97_435   YES PIK3CA NO NO nonMUTnonSNP chr03 3q26.3 ex1-in1 178866408 AMPL394912449 178866301 178866447 77.7     SNV C 1 C/T   PIK3CA intronic             NA     rs2699887 PF00613:PF02192:PF00792:PF00454:PF00794 -0,07 97_435b1 PRO-30-20141121_HE1097_T2_ 179 tumor 65 1539150 81.53 3170 81.59 IonXpress_079   240 67 173 0.72 70 - 80 <=50 Premenopausal
74 17588 HE10/97 4797 97_435   YES PIK3CA YES NO other chr03 3q26.3 ex 10 178936091 AMPL393459515 178935994 178936131 38.6 3 2 SNV G 1 G/A   PIK3CA exonic missense AAG 10 p.Glu545Lys 1633G>A c.1633G>A NA 946 763:27133:295672:125370 rs104886003 PF00613:PF02192:PF00792:PF00454:PF00794 2,72 97_435b1 PRO-30-20141121_HE1097_T2_ 4506 tumor 65 1539150 81.53 3170 81.59 IonXpress_079   1998 1547 451 0.23 20 - 30 <=50 Premenopausal
75 17595 HE10/97 4797 97_435   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 ex4-in4 7579307 AMPL1481773781 7579257 7579411 56.1 2 3 SNV C 1 C/A   TP53 intronic             NA   118935:118934:118933:118932:118937:118936 rs68140816 PF08563:PF07710:PF00870 2,4 97_435b1 PRO-30-20141121_HE1097_T2_ 2976 tumor 65 1539150 81.53 3170 81.59 IonXpress_079   1993 1555 438 0.22 20 - 30 <=50 Premenopausal
76 17596 HE10/97 4797 97_435   YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   45985:250061 rs1042522 PF08563:PF07710:PF00870 1,36 97_435b1 PRO-30-20141121_HE1097_T2_ 1510 tumor 65 1539150 81.53 3170 81.59 IonXpress_079   1396 645 751 0.54 50 - 60 <=50 Premenopausal
77 17616 HE10/97 38 97_436   YES PIK3CA NO NO nonMUTnonSNP chr03 3q26.3 off target 115118900 AMPL6795279620 115118832 115118979 44.9 2 1 SNV C 1 C/T                   NA     rs9821873   -2,3 97_436 PRO-30-20141121_HE1097_T2_ 2143 tumor 85 1033522 80.55 2142 85.59 IonXpress_080   1956 253 1700 0.87 80 - 90 >50 Postmenopausal
78 17618 HE10/97 38 97_436   YES PIK3CA NO NO nonMUTnonSNP chr03 3q26.3 in1 178866408 AMPL4347527835 178866384 178866543 78.2     SNV C 1 C/T   PIK3CA intronic             NA     rs2699887 PF00613:PF02192:PF00792:PF00454:PF00794 -0,07 97_436 PRO-30-20141121_HE1097_T2_ 134 tumor 85 1033522 80.55 2142 85.59 IonXpress_080   134 64 70 0.52 50 - 60 >50 Postmenopausal
79 17619 HE10/97 38 97_436   YES PIK3CA NO NO nonMUTnonSNP chr03 3q26.3 in3 178917762 AMPL2705185935 178917726 178917900 29.9 2 1 INDEL,SNV CTTTTT 1 CTTTTC/CTTTT   PIK3CA intronic             NA     rs11409397 PF00613:PF02192:PF00792:PF00454:PF00794 -0.84,0.17,0.18,0.18,0.18,0.26 97_436 PRO-30-20141121_HE1097_T2_ 1046 tumor 85 1033522 80.55 2142 85.59 IonXpress_080   427 20 116 0.27 20 - 30 >50 Postmenopausal
80 17620 HE10/97 38 97_436   YES PIK3CA YES NO other chr03 3q26.3 ex 10 178936082 AMPL393459515 178935994 178936131 38.6 3 2 SNV G 1 G/A   PIK3CA exonic missense AAA 10 p.Glu542Lys 1624G>A c.1624G>A NA 998 125369:760:326157:17442:1659153:1659152 rs121913273 PF00613:PF02192:PF00792:PF00454:PF00794 2,72 97_436 PRO-30-20141121_HE1097_T2_ 4078 tumor 85 1033522 80.55 2142 85.59 IonXpress_080   1995 1217 778 0.39 30 - 40 >50 Postmenopausal
81 17627 HE10/97 38 97_436   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 ex7-in7 7577407 AMPL3426752792 7577372 7577532 61 2 3 SNV A 1 A/C   TP53 intronic             NA     rs12951053 PF08563:PF07710:PF00870 -1,68 97_436 PRO-30-20141121_HE1097_T2_ 2169 tumor 85 1033522 80.55 2142 85.59 IonXpress_080   1993 1780 213 0.11 10 - 20 >50 Postmenopausal
82 17628 HE10/97 38 97_436   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 ex7-in7 7577427 AMPL3426752792 7577372 7577532 61 2 3 SNV G 1 G/A   TP53 intronic             NA     rs12947788 PF08563:PF07710:PF00870 0,16 97_436 PRO-30-20141121_HE1097_T2_ 2169 tumor 85 1033522 80.55 2142 85.59 IonXpress_080   1997 1788 209 0.1 10 - 20 >50 Postmenopausal
83 17629 HE10/97 38 97_436   YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   45985:250061 rs1042522 PF08563:PF07710:PF00870 1,36 97_436 PRO-30-20141121_HE1097_T2_ 898 tumor 85 1033522 80.55 2142 85.59 IonXpress_080   829 167 662 0.8 80 - 90 >50 Postmenopausal
84 17649 HE10/97 908 97_437   YES TP53 YES NO other chr17 17p13.1 in9-ex10 7574021 AMPL387899835 7573927 7574055 62.8 1 1 SNV C 1 C/A   TP53 exonic nonsense TAG 10 p.Glu336* 1006G>T c.1006G>T NA   11291:1522200:45381   PF08563:PF07710:PF00870 -0,2 97_437 PRO-30-20141121_HE1097_T2_ 278 tumor 70 632245 85.75 1409 72.31 IonXpress_081   271 213 58 0.21 20 - 30 >50 Postmenopausal
85 17650 HE10/97 908 97_437   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 ex7-in7 7577407 AMPL3426752792 7577372 7577532 61 2 3 SNV A 1 A/C   TP53 intronic             NA     rs12951053 PF08563:PF07710:PF00870 -1,68 97_437 PRO-30-20141121_HE1097_T2_ 643 tumor 70 632245 85.75 1409 72.31 IonXpress_081   607 248 359 0.59 50 - 60 >50 Postmenopausal
86 17651 HE10/97 908 97_437   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 ex7-in7 7577427 AMPL3426752792 7577372 7577532 61 2 3 SNV G 1 G/A   TP53 intronic             NA     rs12947788 PF08563:PF07710:PF00870 0,16 97_437 PRO-30-20141121_HE1097_T2_ 643 tumor 70 632245 85.75 1409 72.31 IonXpress_081   608 271 337 0.55 50 - 60 >50 Postmenopausal
87 17652 HE10/97 908 97_437   YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   45985:250061 rs1042522 PF08563:PF07710:PF00870 1,36 97_437 PRO-30-20141121_HE1097_T2_ 715 tumor 70 632245 85.75 1409 72.31 IonXpress_081   676 407 269 0.4 40 - 50 >50 Postmenopausal
88 17672 HE10/97 303 97_438   YES TP53 YES NO other chr17 17p13.1 in5-ex6 7578289 AMPL4392179183 7578209 7578382 58.3 1 2 SNV C 1 C/A   TP53 exonic missense GTT 6 p.Gly187Val 560G>T c.560G>T NA   45471:45495:45240:44023   PF08563:PF07710:PF00870 2,54 97_438a PRO-30-20141121_HE1097_T2_ 133 tumor 80 120434 78.67 247 83.32 IonXpress_082   127 27 100 0.79 70 - 80 <=50 Premenopausal
89 17673 HE10/97 303 97_438   YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   45985:250061 rs1042522 PF08563:PF07710:PF00870 1,36 97_438a PRO-30-20141121_HE1097_T2_ 111 tumor 80 120434 78.67 247 83.32 IonXpress_082   106 19 87 0.82 80 - 90 <=50 Premenopausal
90 17674 HE10/97 4127 97_440 1 NO   NO NO                                                                                             >50 Postmenopausal
91 17701 HE10/97 1377 97_441   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 ex7-in7 7577407 AMPL3426752792 7577372 7577532 61 2 3 SNV A 1 A/C   TP53 intronic             NA     rs12951053 PF08563:PF07710:PF00870 -1,68 97_441 PRO-30-20141121_HE1097_T2_ 155 tumor 92,5 60035 86.2 136.1 76.26 IonXpress_084   140 91 49 0.35 30 - 40 >50 Postmenopausal
92 17702 HE10/97 1377 97_441   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 ex7-in7 7577427 AMPL3426752792 7577372 7577532 61 2 3 SNV G 1 G/A   TP53 intronic             NA     rs12947788 PF08563:PF07710:PF00870 0,16 97_441 PRO-30-20141121_HE1097_T2_ 155 tumor 92,5 60035 86.2 136.1 76.26 IonXpress_084   145 93 52 0.36 30 - 40 >50 Postmenopausal
93 17726 HE10/97 154 97_442   YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   45985:250061 rs1042522 PF08563:PF07710:PF00870 1,36 97_442b PRO-30-20141121_HE1097_T2_ 110 tumor 77,5 93397 86.99 209.5 76.89 IonXpress_085   103 56 47 0.46 40 - 50 <=50 Premenopausal
94 17743 HE10/97 5047 97_443   YES TP53 YES NO other chr17 17p13.1 ex8-in8 7577094 AMPL706844244 7576996 7577170 61.6 1 2 SNV G 1 G/A   TP53 exonic missense TGG 8 p.Arg282Trp 844C>T c.844C>T   1 99934:44918:10704:99925:45521:44437:44348:10992:45872:45816:1636702:45843:43585 rs28934574 PF08563:PF07710:PF00870 0,17 97_443 PRO-30-20141121_HE1097_T2_ 179 tumor 80 356244 91.92 817.1 66.08 IonXpress_086   166 64 102 0.61 60 - 70 >50 Postmenopausal
95 17744 HE10/97 5047 97_443   YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   45985:250061 rs1042522 PF08563:PF07710:PF00870 1,36 97_443 PRO-30-20141121_HE1097_T2_ 112 tumor 80 356244 91.92 817.1 66.08 IonXpress_086   104 18 86 0.83 80 - 90 >50 Postmenopausal
96 17764 HE10/97 953 97_446   YES PIK3CA NO NO nonMUTnonSNP chr03 3q26.3 off target 115118900 AMPL6795279620 115118832 115118979 44.9 2 1 SNV C 1 C/T                   NA     rs9821873   -2,3 97_446 PRO-30-20141121_HE1097_T2_ 1761 tumor 67,5 793506 75.51 1528 84.04 IonXpress_087   1703 1056 647 0.38 30 - 40 <=50 Postmenopausal
97 17769 HE10/97 953 97_446   YES TP53 YES NO other chr17 17p13.1 ex8-in8 7577061 AMPL706844244 7576996 7577170 61.6 1 2 INDEL C 1 C/CT   TP53 exonic frameshiftInsertion   8 p.Gly293Arg 876_877insA c.876_877insA NA   43890:46165:45713:44207:45417:46261   PF08563:PF07710:PF00870 0,76 97_446 PRO-30-20141121_HE1097_T2_ 931 tumor 67,5 793506 75.51 1528 84.04 IonXpress_087   863 687 176 0.2 20 - 30 <=50 Postmenopausal
98 17770 HE10/97 953 97_446   YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   45985:250061 rs1042522 PF08563:PF07710:PF00870 1,36 97_446 PRO-30-20141121_HE1097_T2_ 599 tumor 67,5 793506 75.51 1528 84.04 IonXpress_087   561 78 483 0.86 80 - 90 <=50 Postmenopausal
99 17801 HE10/97 5483 97_455   YES TP53 YES NO other chr17 17p13.1 ex8-in8 7577120 AMPL706844244 7576996 7577170 61.6 1 2 SNV C 1 C/T   TP53 exonic missense CAT 8 p.Arg273His 818G>A c.818G>A NA   1646808:99729:1640828:165077:10779:43896:10660:44701:318169:45787:44324:1645335 rs28934576 PF08563:PF07710:PF00870 2,56 97_455 PRO-30-20141121_HE1097_T2_ 419 tumor 87,5 322119 78.66 651 83.87 IonXpress_088   392 312 80 0.2 20 - 30 >50 Postmenopausal
100 17802 HE10/97 5483 97_455   YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   45985:250061 rs1042522 PF08563:PF07710:PF00870 1,36 97_455 PRO-30-20141121_HE1097_T2_ 173 tumor 87,5 322119 78.66 651 83.87 IonXpress_088   163 51 112 0.69 60 - 70 >50 Postmenopausal
101 17820 HE10/97 1385 97_461   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 in6-ex7-in7 7577610 AMPL4981177402 7577472 7577638 53.4 2 3 SNV T 1 T/C   TP53 splicesite_5     7       NA   25225:119000:118999:323937:119001:323939:45060:323938:98015:98016:6908:12559:33649:1649397:41575   PF08563:PF07710:PF00870 1,75 97_461a PRO-30-20141121_HE1097_T2_ 262 tumor 65 122113 69.43 214.2 76.65 IonXpress_089   236 181 55 0.23 20 - 30 >50 Postmenopausal
102 17821 HE10/97 1385 97_461   YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   45985:250061 rs1042522 PF08563:PF07710:PF00870 1,36 97_461a PRO-30-20141121_HE1097_T2_ 139 tumor 65 122113 69.43 214.2 76.65 IonXpress_089   134 22 112 0.84 80 - 90 >50 Postmenopausal
103 17845 HE10/97 3714 97_464   YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   45985:250061 rs1042522 PF08563:PF07710:PF00870 1,36 97_464b PRO-30-20141121_HE1097_T2_ 839 tumor 60 755737 83.83 1648 83.03 IonXpress_090   776 487 289 0.37 30 - 40 >50 Postmenopausal
104 17857 HE10/97 959 97_071   YES PIK3CA NO NO nonMUTnonSNP chr03 3q26.3 off target 115118900 AMPL6795279620 115118832 115118979 44.9 2 1 SNV C 1 C/T                   NA     rs9821873   -2,3 97_071b PRO-29-HE1097_T1_ 4670 tumor 90 1145418       IonXpress_001   1993 1042 951 0.48 40 - 50 >50 Postmenopausal
105 17858 HE10/97 959 97_071   YES PIK3CA NO NO nonMUTnonSNP chr03 3q26.3 in 10-ex11 178936940 AMPL391535344 178936910 178937071 35.8 3 2 SNV C 1 C/A   PIK3CA intronic             NA     rs141589697 PF00613:PF02192:PF00792:PF00454:PF00794 0,89 97_071b PRO-29-HE1097_T1_ 1947 tumor 90 1145418       IonXpress_001   1710 879 831 0.49 40 - 50 >50 Postmenopausal
106 17868 HE10/97 959 97_071   YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   45985:250061 rs1042522 PF08563:PF07710:PF00870 1,36 97_071b PRO-29-HE1097_T1_ 1098 tumor 90 1145418       IonXpress_001   999 509 490 0.49 40 - 50 >50 Postmenopausal
107 17886 HE10/97 1322 97_074   YES TP53 YES NO other chr17 17p13.1 ex4 (intraexonic) 7579416 AMPL6794971662 7579363 7579535 66.4 1 2 INDEL AGGAG 1 AGGAG/AGAG   TP53 exonic frameshiftDeletion   4 p.Trp91Gly 270_270delC c.270_270delC NA   131024:46356:131025:44019:131026:242659:242658:242657 rs66998338 PF08563:PF07710:PF00870 2.07,0.07,1.24,-1.15,-0.61 97_074a PRO-29-HE1097_T1_ 321 tumor 80 300823       IonXpress_002 7.38E-6 277 216 61 0.22 20 - 30 <=50 Premenopausal
108 17887 HE10/97 1322 97_074   YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   45985:250061 rs1042522 PF08563:PF07710:PF00870 1,36 97_074a PRO-29-HE1097_T1_ 321 tumor 80 300823       IonXpress_002 2.72999953559E-295 306 30 276 0.9 90 - 100 <=50 Premenopausal
109 17905 HE10/97 1330 97_076   YES PIK3CA NO NO nonMUTnonSNP chr03 3q26.3 off target 115118900 AMPL6795279620 115118832 115118979 44.9 2 1 SNV C 1 C/T                   NA     rs9821873   -2,3 97_076b PRO-29-HE1097_T1_ 751 tumor 60 205776       IonXpress_003 1.0E-5 721 303 418 0.58 50 - 60 <=50 Premenopausal
110 17906 HE10/97 1330 97_076   YES PIK3CA YES NO other chr03 3q26.3 ex21 178952085 AMPL1497305257 178951918 178952092 38.1 3 3 SNV A 1 A/T   PIK3CA exonic missense CTT 21 p.His1047Leu 3140A>T c.3140A>T NA 957 94987:94986:776:775:249874 rs121913279 PF00613:PF02192:PF00792:PF00454:PF00794 2,33 97_076b PRO-29-HE1097_T1_ 504 tumor 60 205776       IonXpress_003 7.76E-13 358 302 56 0.16 10 - 20 <=50 Premenopausal
111 17913 HE10/97 1330 97_076   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 in8-ex9-in9 7576841 AMPL1516620128 7576812 7576978 50 1 2 SNV A 1 A/G   TP53 intronic             NA     rs1800899 PF08563:PF07710:PF00870 -1,12 97_076b PRO-29-HE1097_T1_ 231 tumor 60 205776       IonXpress_003 1.95E-12 227 185 42 0.19 10 - 20 <=50 Premenopausal
112 17914 HE10/97 1330 97_076   YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   45985:250061 rs1042522 PF08563:PF07710:PF00870 1,36 97_076b PRO-29-HE1097_T1_ 203 tumor 60 205776       IonXpress_003 3.95E-14 192 138 54 0.28 20 - 30 <=50 Premenopausal
113 17915 HE10/97 1330 97_076   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 in3-ex4 7579579 AMPL6795075395 7579475 7579618 52 2 3 SNV C 1 C/T   TP53 exonic synonymous CCA 4 WT 108G>A c.108G>A NA   53250 rs1800370 PF08563:PF07710:PF00870 -1,05 97_076b PRO-29-HE1097_T1_ 683 tumor 60 205776       IonXpress_003 2.16E-65 664 481 183 0.28 20 - 30 <=50 Premenopausal
114 17932 HE10/97 1389 97_077   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 ex7-in7 7577407 AMPL3426752792 7577372 7577532 61 2 3 SNV A 1 A/C   TP53 intronic             NA     rs12951053 PF08563:PF07710:PF00870 -1,68 97_077a PRO-29-HE1097_T1_ 2380 tumor 60 473532       IonXpress_004 1.04E-266 1994 1381 613 0.31 30 - 40 >50 Postmenopausal
115 17933 HE10/97 1389 97_077   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 ex7-in7 7577427 AMPL3426752792 7577372 7577532 61 2 3 SNV G 1 G/A   TP53 intronic             NA     rs12947788 PF08563:PF07710:PF00870 0,16 97_077a PRO-29-HE1097_T1_ 2380 tumor 60 473532       IonXpress_004 8.38E-254 1997 1397 600 0.3 30 - 40 >50 Postmenopausal
116 17934 HE10/97 1389 97_077   YES TP53 YES NO other chr17 17p13.1 ex6-in6 7578190 AMPL4574207192 7578114 7578273 53.5 1 1 SNV T 1 T/C   TP53 exonic missense TGT 6 p.Tyr220Cys 659A>G c.659A>G NA   44978:99720:1564199:1564198:99718:1564197:99719:10758:251428:43850:1564200:251427:1644277:251426 rs121912666 PF08563:PF07710:PF00870 2,13 97_077a PRO-29-HE1097_T1_ 483 tumor 60 473532       IonXpress_004 1.34E-22 470 369 101 0.21 20 - 30 >50 Postmenopausal
117 17935 HE10/97 1389 97_077   YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   45985:250061 rs1042522 PF08563:PF07710:PF00870 1,36 97_077a PRO-29-HE1097_T1_ 561 tumor 60 473532       IonXpress_004 1.57E-246 533 212 321 0.6 60 - 70 >50 Postmenopausal
118 17969 HE10/97 1361 97_078   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 ex7-in7 7577407 AMPL3426752792 7577372 7577532 61 2 3 SNV A 1 A/C   TP53 intronic             NA     rs12951053 PF08563:PF07710:PF00870 -1,68 97_078a PRO-29-HE1097_T1_ 6014 tumor 60 1469597       IonXpress_006 1.35E-289 1986 1349 637 0.32 30 - 40 <=50 Premenopausal
119 17970 HE10/97 1361 97_078   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 ex7-in7 7577427 AMPL3426752792 7577372 7577532 61 2 3 SNV G 1 G/A   TP53 intronic             NA     rs12947788 PF08563:PF07710:PF00870 0,16 97_078a PRO-29-HE1097_T1_ 6014 tumor 60 1469597       IonXpress_006 8.43E-269 1998 1381 617 0.31 30 - 40 <=50 Premenopausal
120 17972 HE10/97 1361 97_078   YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   45985:250061 rs1042522 PF08563:PF07710:PF00870 1,36 97_078a PRO-29-HE1097_T1_ 1322 tumor 60 1469597       IonXpress_006   1231 516 715 0.58 50 - 60 <=50 Premenopausal
121 18011 HE10/97 670 97_081   YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   45985:250061 rs1042522 PF08563:PF07710:PF00870 1,36 97_081a PRO-29-HE1097_T1_ 192 tumor 80 127277       IonXpress_008 3.62E-50 84 20 64 0.76 70 - 80 >50 Postmenopausal
122 18036 HE10/97 528 97_083   YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   45985:250061 rs1042522 PF08563:PF07710:PF00870 1,36 97_083 PRO-29-HE1097_T1_ 1933 tumor   1572853       IonXpress_009   1811 200 1611 0.89 80 - 90 >50 Postmenopausal
123 18077 HE10/97 5900 97_088   YES TP53 YES NO other chr17 17p13.1 in6-ex7-in7 7577539 AMPL4981177402 7577472 7577638 53.4 2 3 SNV G 1 G/A   TP53 exonic missense TGG 7 p.Arg248Trp 742C>T c.742C>T   1 6546:6545:44920:1640831:120006:120005:1189381:120007:11564:10656:1189383:1189382 rs121912651 PF08563:PF07710:PF00870 0,64 97_088b PRO-29-HE1097_T1_ 290 tumor 90 128687       IonXpress_010 1.52E-11 262 218 44 0.17 10 - 20 >50 Postmenopausal
124 18079 HE10/97 5900 97_088   YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   45985:250061 rs1042522 PF08563:PF07710:PF00870 1,36 97_088b PRO-29-HE1097_T1_ 114 tumor 90 128687       IonXpress_010 1.38E-58 103 28 75 0.73 70 - 80 >50 Postmenopausal
125 18085 HE10/97 3700 97_089 1 NO   NO NO                                                                                             >50 Postmenopausal
126 18110 HE10/97 4804 97_090 1 NO   NO NO                                                                                             >50 Postmenopausal
127 18139 HE10/97 5324 97_092   YES TP53 YES NO other chr17 17p13.1 in8-ex9-in9 7576891 AMPL1516620128 7576812 7576978 50 1 2 INDEL TTGGC 4 TTGGC/T   TP53 exonic frameshiftDeletion   9 p.Pro318Arg 951_954delGCCA c.951_954delGCCA NA   11658:220789:44071   PF08563:PF07710:PF00870 2.17,0.44,-0.1,0.62,-0.46 97_092a PRO-29-HE1097_T1_ 261 tumor 95 409325       IonXpress_013 8.47E-140 245 76 169 0.69 60 - 70 >50 Postmenopausal
128 18141 HE10/05 17839 BR5-002 1 YES TP53 YES NO other chr17 17p13.1 in6-ex7-in7 7577604 AMPL4981177402 7577472 7577638 53.4 2 3 SNV C 1 C/T   TP53 exonic missense GAC 7 p.Gly226Asp 677G>A c.677G>A NA   keratosis:adenocarcinoma:squamous_cell_carcinoma:NK-T_cell_lymphoma:hepatocellular_carcinoma:basal_cell_carcinoma:non_small_cell_carcinoma:carcinoma   P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 0,62 BR5-002T PRO-7-20140313_BR5_T1_ 458 tumor 80 247934 86.49 578 77.85 IonXpress_050 1.0E-5 431 367 64 0.15 10 - 20 >50 Postmenopausal
129 18166 HE10/05 17839 BR5-002   YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR5-002T PRO-7-20140313_BR5_T1_ 152 tumor 80 247934 86.49 578 77.85 IonXpress_050 1.0E-5 144 26 118 0.82 80 - 90 >50 Postmenopausal
130 18188 HE10/05 17500 BR5-006   YES PIK3CA NO YES other chr03 3q26.3 off target 115118900 AMPL6795279620 115118832 115118979 44.9 2 1 SNV C 1 C/T 0.066                 NA     rs9821873   -2,3 BR5-006T PRO-7-20140313_BR5_T1_ 835 tumor 50 139936 83.98 310 73.76 IonXpress_052 1.0E-5 793 371 422 0.53 50 - 60 >50 Postmenopausal
131 18201 HE10/05 17486 BR5-007 1 NO   NO NO                                                                                             >50 Postmenopausal
132 18214 HE10/05 16681 BR5-008 1 YES TP53 YES NO other chr17 17p13.1 ex6-in6 7578196 AMPL4574207192 7578114 7578273 53.5 1 1 SNV A 1 A/C   TP53 exonic missense GGG 6 p.Val218Gly 653T>G c.653T>G NA   astrocytoma_Grade_I:dysplasia:adenocarcinoma:squamous_cell_carcinoma:hepatocellular_carcinoma:NK-T_cell_lymphoma:intestil_adenocarcinoma:Barrett_oesophagus:non_small_cell_carcinoma:follicular_lymphoma:small_cell_carcinoma:carcinoma:serous_carcinoma   P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 2,13 BR5-008T PRO-7-20140313_BR5_T1_ 435 tumor 60 409796 83.39 920.4 77.33 IonXpress_054 1.0E-5 406 276 130 0.32 30 - 40 <=50 Premenopausal
133 18237 HE10/05 16681 BR5-008   YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR5-008T PRO-7-20140313_BR5_T1_ 312 tumor 60 409796 83.39 920.4 77.33 IonXpress_054 1.0E-5 280 201 79 0.28 20 - 30 <=50 Premenopausal
134 18238 HE10/05 17447 BR5-011 1 YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR5-011bT PRO-7-20140313_BR5_T1_ 295 tumor 50 634078 81.89 1369 77.25 IonXpress_055 1.0E-5 274 60 214 0.78 70 - 80 <=50 Premenopausal
135 18439 HE10/05 17485 BR5-013   YES PIK3CA YES NO other chr03 3q26.3 ex 10 178936091 AMPL393459515 178935994 178936131 38.6 3 2 SNV G 1 G/A   PIK3CA exonic missense AAG 10 p.Glu545Lys 1633G>A c.1633G>A NA 946 HER-positive_carcinoma:intestil_adenocarcinoma:Merkel_cell_carcinoma:lobular_carcinoma:endometrioid_carcinoma:carcinoid-endocrine_tumour:mucinous_carcinoma:adenoid_cystic_carcinoma:serrated_carcinoma:adenoma:sopharyngeal_carcinoma:basal_cell_carcinoma rs104886003 PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 2,72 BR5-013T PRO-7-20140313_BR5_T1_ 521 tumor 80 195612 51.67 256 71.4 IonXpress_056 1.0E-5 516 103 413 0.8 80 - 90 >50 Postmenopausal
136 18441 HE10/05 17485 BR5-013   YES PIK3CA YES NO other chr03 3q26.3 ex21 178952096 AMPL392292511 178952020 178952194 36.3 3 2 SNV T 1 T/G   PIK3CA exonic missense GGG 21 p.Trp1051Gly 3151T>G c.3151T>G NA 1 adenocarcinoma   PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 2,33 BR5-013T PRO-7-20140313_BR5_T1_ 733 tumor 80 195612 51.67 256 71.4 IonXpress_056 2.0E-5 407 364 43 0.11 10 - 20 >50 Postmenopausal
137 18442 HE10/05 17485 BR5-013   YES PIK3CA NO NO nonMUTnonSNP chr03 3q26.3 ex21 178952151 AMPL392292511 178952020 178952194 36.3 3 2 SNV G 1 G/A   PIK3CA exonic synonymous TAA 21 WT 3206G>A c.3206G>A NA       PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 2,89 BR5-013T PRO-7-20140313_BR5_T1_ 733 tumor 80 195612 51.67 256 71.4 IonXpress_056 1.0E-5 570 500 70 0.12 10 - 20 >50 Postmenopausal
138 18484 HE10/05 17485 BR5-013   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 ex7-in7 7577443 AMPL3426752792 7577372 7577532 61 2 3 SNV C 1 C/T   TP53 intronic             NA     rs67056327 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 0,45 BR5-013T PRO-7-20140313_BR5_T1_ 271 tumor 80 195612 51.67 256 71.4 IonXpress_056 1.0E-5 260 202 58 0.22 20 - 30 >50 Postmenopausal
139 18485 HE10/05 17485 BR5-013   YES TP53 YES NO other chr17 17p13.1 in6-ex7-in7 7577533 AMPL4981177402 7577472 7577638 53.4 2 3 SNV G 1 G/A   TP53 exonic missense TCC 7 p.Pro250Ser 748C>T c.748C>T NA 1 pheochromocytoma:granulosa_cell_tumour:adenocarcinoma:squamous_cell_carcinoma:adrel_cortical_adenoma:basal_cell_carcinoma:non_small_cell_carcinoma:lobular_carcinoma:ductal_carcinoma:undifferentiated_carcinoma:carcinoma:chronic_lymphocytic_leukaemia-smal   P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 2,56 BR5-013T PRO-7-20140313_BR5_T1_ 275 tumor 80 195612 51.67 256 71.4 IonXpress_056 1.0E-5 261 167 94 0.36 30 - 40 >50 Postmenopausal
140 18486 HE10/05 17485 BR5-013   YES TP53 YES NO other chr17 17p13.1 in6-ex7-in7 7577592 AMPL4981177402 7577472 7577638 53.4 2 3 SNV G 1 G/A   TP53 exonic missense ATC 7 p.Thr230Ile 689C>T c.689C>T NA 1 transitiol_cell_carcinoma:adenocarcinoma:squamous_cell_carcinoma:primitive_neuroectodermal_tumour-medulloblastoma:astrocytoma_Grade_IV:small_round_cell_tumour:actinic_keratosis:ductal_carcinoma:carcinoma   P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 2,48 BR5-013T PRO-7-20140313_BR5_T1_ 275 tumor 80 195612 51.67 256 71.4 IonXpress_056 1.0E-5 270 167 103 0.38 30 - 40 >50 Postmenopausal
141 18528 HE10/05 15727 BR5-016   YES PIK3CA YES NO other chr03 3q26.3 ex21 178952085 AMPL1497305257 178951918 178952092 38.1 3 3 SNV A 1 A/G   PIK3CA exonic missense CGT 21 p.His1047Arg 3140A>G c.3140A>G NA 926 HER-positive_carcinoma:ductal_epithelial_hyperplasia-hyperplasia_of_usual_type:hepatocellular_carcinoma:SHH_subtype:Merkel_cell_carcinoma:lobular_carcinoma:mixed_endometrioid_and_clear_cell_carcinoma:sopharyngeal_carcinoma:endometriosis:papilloma:mixed_ rs121913279 PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 2,33 BR5-016T PRO-7-20140313_BR5_T1_ 14196 tumor 80 2114205 84.14 4709 45.07 IonXpress_058 1.0E-5 124 65 59 0.48 40 - 50 <=50 Premenopausal
142 18644 HE10/05 16365 BR5-017   YES TP53 YES NO other chr17 17p13.1 ex7-in7 7577527 AMPL3426752792 7577372 7577532 61 2 3 SNV G 1 G/A   TP53 exonic missense TTC 7 p.Leu252Phe 754C>T c.754C>T NA 676 adenocarcinoma:squamous_cell_carcinoma:hepatocellular_carcinoma:NK-T_cell_lymphoma:non_small_cell_carcinoma:serous_carcinoma:carcinoma   P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif -0,04 BR5-017T PRO-7-20140313_BR5_T1_ 1485 tumor 75 546175 62.71 872.5 79.19 IonXpress_059 1.0E-5 895 803 92 0.1 10 - 20 >50 Premenopausal
143 18648 HE10/05 16365 BR5-017   YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR5-017T PRO-7-20140313_BR5_T1_ 694 tumor 75 546175 62.71 872.5 79.19 IonXpress_059 1.0E-5 631 153 478 0.76 70 - 80 >50 Premenopausal
144 18657 HE10/05 17467 BR5-019 1 NO   NO NO                                                                                             <=50 Premenopausal
145 18688 HE10/05 17628 BR5-022 1 YES TP53 YES NO other chr17 17p13.1 ex8-in8 7577081 AMPL706844244 7576996 7577170 61.6 1 2 INDEL T 8 T/TCCTCTGTG   TP53 exonic frameshiftInsertion   8 p.Glu286Ala 848_849insCACAGAGG c.848_849insCACAGAGG NA   angiosarcoma:hepatocellular_carcinoma:follicular_lymphoma:Burkitt_lymphoma:small_cell_carcinoma:serous_carcinoma:endometrioid_carcinoma:acute_myeloid_leukaemia:transitiol_cell_carcinoma:diffuse_large_B_cell_lymphoma:adenocarcinoma:squamous_cell_carcinom   P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 0,97 BR5-022T PRO-7-20140313_BR5_T1_ 376 tumor 50 272699 80.99 572.5 76.26 IonXpress_062 1.0E-5 351 279 72 0.21 20 - 30 <=50 Premenopausal
146 18712 HE10/05 17628 BR5-022   YES PIK3CA NO YES other chr03 3q26.3 in3 178917844 AMPL2705185935 178917726 178917900 29.9 2 1 INDEL TA 1 TA/T 0.013 PIK3CA intronic             NA     rs146815076 PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 -0.63,1.03 BR5-022T PRO-7-20140313_BR5_T1_ 385 tumor 50 272699 80.99 572.5 76.26 IonXpress_062 1.0E-5 373 161 212 0.57 50 - 60 <=50 Premenopausal
147 18724 HE10/05 17628 BR5-022   YES TP53 NO YES other chr17 17p13.1 ex7-in7 7577407 AMPL3426752792 7577372 7577532 61 2 3 SNV A 1 A/C 0.163 TP53 intronic             NA     rs12951053 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif -1,68 BR5-022T PRO-7-20140313_BR5_T1_ 552 tumor 50 272699 80.99 572.5 76.26 IonXpress_062 1.0E-5 507 214 293 0.58 50 - 60 <=50 Premenopausal
148 18725 HE10/05 17628 BR5-022   YES TP53 NO YES other chr17 17p13.1 ex7-in7 7577427 AMPL3426752792 7577372 7577532 61 2 3 SNV G 1 G/A 0.163 TP53 intronic             NA     rs12947788 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 0,16 BR5-022T PRO-7-20140313_BR5_T1_ 552 tumor 50 272699 80.99 572.5 76.26 IonXpress_062 1.0E-5 521 225 296 0.57 50 - 60 <=50 Premenopausal
149 18726 HE10/05 17631 BR5-023 1 YES TP53 YES NO other chr17 17p13.1 in6-ex7-in7 7577581 AMPL4981177402 7577472 7577638 53.4 2 3 SNV A 1 A/G   TP53 exonic missense CAC 7 p.Tyr234His 700T>C c.700T>C NA 997 pterygium:keratoacanthoma:malignt_melanoma:MALT_lymphoma:Wilms_tumour:follicular_lymphoma:Burkitt_lymphoma:serous_carcinoma:endometrioid_carcinoma:acute_myeloid_leukaemia:keratosis:transitiol_cell_carcinoma:adenocarcinoma:diffuse_large_B_cell_lymphoma   P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 2,07 BR5-023cT PRO-7-20140313_BR5_T1_ 433 tumor 70 420303 84.88 926.8 77.93 IonXpress_063 9.0E-5 409 368 41 0.1 10 - 20 <=50 Premenopausal
150 18728 HE10/05 17631 BR5-023   YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 C/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR5-023cT PRO-7-20140313_BR5_T1_ 142 tumor 70 420303 84.88 926.8 77.93 IonXpress_063 1.0E-5 129 94 35 0.27 20 - 30 <=50 Premenopausal
151 18757 HE10/05 17001 BR5-024 1 YES TP53 YES NO other chr17 17p13.1 in6-ex7-in7 7577539 AMPL4981177402 7577472 7577638 53.4 2 3 SNV G 1 G/A   TP53 exonic missense TGG 7 p.Arg248Trp 742C>T c.742C>T NA 1 HER-positive_carcinoma:oligodendroglioma:hepatocellular_carcinoma:Merkel_cell_carcinoma:follicular_lymphoma:chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma:superficial_spreading:hyperplasia:basal_cell_carcinoma:osteosarcoma:astrocytoma:pleomorphi rs121912651 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 0,64 BR5-024T PRO-7-20140313_BR5_T1_ 1309 tumor 60 1984616 72.76 3570 77.27 IonXpress_064 1.0E-5 1164 995 169 0.15 10 - 20 <=50 Premenopausal
152 18758 HE10/05 17001 BR5-024   YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR5-024T PRO-7-20140313_BR5_T1_ 389 tumor 60 1984616 72.76 3570 77.27 IonXpress_064 1.0E-5 361 258 103 0.29 20 - 30 <=50 Premenopausal
153 18796 HE10/05 17001 BR5-024   YES TP53 NO YES nonMUTnonSNP chr17 17p13.1 ex6-in6 7578210 AMPL4574207192 7578114 7578273 53.5 1 1 SNV T 1 T/C 0.007 TP53 exonic synonymous CGG 6 WT 639A>G c.639A>G NA   oligodendroglioma_Grade_II:adenocarcinoma:adenoma:carcinoma rs1800372 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif -0,16 BR5-024T PRO-7-20140313_BR5_T1_ 487 tumor 60 1984616 72.76 3570 77.27 IonXpress_064 1.0E-5 466 247 219 0.47 40 - 50 <=50 Premenopausal
154 18797 HE10/05 17001 BR5-024   YES TP53 YES NO other chr17 17p13.1 ex5-in5 7578388 AMPL1992796664 7578284 7578458 63.7 1 2 SNV C 1 C/T   TP53 exonic missense CAC 5 p.Arg181His 542G>A c.542G>A NA   carcinoid-endocrine_tumour:transitiol_cell_carcinoma:adenocarcinoma:squamous_cell_carcinoma:hyperplasia:primitive_neuroectodermal_tumour-medulloblastoma:hepatocellular_carcinoma:astrocytoma_Grade_IV:clear_cell_rel_cell_carcinoma:clear_cell_carcinoma:s   P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,35 BR5-024T PRO-7-20140313_BR5_T1_ 1125 tumor 60 1984616 72.76 3570 77.27 IonXpress_064 1.0E-5 942 857 85 0.09 <10 <=50 Premenopausal
155 18798 HE10/05 17164 BR5-026 1 YES TP53 YES NO other chr17 17p13.1 in4-ex5 7578508 AMPL6326144323 7578407 7578581 61.7 1 3 SNV C 1 C/T   TP53 exonic missense TAC 5 p.Cys141Tyr 422G>A c.422G>A NA   angiosarcoma:lymphoid_neoplasm:oligodendroglioma:hepatocellular_carcinoma:Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour:synovial_sarcoma:intestil_adenocarcinoma:endometrioid_carcinoma:myelodysplastic_syndrome:non_small_cell_carcinoma:diffus   P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,43 BR5-026T PRO-7-20140313_BR5_T1_ 3845 tumor 80 3934114 84.41 8508 80.65 IonXpress_065 1.0E-5 1992 1471 521 0.26 20 - 30 >50 Postmenopausal
156 18823 HE10/05 17164 BR5-026   YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR5-026T PRO-7-20140313_BR5_T1_ 1893 tumor 80 3934114 84.41 8508 80.65 IonXpress_065 1.0E-5 1724 244 1480 0.86 80 - 90 >50 Postmenopausal
157 18889 HE10/05 17265 BR5-027   YES PIK3CA NO NO nonMUTnonSNP chr03 3q26.3 off target 115118855 AMPL6795277223 115118748 115118874 48.8 3 3 SNV C 1 C/T                   NA         0,39 BR5-027T PRO-7-20140313_BR5_T1_ 361 tumor 85 123874 51.92 154.3 53.6 IonXpress_066 1.0E-5 229 165 64 0.28 20 - 30 >50 Postmenopausal
158 18891 HE10/05 17265 BR5-027   YES PIK3CA YES NO other chr03 3q26.3 ex 10 178936093 AMPL393459515 178935994 178936131 38.6 3 2 SNV G 1 G/T   PIK3CA exonic missense GAT 10 p.Glu545Asp 1635G>T c.1635G>T NA 996 HER-positive_carcinoma:adenocarcinoma:squamous_cell_carcinoma:acute_lymphoblastic_T_cell_leukaemia:carcinoma:endometrioid_carcinoma rs121913275 PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 0,24 BR5-027T PRO-7-20140313_BR5_T1_ 814 tumor 85 123874 51.92 154.3 53.6 IonXpress_066 1.0E-5 798 721 77 0.1 10 - 20 >50 Postmenopausal
159 18892 HE10/05 17265 BR5-027   YES PIK3CA YES NO other chr03 3q26.3 ex20-in20 178948154 AMPL1496009646 178948084 178948232 36.3 3 1 SNV G 1 G/A   PIK3CA exonic missense AAA 21 p.Glu976Lys 2926G>A c.2926G>A NA 544     PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 2,46 BR5-027T PRO-7-20140313_BR5_T1_ 437 tumor 85 123874 51.92 154.3 53.6 IonXpress_066 1.0E-5 421 371 50 0.12 10 - 20 >50 Postmenopausal
160 18894 HE10/05 17265 BR5-027   YES PIK3CA NO NO nonMUTnonSNP chr03 3q26.3 ex21 178952047 AMPL392292511 178952020 178952194 36.3 3 2 SNV G 1 G/A   PIK3CA exonic synonymous GAA 21 WT 3102G>A c.3102G>A NA       PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 0,88 BR5-027T PRO-7-20140313_BR5_T1_ 181 tumor 85 123874 51.92 154.3 53.6 IonXpress_066 1.0E-5 107 60 47 0.44 40 - 50 >50 Postmenopausal
161 18928 HE10/05 17265 BR5-027   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 ex4-in4 7579278 AMPL1481773781 7579257 7579411 56.1 2 3 SNV G 1 G/A   TP53 intronic             NA       P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif -0,01 BR5-027T PRO-7-20140313_BR5_T1_ 208 tumor 85 123874 51.92 154.3 53.6 IonXpress_066 1.0E-5 200 142 58 0.29 20 - 30 >50 Postmenopausal
162 18929 HE10/05 17265 BR5-027   YES TP53 YES NO other chr17 17p13.1 in3-ex4 7579550 AMPL6795075395 7579475 7579618 52 2 3 SNV G 1 G/C   TP53 exonic missense TGC 4 p.Ser46Cys 137C>G c.137C>G NA   transitiol_cell_carcinoma:NK-T_cell_lymphoma   P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 0,42 BR5-027T PRO-7-20140313_BR5_T1_ 292 tumor 85 123874 51.92 154.3 53.6 IonXpress_066 1.0E-5 289 246 43 0.15 10 - 20 >50 Postmenopausal
163 18939 HE10/05 17655 BR5-028 1 YES TP53 NO YES other chr17 17p13.1 ex7-in7 7577407 AMPL3426752792 7577372 7577532 61 2 3 SNV A 1 C/C 0.163 TP53 intronic             NA     rs12951053 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif -1,68 BR5-028T PRO-7-20140313_BR5_T1_ 5264 tumor 60 2057872 69.53 3560 47.13 IonXpress_067 1.0E-5 1916   1916 1 90 - 100 >50 Postmenopausal
164 18950 HE10/05 17655 BR5-028   YES PIK3CA NO YES other chr03 3q26.3 off target 115118900 AMPL6795279620 115118832 115118979 44.9 2 1 SNV C 1 C/T 0.066                 NA     rs9821873   -2,3 BR5-028T PRO-7-20140313_BR5_T1_ 8624 tumor 60 2057872 69.53 3560 47.13 IonXpress_067 1.0E-5 1996 1153 843 0.42 40 - 50 >50 Postmenopausal
165 18958 HE10/05 17655 BR5-028   YES TP53 NO YES other chr17 17p13.1 ex7-in7 7577427 AMPL3426752792 7577372 7577532 61 2 3 SNV G 1 A/A 0.163 TP53 intronic             NA     rs12947788 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 0,16 BR5-028T PRO-7-20140313_BR5_T1_ 5264 tumor 60 2057872 69.53 3560 47.13 IonXpress_067 1.0E-5 1976   1976 1 90 - 100 >50 Postmenopausal
166 18960 HE10/05 17961 BR5-029 1 YES TP53 NO YES other chr17 17p13.1 ex7-in7 7577407 AMPL3426752792 7577372 7577532 61 2 3 SNV A 1 A/C 0.163 TP53 intronic             NA     rs12951053 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif -1,68 BR5-029T PRO-7-20140313_BR5_T1_ 1284 tumor 80 395234 71.25 698.4 51.87 IonXpress_068 1.0E-5 1073 296 777 0.72 70 - 80 <=50 Premenopausal
167 18978 HE10/05 17961 BR5-029   YES PIK3CA YES NO other chr03 3q26.3 ex 10 178936091 AMPL393459515 178935994 178936131 38.6 3 2 SNV G 1 G/A   PIK3CA exonic missense AAG 10 p.Glu545Lys 1633G>A c.1633G>A NA 946 HER-positive_carcinoma:intestil_adenocarcinoma:Merkel_cell_carcinoma:lobular_carcinoma:endometrioid_carcinoma:carcinoid-endocrine_tumour:mucinous_carcinoma:adenoid_cystic_carcinoma:serrated_carcinoma:adenoma:sopharyngeal_carcinoma:basal_cell_carcinoma rs104886003 PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 2,72 BR5-029T PRO-7-20140313_BR5_T1_ 6058 tumor 80 395234 71.25 698.4 51.87 IonXpress_068 1.0E-5 1996 1388 608 0.3 30 - 40 <=50 Premenopausal
168 18987 HE10/05 17961 BR5-029   YES TP53 NO YES other chr17 17p13.1 ex7-in7 7577427 AMPL3426752792 7577372 7577532 61 2 3 SNV G 1 G/A 0.163 TP53 intronic             NA     rs12947788 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 0,16 BR5-029T PRO-7-20140313_BR5_T1_ 1284 tumor 80 395234 71.25 698.4 51.87 IonXpress_068 1.0E-5 1180 340 840 0.71 70 - 80 <=50 Premenopausal
169 19014 HE10/05 17850 BR5-030   YES PIK3CA NO YES nonMUTnonSNP chr03 3q26.3 off target 115118838 AMPL6795279620 115118832 115118979 44.9 2 1 SNV T 1 T/C 0.002                 NA     rs191214851   0,44 BR5-030T PRO-7-20140313_BR5_T1_ 2165 tumor 65 729795 70.9 1215 48.77 IonXpress_069 1.0E-5 829 584 245 0.3 30 - 40 >50 Postmenopausal
170 19023 HE10/05 17850 BR5-030   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 ex7-in7 7577429 AMPL3426752792 7577372 7577532 61 2 3 SNV C 1 C/T   TP53 intronic             NA       P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif -0,74 BR5-030T PRO-7-20140313_BR5_T1_ 2117 tumor 65 729795 70.9 1215 48.77 IonXpress_069 1.0E-5 1660 1500 160 0.1 10 - 20 >50 Postmenopausal
171 19025 HE10/05 17850 BR5-030   YES TP53 NO YES nonMUTnonSNP chr17 17p13.1 ex6-in6 7578210 AMPL4574207192 7578114 7578273 53.5 1 1 SNV T 1 T/C 0.007 TP53 exonic synonymous CGG 6 WT 639A>G c.639A>G NA   oligodendroglioma_Grade_II:adenocarcinoma:adenoma:carcinoma rs1800372 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif -0,16 BR5-030T PRO-7-20140313_BR5_T1_ 430 tumor 65 729795 70.9 1215 48.77 IonXpress_069 1.0E-5 357 84 273 0.76 70 - 80 >50 Postmenopausal
172 19029 HE10/05 17426 BR5-031 1 NO   NO NO                                                                                             <=50 Premenopausal
173 19070 HE10/05 18972 BR5-032 1 NO   NO NO                                                                                             <=50 Premenopausal
174 19173 HE10/05 18001 BR5-034   YES PIK3CA NO NO nonMUTnonSNP chr03 3q26.3 off target 115118931 AMPL6795279620 115118832 115118979 44.9 2 1 SNV C 1 C/T                   NA         1,45 BR5-034T PRO-7-20140313_BR5_T1_ 1610 tumor 65 1057183 71.1 1857 75.57 IonXpress_072 1.0E-5 1549 1418 131 0.08 <10 >50 Postmenopausal
175 19174 HE10/05 18001 BR5-034   YES PIK3CA YES NO other chr03 3q26.3 ex2 178916680 AMPL1566372753 178916552 178916726 43 2 1 SNV G 1 G/A   PIK3CA exonic missense AAA 2 p.Glu23Lys 67G>A c.67G>A NA 108     PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 2,62 BR5-034T PRO-7-20140313_BR5_T1_ 518 tumor 65 1057183 71.1 1857 75.57 IonXpress_072 7.0E-5 496 448 48 0.1 10 - 20 >50 Postmenopausal
176 19176 HE10/05 18001 BR5-034   YES PIK3CA YES NO other chr03 3q26.3 ex21 178952085 AMPL392292511 178952020 178952194 36.3 3 2 SNV A 1 A/T   PIK3CA exonic missense CTT 21 p.His1047Leu 3140A>T c.3140A>T NA 957 HER-positive_carcinoma:ductal_epithelial_hyperplasia-hyperplasia_of_usual_type:hepatocellular_carcinoma:SHH_subtype:Merkel_cell_carcinoma:lobular_carcinoma:mixed_endometrioid_and_clear_cell_carcinoma:sopharyngeal_carcinoma:endometriosis:papilloma:mixed_ rs121913279 PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 2,33 BR5-034T PRO-7-20140313_BR5_T1_ 3041 tumor 65 1057183 71.1 1857 75.57 IonXpress_072 1.0E-5 1703 1535 168 0.1 10 - 20 >50 Postmenopausal
177 19188 HE10/05 18001 BR5-034   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 in9-ex10 7574034 AMPL387899835 7573927 7574055 62.8 1 1 SNV C 1 C/T   TP53 splicesite_5             NA   adenocarcinoma:endometrioid_carcinoma:carcinoma:serous_carcinoma   P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 2,55 BR5-034T PRO-7-20140313_BR5_T1_ 858 tumor 65 1057183 71.1 1857 75.57 IonXpress_072 1.0E-5 833 728 105 0.13 10 - 20 >50 Postmenopausal
178 19189 HE10/05 18001 BR5-034   YES TP53 YES NO other chr17 17p13.1 ex8-in8 7577039 AMPL706844244 7576996 7577170 61.6 1 2 SNV G 1 G/A   TP53 exonic missense CTC 8 p.Pro300Leu 899C>T c.899C>T NA   leukoplakia-hyperplakia-erythroplakia:adenocarcinoma:adenoma:basal_cell_carcinoma:serous_carcinoma:endometrioid_carcinoma   P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,37 BR5-034T PRO-7-20140313_BR5_T1_ 558 tumor 65 1057183 71.1 1857 75.57 IonXpress_072 1.0E-5 520 465 55 0.11 10 - 20 >50 Postmenopausal
179 19190 HE10/05 18001 BR5-034   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 in7-ex8 7577159 AMPL1481474315 7577115 7577289 48.1 2 3 SNV C 1 C/T   TP53 intronic             NA       P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif -0,36 BR5-034T PRO-7-20140313_BR5_T1_ 826 tumor 65 1057183 71.1 1857 75.57 IonXpress_072 1.0E-5 788 697 91 0.12 10 - 20 >50 Postmenopausal
180 19192 HE10/05 18001 BR5-034   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 in7-ex8 7577233 AMPL1481474315 7577115 7577289 48.1 2 3 SNV C 1 C/T   TP53 intronic             NA       P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 0,5 BR5-034T PRO-7-20140313_BR5_T1_ 826 tumor 65 1057183 71.1 1857 75.57 IonXpress_072 1.0E-5 782 693 89 0.11 10 - 20 >50 Postmenopausal
181 19193 HE10/05 18001 BR5-034   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 in7-ex8 7577234 AMPL1481474315 7577115 7577289 48.1 2 3 SNV C 1 C/T   TP53 intronic             NA       P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif -0,69 BR5-034T PRO-7-20140313_BR5_T1_ 826 tumor 65 1057183 71.1 1857 75.57 IonXpress_072 8.0E-5 781 713 68 0.09 <10 >50 Postmenopausal
182 19196 HE10/05 18001 BR5-034   YES TP53 YES NO other chr17 17p13.1 ex6-in6 7578230 AMPL4574207192 7578114 7578273 53.5 1 1 SNV C 1 C/T   TP53 exonic missense AAT 6 p.Asp207Asn 619G>A c.619G>A NA 6 transitiol_cell_carcinoma:adenocarcinoma   P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 0,07 BR5-034T PRO-7-20140313_BR5_T1_ 255 tumor 65 1057183 71.1 1857 75.57 IonXpress_072 1.0E-5 246 203 43 0.17 10 - 20 >50 Postmenopausal
183 19197 HE10/05 18001 BR5-034   YES TP53 YES NO other chr17 17p13.1 ex5-in5 7578289 AMPL1992796664 7578284 7578458 63.7 1 2 SNV C 1 C/T   TP53 exonic missense GAT 6 p.Gly187Asp 560G>A c.560G>A NA   carcinoid-endocrine_tumour:adenocarcinoma:squamous_cell_carcinoma:NK-T_cell_lymphoma:hairy_cell_leukaemia:carcinoma   P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 2,54 BR5-034T PRO-7-20140313_BR5_T1_ 285 tumor 65 1057183 71.1 1857 75.57 IonXpress_072 1.0E-5 161 112 49 0.3 30 - 40 >50 Postmenopausal
184 19199 HE10/05 18001 BR5-034   YES TP53 YES NO other chr17 17p13.1 ex5-in5 7578395 AMPL1992796664 7578284 7578458 63.7 1 2 SNV G 1 G/A   TP53 exonic missense TAT 5 p.His179Tyr 535C>T c.535C>T NA 1 lymphoid_neoplasm:hepatocellular_carcinoma:MALT_lymphoma:intestil_adenocarcinoma:Wilms_tumour:lobular_carcinoma:chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma:endometrioid_carcinoma:carcinoid-endocrine_tumour:malignt_peripheral_nerve_sheath_   P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 2,8 BR5-034T PRO-7-20140313_BR5_T1_ 285 tumor 65 1057183 71.1 1857 75.57 IonXpress_072 1.0E-5 227 136 91 0.4 40 - 50 >50 Postmenopausal
185 19200 HE10/05 18001 BR5-034   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 ex4-in4 7579327 AMPL1481773781 7579257 7579411 56.1 2 3 SNV C 1 C/T   TP53 exonic synonymous AAA 4 WT 360G>A c.360G>A NA   transitiol_cell_carcinoma   P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 0,72 BR5-034T PRO-7-20140313_BR5_T1_ 856 tumor 65 1057183 71.1 1857 75.57 IonXpress_072 1.0E-5 832 738 94 0.11 10 - 20 >50 Postmenopausal
186 19201 HE10/05 18001 BR5-034   YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR5-034T PRO-7-20140313_BR5_T1_ 300 tumor 65 1057183 71.1 1857 75.57 IonXpress_072 1.0E-5 276 62 214 0.78 70 - 80 >50 Postmenopausal
187 19298 HE10/05 16232 BR5-035   YES PIK3CA YES NO other chr03 3q26.3 ex2 178916638 AMPL1566372753 178916552 178916726 43 2 1 SNV G 1 G/A   PIK3CA exonic missense AAA 2 p.Glu9Lys 25G>A c.25G>A NA 1     PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 2,51 BR5-035bT PRO-7-20140313_BR5_T1_ 458 tumor 75 201934 77.26 395.1 54.64 IonXpress_073 2.0E-5 386 344 42 0.11 10 - 20 >50 Postmenopausal
188 19300 HE10/05 16232 BR5-035   YES PIK3CA YES NO other chr03 3q26.3 ex21 178952019 AMPL1497305257 178951918 178952092 38.1 3 3 SNV C 1 C/T   PIK3CA exonic missense ATC 21 p.Thr1025Ile 3074C>T c.3074C>T NA 1 adenocarcinoma:astrocytoma_Grade_IV:small_cell_carcinoma:mixed_serous_and_endometrioid_carcinoma:carcinoma:endometrioid_carcinoma   PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 2,89 BR5-035bT PRO-7-20140313_BR5_T1_ 863 tumor 75 201934 77.26 395.1 54.64 IonXpress_073 1.0E-5 826 670 156 0.19 10 - 20 >50 Postmenopausal
189 19301 HE10/05 16232 BR5-035   YES PIK3CA YES NO other chr03 3q26.3 ex21 178952103 AMPL392292511 178952020 178952194 36.3 3 2 SNV C 1 C/T   PIK3CA exonic missense ATA 21 p.Thr1053Ile 3158C>T c.3158C>T NA 1     PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 2,89 BR5-035bT PRO-7-20140313_BR5_T1_ 976 tumor 75 201934 77.26 395.1 54.64 IonXpress_073 1.0E-5 613 530 83 0.14 10 - 20 >50 Postmenopausal
190 19302 HE10/05 16232 BR5-035   YES PIK3CA NO NO nonMUTnonSNP chr03 3q26.3 ex21 178952155 AMPL392292511 178952020 178952194 36.3 3 2 SNV A 1 A/G   PIK3CA utr_3             NA       PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 0,12 BR5-035bT PRO-7-20140313_BR5_T1_ 976 tumor 75 201934 77.26 395.1 54.64 IonXpress_073 5.0E-5 840 766 74 0.09 <10 >50 Postmenopausal
191 19332 HE10/05 16232 BR5-035   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 in8-ex9-in9 7576910 AMPL1516620128 7576812 7576978 50 1 2 SNV G 1 A/A   TP53 exonic synonymous ACT 9 WT 936C>T c.936C>T NA   transitiol_cell_carcinoma:squamous_cell_carcinoma   P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif -0,18 BR5-035bT PRO-7-20140313_BR5_T1_ 193 tumor 75 201934 77.26 395.1 54.64 IonXpress_073 1.0E-5 188 1 187 0.99 90 - 100 >50 Postmenopausal
192 19334 HE10/05 16232 BR5-035   YES TP53 YES NO other chr17 17p13.1 ex8-in8 7577127 AMPL706844244 7576996 7577170 61.6 1 2 SNV C 1 C/T   TP53 exonic missense AAG 8 p.Glu271Lys 811G>A c.811G>A NA 1 mixed_carcinoma:lymphoid_neoplasm:hepatocellular_carcinoma:serous_carcinoma:transitiol_cell_carcinoma:adenocarcinoma:diffuse_large_B_cell_lymphoma:squamous_cell_carcinoma:astrocytoma_Grade_IV:ER-PR-positive_carcinoma:hepatoblastoma:non_small_cell_carcin rs67389650 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 2,67 BR5-035bT PRO-7-20140313_BR5_T1_ 485 tumor 75 201934 77.26 395.1 54.64 IonXpress_073 2.0E-5 439 394 45 0.1 10 - 20 >50 Postmenopausal
193 19335 HE10/05 16232 BR5-035   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 ex7-in7 7577455 AMPL3426752792 7577372 7577532 61 2 3 SNV G 1 G/A   TP53 intronic             NA       P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif -0,47 BR5-035bT PRO-7-20140313_BR5_T1_ 893 tumor 75 201934 77.26 395.1 54.64 IonXpress_073 1.0E-5 840 722 118 0.14 10 - 20 >50 Postmenopausal
194 19336 HE10/05 16232 BR5-035   YES TP53 YES NO other chr17 17p13.1 in6-ex7-in7 7577581 AMPL4981177402 7577472 7577638 53.4 2 3 SNV A 1 A/G   TP53 exonic missense CAC 7 p.Tyr234His 700T>C c.700T>C NA 997 pterygium:keratoacanthoma:malignt_melanoma:MALT_lymphoma:Wilms_tumour:follicular_lymphoma:Burkitt_lymphoma:serous_carcinoma:endometrioid_carcinoma:acute_myeloid_leukaemia:keratosis:transitiol_cell_carcinoma:adenocarcinoma:diffuse_large_B_cell_lymphoma   P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 2,07 BR5-035bT PRO-7-20140313_BR5_T1_ 216 tumor 75 201934 77.26 395.1 54.64 IonXpress_073 1.0E-5 206 89 117 0.57 50 - 60 >50 Postmenopausal
195 19477 HE10/05 18004 BR5-036   YES PIK3CA NO NO nonMUTnonSNP chr03 3q26.3 in 10-ex11 178936976 AMPL391535344 178936910 178937071 35.8 3 2 SNV C 1 C/T   PIK3CA intronic             NA       PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 0,1 BR5-036T PRO-7-20140313_BR5_T1_ 262 tumor 85 121553 51.42 153.3 62.5 IonXpress_074 1.0E-5 257 210 47 0.18 10 - 20 >50 Postmenopausal
196 19478 HE10/05 18004 BR5-036   YES PIK3CA NO NO nonMUTnonSNP chr03 3q26.3 ex21 178952128 AMPL392292511 178952020 178952194 36.3 3 2 SNV A 1 A/G   PIK3CA exonic synonymous ACG 21 WT 3183A>G c.3183A>G NA       PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 0,14 BR5-036T PRO-7-20140313_BR5_T1_ 927 tumor 85 121553 51.42 153.3 62.5 IonXpress_074 1.0E-5 721 634 87 0.12 10 - 20 >50 Postmenopausal
197 19526 HE10/05 18004 BR5-036   YES TP53 YES NO other chr17 17p13.1 ex8-in8 7577093 AMPL706844244 7576996 7577170 61.6 1 2 SNV C 1 C/T   TP53 exonic missense CAG 8 p.Arg282Gln 845G>A c.845G>A NA 996 peritoneal_serous_surface_carcinoma:hepatocellular_carcinoma:intestil_adenocarcinoma:small_cell_carcinoma:serous_carcinoma:chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma:transitiol_cell_carcinoma:acute_lymphoblastic_leukaemia:diffuse_large_B   P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 2,58 BR5-036T PRO-7-20140313_BR5_T1_ 139 tumor 85 121553 51.42 153.3 62.5 IonXpress_074 1.0E-5 128 63 65 0.51 50 - 60 >50 Postmenopausal
198 19527 HE10/05 18004 BR5-036   YES TP53 NO YES other chr17 17p13.1 ex7-in7 7577407 AMPL3426752792 7577372 7577532 61 2 3 SNV A 1 C/C 0.163 TP53 intronic             NA     rs12951053 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif -1,68 BR5-036T PRO-7-20140313_BR5_T1_ 307 tumor 85 121553 51.42 153.3 62.5 IonXpress_074 1.0E-5 280 3 277 0.99 90 - 100 >50 Postmenopausal
199 19528 HE10/05 18004 BR5-036   YES TP53 NO YES other chr17 17p13.1 ex7-in7 7577427 AMPL3426752792 7577372 7577532 61 2 3 SNV G 1 A/A 0.163 TP53 intronic             NA     rs12947788 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 0,16 BR5-036T PRO-7-20140313_BR5_T1_ 307 tumor 85 121553 51.42 153.3 62.5 IonXpress_074 1.0E-5 283 8 275 0.97 90 - 100 >50 Postmenopausal
200 19529 HE10/05 18004 BR5-036   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 ex7-in7 7577466 AMPL3426752792 7577372 7577532 61 2 3 SNV G 1 G/A   TP53 intronic             NA       P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif -0,19 BR5-036T PRO-7-20140313_BR5_T1_ 307 tumor 85 121553 51.42 153.3 62.5 IonXpress_074 1.0E-5 293 189 104 0.35 30 - 40 >50 Postmenopausal
201 19530 HE10/05 18004 BR5-036   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 in6-ex7-in7 7577591 AMPL4981177402 7577472 7577638 53.4 2 3 SNV G 1 A/A   TP53 exonic synonymous ACT 7 WT 690C>T c.690C>T NA   squamous_cell_carcinoma   P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,22 BR5-036T PRO-7-20140313_BR5_T1_ 124 tumor 85 121553 51.42 153.3 62.5 IonXpress_074 1.0E-5 117 1 116 0.99 90 - 100 >50 Postmenopausal
202 19566 HE10/05 18105 BR5-037   YES PIK3CA YES NO other chr03 3q26.3 ex2 178916623 AMPL1566372753 178916552 178916726 43 2 1 SNV C 1 C/T   PIK3CA exonic nonsense TGA 2 p.Arg4* 10C>T c.10C>T NA     rs1051397 PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 1,08 BR5-037bT PRO-7-20140313_BR5_T1_ 708 tumor 70 2504594 79.6 5057 58.17 IonXpress_075 1.0E-5 555 499 56 0.1 10 - 20 <=50 Premenopausal
203 19572 HE10/05 18105 BR5-037   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 ex7-in7 7577429 AMPL3426752792 7577372 7577532 61 2 3 SNV C 1 C/T   TP53 intronic             NA       P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif -0,74 BR5-037bT PRO-7-20140313_BR5_T1_ 1229 tumor 70 2504594 79.6 5057 58.17 IonXpress_075 9.0E-5 785 717 68 0.09 <10 <=50 Premenopausal
204 19573 HE10/05 18105 BR5-037   YES TP53 YES NO other chr17 17p13.1 in6-ex7-in7 7577538 AMPL4981177402 7577472 7577638 53.4 2 3 SNV C 1 C/T   TP53 exonic missense CAG 7 p.Arg248Gln 743G>A c.743G>A NA 1 HER-positive_carcinoma:oligodendroglioma:medullary_carcinoma:SHH_subtype:hepatocellular_carcinoma:Wilms_tumour:Merkel_cell_carcinoma:follicular_lymphoma:lobular_carcinoma:chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma:glioma:benign_melanocytic_n rs11540652 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,31 BR5-037bT PRO-7-20140313_BR5_T1_ 6923 tumor 70 2504594 79.6 5057 58.17 IonXpress_075 1.0E-5 1997 1070 927 0.46 40 - 50 <=50 Premenopausal
205 19574 HE10/05 18105 BR5-037   YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR5-037bT PRO-7-20140313_BR5_T1_ 2045 tumor 70 2504594 79.6 5057 58.17 IonXpress_075 1.0E-5 1916 906 1010 0.53 50 - 60 <=50 Premenopausal
206 19577 HE10/05 17939 BR5-038 1 NO   NO NO                                                                                             <=50 Premenopausal
207 19612 HE10/05 17159 BR5-040 1 NO   NO NO                                                                                             >50 Postmenopausal
208 19638 HE10/05 18380 BR5-042 1 YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR5-042T PRO-7-20140313_BR5_T1_ 625 tumor 75 1610546 69.57 2765 78.84 IonXpress_079 1.0E-5 548 422 126 0.23 20 - 30 >50 Postmenopausal
209 19833 HE10/05 18380 BR5-042   YES PIK3CA YES NO other chr03 3q26.3 ex21 178951957 AMPL1497305257 178951918 178952092 38.1 3 3 SNV G 1 G/A   PIK3CA exonic missense ATA 21 p.Met1004Ile 3012G>A c.3012G>A NA 16 adenocarcinoma:astrocytoma_Grade_IV:small_cell_carcinoma:carcinoma:endometrioid_carcinoma   PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 2,89 BR5-042T PRO-7-20140313_BR5_T1_ 1359 tumor 75 1610546 69.57 2765 78.84 IonXpress_079 2.0E-5 1226 1125 101 0.08 <10 >50 Postmenopausal
210 19878 HE10/05 18380 BR5-042   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 in8-ex9-in9 7576852 AMPL1516620128 7576812 7576978 50 1 2 SNV C 1 C/T   TP53 splicesite_3             NA   adenocarcinoma:squamous_cell_carcinoma:adenoma:neoplasm:intestil_adenocarcinoma:basal_cell_carcinoma:malignt_fibrous_histiocytoma-pleomorphic_sarcoma:NS:small_cell_carcinoma:serous_carcinoma:carcinoma rs11575997 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 2,46 BR5-042T PRO-7-20140313_BR5_T1_ 2160 tumor 75 1610546 69.57 2765 78.84 IonXpress_079 7.0E-5 1998 1849 149 0.07 <10 >50 Postmenopausal
211 19880 HE10/05 18380 BR5-042   YES TP53 YES NO other chr17 17p13.1 in8-ex9-in9 7576899 AMPL1516620128 7576812 7576978 50 1 2 SNV G 1 G/A   TP53 exonic missense CTC 9 p.Pro316Leu 947C>T c.947C>T NA   squamous_cell_carcinoma:malignt_melanoma:serous_carcinoma   P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 2,69 BR5-042T PRO-7-20140313_BR5_T1_ 2160 tumor 75 1610546 69.57 2765 78.84 IonXpress_079 1.0E-5 1999 1830 169 0.08 <10 >50 Postmenopausal
212 19881 HE10/05 18380 BR5-042   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 ex8-in8 7577083 AMPL706844244 7576996 7577170 61.6 1 2 SNV C 1 C/T   TP53 exonic synonymous GAA 8 WT 855G>A c.855G>A NA   transitiol_cell_carcinoma:squamous_cell_carcinoma   P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif -0,06 BR5-042T PRO-7-20140313_BR5_T1_ 1125 tumor 75 1610546 69.57 2765 78.84 IonXpress_079 1.0E-5 1062 888 174 0.16 10 - 20 >50 Postmenopausal
213 19882 HE10/05 18380 BR5-042   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 in7-ex8 7577122 AMPL1481474315 7577115 7577289 48.1 2 3 SNV C 1 C/T   TP53 exonic synonymous GTA 8 WT 816G>A c.816G>A NA   adenocarcinoma:actinic_keratosis:ductal_carcinoma:carcinoma   P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif -1,5 BR5-042T PRO-7-20140313_BR5_T1_ 1366 tumor 75 1610546 69.57 2765 78.84 IonXpress_079 1.0E-5 1051 895 156 0.15 10 - 20 >50 Postmenopausal
214 19884 HE10/05 18380 BR5-042   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 in7-ex8 7577187 AMPL1481474315 7577115 7577289 48.1 2 3 SNV C 1 C/T   TP53 intronic             NA       P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,12 BR5-042T PRO-7-20140313_BR5_T1_ 1366 tumor 75 1610546 69.57 2765 78.84 IonXpress_079 1.0E-5 1315 1126 189 0.14 10 - 20 >50 Postmenopausal
215 19885 HE10/05 18380 BR5-042   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 in7-ex8 7577230 AMPL1481474315 7577115 7577289 48.1 2 3 SNV G 1 G/A   TP53 intronic             NA       P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 0,23 BR5-042T PRO-7-20140313_BR5_T1_ 1366 tumor 75 1610546 69.57 2765 78.84 IonXpress_079 1.0E-5 1233 985 248 0.2 20 - 30 >50 Postmenopausal
216 19886 HE10/05 18380 BR5-042   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 ex6-in6 7578144 AMPL4574207192 7578114 7578273 53.5 1 1 SNV C 1 C/T   TP53 intronic             NA       P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 0,76 BR5-042T PRO-7-20140313_BR5_T1_ 1585 tumor 75 1610546 69.57 2765 78.84 IonXpress_079 1.0E-5 1448 1222 226 0.16 10 - 20 >50 Postmenopausal
217 19887 HE10/05 18380 BR5-042   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 ex6-in6 7578148 AMPL4574207192 7578114 7578273 53.5 1 1 SNV C 1 C/T   TP53 intronic             NA       P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 0,05 BR5-042T PRO-7-20140313_BR5_T1_ 1585 tumor 75 1610546 69.57 2765 78.84 IonXpress_079 1.0E-5 1454 1288 166 0.11 10 - 20 >50 Postmenopausal
218 19889 HE10/05 18380 BR5-042   YES TP53 YES NO other chr17 17p13.1 ex6-in6 7578259 AMPL4574207192 7578114 7578273 53.5 1 1 SNV A 1 A/G   TP53 exonic missense GCG 6 p.Val197Ala 590T>C c.590T>C NA   angiosarcoma:transitiol_cell_carcinoma:adenocarcinoma:pneumocytoma_(sclerosing_haemangioma):squamous_cell_carcinoma:hepatocellular_carcinoma:intestil_adenocarcinoma:astrocytoma_Grade_IV:clear_cell_carcinoma:adult_T_cell_lymphoma-leukaemia:chronic_lymp   P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 0,98 BR5-042T PRO-7-20140313_BR5_T1_ 1585 tumor 75 1610546 69.57 2765 78.84 IonXpress_079 1.0E-5 1090 961 129 0.12 10 - 20 >50 Postmenopausal
219 19890 HE10/05 18380 BR5-042   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 ex5-in5 7578340 AMPL1992796664 7578284 7578458 63.7 1 2 SNV C 1 C/T   TP53 intronic             NA       P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif -0,32 BR5-042T PRO-7-20140313_BR5_T1_ 2046 tumor 75 1610546 69.57 2765 78.84 IonXpress_079 1.0E-5 1994 1824 170 0.09 <10 >50 Postmenopausal
220 19892 HE10/05 18380 BR5-042   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 ex5-in5 7578390 AMPL1992796664 7578284 7578458 63.7 1 2 SNV C 1 C/T   TP53 exonic synonymous GAA 5 WT 540G>A c.540G>A NA   adenocarcinoma:squamous_cell_carcinoma:small_cell_carcinoma:carcinoma   P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 0,38 BR5-042T PRO-7-20140313_BR5_T1_ 2046 tumor 75 1610546 69.57 2765 78.84 IonXpress_079 1.0E-5 1438 1190 248 0.17 10 - 20 >50 Postmenopausal
221 19893 HE10/05 18380 BR5-042   YES TP53 YES NO other chr17 17p13.1 in4-ex5 7578458 AMPL6326144323 7578407 7578581 61.7 1 3 SNV G 1 G/A   TP53 exonic missense TGC 5 p.Arg158Cys 472C>T c.472C>T NA 1 angiosarcoma:lymphoid_neoplasm:small_cell_carcinoma:chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma:endometrioid_carcinoma:acute_myeloid_leukaemia:in_situ_epithelial_neoplasm:transitiol_cell_carcinoma:dysplasia:adenocarcinoma:diffuse_large_B_ce   P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 0,82 BR5-042T PRO-7-20140313_BR5_T1_ 1216 tumor 75 1610546 69.57 2765 78.84 IonXpress_079 1.0E-5 1155 1034 121 0.1 10 - 20 >50 Postmenopausal
222 19894 HE10/05 18380 BR5-042   YES TP53 YES NO other chr17 17p13.1 in4-ex5 7578542 AMPL6326144323 7578407 7578581 61.7 1 3 SNV G 1 G/A   TP53 exonic missense TTC 5 p.Leu130Phe 388C>T c.388C>T NA 1 HER-positive_carcinoma:lymphoid_neoplasm:Barrett_oesophagus:serous_carcinoma:transitiol_cell_carcinoma:adenocarcinoma:myelodysplastic_syndrome:squamous_cell_carcinoma:acute_lymphoblastic_B_cell_leukaemia:basal_cell_carcinoma:astrocytoma_Grade_IV:ductal_   P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 2,73 BR5-042T PRO-7-20140313_BR5_T1_ 1216 tumor 75 1610546 69.57 2765 78.84 IonXpress_079 1.0E-5 1158 1042 116 0.1 10 - 20 >50 Postmenopausal
223 19895 HE10/05 18380 BR5-042   YES TP53 YES NO other chr17 17p13.1 in3-ex4 7579542 AMPL6795075395 7579475 7579618 52 2 3 SNV C 1 C/T   TP53 exonic missense AAT 4 p.Asp49Asn 145G>A c.145G>A NA 1 chronic_myeloid_leukaemia:transitiol_cell_carcinoma:atypical_teratoid-rhabdoid_tumour:gastrointestil_stromal_tumour:squamous_cell_carcinoma:carcinoma   P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 0,13 BR5-042T PRO-7-20140313_BR5_T1_ 4004 tumor 75 1610546 69.57 2765 78.84 IonXpress_079 1.0E-5 1999 1789 210 0.11 10 - 20 >50 Postmenopausal
224 20049 HE10/05 17633 BR5-044   YES PIK3CA NO NO nonMUTnonSNP chr03 3q26.3 off target 115118818 AMPL6795277223 115118748 115118874 48.8 3 3 SNV C 1 C/T                   NA         0,27 BR5-044bT PRO-7-20140313_BR5_T1_ 1275 tumor 65 330719 59.35 485.9 63.92 IonXpress_080 1.0E-5 1014 866 148 0.15 10 - 20 >50 Premenopausal
225 20050 HE10/05 17633 BR5-044   YES PIK3CA NO NO nonMUTnonSNP chr03 3q26.3 in 10-ex11 178936977 AMPL391535344 178936910 178937071 35.8 3 2 SNV C 1 C/T   PIK3CA intronic             NA       PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 0,97 BR5-044bT PRO-7-20140313_BR5_T1_ 665 tumor 65 330719 59.35 485.9 63.92 IonXpress_080 1.0E-5 649 505 144 0.22 20 - 30 >50 Premenopausal
226 20051 HE10/05 17633 BR5-044   YES PIK3CA NO NO nonMUTnonSNP chr03 3q26.3 ex20-in20 178948147 AMPL1496009646 178948084 178948232 36.3 3 1 SNV G 1 G/A   PIK3CA exonic synonymous AAA 20 WT 2919G>A c.2919G>A NA       PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 -0,09 BR5-044bT PRO-7-20140313_BR5_T1_ 651 tumor 65 330719 59.35 485.9 63.92 IonXpress_080 1.0E-5 623 532 91 0.15 10 - 20 >50 Premenopausal
227 20054 HE10/05 17633 BR5-044   YES PIK3CA NO NO nonMUTnonSNP chr03 3q26.3 ex21 178952101 AMPL392292511 178952020 178952194 36.3 3 2 SNV A 1 A/G   PIK3CA exonic synonymous ACG 21 WT 3156A>G c.3156A>G NA   adenocarcinoma   PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 0,17 BR5-044bT PRO-7-20140313_BR5_T1_ 3986 tumor 65 330719 59.35 485.9 63.92 IonXpress_080 1.0E-5 1999 1829 170 0.09 <10 >50 Premenopausal
228 20241 HE10/05 17598 BR5-045   YES PIK3CA YES NO other chr03 3q26.3 ex21 178952103 AMPL392292511 178952020 178952194 36.3 3 2 SNV C 1 C/T   PIK3CA exonic missense ATA 21 p.Thr1053Ile 3158C>T c.3158C>T NA 1     PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 2,89 BR5-045bT PRO-7-20140313_BR5_T1_ 2935 tumor 65 294162 55.36 392.8 60.7 IonXpress_081 1.0E-5 1850 1659 191 0.1 10 - 20 >50 Postmenopausal
229 20274 HE10/05 17598 BR5-045   YES TP53 YES NO other chr17 17p13.1 ex8-in8 7577099 AMPL706844244 7576996 7577170 61.6 1 2 SNV C 1 C/T   TP53 exonic missense AAA 8 p.Arg280Lys 839G>A c.839G>A NA   pleomorphic_carcinoma:lymphoid_neoplasm:medullary_carcinoma:malignt_melanoma:intestil_adenocarcinoma:Burkitt_lymphoma:lobular_carcinoma:small_cell_carcinoma:Bowen_disease:serous_carcinoma:chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma:acute_ rs193920853:rs121912660 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 2,67 BR5-045bT PRO-7-20140313_BR5_T1_ 197 tumor 65 294162 55.36 392.8 60.7 IonXpress_081 1.0E-5 183 13 170 0.93 90 - 100 >50 Postmenopausal
230 20284 HE10/05 17598 BR5-045   YES TP53 YES NO other chr17 17p13.1 in3-ex4 7579533 AMPL6795075395 7579475 7579618 52 2 3 SNV G 1 G/A   TP53 exonic nonsense TAA 4 p.Gln52* 154C>T c.154C>T NA   lymphoid_neoplasm:adenocarcinoma:squamous_cell_carcinoma:NK-T_cell_lymphoma:carcinoma   P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif -0,82 BR5-045bT PRO-7-20140313_BR5_T1_ 268 tumor 65 294162 55.36 392.8 60.7 IonXpress_081 1.0E-5 259 211 48 0.19 10 - 20 >50 Postmenopausal
231 20304 HE10/05 17594 BR5-046 1 NO   NO NO                                                                                             <=50 Postmenopausal
232 20458 HE10/05 16683 BR5-047   YES PIK3CA NO NO nonMUTnonSNP chr03 3q26.3 off target 115118810 AMPL6795277223 115118748 115118874 48.8 3 3 SNV C 1 C/T                   NA         -0,13 BR5-047T PRO-7-20140313_BR5_T1_ 1212 tumor 75 254191 65.59 431.9 45.69 IonXpress_083 1.0E-5 965 737 226 0.23 20 - 30 >50 Postmenopausal
233 20459 HE10/05 16683 BR5-047   YES PIK3CA NO NO nonMUTnonSNP chr03 3q26.3 off target 115118816 AMPL6795277223 115118748 115118874 48.8 3 3 SNV C 1 C/T                   NA         -0,77 BR5-047T PRO-7-20140313_BR5_T1_ 1212 tumor 75 254191 65.59 431.9 45.69 IonXpress_083 1.0E-5 979 859 120 0.12 10 - 20 >50 Postmenopausal
234 20460 HE10/05 16683 BR5-047   YES PIK3CA NO NO nonMUTnonSNP chr03 3q26.3 off target 115118834 AMPL6795277223 115118748 115118874 48.8 3 3 SNV C 1 C/T                   NA         1,46 BR5-047T PRO-7-20140313_BR5_T1_ 1212 tumor 75 254191 65.59 431.9 45.69 IonXpress_083 1.0E-5 897 814 83 0.09 <10 >50 Postmenopausal
235 20499 HE10/05 16683 BR5-047   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 in8-ex9-in9 7576916 AMPL1516620128 7576812 7576978 50 1 2 SNV G 1 G/A   TP53 exonic synonymous AAT 9 WT 930C>T c.930C>T NA   squamous_cell_carcinoma   P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif -0,24 BR5-047T PRO-7-20140313_BR5_T1_ 750 tumor 75 254191 65.59 431.9 45.69 IonXpress_083 1.0E-5 718 645 73 0.1 10 - 20 >50 Postmenopausal
236 20502 HE10/05 16683 BR5-047   YES TP53 YES NO other chr17 17p13.1 in6-ex7-in7 7577581 AMPL4981177402 7577472 7577638 53.4 2 3 SNV A 1 A/G   TP53 exonic missense CAC 7 p.Tyr234His 700T>C c.700T>C NA 997 pterygium:keratoacanthoma:malignt_melanoma:MALT_lymphoma:Wilms_tumour:follicular_lymphoma:Burkitt_lymphoma:serous_carcinoma:endometrioid_carcinoma:acute_myeloid_leukaemia:keratosis:transitiol_cell_carcinoma:adenocarcinoma:diffuse_large_B_cell_lymphoma   P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 2,07 BR5-047T PRO-7-20140313_BR5_T1_ 192 tumor 75 254191 65.59 431.9 45.69 IonXpress_083 1.0E-5 176 54 122 0.69 60 - 70 >50 Postmenopausal
237 20504 HE10/05 16683 BR5-047   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 in5-ex6 7578332 AMPL4392179183 7578209 7578382 58.3 1 2 SNV G 1 G/A   TP53 intronic             NA       P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif -0,26 BR5-047T PRO-7-20140313_BR5_T1_ 163 tumor 75 254191 65.59 431.9 45.69 IonXpress_083 1.0E-5 148 101 47 0.32 30 - 40 >50 Postmenopausal
238 20505 HE10/05 16683 BR5-047   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 in4-ex5 7578462 AMPL6326144323 7578407 7578581 61.7 1 3 SNV G 1 G/A   TP53 exonic synonymous CGT 5 WT 468C>T c.468C>T NA   acute_lymphoblastic_leukaemia:squamous_cell_carcinoma:superficial_spreading:ductal_carcinoma:carcinoma   P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif -4,12 BR5-047T PRO-7-20140313_BR5_T1_ 414 tumor 75 254191 65.59 431.9 45.69 IonXpress_083 1.0E-5 384 277 107 0.28 20 - 30 >50 Postmenopausal
239 20506 HE10/05 16683 BR5-047   YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR5-047T PRO-7-20140313_BR5_T1_ 126 tumor 75 254191 65.59 431.9 45.69 IonXpress_083 1.0E-5 120 25 95 0.79 70 - 80 >50 Postmenopausal
240 20521 HE10/05 16544 BR5-048 1 NO   NO NO                                                                                             >50 Postmenopausal
241 20653 HE10/05 18497 BR5-050   YES TP53 YES NO other chr17 17p13.1 in6-ex7-in7 7577562 AMPL4981177402 7577472 7577638 53.4 2 3 SNV C 1 C/T   TP53 exonic missense AAT 7 p.Ser240Asn 719G>A c.719G>A NA 1 adenocarcinoma:oligodendroglioma:squamous_cell_carcinoma:ductal_carcinoma:carcinoma:serous_carcinoma   P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 2,56 BR5-050aT PRO-7-20140313_BR5_T1_ 819 tumor 50 330539 79.73 678 50.85 IonXpress_086 1.0E-5 780 680 100 0.13 10 - 20 >50 Premenopausal
242 20654 HE10/05 18497 BR5-050   YES TP53 YES NO other chr17 17p13.1 in6-ex7-in7 7577581 AMPL4981177402 7577472 7577638 53.4 2 3 SNV A 1 A/G   TP53 exonic missense CAC 7 p.Tyr234His 700T>C c.700T>C NA 997 pterygium:keratoacanthoma:malignt_melanoma:MALT_lymphoma:Wilms_tumour:follicular_lymphoma:Burkitt_lymphoma:serous_carcinoma:endometrioid_carcinoma:acute_myeloid_leukaemia:keratosis:transitiol_cell_carcinoma:adenocarcinoma:diffuse_large_B_cell_lymphoma   P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 2,07 BR5-050aT PRO-7-20140313_BR5_T1_ 819 tumor 50 330539 79.73 678 50.85 IonXpress_086 1.0E-5 784 579 205 0.26 20 - 30 >50 Premenopausal
243 20655 HE10/05 18497 BR5-050   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 in4-ex5 7578459 AMPL6326144323 7578407 7578581 61.7 1 3 SNV G 1 G/A   TP53 exonic synonymous GTT 5 WT 471C>T c.471C>T NA   adenocarcinoma:squamous_cell_carcinoma:astrocytoma_Grade_IV:carcinoma:undifferentiated_carcinoma   P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 0,06 BR5-050aT PRO-7-20140313_BR5_T1_ 590 tumor 50 330539 79.73 678 50.85 IonXpress_086 1.0E-5 558 495 63 0.11 10 - 20 >50 Premenopausal
244 20658 HE10/05 18497 BR5-050   YES TP53 YES NO other chr17 17p13.1 in4-ex5 7578517 AMPL6326144323 7578407 7578581 61.7 1 3 SNV G 1 G/A   TP53 exonic missense GTC 5 p.Ala138Val 413C>T c.413C>T NA   angiosarcoma:benign_melanocytic_nevus:lymphoid_neoplasm:adenocarcinoma:squamous_cell_carcinoma:hepatocellular_carcinoma:intestil_adenocarcinoma:metaplasia:plasma_cell_myeloma:carcinoma:serous_carcinoma:chronic_lymphocytic_leukaemia-small_lymphocytic_lym   P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 2,73 BR5-050aT PRO-7-20140313_BR5_T1_ 590 tumor 50 330539 79.73 678 50.85 IonXpress_086 1.0E-5 556 488 68 0.12 10 - 20 >50 Premenopausal
245 20660 HE10/05 18497 BR5-050   YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR5-050aT PRO-7-20140313_BR5_T1_ 246 tumor 50 330539 79.73 678 50.85 IonXpress_086 1.0E-5 228 35 193 0.85 80 - 90 >50 Premenopausal
246 20666 HE10/05 18098 BR5-051 1 YES TP53 NO YES nonMUTnonSNP chr17 17p13.1 ex10-in10 7573897 AMPL1481481122 7573824 7573997 62.3 1 1 SNV T 1 T/A 0.003 TP53 intronic             NA   squamous_cell_carcinoma rs17880847 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif -0,75 BR5-051bT PRO-7-20140313_BR5_T1_ 220 tumor 85 1678677 79.24 3392 78.18 IonXpress_087 1.0E-5 193 30 163 0.84 80 - 90 <=50 Premenopausal
247 20691 HE10/05 18098 BR5-051   YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR5-051bT PRO-7-20140313_BR5_T1_ 1040 tumor 85 1678677 79.24 3392 78.18 IonXpress_087 1.0E-5 941 206 735 0.78 70 - 80 <=50 Premenopausal
248 20693 HE10/05 17842 BR5-052 1 YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR5-052T PRO-7-20140313_BR5_T1_ 1237 tumor 75 2702540 70.8 4842 80.17 IonXpress_088 1.0E-5 1129 931 198 0.18 10 - 20 >50 Postmenopausal
249 20726 HE10/05 17842 BR5-052   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 ex5-in5 7578370 AMPL1992796664 7578284 7578458 63.7 1 2 SNV C 1 C/A   TP53 splicesite_3             NA   transitiol_cell_carcinoma:liposarcoma:adenocarcinoma:mantle_cell_lymphoma:squamous_cell_carcinoma:hepatocellular_carcinoma:NS:ductal_carcinoma:chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma:carcinoma:serous_carcinoma   P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,25 BR5-052T PRO-7-20140313_BR5_T1_ 1808 tumor 75 2702540 70.8 4842 80.17 IonXpress_088 1.0E-5 1472 794 678 0.46 40 - 50 >50 Postmenopausal
250 20817 HE10/05 17480 BR5-054   YES PIK3CA YES NO other chr03 3q26.3 ex21 178952085 AMPL392292511 178952020 178952194 36.3 3 2 SNV A 1 A/G   PIK3CA exonic missense CGT 21 p.His1047Arg 3140A>G c.3140A>G NA 926 HER-positive_carcinoma:ductal_epithelial_hyperplasia-hyperplasia_of_usual_type:hepatocellular_carcinoma:SHH_subtype:Merkel_cell_carcinoma:lobular_carcinoma:mixed_endometrioid_and_clear_cell_carcinoma:sopharyngeal_carcinoma:endometriosis:papilloma:mixed_ rs121913279 PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 2,33 BR5-054T PRO-7-20140313_BR5_T1_ 4492 tumor 70 488335 64.87 788 74.78 IonXpress_089 1.0E-5 1999 1818 181 0.09 <10 >50 Postmenopausal
251 20832 HE10/05 17480 BR5-054   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 in7-ex8 7577183 AMPL1481474315 7577115 7577289 48.1 2 3 SNV G 1 G/A   TP53 intronic             NA       P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 0,56 BR5-054T PRO-7-20140313_BR5_T1_ 683 tumor 70 488335 64.87 788 74.78 IonXpress_089 2.0E-5 647 586 61 0.09 <10 >50 Postmenopausal
252 20833 HE10/05 17480 BR5-054   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 in7-ex8 7577237 AMPL1481474315 7577115 7577289 48.1 2 3 SNV C 1 C/T   TP53 intronic             NA       P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif -0,5 BR5-054T PRO-7-20140313_BR5_T1_ 683 tumor 70 488335 64.87 788 74.78 IonXpress_089 1.0E-5 632 549 83 0.13 10 - 20 >50 Postmenopausal
253 20834 HE10/05 17480 BR5-054   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 ex7-in7 7577406 AMPL3426752792 7577372 7577532 61 2 3 SNV G 1 G/A   TP53 intronic             NA       P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 0,83 BR5-054T PRO-7-20140313_BR5_T1_ 558 tumor 70 488335 64.87 788 74.78 IonXpress_089 1.0E-5 496 422 74 0.15 10 - 20 >50 Postmenopausal
254 20835 HE10/05 17480 BR5-054   YES TP53 NO YES other chr17 17p13.1 ex7-in7 7577407 AMPL3426752792 7577372 7577532 61 2 3 SNV A 1 A/C 0.163 TP53 intronic             NA     rs12951053 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif -1,68 BR5-054T PRO-7-20140313_BR5_T1_ 558 tumor 70 488335 64.87 788 74.78 IonXpress_089 1.0E-5 500 265 235 0.47 40 - 50 >50 Postmenopausal
255 20837 HE10/05 17480 BR5-054   YES TP53 NO YES other chr17 17p13.1 ex7-in7 7577427 AMPL3426752792 7577372 7577532 61 2 3 SNV G 1 G/A 0.163 TP53 intronic             NA     rs12947788 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 0,16 BR5-054T PRO-7-20140313_BR5_T1_ 558 tumor 70 488335 64.87 788 74.78 IonXpress_089 1.0E-5 520 281 239 0.46 40 - 50 >50 Postmenopausal
256 20839 HE10/05 17480 BR5-054   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 ex7-in7 7577528 AMPL3426752792 7577372 7577532 61 2 3 SNV G 1 G/A   TP53 exonic synonymous ATT 7 WT 753C>T c.753C>T NA   adenocarcinoma:squamous_cell_carcinoma:hepatocellular_carcinoma:carcinoma   P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 0,02 BR5-054T PRO-7-20140313_BR5_T1_ 558 tumor 70 488335 64.87 788 74.78 IonXpress_089 1.0E-5 468 383 85 0.18 10 - 20 >50 Postmenopausal
257 20843 HE10/05 17480 BR5-054   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 ex5-in5 7578357 AMPL1992796664 7578284 7578458 63.7 1 2 SNV C 1 C/T   TP53 intronic             NA       P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif -0,18 BR5-054T PRO-7-20140313_BR5_T1_ 228 tumor 70 488335 64.87 788 74.78 IonXpress_089 1.0E-5 372 330 42 0.11 10 - 20 >50 Postmenopausal
258 20846 HE10/05 17480 BR5-054   YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR5-054T PRO-7-20140313_BR5_T1_ 282 tumor 70 488335 64.87 788 74.78 IonXpress_089 1.0E-5 254 174 80 0.31 30 - 40 >50 Postmenopausal
259 20983 HE10/05 17646 BR5-055   YES PIK3CA NO NO nonMUTnonSNP chr03 3q26.3 off target 115118808 AMPL6795277223 115118748 115118874 48.8 3 3 SNV C 1 C/T                   NA         0,35 BR5-055T PRO-7-20140313_BR5_T1_ 320 tumor 70 170380 63.99 271 70.1 IonXpress_090 1.0E-5 259 199 60 0.23 20 - 30 >50 Postmenopausal
260 20986 HE10/05 17646 BR5-055   YES PIK3CA YES NO other chr03 3q26.3 ex20-in20 178948160 AMPL1496009646 178948084 178948232 36.3 3 1 SNV G 1 G/A   PIK3CA exonic missense AAG 21 p.Glu978Lys 2932G>A c.2932G>A NA 905     PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 2,46 BR5-055T PRO-7-20140313_BR5_T1_ 210 tumor 70 170380 63.99 271 70.1 IonXpress_090 1.0E-5 200 127 73 0.37 30 - 40 >50 Postmenopausal
261 21042 HE10/05 17646 BR5-055   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 ex4-in4 7579285 AMPL1481773781 7579257 7579411 56.1 2 3 SNV G 1 G/T   TP53 intronic             NA       P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 0,34 BR5-055T PRO-7-20140313_BR5_T1_ 615 tumor 70 170380 63.99 271 70.1 IonXpress_090 1.0E-5 559 446 113 0.2 20 - 30 >50 Postmenopausal
262 21043 HE10/05 17646 BR5-055   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 ex4-in4 7579286 AMPL1481773781 7579257 7579411 56.1 2 3 SNV G 1 G/A   TP53 intronic             NA       P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 0,12 BR5-055T PRO-7-20140313_BR5_T1_ 615 tumor 70 170380 63.99 271 70.1 IonXpress_090 1.0E-5 533 466 67 0.13 10 - 20 >50 Postmenopausal
263 21044 HE10/05 17646 BR5-055   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 ex4-in4 7579300 AMPL1481773781 7579257 7579411 56.1 2 3 SNV A 1 A/G   TP53 intronic             NA     rs67736424:rs68140816 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif -0,01 BR5-055T PRO-7-20140313_BR5_T1_ 615 tumor 70 170380 63.99 271 70.1 IonXpress_090 1.0E-5 538 471 67 0.12 10 - 20 >50 Postmenopausal
264 21045 HE10/05 17646 BR5-055   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 ex4-in4 7579311 AMPL1481773781 7579257 7579411 56.1 2 3 SNV C 1 C/A   TP53 splicesite_3             NA   adenocarcinoma:squamous_cell_carcinoma:hepatocellular_carcinoma:basal_(triple-negative)_carcinoma:basal_cell_carcinoma:serous_carcinoma:carcinoma rs68140816 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 2,4 BR5-055T PRO-7-20140313_BR5_T1_ 615 tumor 70 170380 63.99 271 70.1 IonXpress_090 1.0E-5 540 473 67 0.12 10 - 20 >50 Postmenopausal
265 21046 HE10/05 17646 BR5-055   YES TP53 YES NO other chr17 17p13.1 ex4-in4 7579322 AMPL1481773781 7579257 7579411 56.1 2 3 SNV A 1 A/G   TP53 exonic missense GCG 4 p.Val122Ala 365T>C c.365T>C NA       P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 2,13 BR5-055T PRO-7-20140313_BR5_T1_ 615 tumor 70 170380 63.99 271 70.1 IonXpress_090 1.0E-5 539 470 69 0.13 10 - 20 >50 Postmenopausal
266 21048 HE10/05 17646 BR5-055   YES TP53 YES NO other chr17 17p13.1 in3-ex4 7579550 AMPL6795075395 7579475 7579618 52 2 3 SNV G 1 G/A   TP53 exonic missense TTC 4 p.Ser46Phe 137C>T c.137C>T NA   transitiol_cell_carcinoma:NK-T_cell_lymphoma   P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 0,42 BR5-055T PRO-7-20140313_BR5_T1_ 379 tumor 70 170380 63.99 271 70.1 IonXpress_090 1.0E-5 366 324 42 0.11 10 - 20 >50 Postmenopausal
267 21049 HE10/05 17646 BR5-055   YES TP53 YES NO other chr17 17p13.1 in3-ex4 7579575 AMPL6795075395 7579475 7579618 52 2 3 SNV G 1 G/A   TP53 exonic nonsense TAA 4 p.Gln38* 112C>T c.112C>T NA   adenocarcinoma:small_cell_carcinoma:carcinoma   P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif -0,14 BR5-055T PRO-7-20140313_BR5_T1_ 379 tumor 70 170380 63.99 271 70.1 IonXpress_090 1.0E-5 361 315 46 0.13 10 - 20 >50 Postmenopausal
268 21082 HE10/05 18086 BR5-056   YES TP53 YES NO other chr17 17p13.1 in7-ex8 7577120 AMPL1481474315 7577115 7577289 48.1 2 3 SNV C 1 C/T   TP53 exonic missense CAT 8 p.Arg273His 818G>A c.818G>A NA   HER-positive_carcinoma:hepatocellular_carcinoma:Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour:yolk_sac_tumour:Merkel_cell_carcinoma:chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma:carcinoid-endocrine_tumour:mantle_cell_lymphoma:margi rs28934576 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 2,56 BR5-056T PRO-7-20140313_BR5_T1_ 768 tumor 75 260512 80.86 561.6 76.74 IonXpress_091 1.0E-5 176 101 75 0.43 40 - 50 <=50 Premenopausal
269 21084 HE10/05 18086 BR5-056   YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR5-056T PRO-7-20140313_BR5_T1_ 259 tumor 75 260512 80.86 561.6 76.74 IonXpress_091 1.0E-5 248 59 189 0.76 70 - 80 <=50 Premenopausal
270 21116 HE10/05 18569 BR5-062   YES TP53 YES NO other chr17 17p13.1 in4-ex5 7578442 AMPL6326144323 7578407 7578581 61.7 1 3 SNV T 1 T/C   TP53 exonic missense TGC 5 p.Tyr163Cys 488A>G c.488A>G NA   HER-positive_carcinoma:hepatocellular_carcinoma:astrocytoma_Grade_II:large_cell_carcinoma:intestil_adenocarcinoma:carcinosarcoma-malignt_mesodermal_mixed_tumour:small_cell_carcinoma:endometrioid_carcinoma:serous_carcinoma:transitiol_cell_carcinoma:a rs148924904 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 0,45 BR5-062aT PRO-7-20140313_BR5_T1_ 552 tumor 75 671233 87.25 1509 75.49 IonXpress_094 1.0E-5 481 282 199 0.41 40 - 50 <=50 Postmenopausal
271 21117 HE10/05 18569 BR5-062   YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 C/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36     NA tumor                     1   <=50 Postmenopausal
272 21118 HE10/05 18569 BR5-062   YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR5-062aT PRO-7-20140313_BR5_T1_ 217 tumor 75 671233 87.25 1509 75.49 IonXpress_094 1.0E-5 201 42 159 0.79 70 - 80 <=50 Postmenopausal
273 21180 HE10/05 19451 BR5-063   YES PIK3CA YES NO other chr03 3q26.3 ex 10 178936067 AMPL393459515 178935994 178936131 38.6 3 2 SNV C 1 C/T   PIK3CA exonic nonsense TGA 10 p.Arg537* 1609C>T c.1609C>T NA       PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 2,72 BR5-063bT PRO-7-20140313_BR5_T1_ 555 tumor 50 141560 77.86 278.2 36.8 IonXpress_095 1.0E-5 546 463 83 0.15 10 - 20 >50 Postmenopausal
274 21181 HE10/05 19451 BR5-063   YES PIK3CA NO NO nonMUTnonSNP chr03 3q26.3 ex21 178952095 AMPL392292511 178952020 178952194 36.3 3 2 SNV C 1 C/A   PIK3CA exonic synonymous GGA 21 WT 3150C>A c.3150C>A NA       PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 0,88 BR5-063bT PRO-7-20140313_BR5_T1_ 6521 tumor 50 141560 77.86 278.2 36.8 IonXpress_095 1.0E-5 1920 1722 198 0.1 10 - 20 >50 Postmenopausal
275 21194 HE10/05 18940 BR5-064 1 YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 C/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR5-064T PRO-7-20140313_BR5_T1_ 1240 tumor 60 2347167 79 4746 81.79 IonXpress_096 1.0E-5 1151 258 893 0.78 70 - 80 >50 Postmenopausal
276 21214 HE10/05 18940 BR5-064   YES PIK3CA YES NO other chr03 3q26.3 ex21 178952085 AMPL392292511 178952020 178952194 36.3 3 2 SNV A 1 A/G   PIK3CA exonic missense CGT 21 p.His1047Arg 3140A>G c.3140A>G NA 926 HER-positive_carcinoma:ductal_epithelial_hyperplasia-hyperplasia_of_usual_type:hepatocellular_carcinoma:SHH_subtype:Merkel_cell_carcinoma:lobular_carcinoma:mixed_endometrioid_and_clear_cell_carcinoma:sopharyngeal_carcinoma:endometriosis:papilloma:mixed_ rs121913279 PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 2,33 BR5-064T PRO-7-20140313_BR5_T1_ 8836 tumor 60 2347167 79 4746 81.79 IonXpress_096 1.0E-5 1999 1649 350 0.18 10 - 20 >50 Postmenopausal
277 21224 HE10/05 17816 BR5-068 1 YES TP53 NO YES other chr17 17p13.1 ex7-in7 7577407 AMPL3426752792 7577372 7577532 61 2 3 SNV A 1 A/C 0.163 TP53 intronic             NA     rs12951053 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif -1,68 BR5-068T PRO-7-20140313_BR5_T1_ 3758 tumor 80 1674910 85 3791 82.65 IonXpress_001 6.0E-5 1991 1842 149 0.07 <10 <=50 Postmenopausal
278 21225 HE10/05 17816 BR5-068   YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 C/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR5-068T PRO-7-20140313_BR5_T1_ 1516 tumor 80 1674910 85 3791 82.65 IonXpress_001 1.0E-5 1389 230 1159 0.83 80 - 90 <=50 Postmenopausal
279 21254 HE10/05 17816 BR5-068   YES TP53 YES NO other chr17 17p13.1 ex5-in5 7578415 AMPL1992796664 7578284 7578458 63.7 1 2 SNV A 1 A/T   TP53 exonic missense GAT 5 p.Val172Asp 515T>A c.515T>A NA 1 adenocarcinoma:squamous_cell_carcinoma:NK-T_cell_lymphoma:hepatocellular_carcinoma:MALT_lymphoma:astrocytoma_Grade_IV:Burkitt_lymphoma:ductal_carcinoma:carcinoma:serous_carcinoma rs66983534 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 2,26 BR5-068T PRO-7-20140313_BR5_T1_ 2024 tumor 80 1674910 85 3791 82.65 IonXpress_001 1.0E-5 1422 248 1174 0.83 80 - 90 <=50 Postmenopausal
280 21261 HE10/05 18092 BR5-069 1 NO   NO NO                                                                                             <=50 Premenopausal
281 21275 HE10/05 18375 BR5-070   YES PIK3CA YES NO other chr03 3q26.3 ex 10 178936095 AMPL393459515 178935994 178936131 38.6 3 2 SNV A 1 A/G   PIK3CA exonic missense CGG 10 p.Gln546Arg 1637A>G c.1637A>G NA 996 adenocarcinoma:squamous_cell_carcinoma:ER-PR-positive_carcinoma:oligodendroglioma_Grade_III:clear_cell_carcinoma:ductal_carcinoma:serous_carcinoma:carcinoma:astrocytoma_Grade_III:endometrioid_carcinoma   PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 2,2 BR5-070T PRO-7-20140313_BR5_T1_ 581 tumor 65 263061 85.91 593.8 60.86 IonXpress_003 1.0E-5 562 429 133 0.24 20 - 30 >50 Postmenopausal
282 21276 HE10/05 19277 BR5-071 1 YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR5-071T PRO-7-20140313_BR5_T1_ 593 tumor 80 1036769 82.77 2198 77.9 IonXpress_004 1.0E-5 529 106 423 0.8 80 - 90 >50 Postmenopausal
283 21300 HE10/05 18558 BR5-072 1 YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR5-072T PRO-7-20140313_BR5_T1_ 199 tumor 50 183382 85.17 409.1 77.65 IonXpress_005 1.0E-5 186 97 89 0.48 40 - 50 <=50 Premenopausal
284 21317 HE10/05 18558 BR5-072   YES PIK3CA NO YES other chr03 3q26.3 in3 178917844 AMPL2705185935 178917726 178917900 29.9 2 1 INDEL TA 1 TA/T 0.013 PIK3CA intronic             NA     rs146815076 PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 -0.63,1.03 BR5-072T PRO-7-20140313_BR5_T1_ 704 tumor 50 183382 85.17 409.1 77.65 IonXpress_005 1.0E-5 676 319 357 0.53 50 - 60 <=50 Premenopausal
285 21318 HE10/05 18558 BR5-072   YES PIK3CA YES NO other chr03 3q26.3 ex 10 178936091 AMPL393459515 178935994 178936131 38.6 3 2 SNV G 1 G/A   PIK3CA exonic missense AAG 10 p.Glu545Lys 1633G>A c.1633G>A NA 946 HER-positive_carcinoma:intestil_adenocarcinoma:Merkel_cell_carcinoma:lobular_carcinoma:endometrioid_carcinoma:carcinoid-endocrine_tumour:mucinous_carcinoma:adenoid_cystic_carcinoma:serrated_carcinoma:adenoma:sopharyngeal_carcinoma:basal_cell_carcinoma rs104886003 PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 2,72 BR5-072T PRO-7-20140313_BR5_T1_ 956 tumor 50 183382 85.17 409.1 77.65 IonXpress_005 1.0E-5 939 714 225 0.24 20 - 30 <=50 Premenopausal
286 21349 HE10/05 15429 BR5-073   YES PIK3CA YES NO other chr03 3q26.3 ex21 178952085 AMPL392292511 178952020 178952194 36.3 3 2 SNV A 1 A/G   PIK3CA exonic missense CGT 21 p.His1047Arg 3140A>G c.3140A>G NA 926 HER-positive_carcinoma:ductal_epithelial_hyperplasia-hyperplasia_of_usual_type:hepatocellular_carcinoma:SHH_subtype:Merkel_cell_carcinoma:lobular_carcinoma:mixed_endometrioid_and_clear_cell_carcinoma:sopharyngeal_carcinoma:endometriosis:papilloma:mixed_ rs121913279 PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 2,33 BR5-073T PRO-7-20140313_BR5_T1_ 341 tumor 60 120121 75.16 232.5 78.53 IonXpress_006 1.0E-5 231 100 131 0.57 50 - 60 >50 Postmenopausal
287 21350 HE10/05 15429 BR5-073   YES PIK3CA NO NO nonMUTnonSNP chr03 3q26.3 ex21 178952095 AMPL392292511 178952020 178952194 36.3 3 2 SNV C 1 C/T   PIK3CA exonic synonymous GGT 21 WT 3150C>T c.3150C>T NA       PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 0,88 BR5-073T PRO-7-20140313_BR5_T1_ 341 tumor 60 120121 75.16 232.5 78.53 IonXpress_006 1.0E-5 237 112 125 0.53 50 - 60 >50 Postmenopausal
288 21382 HE10/05 19336 BR5-074   YES PIK3CA YES NO other chr03 3q26.3 ex 10 178936082 AMPL393459515 178935994 178936131 38.6 3 2 SNV G 1 G/A   PIK3CA exonic missense AAA 10 p.Glu542Lys 1624G>A c.1624G>A NA 998 HER-positive_carcinoma:liposarcoma:hepatocellular_carcinoma:intestil_adenocarcinoma:carcinosarcoma-malignt_mesodermal_mixed_tumour:undifferentiated_adenocarcinoma:Merkel_cell_carcinoma:lobular_carcinoma:endometrioid_carcinoma:mucinous_carcinoma:dysemb rs121913273 PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 2,72 BR5-074T PRO-7-20140313_BR5_T1_ 611 tumor 65 68033 84.6 152.7 81.36 IonXpress_007 1.0E-5 598 539 59 0.1 10 - 20 <=50 Premenopausal
289 21393 HE10/05 17289 BR5-075 1 NO   NO NO                                                                                             >50 Postmenopausal
290 21413 HE10/05 19430 BR5-076 1 NO   NO NO                                                                                             <=50 Premenopausal
291 21416 HE10/05 18085 BR5-077 1 YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR5-077T PRO-7-20140313_BR5_T1_ 239 tumor 70 353046 84.61 794.2 81.53 IonXpress_009 1.0E-5 217 40 177 0.82 80 - 90 <=50 Premenopausal
292 21437 HE10/05 16917 BR5-078 1 YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR5-078T PRO-26-20140725_BR08_05_rest_ 280 tumor 40 171329 85.59 386.7 49.14 IonXpress_039   270 28 242 0.9 90 - 100 >50 Postmenopausal
293 21448 HE10/05 16917 BR5-078   YES PIK3CA NO YES other chr03 3q26.3 in3 178917844 AMPL2705185935 178917726 178917900 29.9 2 1 INDEL TA 1 TA/T 0.013 PIK3CA intronic             NA     rs146815076 PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 -0.63,1.03 BR5-078T PRO-26-20140725_BR08_05_rest_ 520 tumor 40 171329 85.59 386.7 49.14 IonXpress_039   487 236 251 0.52 50 - 60 >50 Postmenopausal
294 21449 HE10/05 16529 BR5-079 1 YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR5-079T PRO-7-20140313_BR5_T1_ 204 tumor 75 449207 85.76 981.8 74.26 IonXpress_010 1.0E-5 191 93 98 0.51 50 - 60 <=50 Premenopausal
295 21463 HE10/05 16529 BR5-079   YES PIK3CA NO NO nonMUTnonSNP chr03 3q26.3 off target 115118900 AMPL6795279620 115118832 115118979 44.9 2 1 SNV C 1 C/T                   NA     rs9821873   -2,3 BR5-079T PRO-7-20140313_BR5_T1_ 559 tumor 75 449207 85.76 981.8 74.26 IonXpress_010 1.0E-5 533 284 249 0.47 40 - 50 <=50 Premenopausal
296 21465 HE10/05 16529 BR5-079   YES PIK3CA YES NO other chr03 3q26.3 ex21 178952085 AMPL392292511 178952020 178952194 36.3 3 2 SNV A 1 A/G   PIK3CA exonic missense CGT 21 p.His1047Arg 3140A>G c.3140A>G NA 926 HER-positive_carcinoma:ductal_epithelial_hyperplasia-hyperplasia_of_usual_type:hepatocellular_carcinoma:SHH_subtype:Merkel_cell_carcinoma:lobular_carcinoma:mixed_endometrioid_and_clear_cell_carcinoma:sopharyngeal_carcinoma:endometriosis:papilloma:mixed_ rs121913279 PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 2,33 BR5-079T PRO-7-20140313_BR5_T1_ 1456 tumor 75 449207 85.76 981.8 74.26 IonXpress_010 1.0E-5 831 509 322 0.39 30 - 40 <=50 Premenopausal
297 21490 HE10/05 18384 BR5-082 1 NO   NO NO                                                                                             >50 Postmenopausal
298 21569 HE10/05 16543 BR5-083 1 NO   NO NO                                                                                             >50 Postmenopausal
299 21622 HE10/05 18496 BR5-084   YES PIK3CA YES NO other chr03 3q26.3 ex21 178952085 AMPL392292511 178952020 178952194 36.3 3 2 SNV A 1 A/G   PIK3CA exonic missense CGT 21 p.His1047Arg 3140A>G c.3140A>G NA 926 HER-positive_carcinoma:ductal_epithelial_hyperplasia-hyperplasia_of_usual_type:hepatocellular_carcinoma:SHH_subtype:Merkel_cell_carcinoma:lobular_carcinoma:mixed_endometrioid_and_clear_cell_carcinoma:sopharyngeal_carcinoma:endometriosis:papilloma:mixed_ rs121913279 PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 2,33 BR5-084T PRO-7-20140313_BR5_T1_ 1094 tumor 50 160696 82.02 342 53.39 IonXpress_014 1.0E-5 573 393 180 0.31 30 - 40 >50 Premenopausal
300 21625 HE10/05 18496 BR5-084   YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR5-084T PRO-7-20140313_BR5_T1_ 183 tumor 50 160696 82.02 342 53.39 IonXpress_014 1.0E-5 156 83 71 0.46 40 - 50 >50 Premenopausal
301 21626 HE10/05 18249 BR5-085 1 YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR5-085T PRO-7-20140313_BR5_T1_ 879 tumor 65 888238 88.07 2086 82.27 IonXpress_015 1.0E-5 830 150 680 0.82 80 - 90 >50 Postmenopausal
302 21647 HE10/05 17231 BR5-086 1 YES TP53 NO YES other chr17 17p13.1 ex7-in7 7577407 AMPL3426752792 7577372 7577532 61 2 3 SNV A 1 A/C 0.163 TP53 intronic             NA     rs12951053 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif -1,68 BR5-086T PRO-26-20140725_BR08_05_rest_ 298 tumor 40 63638 82.18 141.2 70.8 IonXpress_041   234 191 43 0.18 10 - 20 <=50 Premenopausal
303 21668 HE10/05 17231 BR5-086   YES TP53 NO YES other chr17 17p13.1 ex7-in7 7577427 AMPL3426752792 7577372 7577532 61 2 3 SNV G 1 G/A 0.163 TP53 intronic             NA     rs12947788 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 0,16 BR5-086T PRO-26-20140725_BR08_05_rest_ 298 tumor 40 63638 82.18 141.2 70.8 IonXpress_041   248 205 43 0.17 10 - 20 <=50 Premenopausal
304 21669 HE10/05 17231 BR5-086   YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR5-086T PRO-26-20140725_BR08_05_rest_ 164 tumor 40 63638 82.18 141.2 70.8 IonXpress_041   149 49 100 0.67 60 - 70 <=50 Premenopausal
305 21685 HE10/05 19349 BR5-087 1 YES PIK3CA YES NO other chr03 3q26.3 ex 10 178936082 AMPL393459515 178935994 178936131 38.6 3 2 SNV G 1 G/A   PIK3CA exonic missense AAA 10 p.Glu542Lys 1624G>A c.1624G>A NA 998 HER-positive_carcinoma:liposarcoma:hepatocellular_carcinoma:intestil_adenocarcinoma:carcinosarcoma-malignt_mesodermal_mixed_tumour:undifferentiated_adenocarcinoma:Merkel_cell_carcinoma:lobular_carcinoma:endometrioid_carcinoma:mucinous_carcinoma:dysemb rs121913273 PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 2,72 BR5-087T PRO-7-20140313_BR5_T1_ 188 tumor 70 17264 73.33 32.67 74.9 IonXpress_016 1.0E-5 184 111 73 0.4 40 - 50 >50 Postmenopausal
306 21691 HE10/05 18925 BR5-088 1 NO   NO NO                                                                                             <=50 Premenopausal
307 21698 HE10/05 17590 BR5-090 1 NO   NO NO                                                                                             >50 Postmenopausal
308 21723 HE10/05 17424 BR5-092   YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR5-092T PRO-7-20140313_BR5_T1_ 131 tumor 50 73282 76.6 143.2 48.37 IonXpress_019 1.0E-5 122 19 103 0.84 80 - 90 <=50 Premenopausal
309 21732 HE10/05 18811 BR5-094 1 NO   NO NO                                                                                             <=50 Premenopausal
310 21769 HE10/05 16984 BR5-098   YES PIK3CA YES NO other chr03 3q26.3 ex 10 178936094 AMPL393459515 178935994 178936131 38.6 3 2 SNV C 1 C/A   PIK3CA exonic missense AAG 10 p.Gln546Lys 1636C>A c.1636C>A NA 958 HER-positive_carcinoma:diffuse_adenocarcinoma:Merkel_cell_carcinoma:small_cell_carcinoma:clear_cell_carcinoma:serous_carcinoma:endometrioid_carcinoma:WNT_subtype:adenocarcinoma:squamous_cell_carcinoma:serrated_carcinoma:acute_lymphoblastic_T_cell_leukaemi rs121913286 PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 2,72 BR5-098aT PRO-7-20140313_BR5_T1_ 487 tumor 65 62189 79.3 125.8 72.44 IonXpress_023 1.0E-5 478 349 129 0.27 20 - 30 >50 Postmenopausal
311 21788 HE10/05 19386 BR5-099 1 YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 C/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR5-099T PRO-7-20140313_BR5_T1_ 203 tumor 70 393858 91.31 967.5 79.82 IonXpress_024 1.0E-5 185 28 157 0.85 80 - 90 <=50 Premenopausal
312 21846 HE10/05 18091 BR5-100   YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR5-100T PRO-7-20140313_BR5_T1_ 204 tumor 70 394542 89.11 937.1 80.2 IonXpress_025 1.0E-5 196 97 99 0.51 50 - 60 >50 Premenopausal
313 21849 HE10/05 15421 BR5-104 1 YES TP53 NO YES other chr17 17p13.1 ex7-in7 7577407 AMPL3426752792 7577372 7577532 61 2 3 SNV A 1 A/C 0.163 TP53 intronic             NA     rs12951053 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif -1,68 BR5-104aT PRO-7-20140313_BR5_T1_ 334 tumor 75 133654 75.82 255.9 69.94 IonXpress_028 1.0E-5 295 197 98 0.33 30 - 40 <=50 Premenopausal
314 21866 HE10/05 15421 BR5-104   YES TP53 NO YES other chr17 17p13.1 ex7-in7 7577427 AMPL3426752792 7577372 7577532 61 2 3 SNV G 1 G/A 0.163 TP53 intronic             NA     rs12947788 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 0,16 BR5-104aT PRO-7-20140313_BR5_T1_ 334 tumor 75 133654 75.82 255.9 69.94 IonXpress_028 1.0E-5 311 210 101 0.32 30 - 40 <=50 Premenopausal
315 21875 HE10/05 17443 BR5-105 1 NO   NO NO                                                                                             <=50 Premenopausal
316 21913 HE10/05 17444 BR5-108 1 NO   NO NO                                                                                             >50 Premenopausal
317 21976 HE10/05 9791 BR5-109   YES TP53 YES NO other chr17 17p13.1 in7-ex8 7577120 AMPL1481474315 7577115 7577289 48.1 2 3 SNV C 1 C/T   TP53 exonic missense CAT 8 p.Arg273His 818G>A c.818G>A NA   HER-positive_carcinoma:hepatocellular_carcinoma:Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour:yolk_sac_tumour:Merkel_cell_carcinoma:chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma:carcinoid-endocrine_tumour:mantle_cell_lymphoma:margi rs28934576 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 2,56 BR5-109T PRO-7-20140313_BR5_T1_ 168 tumor 60 156025 85.32 347.2 77.68 IonXpress_032 1.0E-5 148 87 61 0.41 40 - 50 <=50 Premenopausal
318 21987 HE10/05 16918 BR5-110 1 NO   NO NO                                                                                             >50 Postmenopausal
319 22043 HE10/05 19100 BR5-111   YES TP53 NO YES other chr17 17p13.1 ex7-in7 7577407 AMPL3426752792 7577372 7577532 61 2 3 SNV A 1 A/C 0.163 TP53 intronic             NA     rs12951053 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif -1,68 BR5-111T PRO-7-20140313_BR5_T1_ 130 tumor 80 121171 90.05 291.2 78.93 IonXpress_034 1.0E-5 126 24 102 0.81 80 - 90 <=50 Premenopausal
320 22044 HE10/05 19100 BR5-111   YES TP53 NO YES other chr17 17p13.1 ex7-in7 7577427 AMPL3426752792 7577372 7577532 61 2 3 SNV G 1 G/A 0.163 TP53 intronic             NA     rs12947788 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 0,16 BR5-111T PRO-7-20140313_BR5_T1_ 130 tumor 80 121171 90.05 291.2 78.93 IonXpress_034 1.0E-5 123 24 99 0.8 80 - 90 <=50 Premenopausal
321 22047 HE10/05 16678 BR5-112 1 NO   NO NO                                                                                             <=50 Premenopausal
322 22077 HE10/05 18713 BR5-113 1 NO   NO NO                                                                                             <=50 Premenopausal
323 22103 HE10/05 17625 BR5-114   YES PIK3CA NO YES other chr03 3q26.3 off target 115118900 AMPL6795279620 115118832 115118979 44.9 2 1 SNV C 1 C/T 0.066                 NA     rs9821873   -2,3 BR5-114T PRO-7-20140313_BR5_T1_ 466 tumor 60 118888 75.18 223.1 57.4 IonXpress_037 1.0E-5 447 251 196 0.44 40 - 50 <=50 Premenopausal
324 22123 HE10/05 15420 BR5-115   YES PIK3CA NO YES other chr03 3q26.3 ex21 178952020 AMPL1497305257 178951918 178952092 38.1 3 3 SNV C 1 C/T 0.016 PIK3CA exonic synonymous ACT 21 WT 3075C>T c.3075C>T NA   squamous_cell_carcinoma:Hurthle_cell_carcinoma:hepatocellular_carcinoma:acute_lymphoblastic_T_cell_leukaemia:serous_carcinoma:endometrioid_carcinoma:chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma:carcinoma rs17849079 PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 0,12 BR5-115aT PRO-7-20140313_BR5_T1_ 564 tumor 50 145399 79.51 296.3 52.19 IonXpress_038 1.0E-5 541 243 298 0.55 50 - 60 <=50 Premenopausal
325 22133 HE10/05 17234 BR5-117 1 NO   NO NO                                                                                             <=50 Premenopausal
326 22154 HE10/05 17448 BR5-119 1 NO   NO NO                                                                                             <=50 Premenopausal
327 22190 HE10/05 19293 BR5-120 1 NO   NO NO                                                                                             >50 Postmenopausal
328 22241 HE10/05 19338 BR5-121   YES PIK3CA YES NO other chr03 3q26.3 ex 10 178936091 AMPL393459515 178935994 178936131 38.6 3 2 SNV G 1 G/A   PIK3CA exonic missense AAG 10 p.Glu545Lys 1633G>A c.1633G>A NA 946 HER-positive_carcinoma:intestil_adenocarcinoma:Merkel_cell_carcinoma:lobular_carcinoma:endometrioid_carcinoma:carcinoid-endocrine_tumour:mucinous_carcinoma:adenoid_cystic_carcinoma:serrated_carcinoma:adenoma:sopharyngeal_carcinoma:basal_cell_carcinoma rs104886003 PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 2,72 BR5-121T PRO-7-20140313_BR5_T1_ 1704 tumor 75 110826 86.33 245.1 63.99 IonXpress_042 1.0E-5 1679 954 725 0.43 40 - 50 <=50 Premenopausal
329 22247 HE10/05 19338 BR5-121   YES TP53 NO YES other chr17 17p13.1 ex7-in7 7577407 AMPL3426752792 7577372 7577532 61 2 3 SNV A 1 A/C 0.163 TP53 intronic             NA     rs12951053 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif -1,68 BR5-121T PRO-7-20140313_BR5_T1_ 390 tumor 75 110826 86.33 245.1 63.99 IonXpress_042 1.0E-5 336 180 156 0.46 40 - 50 <=50 Premenopausal
330 22248 HE10/05 19338 BR5-121   YES TP53 NO YES other chr17 17p13.1 ex7-in7 7577427 AMPL3426752792 7577372 7577532 61 2 3 SNV G 1 G/A 0.163 TP53 intronic             NA     rs12947788 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 0,16 BR5-121T PRO-7-20140313_BR5_T1_ 390 tumor 75 110826 86.33 245.1 63.99 IonXpress_042 1.0E-5 363 190 173 0.48 40 - 50 <=50 Premenopausal
331 22249 HE10/05 19338 BR5-121   YES TP53 NO YES other chr17 17p13.1 in3-ex4 7579579 AMPL6795075395 7579475 7579618 52 2 3 SNV C 1 C/T 0.012 TP53 exonic synonymous CCA 4 WT 108G>A c.108G>A NA   adenocarcinoma rs1800370 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif -1,05 BR5-121T PRO-7-20140313_BR5_T1_ 487 tumor 75 110826 86.33 245.1 63.99 IonXpress_042 1.0E-5 467 248 219 0.47 40 - 50 <=50 Premenopausal
332 22250 HE10/05 18813 BR5-122 1 NO   NO NO                                                                                             >50 Premenopausal
333 22306 HE10/05 17725 BR5-125   YES PIK3CA YES NO other chr03 3q26.3 ex 10 178936082 AMPL393459515 178935994 178936131 38.6 3 2 SNV G 1 G/A   PIK3CA exonic missense AAA 10 p.Glu542Lys 1624G>A c.1624G>A NA 998 HER-positive_carcinoma:liposarcoma:hepatocellular_carcinoma:intestil_adenocarcinoma:carcinosarcoma-malignt_mesodermal_mixed_tumour:undifferentiated_adenocarcinoma:Merkel_cell_carcinoma:lobular_carcinoma:endometrioid_carcinoma:mucinous_carcinoma:dysemb rs121913273 PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 2,72 BR5-125T PRO-7-20140313_BR5_T1_ 984 tumor 65 89248 79.33 179.7 75.55 IonXpress_046 1.0E-5 965 556 409 0.42 40 - 50 >50 Postmenopausal
334 22315 HE10/05 16923 BR5-126 1 YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR5-126T PRO-7-20140313_BR5_T1_ 986 tumor 50 1344134 86.02 3065 82.18 IonXpress_047 1.0E-5 908 146 762 0.84 80 - 90 >50 Postmenopausal
335 22332 HE10/05 16923 BR5-126   YES PIK3CA YES NO other chr03 3q26.3 ex21 178952085 AMPL392292511 178952020 178952194 36.3 3 2 SNV A 1 A/T   PIK3CA exonic missense CTT 21 p.His1047Leu 3140A>T c.3140A>T NA 957 HER-positive_carcinoma:ductal_epithelial_hyperplasia-hyperplasia_of_usual_type:hepatocellular_carcinoma:SHH_subtype:Merkel_cell_carcinoma:lobular_carcinoma:mixed_endometrioid_and_clear_cell_carcinoma:sopharyngeal_carcinoma:endometriosis:papilloma:mixed_ rs121913279 PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 2,33 BR5-126T PRO-7-20140313_BR5_T1_ 5332 tumor 50 1344134 86.02 3065 82.18 IonXpress_047 1.0E-5 1998 1612 386 0.19 10 - 20 >50 Postmenopausal
336 22342 HE10/05 16739 BR5-127 1 NO   NO NO                                                                                             >50 Postmenopausal
337 22401 HE10/05 19280 BR5-128   YES TP53 NO YES other chr17 17p13.1 ex7-in7 7577427 AMPL3426752792 7577372 7577532 61 2 3 SNV G 1 G/A 0.163 TP53 intronic             NA     rs12947788 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 0,16 BR5-128T PRO-8-20140314_BR5_T2_ 112 tumor 65 41784 86.52 98.34 80.38 IonXpress_049 1.0E-5 101 55 46 0.46 40 - 50 >50 Postmenopausal
338 22404 HE10/05 18244 BR5-130 1 NO   NO NO                                                                                             >50 Postmenopausal
339 22432 HE10/05 17284 BR5-131 1 NO   NO NO                                                                                             <=50 Premenopausal
340 22441 HE10/05 16367 BR5-132 1 YES TP53 NO YES other chr17 17p13.1 ex7-in7 7577407 AMPL3426752792 7577372 7577532 61 2 3 SNV A 1 A/C 0.163 TP53 intronic             NA     rs12951053 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif -1,68 BR5-132T PRO-8-20140314_BR5_T2_ 428 tumor 65 121574 85.04 283.8 76.42 IonXpress_053 1.0E-5 385 125 260 0.68 60 - 70 >50 Premenopausal
341 22467 HE10/05 16367 BR5-132   YES TP53 NO YES other chr17 17p13.1 ex7-in7 7577427 AMPL3426752792 7577372 7577532 61 2 3 SNV G 1 G/A 0.163 TP53 intronic             NA     rs12947788 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 0,16 BR5-132T PRO-8-20140314_BR5_T2_ 428 tumor 65 121574 85.04 283.8 76.42 IonXpress_053 1.0E-5 395 133 262 0.66 60 - 70 >50 Premenopausal
342 22473 HE10/05 17445 BR5-137 1 NO   NO NO                                                                                             <=50 Premenopausal
343 22513 HE10/05 18373 BR5-138   YES PIK3CA YES NO other chr03 3q26.3 ex21 178952085 AMPL392292511 178952020 178952194 36.3 3 2 SNV A 1 A/G   PIK3CA exonic missense CGT 21 p.His1047Arg 3140A>G c.3140A>G NA 926 HER-positive_carcinoma:ductal_epithelial_hyperplasia-hyperplasia_of_usual_type:hepatocellular_carcinoma:SHH_subtype:Merkel_cell_carcinoma:lobular_carcinoma:mixed_endometrioid_and_clear_cell_carcinoma:sopharyngeal_carcinoma:endometriosis:papilloma:mixed_ rs121913279 PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 2,33 BR5-138T PRO-8-20140314_BR5_T2_ 416 tumor 50 63671 83.58 143.4 76.68 IonXpress_056 1.0E-5 209 150 59 0.28 20 - 30 >50 Postmenopausal
344 22531 HE10/05 19114 BR5-139   YES PIK3CA NO YES other chr03 3q26.3 in3 178917844 AMPL2705185935 178917726 178917900 29.9 2 1 INDEL TA 1 TA/T 0.013 PIK3CA intronic             NA     rs146815076 PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 -0.63,1.03 BR5-139T PRO-8-20140314_BR5_T2_ 526 tumor 75 117190 85.33 266.1 79.14 IonXpress_057 1.0E-5 508 198 310 0.61 60 - 70 >50 Postmenopausal
345 22538 HE10/05 18924 BR5-140 1 NO   NO NO                                                                                             <=50 Premenopausal
346 22556 HE10/05 19122 BR5-144 1 NO   NO NO                                                                                             >50 Postmenopausal
347 22580 HE10/05 18099 BR5-147   YES PIK3CA YES NO other chr03 3q26.3 ex 10 178936091 AMPL393459515 178935994 178936131 38.6 3 2 SNV G 1 G/A   PIK3CA exonic missense AAG 10 p.Glu545Lys 1633G>A c.1633G>A NA 946 HER-positive_carcinoma:intestil_adenocarcinoma:Merkel_cell_carcinoma:lobular_carcinoma:endometrioid_carcinoma:carcinoid-endocrine_tumour:mucinous_carcinoma:adenoid_cystic_carcinoma:serrated_carcinoma:adenoma:sopharyngeal_carcinoma:basal_cell_carcinoma rs104886003 PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 2,72 BR5-147T PRO-8-20140314_BR5_T2_ 1363 tumor 60 149663 84.87 331.9 75.72 IonXpress_063 1.0E-5 1348 947 401 0.3 30 - 40 <=50 Premenopausal
348 22595 HE10/05 16913 BR5-148 1 NO   NO NO                                                                                             <=50 Postmenopausal
349 22664 HE10/05 16575 BR5-150   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 in9-ex10 7574013 AMPL387899835 7573927 7574055 62.8 1 1 SNV G 1 G/A   TP53 exonic synonymous TTT 10 WT 1014C>T c.1014C>T NA   squamous_cell_carcinoma rs150293825 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif -1,36 BR5-150T PRO-8-20140314_BR5_T2_ 1189 tumor 70 1303079 77.26 2582 77.95 IonXpress_065 1.0E-5 1170 302 868 0.74 70 - 80 <=50 Premenopausal
350 22665 HE10/05 16575 BR5-150   YES TP53 YES NO other chr17 17p13.1 ex4-in4 7579358 AMPL1481773781 7579257 7579411 56.1 2 3 INDEL CG 1 CG/C   TP53 exonic frameshiftDeletion   4 p.Arg110Val 328_328delC c.328_328delC NA   HER-positive_carcinoma:leiomyosarcoma:hepatocellular_carcinoma:large_cell_carcinoma:NS:serous_carcinoma:transitiol_cell_carcinoma:adenocarcinoma:squamous_cell_carcinoma:malignt_peripheral_nerve_sheath_tumour:neoplasm:acute_lymphoblastic_T_cell_leukaem rs11540654 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif -0.19,-0.01 BR5-150T PRO-8-20140314_BR5_T2_ 2037 tumor 70 1303079 77.26 2582 77.95 IonXpress_065 1.0E-5 1931 914 1017 0.53 50 - 60 <=50 Premenopausal
351 22666 HE10/05 16575 BR5-150   YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR5-150T PRO-8-20140314_BR5_T2_ 331 tumor 70 1303079 77.26 2582 77.95 IonXpress_065 1.0E-5 294 60 234 0.8 80 - 90 <=50 Premenopausal
352 22668 HE10/05 15730 BR5-151 1 NO   NO NO                                                                                             >50 Postmenopausal
353 22672 HE10/05 18385 BR5-153 1 YES TP53 NO YES nonMUTnonSNP chr17 17p13.1 ex6-in6 7578210 AMPL4574207192 7578114 7578273 53.5 1 1 SNV T 1 T/C 0.007 TP53 exonic synonymous CGG 6 WT 639A>G c.639A>G NA   oligodendroglioma_Grade_II:adenocarcinoma:adenoma:carcinoma rs1800372 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif -0,16 BR5-153bT PRO-8-20140314_BR5_T2_ 163 tumor 80 317964 80.52 668.4 62.3 IonXpress_067 1.0E-5 161 60 101 0.63 60 - 70 >50 Postmenopausal
354 22692 HE10/05 17845 BR5-154 1 YES TP53 YES NO other chr17 17p13.1 ex8-in8 7577082 AMPL706844244 7576996 7577170 61.6 1 2 SNV C 1 C/T   TP53 exonic missense AAA 8 p.Glu286Lys 856G>A c.856G>A NA 1 lymphoid_neoplasm:medullary_carcinoma:oligodendroglioma:hepatocellular_carcinoma:lobular_carcinoma:Bowen_disease:chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma:myelodysplastic_syndrome:mantle_cell_lymphoma:margil_zone_lymphoma:basal_cell_carci   P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 2,58 BR5-154T PRO-8-20140314_BR5_T2_ 794 tumor 90 461650 83.56 1021 46.49 IonXpress_068 1.0E-5 763 209 554 0.73 70 - 80 >50 Postmenopausal
355 22709 HE10/05 17845 BR5-154   YES TP53 NO YES nonMUTnonSNP chr17 17p13.1 ex6-in6 7578210 AMPL4574207192 7578114 7578273 53.5 1 1 SNV T 1 T/C 0.007 TP53 exonic synonymous CGG 6 WT 639A>G c.639A>G NA   oligodendroglioma_Grade_II:adenocarcinoma:adenoma:carcinoma rs1800372 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif -0,16 BR5-154T PRO-8-20140314_BR5_T2_ 528 tumor 90 461650 83.56 1021 46.49 IonXpress_068 1.0E-5 512 94 418 0.82 80 - 90 >50 Postmenopausal
356 22711 HE10/05 16533 BR5-155 1 NO   NO NO                                                                                             <=50 Premenopausal
357 22744 HE10/05 17076 BR5-157   YES PIK3CA YES NO other chr03 3q26.3 ex21 178952030 AMPL1497305257 178951918 178952092 38.1 3 3 SNV G 1 G/A   PIK3CA exonic missense AAT 21 p.Asp1029Asn 3085G>A c.3085G>A NA 25 small_cell_carcinoma:carcinoma:endometrioid_carcinoma   PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 2,89 BR5-157T PRO-8-20140314_BR5_T2_ 636 tumor 75 84648 72.18 157.5 44.74 IonXpress_070 1.0E-5 628 566 62 0.1 10 - 20 >50 Postmenopausal
358 22838 HE10/05 16221 BR5-159   YES PIK3CA NO YES other chr03 3q26.3 off target 115118900 AMPL6795279620 115118832 115118979 44.9 2 1 SNV C 1 C/T 0.066                 NA     rs9821873   -2,3 BR5-159T PRO-8-20140314_BR5_T2_ 499 tumor 65 191052 75.3 371.5 78.24 IonXpress_072 1.0E-5 483 262 221 0.46 40 - 50 <=50 Premenopausal
359 22884 HE10/05 16368 BR5-160 1 NO   NO NO                                                                                             <=50 Premenopausal
360 22899 HE10/05 16372 BR5-164 1 NO   NO NO                                                                                             >50 Postmenopausal
361 22931 HE10/05 17452 BR5-165   YES TP53 NO YES other chr17 17p13.1 in3-ex4 7579579 AMPL6795075395 7579475 7579618 52 2 3 SNV C 1 C/T 0.012 TP53 exonic synonymous CCA 4 WT 108G>A c.108G>A NA   adenocarcinoma rs1800370 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif -1,05 BR5-165IS PRO-16-20140515_BR5_N_IS_ 290 tumor 75 135697 59.82 201 48.97 IonXpress_003 1.0E-5 283 123 160 0.57 50 - 60 <=50 Premenopausal
362 22947 HE10/05 19244 BR5-169   YES PIK3CA YES NO other chr03 3q26.3 ex 10 178936082 AMPL393459515 178935994 178936131 38.6 3 2 SNV G 1 G/A   PIK3CA exonic missense AAA 10 p.Glu542Lys 1624G>A c.1624G>A NA 998 HER-positive_carcinoma:liposarcoma:hepatocellular_carcinoma:intestil_adenocarcinoma:carcinosarcoma-malignt_mesodermal_mixed_tumour:undifferentiated_adenocarcinoma:Merkel_cell_carcinoma:lobular_carcinoma:endometrioid_carcinoma:mucinous_carcinoma:dysemb rs121913273 PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 2,72 BR5-169T PRO-8-20140314_BR5_T2_ 1956 tumor 90 229123 85.14 523.7 77.9 IonXpress_081 1.0E-5 1929 1141 788 0.41 40 - 50 >50 Premenopausal
363 22948 HE10/05 19244 BR5-169   YES PIK3CA YES NO other chr03 3q26.3 ex21 178952018 AMPL1497305257 178951918 178952092 38.1 3 3 SNV A 1 A/G   PIK3CA exonic missense GCC 21 p.Thr1025Ala 3073A>G c.3073A>G NA 998 adenocarcinoma:intestil_adenocarcinoma:aplastic_carcinoma:PRL:serous_carcinoma:endometrioid_carcinoma:carcinoma   PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 2,33 BR5-169T PRO-8-20140314_BR5_T2_ 528 tumor 90 229123 85.14 523.7 77.9 IonXpress_081 1.0E-5 518 253 265 0.51 50 - 60 >50 Premenopausal
364 22971 HE10/05 17721 BR5-171   YES TP53 YES NO other chr17 17p13.1 in8-ex9-in9 7576889 AMPL1516620128 7576812 7576978 50 1 2 INDEL CT 1 CT/C   TP53 exonic frameshiftDeletion   9 p.Lys319Arg 956_956delA c.956_956delA NA   transitiol_cell_carcinoma:squamous_cell_carcinoma   P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1.4,0.95 BR5-171T PRO-8-20140314_BR5_T2_ 219 tumor 50 61728 87.76 151.2 46.79 IonXpress_083 1.0E-5 217 121 96 0.44 40 - 50 <=50 Premenopausal
365 22993 HE10/05 17836 BR5-173   YES PIK3CA YES NO other chr03 3q26.3 ex21 178952085 AMPL392292511 178952020 178952194 36.3 3 2 SNV A 1 A/G   PIK3CA exonic missense CGT 21 p.His1047Arg 3140A>G c.3140A>G NA 926 HER-positive_carcinoma:ductal_epithelial_hyperplasia-hyperplasia_of_usual_type:hepatocellular_carcinoma:SHH_subtype:Merkel_cell_carcinoma:lobular_carcinoma:mixed_endometrioid_and_clear_cell_carcinoma:sopharyngeal_carcinoma:endometriosis:papilloma:mixed_ rs121913279 PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 2,33 BR5-173T PRO-26-20140725_BR08_05_rest_ 2431 tumor 40 658638 87.55 1545 85.22 IonXpress_048   1859 1055 804 0.43 40 - 50 >50 Postmenopausal
366 23002 HE10/05 18367 BR5-174 1 YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif   BR5-174IS PRO-16-20140515_BR5_N_IS_ 255 tumor 50 2347677 86.56 5353 55.83 IonXpress_004 1.0E-5 216 147 69 0.32 30 - 40 <=50 Premenopausal
367 23014 HE10/05 18367 BR5-174   YES PIK3CA NO YES other chr03 3q26.3 in1 178866408 AMPL4347527835 178866384 178866543 78.2     SNV C 1 C/T 0.149 PIK3CA intronic             NA     rs2699887 PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2   BR5-174IS PRO-16-20140515_BR5_N_IS_ 459 tumor 50 2347677 86.56 5353 55.83 IonXpress_004 1.0E-5 214 68 146 0.68 60 - 70 <=50 Premenopausal
368 23024 HE10/05 18367 BR5-174   YES TP53 YES NO other chr17 17p13.1 ex5-in5 7578393 AMPL1992796664 7578284 7578458 63.7 1 2 SNV A 1 A/T   TP53 exonic missense CAA 5 p.His179Gln 537T>A c.537T>A NA   mucinous_carcinoma:diffuse_large_B_cell_lymphoma:adenocarcinoma:squamous_cell_carcinoma:hepatocellular_carcinoma:NK-T_cell_lymphoma:basal_(triple-negative)_carcinoma:intestil_adenocarcinoma:astrocytoma_Grade_IV:ductal_carcinoma:carcinoma:serous_carcinom   P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif   BR5-174IS PRO-16-20140515_BR5_N_IS_ 6876 tumor 50 2347677 86.56 5353 55.83 IonXpress_004 1.0E-5 1999 1605 394 0.2 20 - 30 <=50 Premenopausal
369 23028 HE10/05 17156 BR5-176 1 NO   NO NO                                                                                             >50 Postmenopausal
370 23038 HE10/05 18122 BR5-177 1 NO   NO NO                                                                                             >50 Postmenopausal
371 23092 HE10/05 17945 BR5-178   YES PIK3CA NO YES other chr03 3q26.3 off target 115118900 AMPL6795279620 115118832 115118979 44.9 2 1 SNV C 1 C/T 0.066                 NA     rs9821873   -2,3 BR5-178T PRO-8-20140314_BR5_T2_ 190 tumor 60 159749 56.3 224.5 77.1 IonXpress_088 1.0E-5 185 105 80 0.43 40 - 50 <=50 Postmenopausal
372 23107 HE10/05 17945 BR5-178   YES TP53 YES NO other chr17 17p13.1 ex8-in8 7577106 AMPL706844244 7576996 7577170 61.6 1 2 SNV G 1 G/A   TP53 exonic missense TCT 8 p.Pro278Ser 832C>T c.832C>T NA 1 hepatocellular_carcinoma:carcinosarcoma-malignt_mesodermal_mixed_tumour:Bowen_disease:endometrioid_carcinoma:papillary_rel_cell_carcinoma:mantle_cell_lymphoma:malignt_peripheral_nerve_sheath_tumour:superficial_spreading:basal_cell_carcinoma:non_smal rs17849781 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 2,67 BR5-178T PRO-8-20140314_BR5_T2_ 138 tumor 60 159749 56.3 224.5 77.1 IonXpress_088 1.0E-5 134 78 56 0.42 40 - 50 <=50 Postmenopausal
373 23108 HE10/05 17945 BR5-178   YES TP53 NO YES other chr17 17p13.1 ex7-in7 7577407 AMPL3426752792 7577372 7577532 61 2 3 SNV A 1 A/C 0.163 TP53 intronic             NA     rs12951053 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif -1,68 BR5-178T PRO-8-20140314_BR5_T2_ 222 tumor 60 159749 56.3 224.5 77.1 IonXpress_088 1.0E-5 205 80 125 0.61 60 - 70 <=50 Postmenopausal
374 23109 HE10/05 17945 BR5-178   YES TP53 NO YES other chr17 17p13.1 ex7-in7 7577427 AMPL3426752792 7577372 7577532 61 2 3 SNV G 1 G/A 0.163 TP53 intronic             NA     rs12947788 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 0,16 BR5-178T PRO-8-20140314_BR5_T2_ 222 tumor 60 159749 56.3 224.5 77.1 IonXpress_088 1.0E-5 210 84 126 0.6 60 - 70 <=50 Postmenopausal
375 23112 HE10/05 19109 BR5-179 1 NO   NO NO                                                                                             >50 Postmenopausal
376 23126 HE10/05 17654 BR5-184 1 NO   NO NO                                                                                             >50 Postmenopausal
377 23130 HE10/05 17437 BR5-185 1 NO   NO NO                                                                                             <=50 Premenopausal
378 23138 HE10/05 15756 BR5-186 1 NO   NO NO                                                                                             <=50 Premenopausal
379 23164 HE10/05 18370 BR5-188 1 NO   NO NO                                                                                             >50 Postmenopausal
380 23239 HE10/05 18725 BR5-190   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 in8-ex9-in9 7576852 AMPL1516620128 7576812 7576978 50 1 2 SNV C 1 C/T   TP53 splicesite_3             NA   adenocarcinoma:squamous_cell_carcinoma:adenoma:neoplasm:intestil_adenocarcinoma:basal_cell_carcinoma:malignt_fibrous_histiocytoma-pleomorphic_sarcoma:NS:small_cell_carcinoma:serous_carcinoma:carcinoma rs11575997 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 2,46 BR5-190T PRO-8-20140314_BR5_T2_ 539 tumor 80 644538 77.82 1316 78.55 IonXpress_001 1.0E-5 520 372 148 0.49 40 - 50 >50 Postmenopausal
381 23240 HE10/05 18725 BR5-190   YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR5-190T PRO-8-20140314_BR5_T2_ 248 tumor 80 644538 77.82 1316 78.55 IonXpress_001 1.0E-5 221 111 110 0.49 40 - 50 >50 Postmenopausal
382 23241 HE10/05 16925 BR5-192 1 YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR5-192T PRO-8-20140314_BR5_T2_ 283 tumor 60 985566 85.24 2154 81.11 IonXpress_002 1.0E-5 256 60 196 0.49 40 - 50 >50 Postmenopausal
383 23254 HE10/05 16925 BR5-192   YES PIK3CA YES NO other chr03 3q26.3 ex 10 178936082 AMPL393459515 178935994 178936131 38.6 3 2 SNV G 1 G/A   PIK3CA exonic missense AAA 10 p.Glu542Lys 1624G>A c.1624G>A NA 998 HER-positive_carcinoma:liposarcoma:hepatocellular_carcinoma:intestil_adenocarcinoma:carcinosarcoma-malignt_mesodermal_mixed_tumour:undifferentiated_adenocarcinoma:Merkel_cell_carcinoma:lobular_carcinoma:endometrioid_carcinoma:mucinous_carcinoma:dysemb rs121913273 PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 2,72 BR5-192T PRO-8-20140314_BR5_T2_ 3612 tumor 60 985566 85.24 2154 81.11 IonXpress_002 1.0E-5 1997 1678 319 0.49 40 - 50 >50 Postmenopausal
384 23262 HE10/05 16925 BR5-192   YES TP53 YES NO other chr17 17p13.1 in6-ex7-in7 7577559 AMPL4981177402 7577472 7577638 53.4 2 3 SNV G 1 G/C   TP53 exonic missense TGC 7 p.Ser241Cys 722C>G c.722C>G NA   acute_myeloid_leukaemia_myelodysplastic_syndrome_therapy_related_NOS:hepatocellular_carcinoma:intestil_adenocarcinoma:hairy_cell_leukaemia:endometrioid_carcinoma:chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma:carcinoid-endocrine_tumour:myelody rs28934573 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,3 BR5-192T PRO-8-20140314_BR5_T2_ 920 tumor 60 985566 85.24 2154 81.11 IonXpress_002 1.0E-5 894 558 336 0.49 40 - 50 >50 Postmenopausal
385 23264 HE10/05 16925 BR5-192   YES TP53 NO YES nonMUTnonSNP chr17 17p13.1 ex6-in6 7578210 AMPL4574207192 7578114 7578273 53.5 1 1 SNV T 1 T/C 0.007 TP53 exonic synonymous CGG 6 WT 639A>G c.639A>G NA   oligodendroglioma_Grade_II:adenocarcinoma:adenoma:carcinoma rs1800372 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif -0,16 BR5-192T PRO-8-20140314_BR5_T2_ 625 tumor 60 985566 85.24 2154 81.11 IonXpress_002 1.0E-5 616 206 410 0.49 40 - 50 >50 Postmenopausal
386 23265 HE10/05 15430 BR5-193 1 YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR5-193T PRO-8-20140314_BR5_T2_ 162 tumor 75 847271 72.33 1591 76.55 IonXpress_003 1.0E-5 142 32 110 0.49 40 - 50 >50 Postmenopausal
387 23277 HE10/05 15430 BR5-193   YES PIK3CA YES NO other chr03 3q26.3 ex21 178952085 AMPL1497305257 178951918 178952092 38.1 3 3 SNV A 1 A/G   PIK3CA exonic missense CGT 21 p.His1047Arg 3140A>G c.3140A>G NA 926 HER-positive_carcinoma:ductal_epithelial_hyperplasia-hyperplasia_of_usual_type:hepatocellular_carcinoma:SHH_subtype:Merkel_cell_carcinoma:lobular_carcinoma:mixed_endometrioid_and_clear_cell_carcinoma:sopharyngeal_carcinoma:endometriosis:papilloma:mixed_ rs121913279 PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 2,33 BR5-193T PRO-8-20140314_BR5_T2_ 1594 tumor 75 847271 72.33 1591 76.55 IonXpress_003 1.0E-5 412 181 231 0.49 40 - 50 >50 Postmenopausal
388 23286 HE10/05 15430 BR5-193   YES TP53 YES NO other chr17 17p13.1 in6-ex7-in7 7577559 AMPL4981177402 7577472 7577638 53.4 2 3 SNV G 1 G/A   TP53 exonic missense TTC 7 p.Ser241Phe 722C>T c.722C>T NA   acute_myeloid_leukaemia_myelodysplastic_syndrome_therapy_related_NOS:hepatocellular_carcinoma:intestil_adenocarcinoma:hairy_cell_leukaemia:endometrioid_carcinoma:chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma:carcinoid-endocrine_tumour:myelody rs28934573 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,3 BR5-193T PRO-8-20140314_BR5_T2_ 1043 tumor 75 847271 72.33 1591 76.55 IonXpress_003 1.0E-5 1003 278 725 0.49 40 - 50 >50 Postmenopausal
389 23302 HE10/05 16546 BR5-195   YES PIK3CA YES NO other chr03 3q26.3 ex 10 178936082 AMPL393459515 178935994 178936131 38.6 3 2 SNV G 1 G/A   PIK3CA exonic missense AAA 10 p.Glu542Lys 1624G>A c.1624G>A NA 998 HER-positive_carcinoma:liposarcoma:hepatocellular_carcinoma:intestil_adenocarcinoma:carcinosarcoma-malignt_mesodermal_mixed_tumour:undifferentiated_adenocarcinoma:Merkel_cell_carcinoma:lobular_carcinoma:endometrioid_carcinoma:mucinous_carcinoma:dysemb rs121913273 PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 2,72 BR5-195T PRO-8-20140314_BR5_T2_ 3137 tumor 90 234544 66.8 395 51.93 IonXpress_005 1.0E-5 1999 1418 581 0.49 40 - 50 >50 Postmenopausal
390 23311 HE10/05 17449 BR5-196 1 YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR5-196T PRO-8-20140314_BR5_T2_ 168 tumor 70 539279 75.85 1054 80.39 IonXpress_006 1.0E-5 146 92 54 0.49 40 - 50 <=50 Premenopausal
391 23334 HE10/05 19389 BR5-198 1 NO   NO NO                                                                                             >50 Premenopausal
392 23362 HE10/05 16927 BR5-200 1 NO   NO NO                                                                                             >50 Postmenopausal
393 23392 HE10/05 16383 BR5-203 1 NO   NO NO                                                                                             >50 Postmenopausal
394 23413 HE10/05 16911 BR5-204 1 NO   NO NO                                                                                             >50 Postmenopausal
395 23433 HE10/05 16738 BR5-205 1 NO   NO NO                                                                                             >50 Postmenopausal
396 23474 HE10/05 16915 BR5-206   YES PIK3CA YES NO other chr03 3q26.3 ex 10 178936091 AMPL393459515 178935994 178936131 38.6 3 2 SNV G 1 G/A   PIK3CA exonic missense AAG 10 p.Glu545Lys 1633G>A c.1633G>A NA 946 HER-positive_carcinoma:intestil_adenocarcinoma:Merkel_cell_carcinoma:lobular_carcinoma:endometrioid_carcinoma:carcinoid-endocrine_tumour:mucinous_carcinoma:adenoid_cystic_carcinoma:serrated_carcinoma:adenoma:sopharyngeal_carcinoma:basal_cell_carcinoma rs104886003 PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 2,72 BR5-206T PRO-8-20140314_BR5_T2_ 1669 tumor 60 191466 76.23 379.6 78.83 IonXpress_016 1.0E-5 1654 965 689 0.49 40 - 50 >50 Postmenopausal
397 23478 HE10/05 16915 BR5-206   YES TP53 YES NO other chr17 17p13.1 ex8-in8 7577022 AMPL706844244 7576996 7577170 61.6 1 2 SNV G 1 G/A   TP53 exonic nonsense TGA 8 p.Arg306* 916C>T c.916C>T NA   poorly_differentiated_carcinoma:hepatocellular_carcinoma:intestil_adenocarcinoma:NS:Barrett_oesophagus:serous_carcinoma:endometrioid_carcinoma:acute_lymphoblastic_leukaemia:adenocarcinoma:squamous_cell_carcinoma:adenoma:mixed_adenosquamous_carcinoma:neo rs121913344 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 0,74 BR5-206T PRO-8-20140314_BR5_T2_ 241 tumor 60 191466 76.23 379.6 78.83 IonXpress_016 1.0E-5 224 163 61 0.49 40 - 50 >50 Postmenopausal
398 23479 HE10/05 16915 BR5-206   YES TP53 NO YES other chr17 17p13.1 ex7-in7 7577407 AMPL3426752792 7577372 7577532 61 2 3 SNV A 1 A/C 0.163 TP53 intronic             NA     rs12951053 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif -1,68 BR5-206T PRO-8-20140314_BR5_T2_ 433 tumor 60 191466 76.23 379.6 78.83 IonXpress_016 1.0E-5 404 129 275 0.49 40 - 50 >50 Postmenopausal
399 23480 HE10/05 16915 BR5-206   YES TP53 NO YES other chr17 17p13.1 ex7-in7 7577427 AMPL3426752792 7577372 7577532 61 2 3 SNV G 1 G/A 0.163 TP53 intronic             NA     rs12947788 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 0,16 BR5-206T PRO-8-20140314_BR5_T2_ 433 tumor 60 191466 76.23 379.6 78.83 IonXpress_016 1.0E-5 409 132 277 0.49 40 - 50 >50 Postmenopausal
400 23483 HE10/05 16550 BR5-208 1 NO   NO NO                                                                                             >50 Postmenopausal
401 23505 HE10/05 18116 BR5-215 1 NO   NO NO                                                                                             >50 Postmenopausal
402 23526 HE10/05 17491 BR5-218 1 YES TP53 NO YES other chr17 17p13.1 ex7-in7 7577407 AMPL3426752792 7577372 7577532 61 2 3 SNV A 1 A/C 0.163 TP53 intronic             NA     rs12951053 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif -1,68 BR5-218T PRO-8-20140314_BR5_T2_ 4280 tumor 70 1752439 83.2 3963 80.11 IonXpress_025 1.0E-5 1984 387 1597 0.49 40 - 50 >50 Postmenopausal
403 23543 HE10/05 17491 BR5-218   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 ex7-in7 7577427 AMPL3426752792 7577372 7577532 61 2 3 SNV G 1 G/A   TP53 intronic             NA     rs12947788 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 0,16 BR5-218T PRO-8-20140314_BR5_T2_ 4280 tumor 70 1752439 83.2 3963 80.11 IonXpress_025 1.0E-5 1996 382 1614 0.49 40 - 50 >50 Postmenopausal
404 23544 HE10/05 18923 BR5-219 1 YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR5-219T PRO-8-20140314_BR5_T2_ 427 tumor 50 1494017 88.56 3445 79.19 IonXpress_026 1.0E-5 392 93 299 0.49 40 - 50 <=50 Premenopausal
405 23569 HE10/05 18923 BR5-219   YES TP53 NO YES nonMUTnonSNP chr17 17p13.1 ex6-in6 7578210 AMPL4574207192 7578114 7578273 53.5 1 1 SNV T 1 T/C 0.007 TP53 exonic synonymous CGG 6 WT 639A>G c.639A>G NA   oligodendroglioma_Grade_II:adenocarcinoma:adenoma:carcinoma rs1800372 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif -0,16 BR5-219T PRO-8-20140314_BR5_T2_ 956 tumor 50 1494017 88.56 3445 79.19 IonXpress_026 1.0E-5 935 280 655 0.49 40 - 50 <=50 Premenopausal
406 23570 HE10/05 17726 BR5-220 1 YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR5-220T PRO-8-20140314_BR5_T2_ 654 tumor 60 1540329 82.56 3363 80.2 IonXpress_027 1.0E-5 601 465 136 0.49 40 - 50 <=50 Postmenopausal
407 23596 HE10/05 17726 BR5-220   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 ex7-in7 7577407 AMPL3426752792 7577372 7577532 61 2 3 SNV A 1 A/C   TP53 intronic             NA     rs12951053 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif -1,68 BR5-220T PRO-8-20140314_BR5_T2_ 4594 tumor 60 1540329 82.56 3363 80.2 IonXpress_027 1.0E-5 1983 625 1358 0.49 40 - 50 <=50 Postmenopausal
408 23597 HE10/05 17726 BR5-220   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 ex7-in7 7577427 AMPL3426752792 7577372 7577532 61 2 3 SNV G 1 G/A   TP53 intronic             NA     rs12947788 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 0,16 BR5-220T PRO-8-20140314_BR5_T2_ 4594 tumor 60 1540329 82.56 3363 80.2 IonXpress_027 1.0E-5 1997 683 1314 0.49 40 - 50 <=50 Postmenopausal
409 23598 HE10/05 17726 BR5-220   YES TP53 YES NO other chr17 17p13.1 in6-ex7-in7 7577551 AMPL4981177402 7577472 7577638 53.4 2 3 SNV C 1 C/A   TP53 exonic missense TGC 7 p.Gly244Cys 730G>T c.730G>T NA 1 lymphoid_neoplasm:liposarcoma:hepatocellular_carcinoma:intestil_adenocarcinoma:diffuse_adenocarcinoma:small_cell_carcinoma:serous_carcinoma:endometrioid_carcinoma:chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma:carcinoid-endocrine_tumour:transi   P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 2,56 BR5-220T PRO-8-20140314_BR5_T2_ 3420 tumor 60 1540329 82.56 3363 80.2 IonXpress_027 1.0E-5 1997 1211 786 0.49 40 - 50 <=50 Postmenopausal
410 23599 HE10/05 17147 BR5-221 1 YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR5-221T PRO-8-20140314_BR5_T2_ 1152 tumor 65 3003557 82.04 6461 80.88 IonXpress_028 1.0E-5 1074 213 861 0.49 40 - 50 <=50 Premenopausal
411 23617 HE10/05 17147 BR5-221   YES PIK3CA YES NO other chr03 3q26.3 ex21 178952085 AMPL392292511 178952020 178952194 36.3 3 2 SNV A 1 A/T   PIK3CA exonic missense CTT 21 p.His1047Leu 3140A>T c.3140A>T NA 957 HER-positive_carcinoma:ductal_epithelial_hyperplasia-hyperplasia_of_usual_type:hepatocellular_carcinoma:SHH_subtype:Merkel_cell_carcinoma:lobular_carcinoma:mixed_endometrioid_and_clear_cell_carcinoma:sopharyngeal_carcinoma:endometriosis:papilloma:mixed_ rs121913279 PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 2,33 BR5-221T PRO-8-20140314_BR5_T2_ 13641 tumor 65 3003557 82.04 6461 80.88 IonXpress_028 1.0E-5 1997 1608 389 0.49 40 - 50 <=50 Premenopausal
412 23643 HE10/05 16912 BR5-222   YES PIK3CA YES NO other chr03 3q26.3 ex 10 178936091 AMPL393459515 178935994 178936131 38.6 3 2 SNV G 1 G/A   PIK3CA exonic missense AAG 10 p.Glu545Lys 1633G>A c.1633G>A NA 946 HER-positive_carcinoma:intestil_adenocarcinoma:Merkel_cell_carcinoma:lobular_carcinoma:endometrioid_carcinoma:carcinoid-endocrine_tumour:mucinous_carcinoma:adenoid_cystic_carcinoma:serrated_carcinoma:adenoma:sopharyngeal_carcinoma:basal_cell_carcinoma rs104886003 PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 2,72 BR5-222bT   8086 tumor                     0.16 10 - 20 >50 Postmenopausal
413 23652 HE10/05 18825 BR5-223 1 YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR5-223T PRO-8-20140314_BR5_T2_ 371 tumor 65 1332920 73.37 2501 78.52 IonXpress_030 1.0E-5 330 44 286 0.49 40 - 50 >50 Postmenopausal
414 23668 HE10/05 18825 BR5-223   YES PIK3CA YES NO other chr03 3q26.3 ex21 178952090 AMPL392292511 178952020 178952194 36.3 3 2 SNV G 1 G/C   PIK3CA exonic missense CGT 21 p.Gly1049Arg 3145G>C c.3145G>C NA 871 dysplasia-in_situ_neoplasm:aplastic_carcinoma:papillary_carcinoma:small_cell_carcinoma:clear_cell_carcinoma:endometrioid_carcinoma:carcinoid-endocrine_tumour:transitiol_cell_carcinoma:adenocarcinoma:squamous_cell_carcinoma:adenoma:basal_(triple-negati rs121913277 PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 2,89 BR5-223T PRO-8-20140314_BR5_T2_ 2786 tumor 65 1332920 73.37 2501 78.52 IonXpress_030 1.0E-5 1765 1027 738 0.49 40 - 50 >50 Postmenopausal
415 23686 HE10/05 19107 BR5-225   YES PIK3CA NO YES other chr03 3q26.3 off target 115118900 AMPL6795279620 115118832 115118979 44.9 2 1 SNV C 1 C/T 0.066                 NA     rs9821873   -2,3 BR5-225T PRO-8-20140314_BR5_T2_ 124 tumor 55 100400 76.09 199.7 75.03 IonXpress_031 1.0E-5 121 58 63 0.49 40 - 50 >50 Postmenopausal
416 23688 HE10/05 19107 BR5-225   YES PIK3CA YES NO other chr03 3q26.3 ex21 178952085 AMPL392292511 178952020 178952194 36.3 3 2 SNV A 1 A/G   PIK3CA exonic missense CGT 21 p.His1047Arg 3140A>G c.3140A>G NA 926 HER-positive_carcinoma:ductal_epithelial_hyperplasia-hyperplasia_of_usual_type:hepatocellular_carcinoma:SHH_subtype:Merkel_cell_carcinoma:lobular_carcinoma:mixed_endometrioid_and_clear_cell_carcinoma:sopharyngeal_carcinoma:endometriosis:papilloma:mixed_ rs121913279 PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 2,33 BR5-225T PRO-8-20140314_BR5_T2_ 337 tumor 55 100400 76.09 199.7 75.03 IonXpress_031 1.0E-5 180 128 52 0.49 40 - 50 >50 Postmenopausal
417 23694 HE10/05 19433 BR5-226 1 YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR5-226T PRO-8-20140314_BR5_T2_ 348 tumor 65 3232643 92.85 6912 43.86 IonXpress_032 1.0E-5 329 242 87 0.49 40 - 50 >50 Premenopausal
418 23706 HE10/05 19433 BR5-226   YES PIK3CA NO YES other chr03 3q26.3 off target 115118900 AMPL6795279620 115118832 115118979 44.9 2 1 SNV C 1 T/T 0.066                 NA     rs9821873   -2,3 BR5-226T PRO-8-20140314_BR5_T2_ 2014 tumor 65 3232643 92.85 6912 43.86 IonXpress_032 1.0E-5 1926 30 1896 0.49 40 - 50 >50 Premenopausal
419 23707 HE10/05 19433 BR5-226   YES PIK3CA YES NO other chr03 3q26.3 ex 10 178936082 AMPL393459515 178935994 178936131 38.6 3 2 SNV G 1 G/A   PIK3CA exonic missense AAA 10 p.Glu542Lys 1624G>A c.1624G>A NA 998 HER-positive_carcinoma:liposarcoma:hepatocellular_carcinoma:intestil_adenocarcinoma:carcinosarcoma-malignt_mesodermal_mixed_tumour:undifferentiated_adenocarcinoma:Merkel_cell_carcinoma:lobular_carcinoma:endometrioid_carcinoma:mucinous_carcinoma:dysemb rs121913273 PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 2,72 BR5-226T PRO-8-20140314_BR5_T2_ 5123 tumor 65 3232643 92.85 6912 43.86 IonXpress_032 1.0E-5 1995 1207 788 0.49 40 - 50 >50 Premenopausal
420 23716 HE10/05 19433 BR5-226   YES TP53 NO YES other chr17 17p13.1 ex7-in7 7577407 AMPL3426752792 7577372 7577532 61 2 3 SNV A 1 A/C 0.163 TP53 intronic             NA     rs12951053 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif -1,68 BR5-226T PRO-8-20140314_BR5_T2_ 1663 tumor 65 3232643 92.85 6912 43.86 IonXpress_032 1.0E-5 1513 517 996 0.49 40 - 50 >50 Premenopausal
421 23717 HE10/05 19433 BR5-226   YES TP53 NO YES other chr17 17p13.1 ex7-in7 7577427 AMPL3426752792 7577372 7577532 61 2 3 SNV G 1 G/A 0.163 TP53 intronic             NA     rs12947788 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 0,16 BR5-226T PRO-8-20140314_BR5_T2_ 1663 tumor 65 3232643 92.85 6912 43.86 IonXpress_032 1.0E-5 1550 544 1006 0.49 40 - 50 >50 Premenopausal
422 23718 HE10/05 19433 BR5-226   YES TP53 YES NO other chr17 17p13.1 in6-ex7-in7 7577599 AMPL4981177402 7577472 7577638 53.4 2 3 INDEL C 1 C/CA   TP53 exonic nonsense   7 p.Asp228* 680_681insT c.680_681insT NA   adenocarcinoma:squamous_cell_carcinoma:hepatocellular_carcinoma:basal_cell_carcinoma:astrocytoma_Grade_IV:ductal_carcinoma:chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma:carcinoma   P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 2,48 BR5-226T PRO-8-20140314_BR5_T2_ 1119 tumor 65 3232643 92.85 6912 43.86 IonXpress_032 1.0E-5 1064 761 303 0.28 20 - 30 >50 Premenopausal
423 23720 HE10/05 18372 BR5-228 1 NO   NO NO                                                                                             >50 Postmenopausal
424 23740 HE10/05 16686 BR5-229 1 YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR5-229T PRO-8-20140314_BR5_T2_ 197 tumor 65 372882 84.62 838.7 81.39 IonXpress_034 1.0E-5 185 47 138 0.49 40 - 50 >50 Postmenopausal
425 23760 HE10/05 16686 BR5-229   YES TP53 YES NO other chr17 17p13.1 ex5-in5 7578404 AMPL1992796664 7578284 7578458 63.7 1 2 SNV A 1 A/T   TP53 exonic missense AGC 5 p.Cys176Ser 526T>A c.526T>A NA 318 acute_myeloid_leukaemia_myelodysplastic_syndrome_therapy_related_NOS:lymphoid_neoplasm:signet_ring_adenocarcinoma:diffuse_large_B_cell_lymphoma:adenocarcinoma:tubular_adenocarcinoma:squamous_cell_carcinoma:adrel_cortical_adenoma:hepatocellular_carcinoma   P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 2,26 BR5-229T PRO-8-20140314_BR5_T2_ 444 tumor 65 372882 84.62 838.7 81.39 IonXpress_034 1.0E-5 312 257 55 0.49 40 - 50 >50 Postmenopausal
426 23765 HE10/05 17149 BR5-230 1 NO   NO NO