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1 ID STUDY PNUMBER sample_id_to_use Case_First_row_INCOMPLETE TP53&PIK3CA YES/NO Gene_Symbol_merged mut non-synonymous YES/NO common SNP YES/NO nonMUTnonSNP Chr__merged Chr__Band_merged location__intron_exon__merged pos_merged Amplicon_ID_merged Amplicon_Start_merged Amplicon_Stop_merged Amplicon_GC_content_merged ampEVAL_cat10_TUMOR_merged ampEVAL_cat10_BLOOD_merged type_merged ref_merged length_merged genotype_merged maf_merged gene_merged location_merged function_merged codon_merged exon_merged protein_merged coding coding_merged sift_merged polyphen_merged cosmic_merged dbsnp_merged pfam_merged phylop_merged sampleIDOriginal_T1 Run_ID_Common_T1 Reads_T1 sample_description_T1 TCC_T1 Mapped_Reads_T1 On_Target_T1 Mean_Depth_T1 Uniformity_T1 barcode_T1 pvalue_T1 coverage_T1 ref_coverage_T1 var1_coverage_T1 freqVAR1_T1 freqVAR1_T1_CAT Age_cat_years_at_50 MenopDiagn
2 31895 HE10/05 19285 BR5-779 1 YES TP53 YES NO other chr17 17p13.1 in6-ex7-in7 7577511 AMPL4981177402 7577472 7577638 53.4 2 3 SNV A 1 A/G   TP53 exonic missense CCG 7 p.Leu257Pro 770T>C c.770T>C NA   lymphoid_neoplasm:diffuse_large_B_cell_lymphoma:adenocarcinoma:squamous_cell_carcinoma:margil_zone_lymphoma:hepatocellular_carcinoma:basal_cell_carcinoma:Wilms_tumour:ductal_carcinoma:endometrioid_carcinoma:serous_carcinoma:carcinoma rs28934577 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 0,89 BR5-779T PRO-27-20140729_BR05_10_rest_ 880 tumor 35 565305 83.81 1259 81.69 IonXpress_017   790 694 96 0.12 10 - 20 >50 Postmenopausal
3 31918 HE10/05 19285 BR5-779   YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR5-779T PRO-27-20140729_BR05_10_rest_ 466 tumor 35 565305 83.81 1259 81.69 IonXpress_017   433 238 195 0.45 40 - 50 >50 Postmenopausal
4 31921 HE10/05 16235 BR5-781 1 NO   NO NO                                                                                             >50 Postmenopausal
5 31930 HE10/05 16593 BR5-782 1 NO   NO NO                                                                                             >50 Postmenopausal
6 31989 HE10/05 17083 BR5-783   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 in7-ex8 7577153 AMPL1481474315 7577115 7577289 48.1 2 3 INDEL CCA 2 CCA/C   TP53 exonic frameshiftDeletion   8   783_784delTG c.783_784delTG NA   mucinous_carcinoma:transitiol_cell_carcinoma:diffuse_large_B_cell_lymphoma:adenocarcinoma:squamous_cell_carcinoma:ductal_carcinoma:serous_carcinoma:carcinoma:astrocytoma_Grade_III:endometrioid_carcinoma rs200579969 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 2.62,2.62,0.95 BR5-783T PRO-14-20140415_BR5_T7_ 142 tumor 70 135873 77.01 278.8 77.79 IonXpress_063   136 92 44 0.32 30 - 40 >50 Postmenopausal
7 32009 HE10/05 17084 BR5-784   YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR5-784T PRO-14-20140415_BR5_T7_ 189 tumor 70 283761 75.07 562.6 83.3 IonXpress_064   186 29 157 0.84 80 - 90 >50 Postmenopausal
8 32010 HE10/05 17508 BR5-785 1 YES TP53 YES NO other chr17 17p13.1 in8-ex9-in9 7576897 AMPL1516620128 7576812 7576978 50 1 2 SNV G 1 G/A   TP53 exonic nonsense TAG 9 p.Gln317* 949C>T c.949C>T NA   malignt_melanoma:hepatocellular_carcinoma:aplastic_carcinoma:NS:small_cell_carcinoma:serous_carcinoma:endometrioid_carcinoma:acute_myeloid_leukaemia:transitiol_cell_carcinoma:diffuse_large_B_cell_lymphoma:adenocarcinoma:squamous_cell_carcinoma:basal   P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,32 BR5-785T PRO-27-20140729_BR05_10_rest_ 1769 tumor 40 924546 76.58 1845 84.43 IonXpress_018   1722 1493 229 0.13 10 - 20 >50 Postmenopausal
9 32033 HE10/05 17508 BR5-785   YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR5-785T PRO-27-20140729_BR05_10_rest_ 785 tumor 40 924546 76.58 1845 84.43 IonXpress_018   723 148 575 0.8 80 - 90 >50 Postmenopausal
10 32046 HE10/05 18388 BR5-787 1 NO   NO NO                                                                                             >50 Postmenopausal
11 32066 HE10/05 18389 BR5-788 1 YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR5-788aT PRO-14-20140415_BR5_T7_ 254 tumor 80 486157 72.38 917.3 80.42 IonXpress_066   237 54 183 0.77 70 - 80 >50 Postmenopausal
12 32096 HE10/05 18389 BR5-788   YES TP53 YES NO other chr17 17p13.1 in9-ex10 7574001 AMPL387899835 7573927 7574055 62.8 1 1 INDEL TC 1 TC/T   TP53 exonic frameshiftDeletion   10 p.Arg342Gln 1025_1025delG c.1025_1025delG NA   adenocarcinoma:squamous_cell_carcinoma   P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif -0.49,0.27 BR5-788aT PRO-14-20140415_BR5_T7_ 877 tumor 80 486157 72.38 917.3 80.42 IonXpress_066   844 542 302 0.36 30 - 40 >50 Postmenopausal
13 32097 HE10/05 18732 BR5-790 1 YES TP53 YES NO other chr17 17p13.1 ex4-in4 7579329 AMPL1481773781 7579257 7579411 56.1 2 3 SNV T 1 T/C   TP53 exonic missense GAG 4 p.Lys120Glu 358A>G c.358A>G NA 1 mucinous_carcinoma:adenocarcinoma:malignt_melanoma:basal_(triple-negative)_carcinoma:large_cell_carcinoma:carcinoma rs121912658 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 2,13 BR5-790T PRO-14-20140415_BR5_T7_ 837 tumor 75 135758 75.74 272.1 50.92 IonXpress_067   819 739 80 0.1 10 - 20 >50 Postmenopausal
14 32115 HE10/05 18835 BR5-791 1 NO   NO NO                                                                                             >50 Postmenopausal
15 32150 HE10/05 18954 BR5-792   YES PIK3CA NO YES other chr03 3q26.3 off target 115118900 AMPL6795279620 115118832 115118979 44.9 2 1 SNV C 1 C/T 0.066                 NA     rs9821873   -2,3 BR5-792bT PRO-14-20140415_BR5_T7_ 1536 tumor 65 426654 86.88 993 49.26 IonXpress_069   1490 836 654 0.44 40 - 50 >50 Postmenopausal
16 32157 HE10/05 18954 BR5-792   YES TP53 YES NO other chr17 17p13.1 in9-ex10 7573991 AMPL387899835 7573927 7574055 62.8 1 1 SNV C 1 C/A   TP53 exonic nonsense TAG 10 p.Glu346* 1036G>T c.1036G>T NA   transitiol_cell_carcinoma:adrel_cortical_carcinoma:adenocarcinoma:carcinoma   P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 2,55 BR5-792bT PRO-14-20140415_BR5_T7_ 437 tumor 65 426654 86.88 993 49.26 IonXpress_069   428 318 110 0.26 20 - 30 >50 Postmenopausal
17 32160 HE10/05 17008 BR5-795 1 NO   NO NO                                                                                             >50 Postmenopausal
18 32165 HE10/05 17243 BR5-796 1 YES TP53 YES NO other chr17 17p13.1 ex4-in4 7579363 AMPL1481773781 7579257 7579411 56.1 2 3 INDEL AC 1 AC/A   TP53 exonic frameshiftDeletion   4 p.Gly108Val 323_323delG c.323_323delG NA   transitiol_cell_carcinoma:adenocarcinoma:carcinoma   P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif -0.28,0.73 BR5-796T PRO-27-20140729_BR05_10_rest_ 1069 tumor 40 742618 75.58 1468 84.94 IonXpress_019   995 841 154 0.15 10 - 20 >50 Postmenopausal
19 32194 HE10/05 17243 BR5-796   YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR5-796T PRO-27-20140729_BR05_10_rest_ 707 tumor 40 742618 75.58 1468 84.94 IonXpress_019   656 387 269 0.41 40 - 50 >50 Postmenopausal
20 32195 HE10/05 17510 BR5-797 1 YES TP53 YES NO other chr17 17p13.1 ex5-in5 7578406 AMPL1992796664 7578284 7578458 63.7 1 2 SNV C 1 C/T   TP53 exonic missense CAC 5 p.Arg175His 524G>A c.524G>A NA   HER-positive_carcinoma:acute_myeloid_leukaemia_myelodysplastic_syndrome_therapy_related_NOS:granulosa_cell_tumour:gliosarcoma:medullary_carcinoma:hepatocellular_carcinoma:Wilms_tumour:lobular_carcinoma:chronic_lymphocytic_leukaemia-small_lymphocytic_lymph rs28934578 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 2,7 BR5-797aT PRO-14-20140415_BR5_T7_ 324 tumor 60 509213 74.45 994.4 82.83 IonXpress_070   310 160 150 0.48 40 - 50 >50 Postmenopausal
21 32196 HE10/05 17510 BR5-797   YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR5-797aT   569 tumor                     0.89 80 - 90 >50 Postmenopausal
22 32226 HE10/05 17550 BR5-798 1 NO   NO NO                                                                                             >50 Postmenopausal
23 32311 HE10/05 17852 BR5-799   YES TP53 YES NO other chr17 17p13.1 ex8-in8 7577121 AMPL706844244 7576996 7577170 61.6 1 2 SNV G 1 G/A   TP53 exonic missense TGT 8 p.Arg273Cys 817C>T c.817C>T NA 1 gliosarcoma:oligodendroglioma:Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour:hepatocellular_carcinoma:yolk_sac_tumour:follicular_lymphoma:chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma:carcinoid-endocrine_tumour:lymphoepithelioma_lik rs121913343 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,3 BR5-799T PRO-14-20140415_BR5_T7_ 294 tumor 55 297715 85.16 683.8 75.14 IonXpress_073   277 163 114 0.41 40 - 50 >50 Postmenopausal
24 32312 HE10/05 17852 BR5-799   YES TP53 NO YES other chr17 17p13.1 ex7-in7 7577407 AMPL3426752792 7577372 7577532 61 2 3 SNV A 1 A/C 0.163 TP53 intronic             NA     rs12951053 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif -1,68 BR5-799T PRO-14-20140415_BR5_T7_ 549 tumor 55 297715 85.16 683.8 75.14 IonXpress_073   512 457 55 0.11 10 - 20 >50 Postmenopausal
25 32313 HE10/05 17852 BR5-799   YES TP53 NO YES other chr17 17p13.1 ex7-in7 7577427 AMPL3426752792 7577372 7577532 61 2 3 SNV G 1 G/A 0.163 TP53 intronic             NA     rs12947788 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 0,16 BR5-799T PRO-14-20140415_BR5_T7_ 549 tumor 55 297715 85.16 683.8 75.14 IonXpress_073   528 473 55 0.1 10 - 20 >50 Postmenopausal
26 32318 HE10/05 17852 BR5-799   YES TP53 NO YES nonMUTnonSNP chr17 17p13.1 ex6-in6 7578210 AMPL4574207192 7578114 7578273 53.5 1 1 SNV T 1 T/C 0.007 TP53 exonic synonymous CGG 6 WT 639A>G c.639A>G NA   oligodendroglioma_Grade_II:adenocarcinoma:adenoma:carcinoma rs1800372 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif -0,16 BR5-799T PRO-14-20140415_BR5_T7_ 183 tumor 55 297715 85.16 683.8 75.14 IonXpress_073   177 70 107 0.6 60 - 70 >50 Postmenopausal
27 32320 HE10/05 17852 BR5-799   YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR5-799T PRO-14-20140415_BR5_T7_ 247 tumor 55 297715 85.16 683.8 75.14 IonXpress_073   238 80 158 0.66 60 - 70 >50 Postmenopausal
28 32321 HE10/05 18468 BR5-800 1 YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR5-800T PRO-14-20140415_BR5_T7_ 1026 tumor 65 1334158 89.91 3258 81.01 IonXpress_074   987 332 655 0.66 60 - 70 >50 Postmenopausal
29 32356 HE10/05 18468 BR5-800   YES TP53 YES NO other chr17 17p13.1 in6-ex7-in7 7577574 AMPL4981177402 7577472 7577638 53.4 2 3 SNV T 1 T/G   TP53 exonic missense TCC 7 p.Tyr236Ser 707A>C c.707A>C NA   lymphoid_neoplasm:medullary_carcinoma:hepatocellular_carcinoma:intestil_adenocarcinoma:small_cell_carcinoma:serous_carcinoma:chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma:endometrioid_carcinoma:transitiol_cell_carcinoma:gastrointestil_str   P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 0,03 BR5-800T PRO-14-20140415_BR5_T7_ 2802 tumor 65 1334158 89.91 3258 81.01 IonXpress_074   1994 801 1193 0.6 60 - 70 >50 Postmenopausal
30 32357 HE10/05 19768 BR5-804 1 NO   NO NO                                                                                             >50 Postmenopausal
31 32373 HE10/05 19357 BR5-805 1 NO   NO NO                                                                                             >50 Postmenopausal
32 32395 HE10/05 18824 BR5-806 1 NO   NO NO                                                                                             >50 Postmenopausal
33 32409 HE10/05 18942 BR5-807 1 NO   NO NO                                                                                             >50 Postmenopausal
34 32413 HE10/05 18922 BR5-808 1 YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR5-808T PRO-14-20140415_BR5_T7_ 568 tumor 65 769499 87.27 1768 79.36 IonXpress_079   548 189 359 0.66 60 - 70 <=50 Premenopausal
35 32432 HE10/05 18922 BR5-808   YES TP53 NO YES other chr17 17p13.1 ex7-in7 7577407 AMPL3426752792 7577372 7577532 61 2 3 SNV A 1 A/C 0.163 TP53 intronic             NA     rs12951053 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif -1,68 BR5-808T PRO-14-20140415_BR5_T7_ 1358 tumor 65 769499 87.27 1768 79.36 IonXpress_079   1280 1081 199 0.16 10 - 20 <=50 Premenopausal
36 32433 HE10/05 18922 BR5-808   YES TP53 NO YES other chr17 17p13.1 ex7-in7 7577427 AMPL3426752792 7577372 7577532 61 2 3 SNV G 1 G/A 0.163 TP53 intronic             NA     rs12947788 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 0,16 BR5-808T PRO-14-20140415_BR5_T7_ 1358 tumor 65 769499 87.27 1768 79.36 IonXpress_079   1296 1098 198 0.15 10 - 20 <=50 Premenopausal
37 32434 HE10/05 18361 BR5-809 1 YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR5-809T PRO-14-20140415_BR5_T7_ 2154 tumor 50 4417969 85.51 9816 82.1 IonXpress_080   1992 343 1649 0.83 80 - 90 <=50 Premenopausal
38 32446 HE10/05 18361 BR5-809   YES PIK3CA NO NO nonMUTnonSNP chr03 3q26.3 off target 115118900 AMPL6795279620 115118832 115118979 44.9 2 1 SNV C 1 C/T                   NA     rs9821873   -2,3 BR5-809T PRO-14-20140415_BR5_T7_ 9100 tumor 50 4417969 85.51 9816 82.1 IonXpress_080   1995 771 1224 0.61 60 - 70 <=50 Premenopausal
39 32448 HE10/05 18361 BR5-809   YES PIK3CA NO YES other chr03 3q26.3 in1 178866408 AMPL4347527835 178866384 178866543 78.2     SNV C 1 C/T 0.149 PIK3CA intronic             NA     rs2699887 PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 -0,07 BR5-809T PRO-14-20140415_BR5_T7_ 140 tumor 50 4417969 85.51 9816 82.1 IonXpress_080   123 56 67 0.54 50 - 60 <=50 Premenopausal
40 32459 HE10/05 18361 BR5-809   YES TP53 YES NO other chr17 17p13.1 ex8-in8 7577085 AMPL706844244 7576996 7577170 61.6 1 2 SNV C 1 C/T   TP53 exonic missense AAG 8 p.Glu285Lys 853G>A c.853G>A NA 999 hepatocellular_carcinoma:intestil_adenocarcinoma:lobular_carcinoma:adult_T_cell_lymphoma-leukaemia:chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma:carcinoid-endocrine_tumour:adrel_cortical_carcinoma:tubular_adenocarcinoma:malignt_peripheral rs112431538 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 2,58 BR5-809T PRO-14-20140415_BR5_T7_ 4124 tumor 50 4417969 85.51 9816 82.1 IonXpress_080   1996 1422 574 0.29 20 - 30 <=50 Premenopausal
41 32460 HE10/05 19111 BR5-810 1 YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR5-810aT PRO-14-20140415_BR5_T7_ 497 tumor 70 688866 79.98 1449 81.67 IonXpress_081   472 69 403 0.85 80 - 90 >50 Postmenopausal
42 32477 HE10/05 19111 BR5-810   YES PIK3CA YES NO other chr03 3q26.3 ex 10 178936082 AMPL393459515 178935994 178936131 38.6 3 2 SNV G 1 G/A   PIK3CA exonic missense AAA 10 p.Glu542Lys 1624G>A c.1624G>A NA 998 HER-positive_carcinoma:liposarcoma:hepatocellular_carcinoma:intestil_adenocarcinoma:carcinosarcoma-malignt_mesodermal_mixed_tumour:undifferentiated_adenocarcinoma:Merkel_cell_carcinoma:lobular_carcinoma:endometrioid_carcinoma:mucinous_carcinoma:dysemb rs121913273 PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 2,72 BR5-810aT PRO-14-20140415_BR5_T7_ 4978 tumor 70 688866 79.98 1449 81.67 IonXpress_081   1998 1546 452 0.23 20 - 30 >50 Postmenopausal
43 32484 HE10/05 19111 BR5-810   YES TP53 YES NO other chr17 17p13.1 ex8-in8 7577111 AMPL706844244 7576996 7577170 61.6 1 2 INDEL G 1 G/GA   TP53 exonic frameshiftInsertion   8 p.Ala276Val 825_826insT c.825_826insT NA   mixed_carcinoma:astrocytoma_Grade_I:adenocarcinoma:myelodysplastic_syndrome:squamous_cell_carcinoma:large_cell_carcinoma:astrocytoma_Grade_IV:ductal_carcinoma:carcinoma   P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 2,56 BR5-810aT PRO-14-20140415_BR5_T7_ 614 tumor 70 688866 79.98 1449 81.67 IonXpress_081   558 173 385 0.69 60 - 70 >50 Postmenopausal
44 32485 HE10/05 16905 BR5-812 1 YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR5-812aT PRO-14-20140415_BR5_T7_ 161 tumor 80 248753 85.96 580.7 79.63 IonXpress_082   157 32 125 0.8 80 - 90 <=50 Premenopausal
45 32506 HE10/05 16905 BR5-812   YES PIK3CA NO YES other chr03 3q26.3 in1 178866408 AMPL4347527835 178866384 178866543 78.2     SNV C 1 C/T 0.149 PIK3CA intronic             NA     rs2699887 PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 -0,07 BR5-812aT   373 tumor                     0.58 50 - 60 <=50 Premenopausal
46 32517 HE10/05 18935 BR5-813 1 NO   NO NO                                                                                             >50 Postmenopausal
47 32524 HE10/05 18550 BR5-814 1 NO   NO NO                                                                                             <=50 Premenopausal
48 32535 HE10/05 19597 BR5-815 1 YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR5-815T PRO-14-20140415_BR5_T7_ 900 tumor 50 1118124 87.54 2669 80.21 IonXpress_086   851 568 283 0.33 30 - 40 <=50 Premenopausal
49 32568 HE10/05 19597 BR5-815   YES TP53 NO YES other chr17 17p13.1 ex7-in7 7577407 AMPL3426752792 7577372 7577532 61 2 3 SNV A 1 A/C 0.163 TP53 intronic             NA     rs12951053 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif -1,68 BR5-815T PRO-14-20140415_BR5_T7_ 2025 tumor 50 1118124 87.54 2669 80.21 IonXpress_086   1929 678 1251 0.65 60 - 70 <=50 Premenopausal
50 32569 HE10/05 19597 BR5-815   YES TP53 NO YES other chr17 17p13.1 ex7-in7 7577427 AMPL3426752792 7577372 7577532 61 2 3 SNV G 1 G/A 0.163 TP53 intronic             NA     rs12947788 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 0,16 BR5-815T PRO-14-20140415_BR5_T7_ 2025 tumor 50 1118124 87.54 2669 80.21 IonXpress_086   1951 708 1243 0.64 60 - 70 <=50 Premenopausal
51 32616 HE10/05 15074 BR5-816   YES TP53 NO YES other chr17 17p13.1 ex7-in7 7577407 AMPL3426752792 7577372 7577532 61 2 3 SNV A 1 A/C 0.163 TP53 intronic             NA     rs12951053 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif -1,68 BR5-816T PRO-14-20140415_BR5_T7_ 241 tumor 50 195419 85.61 439 72.79 IonXpress_087   227 111 116 0.51 50 - 60 >50 Premenopausal
52 32617 HE10/05 15074 BR5-816   YES TP53 NO YES other chr17 17p13.1 ex7-in7 7577427 AMPL3426752792 7577372 7577532 61 2 3 SNV G 1 G/A 0.163 TP53 intronic             NA     rs12947788 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 0,16 BR5-816T PRO-14-20140415_BR5_T7_ 241 tumor 50 195419 85.61 439 72.79 IonXpress_087   226 110 116 0.51 50 - 60 >50 Premenopausal
53 32619 HE10/05 16525 BR5-817 1 YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR5-817T PRO-14-20140415_BR5_T7_ 344 tumor 60 1106090 87.55 2478 76.31 IonXpress_088 1.0E-5 329 15 301 0.91 90 - 100 <=50 Premenopausal
54 32640 HE10/05 16525 BR5-817   YES PIK3CA YES NO other chr03 3q26.3 ex21 178952085 AMPL392292511 178952020 178952194 36.3 3 2 SNV A 1 A/G   PIK3CA exonic missense CGT 21 p.His1047Arg 3140A>G c.3140A>G NA 926 HER-positive_carcinoma:ductal_epithelial_hyperplasia-hyperplasia_of_usual_type:hepatocellular_carcinoma:SHH_subtype:Merkel_cell_carcinoma:lobular_carcinoma:mixed_endometrioid_and_clear_cell_carcinoma:sopharyngeal_carcinoma:endometriosis:papilloma:mixed_ rs121913279 PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 2,33 BR5-817T PRO-14-20140415_BR5_T7_ 3741 tumor 60 1106090 87.55 2478 76.31 IonXpress_088   1780 979 801 0.45 40 - 50 <=50 Premenopausal
55 32662 HE10/05 18729 BR5-818   YES PIK3CA YES NO other chr03 3q26.3 ex21 178952103 AMPL392292511 178952020 178952194 36.3 3 2 INDEL CA 1 CA/C   PIK3CA exonic frameshiftDeletion TGG 21 p.Met1055Trp 3159_3159delA c.3159_3159delA NA       PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 2.89,2.33 BR5-818cT PRO-14-20140415_BR5_T7_ 215 tumor 90 39337 86.78 95.49 39.78 IonXpress_089   171 94 77 0.45 40 - 50 >50 Postmenopausal
56 32663 HE10/05 19354 BR5-820 1 YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR5-820T PRO-14-20140415_BR5_T7_ 709 tumor 50 725463 84.86 1668 83.78 IonXpress_090   685 114 571 0.83 80 - 90 >50 Postmenopausal
57 32683 HE10/05 19354 BR5-820   YES PIK3CA YES NO other chr03 3q26.3 ex 10 178936091 AMPL393459515 178935994 178936131 38.6 3 2 SNV G 1 G/A   PIK3CA exonic missense AAG 10 p.Glu545Lys 1633G>A c.1633G>A NA 946 HER-positive_carcinoma:intestil_adenocarcinoma:Merkel_cell_carcinoma:lobular_carcinoma:endometrioid_carcinoma:carcinoid-endocrine_tumour:mucinous_carcinoma:adenoid_cystic_carcinoma:serrated_carcinoma:adenoma:sopharyngeal_carcinoma:basal_cell_carcinoma rs104886003 PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 2,72 BR5-820T PRO-14-20140415_BR5_T7_ 5598 tumor 50 725463 84.86 1668 83.78 IonXpress_090   1999 1359 640 0.32 30 - 40 >50 Postmenopausal
58 32692 HE10/05 19432 BR5-821 1 YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR5-821T PRO-14-20140415_BR5_T7_ 159 tumor 75 252678 89.31 624.8 77.62 IonXpress_091   152 32 120 0.79 70 - 80 <=50 Premenopausal
59 32706 HE10/05 19432 BR5-821   YES PIK3CA YES NO other chr03 3q26.3 ex21 178952085 AMPL392292511 178952020 178952194 36.3 3 2 SNV A 1 A/G   PIK3CA exonic missense CGT 21 p.His1047Arg 3140A>G c.3140A>G NA 926 HER-positive_carcinoma:ductal_epithelial_hyperplasia-hyperplasia_of_usual_type:hepatocellular_carcinoma:SHH_subtype:Merkel_cell_carcinoma:lobular_carcinoma:mixed_endometrioid_and_clear_cell_carcinoma:sopharyngeal_carcinoma:endometriosis:papilloma:mixed_ rs121913279 PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 2,33 BR5-821T PRO-14-20140415_BR5_T7_ 1813 tumor 75 252678 89.31 624.8 77.62 IonXpress_091   944 298 646 0.68 60 - 70 <=50 Premenopausal
60 32716 HE10/05 16541 BR5-822   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 ex7-in7 7577407 AMPL3426752792 7577372 7577532 61 2 3 SNV A 1 A/C   TP53 intronic             NA     rs12951053 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif -1,68 BR5-822T PRO-14-20140415_BR5_T7_ 2070 tumor 70 1101951 90.43 2750 75.59 IonXpress_092   1977 467 1510 0.76 70 - 80 >50 Postmenopausal
61 32735 HE10/05 16541 BR5-822   YES TP53 YES NO other chr17 17p13.1 in7-ex8 7577120 AMPL1481474315 7577115 7577289 48.1 2 3 SNV C 1 C/T   TP53 exonic missense CAT 8 p.Arg273His 818G>A c.818G>A NA   HER-positive_carcinoma:hepatocellular_carcinoma:Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour:yolk_sac_tumour:Merkel_cell_carcinoma:chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma:carcinoid-endocrine_tumour:mantle_cell_lymphoma:margi rs28934576 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 2,56 BR5-822T PRO-14-20140415_BR5_T7_ 1292 tumor 70 1101951 90.43 2750 75.59 IonXpress_092   1002 486 516 0.51 50 - 60 >50 Postmenopausal
62 32737 HE10/05 16541 BR5-822   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 ex7-in7 7577427 AMPL3426752792 7577372 7577532 61 2 3 SNV G 1 G/A   TP53 intronic             NA     rs12947788 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 0,16 BR5-822T PRO-14-20140415_BR5_T7_ 2070 tumor 70 1101951 90.43 2750 75.59 IonXpress_092   1996 502 1494 0.75 70 - 80 >50 Postmenopausal
63 32738 HE10/05 16541 BR5-822   YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR5-822T PRO-14-20140415_BR5_T7_ 691 tumor 70 1101951 90.43 2750 75.59 IonXpress_092   652 518 134 0.21 20 - 30 >50 Postmenopausal
64 32743 HE10/05 19434 BR5-824 1 NO   NO NO                                                                                             <=50 Premenopausal
65 32768 HE10/05 19341 BR5-826 1 YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR5-826T PRO-14-20140415_BR5_T7_ 781 tumor 70 1081214 85.3 2453 80.97 IonXpress_094   753 581 172 0.23 20 - 30 <=50 Premenopausal
66 32788 HE10/05 16535 BR5-827 1 YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR5-827T PRO-27-20140729_BR05_10_rest_ 206 tumor 40 264726 87.02 609.9 79.48 IonXpress_020   191 58 133 0.7 70 - 80 <=50 Premenopausal
67 32829 HE10/05 16535 BR5-827   YES PIK3CA YES NO other chr03 3q26.3 ex 10 178936091 AMPL393459515 178935994 178936131 38.6 3 2 SNV G 1 G/A   PIK3CA exonic missense AAG 10 p.Glu545Lys 1633G>A c.1633G>A NA 946 HER-positive_carcinoma:intestil_adenocarcinoma:Merkel_cell_carcinoma:lobular_carcinoma:endometrioid_carcinoma:carcinoid-endocrine_tumour:mucinous_carcinoma:adenoid_cystic_carcinoma:serrated_carcinoma:adenoma:sopharyngeal_carcinoma:basal_cell_carcinoma rs104886003 PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 2,72 BR5-827T PRO-27-20140729_BR05_10_rest_ 3676 tumor 40 264726 87.02 609.9 79.48 IonXpress_020   1999 1141 858 0.43 40 - 50 <=50 Premenopausal
68 32848 HE10/05 16904 BR5-828 1 YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR5-828T PRO-14-20140415_BR5_T7_ 776 tumor 75 2122912 72.93 3957 79.98 IonXpress_095   744 118 626 0.84 80 - 90 <=50 Premenopausal
69 32991 HE10/05 18241 BR5-830   YES PIK3CA NO NO nonMUTnonSNP chr03 3q26.3 off target 115118885 AMPL6795279620 115118832 115118979 44.9 2 1 SNV G 1 G/A                   NA         -0,64 BR5-830T PRO-14-20140415_BR5_T7_ 312 tumor 65 290249 82.06 627.8 65.89 IonXpress_096   302 258 44 0.15 10 - 20 >50 Postmenopausal
70 33029 HE10/05 18241 BR5-830   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 ex7-in7 7577451 AMPL3426752792 7577372 7577532 61 2 3 SNV G 1 G/A   TP53 intronic             NA       P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 0,74 BR5-830T PRO-14-20140415_BR5_T7_ 159 tumor 65 290249 82.06 627.8 65.89 IonXpress_096   157 106 51 0.32 30 - 40 >50 Postmenopausal
71 33035 HE10/05 18241 BR5-830   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 in3-ex4 7579588 AMPL6795075395 7579475 7579618 52 2 3 SNV G 1 G/A   TP53 exonic synonymous TCT 3 WT 99C>T c.99C>T NA       P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 0,17 BR5-830T PRO-14-20140415_BR5_T7_ 134 tumor 65 290249 82.06 627.8 65.89 IonXpress_096   132 91 41 0.31 30 - 40 >50 Postmenopausal
72 33045 HE10/05 20067 BR5-831 1 YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR5-831T PRO-15-20140513_BR5_T8_ 769 tumor 70 591922 89.93 1460 80.79 IonXpress_001   697 428 269 0.39 30 - 40 >50 Postmenopausal
73 33059 HE10/05 20102 BR5-832   YES PIK3CA NO YES other chr03 3q26.3 off target 115118900 AMPL6795279620 115118832 115118979 44.9 2 1 SNV C 1 C/T 0.066                 NA     rs9821873   -2,3 BR5-832T PRO-15-20140513_BR5_T8_ 301 tumor 75 107018 90.82 268.6 79.53 IonXpress_002   291 141 150 0.52 50 - 60 >50 Postmenopausal
74 33060 HE10/05 19452 BR5-833 1 YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR5-833aT PRO-15-20140513_BR5_T8_ 248 tumor 75 485393 83.41 1072 83.68 IonXpress_003   230 60 170 0.74 70 - 80 >50 Postmenopausal
75 33073 HE10/05 17453 BR5-834 1 YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR5-834T PRO-15-20140513_BR5_T8_ 248 tumor 70 270360 77.06 535.2 83.46 IonXpress_004   239 157 82 0.34 30 - 40 <=50 Premenopausal
76 33082 HE10/05 17453 BR5-834   YES PIK3CA YES NO other chr03 3q26.3 ex21 178952085 AMPL392292511 178952020 178952194 36.3 3 2 SNV A 1 A/G   PIK3CA exonic missense CGT 21 p.His1047Arg 3140A>G c.3140A>G NA 926 HER-positive_carcinoma:ductal_epithelial_hyperplasia-hyperplasia_of_usual_type:hepatocellular_carcinoma:SHH_subtype:Merkel_cell_carcinoma:lobular_carcinoma:mixed_endometrioid_and_clear_cell_carcinoma:sopharyngeal_carcinoma:endometriosis:papilloma:mixed_ rs121913279 PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 2,33 BR5-834T PRO-15-20140513_BR5_T8_ 805 tumor 70 270360 77.06 535.2 83.46 IonXpress_004   231 159 72 0.31 30 - 40 <=50 Premenopausal
77 33083 HE10/05 18008 BR5-835 1 NO   NO NO                                                                                             >50 Postmenopausal
78 33090 HE10/05 17722 BR5-836 1 YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR5-836T PRO-15-20140513_BR5_T8_ 281 tumor 75 358341 66.76 609.2 84.45 IonXpress_006   262 54 208 0.79 70 - 80 <=50 Premenopausal
79 33103 HE10/05 17722 BR5-836   YES PIK3CA NO YES other chr03 3q26.3 in1-ex2 178916519 AMPL1786991673 178916463 178916617 30.9 1 1 SNV T 1 T/C 0.03 PIK3CA intronic             NA     rs11709323 PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 0,03 BR5-836T PRO-15-20140513_BR5_T8_ 206 tumor 75 358341 66.76 609.2 84.45 IonXpress_006   194 88 104 0.54 50 - 60 <=50 Premenopausal
80 33111 HE10/05 17722 BR5-836   YES TP53 YES NO other chr17 17p13.1 in8-ex9-in9 7576904 AMPL1516620128 7576812 7576978 50 1 2 INDEL GGAGCTGGT 8 GGAGCTGGT/G   TP53 exonic frameshiftDeletion   9 p.Thr312Leu 934_941delACCAGCTC c.934_941delACCAGCTC NA     rs145151284 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif -0.41,2.69,0.41,0.32,0.33,0.1,-0.18,2.69,0.95 BR5-836T PRO-15-20140513_BR5_T8_ 387 tumor 75 358341 66.76 609.2 84.45 IonXpress_006   349 213 136 0.39 30 - 40 <=50 Premenopausal
81 33124 HE10/05 18119 BR5-837   YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR5-837aT PRO-15-20140513_BR5_T8_ 178 tumor 70 171207 79.55 354.7 84.74 IonXpress_007   165 86 79 0.48 40 - 50 >50 Postmenopausal
82 33125 HE10/05 18722 BR5-838 1 YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 ex5-in5 7578370 AMPL1992796664 7578284 7578458 63.7 1 2 SNV C 1 C/A   TP53 splicesite_3             NA   transitiol_cell_carcinoma:liposarcoma:adenocarcinoma:mantle_cell_lymphoma:squamous_cell_carcinoma:hepatocellular_carcinoma:NS:ductal_carcinoma:chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma:carcinoma:serous_carcinoma   P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,25 BR5-838aT PRO-15-20140513_BR5_T8_ 402 tumor 50 493421 81.6 1065 84.6 IonXpress_008   288 230 58 0.2 20 - 30 <=50 Premenopausal
83 33154 HE10/05 19340 BR5-839   YES TP53 NO YES other chr17 17p13.1 in8-ex9-in9 7576841 AMPL1516620128 7576812 7576978 50 1 2 SNV A 1 A/G 0.017 TP53 intronic             NA     rs1800899 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif -1,12 BR5-839T PRO-15-20140513_BR5_T8_ 126 tumor 70 88420 84.05 192.4 78.79 IonXpress_009   118 57 61 0.52 50 - 60 <=50 Premenopausal
84 33447 HE10/05 17479 BR5-840   YES PIK3CA NO NO nonMUTnonSNP chr03 3q26.3 off target 115118856 AMPL6795277223 115118748 115118874 48.8 3 3 SNV C 1 C/T                   NA         -0,59 BR5-840T   150 tumor                     0.08 <10 >50 Postmenopausal
85 33449 HE10/05 17479 BR5-840   YES PIK3CA NO YES other chr03 3q26.3 off target 115118900 AMPL6795279620 115118832 115118979 44.9 2 1 SNV C 1 C/T 0.066                 NA     rs9821873   -2,3 BR5-840T   1273 tumor                     0.48 40 - 50 >50 Postmenopausal
86 33450 HE10/05 17479 BR5-840   YES PIK3CA YES NO other chr03 3q26.3 ex2 178916647 AMPL1566372753 178916552 178916726 43 2 1 SNV G 1 G/A   PIK3CA exonic missense AGC 2 p.Gly12Ser 34G>A c.34G>A NA 1 endometrioid_carcinoma   PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 2,51 BR5-840T   237 tumor                     0.3 30 - 40 >50 Postmenopausal
87 33452 HE10/05 17479 BR5-840   YES PIK3CA YES NO other chr03 3q26.3 ex21 178952037 AMPL392292511 178952020 178952194 36.3 3 2 SNV C 1 C/T   PIK3CA exonic missense ATT 21 p.Thr1031Ile 3092C>T c.3092C>T NA 933 aplastic_carcinoma   PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 2,89 BR5-840T   364 tumor                     0.21 20 - 30 >50 Postmenopausal
88 33455 HE10/05 17479 BR5-840   YES PIK3CA YES NO other chr03 3q26.3 ex21 178952097 AMPL392292511 178952020 178952194 36.3 3 2 SNV G 1 G/A   PIK3CA exonic nonsense TAG 21 p.Trp1051* 3152G>A c.3152G>A NA   adenocarcinoma:carcinoma   PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 2,89 BR5-840T   364 tumor                     0.32 30 - 40 >50 Postmenopausal
89 33456 HE10/05 17479 BR5-840   YES PIK3CA YES NO other chr03 3q26.3 ex21 178952114 AMPL392292511 178952020 178952194 36.3 3 2 SNV T 1 T/A   PIK3CA exonic missense AGG 21 p.Trp1057Arg 3169T>A c.3169T>A NA 1 adenocarcinoma   PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 2,33 BR5-840T   364 tumor                     0.13 10 - 20 >50 Postmenopausal
90 33457 HE10/05 17479 BR5-840   YES PIK3CA NO NO nonMUTnonSNP chr03 3q26.3 ex21 178952149 AMPL392292511 178952020 178952194 36.3 3 2 SNV C 1 C/T   PIK3CA exonic synonymous AAT 21 WT 3204C>T c.3204C>T NA       PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 2,89 BR5-840T   364 tumor                     0.13 10 - 20 >50 Postmenopausal
91 33458 HE10/05 17479 BR5-840   YES PIK3CA NO NO nonMUTnonSNP chr03 3q26.3 ex21 178952160 AMPL392292511 178952020 178952194 36.3 3 2 SNV A 1 A/G   PIK3CA utr_3             NA       PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 -0,14 BR5-840T   364 tumor                     0.13 10 - 20 >50 Postmenopausal
92 33516 HE10/05 17479 BR5-840   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 ex8-in8 7577145 AMPL706844244 7576996 7577170 61.6 1 2 SNV G 1 G/A   TP53 exonic synonymous TTG 8 WT 793C>T c.793C>T NA   adenocarcinoma:ductal_carcinoma:carcinoma:serous_carcinoma   P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,38 BR5-840T   392 tumor                     0.13 10 - 20 >50 Postmenopausal
93 33518 HE10/05 17479 BR5-840   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 ex8-in8 7577163 AMPL706844244 7576996 7577170 61.6 1 2 SNV G 1 G/A   TP53 intronic             NA       P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 0,39 BR5-840T   392 tumor                     0.13 10 - 20 >50 Postmenopausal
94 33519 HE10/05 17479 BR5-840   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 in7-ex8 7577189 AMPL1481474315 7577115 7577289 48.1 2 3 SNV G 1 G/A   TP53 intronic             NA       P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif -0,48 BR5-840T   322 tumor                     0.16 10 - 20 >50 Postmenopausal
95 33520 HE10/05 17479 BR5-840   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 in7-ex8 7577229 AMPL1481474315 7577115 7577289 48.1 2 3 SNV G 1 G/A   TP53 intronic             NA       P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 0,28 BR5-840T   322 tumor                     0.16 10 - 20 >50 Postmenopausal
96 33522 HE10/05 17479 BR5-840   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 ex7-in7 7577462 AMPL3426752792 7577372 7577532 61 2 3 SNV A 1 A/G   TP53 intronic             NA   acute_lymphoblastic_leukaemia   P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif   BR5-840T   350 tumor                     0.13 10 - 20 >50 Postmenopausal
97 33524 HE10/05 17479 BR5-840   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 ex4-in4 7579302 AMPL1481773781 7579257 7579411 56.1 2 3 SNV G 1 G/A   TP53 intronic             NA     rs68140816 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 2,4 BR5-840T   502 tumor                     0.14 10 - 20 >50 Postmenopausal
98 33543 HE10/05 17428 BR5-841 1 NO   NO NO                                                                                             >50 Premenopausal
99 33557 HE10/05 17659 BR5-842 1 NO   NO NO                                                                                             <=50 Premenopausal
100 33566 HE10/05 18498 BR5-843 1 NO   NO NO                                                                                             <=50 Premenopausal
101 33593 HE10/05 18626 BR5-844   YES PIK3CA YES NO other chr03 3q26.3 ex21 178952018 AMPL1497305257 178951918 178952092 38.1 3 3 SNV A 1 A/T   PIK3CA exonic missense TCC 21 p.Thr1025Ser 3073A>T c.3073A>T NA 1 adenocarcinoma:intestil_adenocarcinoma:aplastic_carcinoma:PRL:serous_carcinoma:endometrioid_carcinoma:carcinoma   PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 2,33 BR5-844bT PRO-15-20140513_BR5_T8_ 369 tumor 70 158154 72.57 287.8 75.6 IonXpress_014   326 237 89 0.27 20 - 30 <=50 Premenopausal
102 33595 HE10/05 17514 BR5-845 1 YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR5-845T PRO-15-20140513_BR5_T8_ 1186 tumor 75 1646567 85.59 3756 81.96 IonXpress_015   1061 937 124 0.12 10 - 20 >50 Postmenopausal
103 33599 HE10/05 17514 BR5-845   YES PIK3CA YES NO other chr03 3q26.3 ex21 178952103 AMPL392292511 178952020 178952194 36.3 3 2 INDEL CAA 1 CAA/CA   PIK3CA exonic frameshiftDeletion TGG 21 p.Met1055Trp 3159_3159delA c.3159_3159delA NA       PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 2.89,2.33,2.33 BR5-845T PRO-15-20140513_BR5_T8_ 5542 tumor 75 1646567 85.59 3756 81.96 IonXpress_015   551 429 99 0.18 10 - 20 >50 Postmenopausal
104 33604 HE10/05 19276 BR5-846 1 NO   NO NO                                                                                             >50 Postmenopausal
105 33622 HE10/05 18927 BR5-847 1 YES TP53 YES NO other chr17 17p13.1 ex6-in6 7578257 AMPL4574207192 7578114 7578273 53.5 1 1 SNV C 1 C/A   TP53 exonic nonsense TAA 6 p.Glu198* 592G>T c.592G>T NA   transitiol_cell_carcinoma:adenocarcinoma:superficial_spreading:squamous_cell_carcinoma:hepatocellular_carcinoma:basal_cell_carcinoma:mycosis_fungoides-Sezary_syndrome:small_round_cell_tumour:small_cell_carcinoma:actinic_keratosis:serous_carcinoma:carcin   P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 2,63 BR5-847aT PRO-15-20140513_BR5_T8_ 448 tumor 50 671895 82.07 1452 84.88 IonXpress_017   274 176 98 0.36 30 - 40 >50 Postmenopausal
106 33636 HE10/05 19261 BR5-848 1 NO   NO NO                                                                                             >50 Postmenopausal
107 33755 HE10/05 15424 BR5-850   YES PIK3CA NO NO nonMUTnonSNP chr03 3q26.3 in3 178917792 AMPL2705185935 178917726 178917900 29.9 2 1 SNV C 1 C/T   PIK3CA intronic             NA       PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 0,84 BR5-850T PRO-27-20140729_BR05_10_rest_ 419 tumor 40 348204 67.34 601.8 84.79 IonXpress_021   408 341 67 0.16 10 - 20 >50 Postmenopausal
108 33756 HE10/05 15424 BR5-850   YES PIK3CA NO NO nonMUTnonSNP chr03 3q26.3 in3 178917795 AMPL2705185935 178917726 178917900 29.9 2 1 SNV C 1 C/T   PIK3CA intronic             NA       PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 1,14 BR5-850T PRO-27-20140729_BR05_10_rest_ 419 tumor 40 348204 67.34 601.8 84.79 IonXpress_021   408 340 68 0.17 10 - 20 >50 Postmenopausal
109 33757 HE10/05 15424 BR5-850   YES PIK3CA YES NO other chr03 3q26.3 ex 10 178936091 AMPL393459515 178935994 178936131 38.6 3 2 SNV G 1 G/A   PIK3CA exonic missense AAG 10 p.Glu545Lys 1633G>A c.1633G>A NA 946 HER-positive_carcinoma:intestil_adenocarcinoma:Merkel_cell_carcinoma:lobular_carcinoma:endometrioid_carcinoma:carcinoid-endocrine_tumour:mucinous_carcinoma:adenoid_cystic_carcinoma:serrated_carcinoma:adenoma:sopharyngeal_carcinoma:basal_cell_carcinoma rs104886003 PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 2,72 BR5-850T PRO-27-20140729_BR05_10_rest_ 2119 tumor 40 348204 67.34 601.8 84.79 IonXpress_021   2000 1604 396 0.2 20 - 30 >50 Postmenopausal
110 33758 HE10/05 15424 BR5-850   YES PIK3CA YES NO other chr03 3q26.3 in 10-ex11 178937013 AMPL391535344 178936910 178937071 35.8 3 2 SNV T 1 T/C   PIK3CA exonic missense CCA 11 p.Leu565Pro 1694T>C c.1694T>C NA 1     PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 2,2 BR5-850T PRO-27-20140729_BR05_10_rest_ 851 tumor 40 348204 67.34 601.8 84.79 IonXpress_021 3.0E-5 827 754 73 0.09 <10 >50 Postmenopausal
111 33759 HE10/05 15424 BR5-850   YES PIK3CA YES NO other chr03 3q26.3 ex21 178951957 AMPL1497305257 178951918 178952092 38.1 3 3 SNV G 1 G/A   PIK3CA exonic missense ATA 21 p.Met1004Ile 3012G>A c.3012G>A NA 16 adenocarcinoma:astrocytoma_Grade_IV:small_cell_carcinoma:carcinoma:endometrioid_carcinoma   PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 2,89 BR5-850T PRO-27-20140729_BR05_10_rest_ 499 tumor 40 348204 67.34 601.8 84.79 IonXpress_021 2.0E-5 478 430 48 0.1 10 - 20 >50 Postmenopausal
112 33785 HE10/05 15424 BR5-850   YES TP53 YES NO other chr17 17p13.1 ex8-in8 7577030 AMPL706844244 7576996 7577170 61.6 1 2 SNV C 1 C/T   TP53 exonic missense AAC 8 p.Ser303Asn 908G>A c.908G>A NA   carcinoid-endocrine_tumour:transitiol_cell_carcinoma:basal_cell_carcinoma:essential_thrombocythaemia:carcinoma   P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 0,37 BR5-850T PRO-27-20140729_BR05_10_rest_ 356 tumor 40 348204 67.34 601.8 84.79 IonXpress_021   344 298 46 0.13 10 - 20 >50 Postmenopausal
113 33787 HE10/05 15424 BR5-850   YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR5-850T PRO-27-20140729_BR05_10_rest_ 313 tumor 40 348204 67.34 601.8 84.79 IonXpress_021   288 80 208 0.72 70 - 80 >50 Postmenopausal
114 33790 HE10/05 17237 BR5-852 1 NO   NO NO                                                                                             <=50 Premenopausal
115 33800 HE10/05 18188 BR5-853 1 NO   NO NO                                                                                             >50 Postmenopausal
116 33805 HE10/05 18359 BR5-855 1 YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR5-855T PRO-15-20140513_BR5_T8_ 169 tumor 70 197338 78.39 399 81.44 IonXpress_023   156 76 80 0.51 50 - 60 <=50 Premenopausal
117 33828 HE10/05 19352 BR5-856 1 YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR5-856T PRO-15-20140513_BR5_T8_ 352 tumor 90 491626 83.23 1076 82.48 IonXpress_024   327 60 267 0.82 80 - 90 >50 Postmenopausal
118 33838 HE10/05 19352 BR5-856   YES TP53 YES NO other chr17 17p13.1 in5-ex6 7578268 AMPL4392179183 7578209 7578382 58.3 1 2 SNV A 1 A/C   TP53 exonic missense CGT 6 p.Leu194Arg 581T>G c.581T>G NA   lymphoid_neoplasm:leiomyosarcoma:malignt_melanoma:hepatocellular_carcinoma:intestil_adenocarcinoma:MALT_lymphoma:small_cell_carcinoma:serous_carcinoma:chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma:adenocarcinoma:mantle_cell_lymphoma:squamou   P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 2,18 BR5-856T PRO-15-20140513_BR5_T8_ 202 tumor 90 491626 83.23 1076 82.48 IonXpress_024   181 31 150 0.83 80 - 90 >50 Postmenopausal
119 33849 HE10/05 18826 BR5-857   YES PIK3CA NO YES other chr03 3q26.3 off target 115118900 AMPL6795279620 115118832 115118979 44.9 2 1 SNV C 1 C/T 0.066                 NA     rs9821873   -2,3 BR5-857T PRO-15-20140513_BR5_T8_ 109 tumor 70 56418 76.09 109.8 81.21 IonXpress_025   105 60 45 0.43 40 - 50 >50 Postmenopausal
120 33850 HE10/05 18826 BR5-857   YES PIK3CA YES NO other chr03 3q26.3 ex 10 178936082 AMPL393459515 178935994 178936131 38.6 3 2 SNV G 1 G/A   PIK3CA exonic missense AAA 10 p.Glu542Lys 1624G>A c.1624G>A NA 998 HER-positive_carcinoma:liposarcoma:hepatocellular_carcinoma:intestil_adenocarcinoma:carcinosarcoma-malignt_mesodermal_mixed_tumour:undifferentiated_adenocarcinoma:Merkel_cell_carcinoma:lobular_carcinoma:endometrioid_carcinoma:mucinous_carcinoma:dysemb rs121913273 PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 2,72 BR5-857T PRO-15-20140513_BR5_T8_ 512 tumor 70 56418 76.09 109.8 81.21 IonXpress_025 5.0E-5 504 455 49 0.1 10 - 20 >50 Postmenopausal
121 33851 HE10/05 18826 BR5-857   YES PIK3CA YES NO other chr03 3q26.3 ex 10 178936091 AMPL393459515 178935994 178936131 38.6 3 2 SNV G 1 G/A   PIK3CA exonic missense AAG 10 p.Glu545Lys 1633G>A c.1633G>A NA 946 HER-positive_carcinoma:intestil_adenocarcinoma:Merkel_cell_carcinoma:lobular_carcinoma:endometrioid_carcinoma:carcinoid-endocrine_tumour:mucinous_carcinoma:adenoid_cystic_carcinoma:serrated_carcinoma:adenoma:sopharyngeal_carcinoma:basal_cell_carcinoma rs104886003 PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 2,72 BR5-857T PRO-15-20140513_BR5_T8_ 512 tumor 70 56418 76.09 109.8 81.21 IonXpress_025   506 449 57 0.11 10 - 20 >50 Postmenopausal
122 33864 HE10/05 19288 BR5-858 1 NO   NO NO                                                                                             >50 Postmenopausal
123 33870 HE10/05 19370 BR5-859 1 NO   NO NO                                                                                             <=50 Premenopausal
124 33872 HE10/05 20345 BR5-860 1 NO   NO NO                                                                                             >50 Postmenopausal
125 33879 HE10/05 18562 BR5-861 1 NO   NO NO                                                                                             >50 Postmenopausal
126 33885 HE10/05 18975 BR5-862 1 NO   NO NO                                                                                             >50 Postmenopausal
127 33892 HE10/05 15414 BR5-863 1 NO   NO NO                                                                                             <=50 Premenopausal
128 33901 HE10/05 17630 BR5-864   YES PIK3CA NO YES other chr03 3q26.3 in1-ex2 178916519 AMPL1786991673 178916463 178916617 30.9 1 1 SNV T 1 T/C 0.03 PIK3CA intronic             NA     rs11709323 PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 0,03 BR5-864T PRO-15-20140513_BR5_T8_ 230 tumor 75 111216 72.74 213 75.59 IonXpress_032   212 104 108 0.51 50 - 60 <=50 Premenopausal
129 33916 HE10/05 16684 BR5-865   YES PIK3CA YES NO other chr03 3q26.3 ex 10 178936091 AMPL393459515 178935994 178936131 38.6 3 2 SNV G 1 G/A   PIK3CA exonic missense AAG 10 p.Glu545Lys 1633G>A c.1633G>A NA 946 HER-positive_carcinoma:intestil_adenocarcinoma:Merkel_cell_carcinoma:lobular_carcinoma:endometrioid_carcinoma:carcinoid-endocrine_tumour:mucinous_carcinoma:adenoid_cystic_carcinoma:serrated_carcinoma:adenoma:sopharyngeal_carcinoma:basal_cell_carcinoma rs104886003 PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 2,72 BR5-865T PRO-15-20140513_BR5_T8_ 1012 tumor 70 159494 82.74 340.9 81.53 IonXpress_033   996 628 368 0.37 30 - 40 >50 Postmenopausal
130 33923 HE10/05 16684 BR5-865   YES TP53 YES NO other chr17 17p13.1 ex7-in7 7577508 AMPL3426752792 7577372 7577532 61 2 3 SNV T 1 T/C   TP53 exonic missense GGA 7 p.Glu258Gly 773A>G c.773A>G NA   transitiol_cell_carcinoma:adenocarcinoma:malignt_peripheral_nerve_sheath_tumour:squamous_cell_carcinoma:NK-T_cell_lymphoma:hepatocellular_carcinoma:astrocytoma_Grade_IV:seminoma:non_small_cell_carcinoma:ductal_carcinoma:serous_carcinoma:carcinoma   P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 2,07 BR5-865T PRO-15-20140513_BR5_T8_ 266 tumor 70 159494 82.74 340.9 81.53 IonXpress_033   373 182 191 0.51 50 - 60 >50 Postmenopausal
131 33928 HE10/05 16378 BR5-866 1 NO   NO NO                                                                                             >50 Postmenopausal
132 33933 HE10/05 17441 BR5-867 1 NO   NO NO                                                                                             <=50 Premenopausal
133 33938 HE10/05 18383 BR5-868 1 NO   NO NO                                                                                             >50 Postmenopausal
134 33945 HE10/05 18392 BR5-869 1 YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR5-869T PRO-15-20140513_BR5_T8_ 274 tumor 50 238831 83.92 512.9 55.77 IonXpress_037   258 32 226 0.88 80 - 90 >50 Postmenopausal
135 33951 HE10/05 18392 BR5-869   YES TP53 YES NO other chr17 17p13.1 in4-ex5 7578461 AMPL6326144323 7578407 7578581 61.7 1 3 SNV C 1 C/A   TP53 exonic missense TTC 5 p.Val157Phe 469G>T c.469G>T NA 998 hepatocellular_carcinoma:intestil_adenocarcinoma:undifferentiated_adenocarcinoma:endometrioid_carcinoma:adrel_cortical_carcinoma:adenoid_cystic_carcinoma:acute_lymphoblastic_B_cell_leukaemia:non_small_cell_carcinoma:chondrosarcoma:chromophobe_rel_ce rs121912654 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 0,39 BR5-869T PRO-15-20140513_BR5_T8_ 453 tumor 50 238831 83.92 512.9 55.77 IonXpress_037   428 378 50 0.12 10 - 20 >50 Postmenopausal
136 34079 HE10/05 19429 BR5-870   YES TP53 NO YES other chr17 17p13.1 in8-ex9-in9 7576841 AMPL1516620128 7576812 7576978 50 1 2 SNV A 1 A/G 0.017 TP53 intronic             NA     rs1800899 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif -1,12 BR5-870T   177 tumor                     0.56 50 - 60 >50 Postmenopausal
137 34089 HE10/05 18856 BR5-871 1 YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR5-871aT PRO-15-20140513_BR5_T8_ 272 tumor 55 249242 79.09 525.8 79.24 IonXpress_039   257 97 160 0.62 60 - 70 <=50 Premenopausal
138 34104 HE10/05 17152 BR5-872 1 NO   NO NO                                                                                             <=50 Premenopausal
139 34117 HE10/05 16370 BR5-873 1 NO   NO NO                                                                                             >50 Postmenopausal
140 34132 HE10/05 18366 BR5-874 1 NO   NO NO                                                                                             >50 Premenopausal
141 34143 HE10/05 19009 BR5-875 1 NO   NO NO                                                                                             >50 Postmenopausal
142 34149 HE10/05 18258 BR5-876 1 NO   NO NO                                                                                             >50 Postmenopausal
143 34160 HE10/05 17446 BR5-877 1 NO   NO NO                                                                                             <=50 Premenopausal
144 34170 HE10/05 17587 BR5-878 1 YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR5-878T PRO-15-20140513_BR5_T8_ 133 tumor 75 159383 78.4 324.6 77.55 IonXpress_046   121 43 78 0.64 60 - 70 <=50 Premenopausal
145 34182 HE10/05 17587 BR5-878   YES PIK3CA NO YES other chr03 3q26.3 off target 115118900 AMPL6795279620 115118832 115118979 44.9 2 1 SNV C 1 C/T 0.066                 NA     rs9821873   -2,3 BR5-878T PRO-15-20140513_BR5_T8_ 121 tumor 75 159383 78.4 324.6 77.55 IonXpress_046   117 56 61 0.52 50 - 60 <=50 Premenopausal
146 34184 HE10/05 17587 BR5-878   YES PIK3CA YES NO other chr03 3q26.3 ex21 178952090 AMPL392292511 178952020 178952194 36.3 3 2 SNV G 1 G/C   PIK3CA exonic missense CGT 21 p.Gly1049Arg 3145G>C c.3145G>C NA 871 dysplasia-in_situ_neoplasm:aplastic_carcinoma:papillary_carcinoma:small_cell_carcinoma:clear_cell_carcinoma:endometrioid_carcinoma:carcinoid-endocrine_tumour:transitiol_cell_carcinoma:adenocarcinoma:squamous_cell_carcinoma:adenoma:basal_(triple-negati rs121913277 PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 2,89 BR5-878T PRO-15-20140513_BR5_T8_ 525 tumor 75 159383 78.4 324.6 77.55 IonXpress_046   257 107 150 0.58 50 - 60 <=50 Premenopausal
147 34191 HE10/05 17460 BR5-879 1 NO   NO NO                                                                                             <=50 Premenopausal
148 34195 HE10/05 17635 BR5-880 1 YES TP53 NO YES other chr17 17p13.1 in3-ex4 7579579 AMPL6795075395 7579475 7579618 52 2 3 SNV C 1 C/T 0.012 TP53 exonic synonymous CCA 4 WT 108G>A c.108G>A NA   adenocarcinoma rs1800370 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif -1,05 BR5-880T PRO-15-20140513_BR5_T8_ 261 tumor 60 172041 67.05 290.7 82.3 IonXpress_048   253 155 98 0.39 30 - 40 <=50 Premenopausal
149 34212 HE10/05 17635 BR5-880   YES TP53 NO YES other chr17 17p13.1 in8-ex9-in9 7576841 AMPL1516620128 7576812 7576978 50 1 2 SNV A 1 A/G 0.017 TP53 intronic             NA     rs1800899 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif -1,12 BR5-880T PRO-15-20140513_BR5_T8_ 195 tumor 60 172041 67.05 290.7 82.3 IonXpress_048   181 102 79 0.44 40 - 50 <=50 Premenopausal
150 34225 HE10/05 17074 BR5-881   YES PIK3CA YES NO other chr03 3q26.3 ex 10 178936082 AMPL393459515 178935994 178936131 38.6 3 2 SNV G 1 G/A   PIK3CA exonic missense AAA 10 p.Glu542Lys 1624G>A c.1624G>A NA 998 HER-positive_carcinoma:liposarcoma:hepatocellular_carcinoma:intestil_adenocarcinoma:carcinosarcoma-malignt_mesodermal_mixed_tumour:undifferentiated_adenocarcinoma:Merkel_cell_carcinoma:lobular_carcinoma:endometrioid_carcinoma:mucinous_carcinoma:dysemb rs121913273 PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 2,72 BR5-881T PRO-15-20140513_BR5_T8_ 161 tumor 65 31591 44.79 34.13 63.21 IonXpress_049   160 100 60 0.38 30 - 40 >50 Postmenopausal
151 34249 HE10/05 16377 BR5-882   YES PIK3CA NO YES other chr03 3q26.3 off target 115118900 AMPL6795279620 115118832 115118979 44.9 2 1 SNV C 1 C/T 0.066                 NA     rs9821873   -2,3 BR5-882T PRO-15-20140513_BR5_T8_ 250 tumor 50 64144 75.57 123 75.78 IonXpress_050   240 134 106 0.44 40 - 50 >50 Postmenopausal
152 34253 HE10/05 17495 BR5-883 1 NO   NO NO                                                                                             >50 Postmenopausal
153 34277 HE10/05 17150 BR5-884 1 NO   NO NO                                                                                             <=50 Premenopausal
154 34297 HE10/05 16222 BR5-885 1 NO   NO NO                                                                                             <=50 Premenopausal
155 34371 HE10/05 15417 BR5-886 1 NO   NO NO                                                                                             <=50 Premenopausal
156 34377 HE10/05 15419 BR5-887 1 NO   NO NO                                                                                             <=50 Premenopausal
157 34537 HE10/05 16526 BR5-888   YES PIK3CA NO YES other chr03 3q26.3 in3 178917844 AMPL2705185935 178917726 178917900 29.9 2 1 INDEL TA 1 TA/T 0.013 PIK3CA intronic             NA     rs146815076 PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 -0.63,1.03 BR5-888T PRO-27-20140729_BR05_10_rest_ 397 tumor 30 262170 60.13 396.7 81.51 IonXpress_022   378 302 76 0.2 20 - 30 <=50 Premenopausal
158 34538 HE10/05 16526 BR5-888   YES PIK3CA YES NO other chr03 3q26.3 ex 10 178936103 AMPL393459515 178935994 178936131 38.6 3 2 SNV G 1 G/A   PIK3CA exonic missense AAT 10 p.Asp549Asn 1645G>A c.1645G>A NA 752 adenocarcinoma:hepatocellular_carcinoma   PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 2,72 BR5-888T PRO-27-20140729_BR05_10_rest_ 1167 tumor 30 262170 60.13 396.7 81.51 IonXpress_022   1135 1011 124 0.11 10 - 20 <=50 Premenopausal
159 34539 HE10/05 16526 BR5-888   YES PIK3CA YES NO other chr03 3q26.3 in 10-ex11 178937030 AMPL391535344 178936910 178937071 35.8 3 2 SNV T 1 T/C   PIK3CA exonic missense CCT 11 p.Ser571Pro 1711T>C c.1711T>C NA 882     PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 2,16 BR5-888T PRO-27-20140729_BR05_10_rest_ 700 tumor 30 262170 60.13 396.7 81.51 IonXpress_022   668 603 65 0.1 10 - 20 <=50 Premenopausal
160 34540 HE10/05 16526 BR5-888   YES PIK3CA YES NO other chr03 3q26.3 ex21 178951985 AMPL1497305257 178951918 178952092 38.1 3 3 SNV C 1 C/T   PIK3CA exonic nonsense TAA 21 p.Gln1014* 3040C>T c.3040C>T NA       PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 2,89 BR5-888T PRO-27-20140729_BR05_10_rest_ 278 tumor 30 262170 60.13 396.7 81.51 IonXpress_022   250 199 51 0.2 20 - 30 <=50 Premenopausal
161 34563 HE10/05 16526 BR5-888   YES TP53 YES NO other chr17 17p13.1 in9-ex10 7574002 AMPL387899835 7573927 7574055 62.8 1 1 INDEL CG 1 CG/C   TP53 exonic frameshiftDeletion   10 p.Arg342Glu 1024_1024delC c.1024_1024delC NA   acute_myeloid_leukaemia:glioma:squamous_cell_carcinoma:adenoma:hepatocellular_carcinoma:neoplasm:serous_carcinoma:endometrioid_carcinoma:carcinoma   P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 0.27,0.66 BR5-888T PRO-27-20140729_BR05_10_rest_ 348 tumor 30 262170 60.13 396.7 81.51 IonXpress_022   335 259 76 0.23 20 - 30 <=50 Premenopausal
162 34568 HE10/05 16526 BR5-888   YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR5-888T PRO-27-20140729_BR05_10_rest_ 189 tumor 30 262170 60.13 396.7 81.51 IonXpress_022   172 51 121 0.7 70 - 80 <=50 Premenopausal
163 34571 HE10/05 17282 BR5-889 1 NO   NO NO                                                                                             <=50 Premenopausal
164 34582 HE10/05 19255 BR5-890 1 NO   NO NO                                                                                             <=50 Premenopausal
165 34585 HE10/05 15418 BR5-891 1 YES TP53 YES NO other chr17 17p13.1 in7-ex8 7577120 AMPL1481474315 7577115 7577289 48.1 2 3 SNV C 1 C/T   TP53 exonic missense CAT 8 p.Arg273His 818G>A c.818G>A NA   HER-positive_carcinoma:hepatocellular_carcinoma:Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour:yolk_sac_tumour:Merkel_cell_carcinoma:chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma:carcinoid-endocrine_tumour:mantle_cell_lymphoma:margi rs28934576 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 2,56 BR5-891T PRO-27-20140729_BR05_10_rest_ 1085 tumor 45 837502 82.89 1825 82.08 IonXpress_023   619 512 107 0.17 10 - 20 >50 Premenopausal
166 34620 HE10/05 15418 BR5-891   YES PIK3CA YES NO other chr03 3q26.3 ex 10 178936082 AMPL393459515 178935994 178936131 38.6 3 2 SNV G 1 G/A   PIK3CA exonic missense AAA 10 p.Glu542Lys 1624G>A c.1624G>A NA 998 HER-positive_carcinoma:liposarcoma:hepatocellular_carcinoma:intestil_adenocarcinoma:carcinosarcoma-malignt_mesodermal_mixed_tumour:undifferentiated_adenocarcinoma:Merkel_cell_carcinoma:lobular_carcinoma:endometrioid_carcinoma:mucinous_carcinoma:dysemb rs121913273 PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 2,72 BR5-891T PRO-27-20140729_BR05_10_rest_ 4392 tumor 45 837502 82.89 1825 82.08 IonXpress_023   1999 1499 500 0.25 20 - 30 >50 Premenopausal
167 34629 HE10/05 15418 BR5-891   YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR5-891T PRO-27-20140729_BR05_10_rest_ 1033 tumor 45 837502 82.89 1825 82.08 IonXpress_023   978 259 719 0.74 70 - 80 >50 Premenopausal
168 34631 HE10/05 19013 BR5-892 1 YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR5-892bT   112 tumor                     0.87 80 - 90 >50 Postmenopausal
169 34644 HE10/05 19013 BR5-892   YES PIK3CA YES NO other chr03 3q26.3 ex 10 178936091 AMPL393459515 178935994 178936131 38.6 3 2 SNV G 1 G/A   PIK3CA exonic missense AAG 10 p.Glu545Lys 1633G>A c.1633G>A NA 946 HER-positive_carcinoma:intestil_adenocarcinoma:Merkel_cell_carcinoma:lobular_carcinoma:endometrioid_carcinoma:carcinoid-endocrine_tumour:mucinous_carcinoma:adenoid_cystic_carcinoma:serrated_carcinoma:adenoma:sopharyngeal_carcinoma:basal_cell_carcinoma rs104886003 PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 2,72 BR5-892bT PRO-15-20140513_BR5_T8_ 1409 tumor 50 136027 76.94 268.3 69.32 IonXpress_059   1398 986 412 0.29 20 - 30 >50 Postmenopausal
170 34650 HE10/05 16557 BR5-893 1 NO   NO NO                                                                                             <=50 Premenopausal
171 34657 HE10/05 16263 BR5-894 1 NO   NO NO                                                                                             <=50 Premenopausal
172 34680 HE10/05 17069 BR5-895 1 NO   NO NO                                                                                             >50 Postmenopausal
173 34775 HE10/05 17241 BR5-896 1 NO   NO NO                                                                                             >50 Postmenopausal
174 34805 HE10/05 16234 BR5-897 1 YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR5-897T PRO-15-20140513_BR5_T8_ 214 tumor 80 451851 78.81 904.2 84.4 IonXpress_065   202 25 177 0.88 80 - 90 >50 Postmenopausal
175 34817 HE10/05 19010 BR5-898 1 YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR5-898T PRO-15-20140513_BR5_T8_ 250 tumor 70 2175492 84.85 4672 67.84 IonXpress_066   221 114 107 0.48 40 - 50 >50 Postmenopausal
176 34830 HE10/05 19010 BR5-898   YES PIK3CA NO YES other chr03 3q26.3 in3 178917844 AMPL2705185935 178917726 178917900 29.9 2 1 INDEL TA 1 TA/T 0.013 PIK3CA intronic             NA     rs146815076 PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 -0.63,1.03 BR5-898T PRO-15-20140513_BR5_T8_ 408 tumor 70 2175492 84.85 4672 67.84 IonXpress_066   389 165 224 0.58 50 - 60 >50 Postmenopausal
177 34836 HE10/05 19283 BR5-901 1 NO   NO NO                                                                                             >50 Postmenopausal
178 34849 HE10/08 40247 BR8-005 1 YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 ex6-in6 7578210 AMPL4574207192 7578114 7578273 53.5 1 1 SNV T 1 T/C   TP53 exonic synonymous CGG 6 WT 639A>G c.639A>G NA   oligodendroglioma_Grade_II:adenocarcinoma:adenoma:carcinoma rs1800372 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif -0,16 BR8-005T PRO-17-20140520_BR08_T1_ 315 tumor 60 393251 81.28 824.7 50.1 IonXpress_005   300 153 147 0.49 40 - 50 <=50 Premenopausal
179 34879 HE10/08 42169 BR8-008   YES PIK3CA NO NO nonMUTnonSNP chr03 3q26.3 off target 115118900 AMPL6795279620 115118832 115118979 44.9 2 1 SNV C 1 C/T                   NA     rs9821873   -2,3 BR8-008T PRO-17-20140520_BR08_T1_ 895 tumor 70 230016 64.07 379.3 49.44 IonXpress_008   876 485 391 0.45 40 - 50 >50 Postmenopausal
180 34882 HE10/08 40458 BR8-009 1 NO   NO NO                                                                                             >50 Postmenopausal
181 34892 HE10/08 40927 BR8-010 1 NO   NO NO                                                                                             >50 Postmenopausal
182 34912 HE10/08 40815 BR8-013 1 NO   NO NO                                                                                             >50 Postmenopausal
183 34929 HE10/08 41207 BR8-015 1 NO   NO NO                                                                                             <=50 Premenopausal
184 34941 HE10/08 40404 BR8-016 1 NO   NO NO                                                                                             >50 Postmenopausal
185 34962 HE10/08 40864 BR8-025 1 YES PIK3CA YES NO other chr03 3q26.3 ex 10 178936091 AMPL393459515 178935994 178936131 38.6 3 2 SNV G 1 G/A   PIK3CA exonic missense AAG 10 p.Glu545Lys 1633G>A c.1633G>A NA 946 ############################################################################################################################################################################################################################################################### rs104886003 PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 2,72 BR8-025T PRO-17-20140520_BR08_T1_ 268 tumor 60 33019 33.27 29.11 47.84 IonXpress_024   265 218 47 0.18 10 - 20 >50 Premenopausal
186 34965 HE10/08 40343 BR8-028 1 YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR8-028T PRO-17-20140520_BR08_T1_ 2190 tumor 60 2181769 87.14 5120 80.09 IonXpress_026   1998 1194 804 0.4 40 - 50 <=50 Premenopausal
187 34966 HE10/08 40343 BR8-028   YES TP53 NO YES other chr17 17p13.1 ex7-in7 7577407 AMPL3426752792 7577372 7577532 61 2 3 SNV A 1 A/C 0.163 TP53 intronic             NA     rs12951053 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif -1,68 BR8-028T PRO-17-20140520_BR08_T1_ 8908 tumor 60 2181769 87.14 5120 80.09 IonXpress_026   1992 1119 873 0.44 40 - 50 <=50 Premenopausal
188 34982 HE10/08 40343 BR8-028   YES PIK3CA NO NO nonMUTnonSNP chr03 3q26.3 in1 178866408 AMPL4347527835 178866384 178866543 78.2     SNV C 1 C/T   PIK3CA intronic             NA     rs2699887 PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 -0,07 BR8-028T PRO-17-20140520_BR08_T1_ 174 tumor 60 2181769 87.14 5120 80.09 IonXpress_026   103 44 59 0.57 50 - 60 <=50 Premenopausal
189 34983 HE10/08 40343 BR8-028   YES PIK3CA YES NO other chr03 3q26.3 ex21 178952103 AMPL392292511 178952020 178952194 36.3 3 2 INDEL CA 1 CA/C   PIK3CA exonic frameshiftDeletion TGG 21 p.Met1055Trp 3159_3159delA c.3159_3159delA NA       PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 2.89,2.33 BR8-028T PRO-17-20140520_BR08_T1_ 6969 tumor 60 2181769 87.14 5120 80.09 IonXpress_026   1951 397 1554 0.8 80 - 90 <=50 Premenopausal
190 34991 HE10/08 40343 BR8-028   YES TP53 NO YES other chr17 17p13.1 ex7-in7 7577427 AMPL3426752792 7577372 7577532 61 2 3 SNV G 1 G/A 0.163 TP53 intronic             NA     rs12947788 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 0,16 BR8-028T PRO-17-20140520_BR08_T1_ 8908 tumor 60 2181769 87.14 5120 80.09 IonXpress_026   1996 1161 835 0.42 40 - 50 <=50 Premenopausal
191 34992 HE10/08 40198 BR8-029 1 YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 ex7-in7 7577407 AMPL3426752792 7577372 7577532 61 2 3 SNV A 1 A/C   TP53 intronic             NA     rs12951053 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif -1,68 BR8-029T PRO-17-20140520_BR08_T1_ 3225 tumor 45 1391380 84.57 3045 72.47 IonXpress_027   1994 1354 640 0.32 30 - 40 <=50 Premenopausal
192 35006 HE10/08 40198 BR8-029   YES PIK3CA YES NO other chr03 3q26.3 ex21 178952103 AMPL392292511 178952020 178952194 36.3 3 2 INDEL CA 1 CA/C   PIK3CA exonic frameshiftDeletion TGG 21 p.Met1055Trp 3159_3159delA c.3159_3159delA NA       PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 2.89,2.33 BR8-029T PRO-17-20140520_BR08_T1_ 3382 tumor 45 1391380 84.57 3045 72.47 IonXpress_027   951 167 784 0.82 80 - 90 <=50 Premenopausal
193 35015 HE10/08 40198 BR8-029   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 ex7-in7 7577427 AMPL3426752792 7577372 7577532 61 2 3 SNV G 1 G/A   TP53 intronic             NA     rs12947788 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 0,16 BR8-029T PRO-17-20140520_BR08_T1_ 3225 tumor 45 1391380 84.57 3045 72.47 IonXpress_027   1995 1409 586 0.29 20 - 30 <=50 Premenopausal
194 35016 HE10/08 40198 BR8-029   YES TP53 YES NO other chr17 17p13.1 in4-ex5 7578516 AMPL6326144323 7578407 7578581 61.7 1 3 INDEL GGCCAGT 6 GGCCAGT/G   TP53 exonic nonframeshiftDeletion   5 p.Gln136His 408_413delACTGGC c.408_413delACTGGC NA   squamous_cell_carcinoma:carcinoma rs28934875:rs137852794 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif -1.91,2.73,2.73,0.35,2.21,0.75,0.8 BR8-029T PRO-17-20140520_BR08_T1_ 1631 tumor 45 1391380 84.57 3045 72.47 IonXpress_027   1541 973 568 0.37 30 - 40 <=50 Premenopausal
195 35017 HE10/08 40902 BR8-030 1 YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR8-030T PRO-17-20140520_BR08_T1_ 163 tumor 75 148646 87.7 344.4 49.3 IonXpress_028   156 32 124 0.79 70 - 80 >50 Postmenopausal
196 35025 HE10/08 40902 BR8-030   YES PIK3CA YES NO other chr03 3q26.3 ex21 178952103 AMPL392292511 178952020 178952194 36.3 3 2 INDEL CA 1 CA/C   PIK3CA exonic frameshiftDeletion TGG 21 p.Met1055Trp 3159_3159delA c.3159_3159delA NA       PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 2.89,2.33 BR8-030T PRO-17-20140520_BR08_T1_ 705 tumor 75 148646 87.7 344.4 49.3 IonXpress_028   304 101 203 0.67 60 - 70 >50 Postmenopausal
197 35029 HE10/08 41547 BR8-032 1 YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR8-032T PRO-17-20140520_BR08_T1_ 802 tumor 80 568097 84.86 1285 63.22 IonXpress_030 1.0E-5 749 651 98 0.13 10 - 20 >50 Postmenopausal
198 35050 HE10/08 41547 BR8-032   YES TP53 YES NO other chr17 17p13.1 in6-ex7-in7 7577538 AMPL4981177402 7577472 7577638 53.4 2 3 SNV C 1 C/T   TP53 exonic missense CAG 7 p.Arg248Gln 743G>A c.743G>A NA 1 ############################################################################################################################################################################################################################################################### rs11540652 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,31 BR8-032T PRO-17-20140520_BR08_T1_ 4006 tumor 80 568097 84.86 1285 63.22 IonXpress_030   1998 682 1316 0.66 60 - 70 >50 Postmenopausal
199 35054 HE10/08 41938 BR8-034 1 YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR8-034T PRO-17-20140520_BR08_T1_ 632 tumor 60 1039291 89.96 2443 79.3 IonXpress_032   597 429 168 0.28 20 - 30 <=50 Premenopausal
200 35066 HE10/08 41938 BR8-034   YES PIK3CA YES NO other chr03 3q26.3 ex21 178952103 AMPL392292511 178952020 178952194 36.3 3 2 INDEL CAA 1 CA/CA   PIK3CA exonic frameshiftDeletion TGG 21 p.Met1055Trp 3159_3159delA c.3159_3159delA NA       PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 2.89,2.33,2.33 BR8-034T PRO-17-20140520_BR08_T1_ 2695 tumor 60 1039291 89.96 2443 79.3 IonXpress_032   1001 37 964 0.96 90 - 100 <=50 Premenopausal
201 35071 HE10/08 41938 BR8-034   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 in8-ex9-in9 7576841 AMPL1516620128 7576812 7576978 50 1 2 SNV A 1 A/G   TP53 intronic             NA     rs1800899 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif -1,12 BR8-034T PRO-17-20140520_BR08_T1_ 341 tumor 60 1039291 89.96 2443 79.3 IonXpress_032   320 116 204 0.64 60 - 70 <=50 Premenopausal
202 35072 HE10/08 41938 BR8-034   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 in3-ex4 7579579 AMPL6795075395 7579475 7579618 52 2 3 SNV C 1 C/T   TP53 exonic synonymous CCA 4 WT 108G>A c.108G>A NA   adenocarcinoma rs1800370 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif -1,05 BR8-034T PRO-17-20140520_BR08_T1_ 2446 tumor 60 1039291 89.96 2443 79.3 IonXpress_032   1988 708 1280 0.64 60 - 70 <=50 Premenopausal
203 35073 HE10/08 40984 BR8-035 1 YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR8-035T PRO-17-20140520_BR08_T1_ 5521 tumor 85 8372779 84.88 18646 82.76 IonXpress_033   1995 492 1503 0.75 70 - 80 >50 Postmenopausal
204 35113 HE10/08 40158 BR8-036   YES PIK3CA YES NO other chr03 3q26.3 ex 10 178936091 AMPL393459515 178935994 178936131 38.6 3 2 SNV G 1 G/A   PIK3CA exonic missense AAG 10 p.Glu545Lys 1633G>A c.1633G>A NA 946 ############################################################################################################################################################################################################################################################### rs104886003 PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 2,72 BR8-036T PRO-17-20140520_BR08_T1_ 8892 tumor 55 955845 87.53 2210 77.33 IonXpress_034   1996 1505 491 0.25 20 - 30 >50 Postmenopausal
205 35121 HE10/08 40158 BR8-036   YES TP53 YES NO other chr17 17p13.1 ex4-in4 7579389 AMPL1481773781 7579257 7579411 56.1 2 3 SNV G 1 G/A   TP53 exonic nonsense TAG 4 p.Gln100* 298C>T c.298C>T NA   lymphoid_neoplasm:adenocarcinoma:squamous_cell_carcinoma:malignt_melanoma:adrel_cortical_adenoma:NK-T_cell_lymphoma:basal_cell_carcinoma:non_small_cell_carcinoma:small_cell_carcinoma:serous_carcinoma   P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,33 BR8-036T PRO-17-20140520_BR08_T1_ 1402 tumor 55 955845 87.53 2210 77.33 IonXpress_034   1483 1114 369 0.25 20 - 30 >50 Postmenopausal
206 35123 HE10/08 40158 BR8-036   YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR8-036T PRO-17-20140520_BR08_T1_ 553 tumor 55 955845 87.53 2210 77.33 IonXpress_034   536 116 420 0.78 70 - 80 >50 Postmenopausal
207 35126 HE10/08 40912 BR8-039 1 YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR8-039T PRO-17-20140520_BR08_T1_ 2092 tumor 55 1611496 89.88 3883 77.1 IonXpress_036   1993 1122 871 0.44 40 - 50 <=50 Premenopausal
208 35142 HE10/08 40912 BR8-039   YES PIK3CA YES NO other chr03 3q26.3 ex21 178952103 AMPL392292511 178952020 178952194 36.3 3 2 INDEL CAA 1 CAA/CA   PIK3CA exonic frameshiftDeletion TGG 21 p.Met1055Trp 3159_3159delA c.3159_3159delA NA       PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 2.89,2.33,2.33 BR8-039T PRO-17-20140520_BR08_T1_ 8502 tumor 55 1611496 89.88 3883 77.1 IonXpress_036   1616 380 1188 0.74 70 - 80 <=50 Premenopausal
209 35149 HE10/08 40912 BR8-039   YES TP53 YES NO other chr17 17p13.1 in6-ex7-in7 7577580 AMPL4981177402 7577472 7577638 53.4 2 3 SNV T 1 T/C   TP53 exonic missense TGC 7 p.Tyr234Cys 701A>G c.701A>G NA   ###############################################################################################################################################################################################################################################################   P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 0,84 BR8-039T PRO-17-20140520_BR08_T1_ 7415 tumor 55 1611496 89.88 3883 77.1 IonXpress_036   1997 1744 253 0.13 10 - 20 <=50 Premenopausal
210 35151 HE10/08 40813 BR8-042 1 YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR8-042T PRO-17-20140520_BR08_T1_ 2178 tumor 55 2618434 81.44 5401 70.43 IonXpress_038   1994 1462 532 0.27 20 - 30 >50 Postmenopausal
211 35168 HE10/08 40813 BR8-042   YES PIK3CA YES NO other chr03 3q26.3 ex21 178952103 AMPL392292511 178952020 178952194 36.3 3 2 INDEL CAA 1 CAA/CA   PIK3CA exonic frameshiftDeletion TGG 21 p.Met1055Trp 3159_3159delA c.3159_3159delA NA       PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 2.89,2.33,2.33 BR8-042T PRO-17-20140520_BR08_T1_ 5203 tumor 55 2618434 81.44 5401 70.43 IonXpress_038   1010 244 741 0.73 70 - 80 >50 Postmenopausal
212 35175 HE10/08 40813 BR8-042   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 ex7-in7 7577407 AMPL3426752792 7577372 7577532 61 2 3 SNV A 1 A/C   TP53 intronic             NA     rs12951053 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif -1,68 BR8-042T PRO-17-20140520_BR08_T1_ 3155 tumor 55 2618434 81.44 5401 70.43 IonXpress_038   1992 851 1141 0.57 50 - 60 >50 Postmenopausal
213 35176 HE10/08 40813 BR8-042   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 ex7-in7 7577427 AMPL3426752792 7577372 7577532 61 2 3 SNV G 1 G/A   TP53 intronic             NA     rs12947788 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 0,16 BR8-042T PRO-17-20140520_BR08_T1_ 3155 tumor 55 2618434 81.44 5401 70.43 IonXpress_038   1992 916 1076 0.54 50 - 60 >50 Postmenopausal
214 35178 HE10/08 41233 BR8-044 1 NO   NO NO                                                                                             >50 Postmenopausal
215 35188 HE10/08 40939 BR8-051 1 YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR8-051T PRO-17-20140520_BR08_T1_ 611 tumor 90 2480959 95.38 5434 54.48 IonXpress_045   573 147 426 0.74 70 - 80 >50 Postmenopausal
216 35200 HE10/08 40939 BR8-051   YES PIK3CA NO NO nonMUTnonSNP chr03 3q26.3 off target 115118900 AMPL6795279620 115118832 115118979 44.9 2 1 SNV C 1 C/T                   NA     rs9821873   -2,3 BR8-051T PRO-17-20140520_BR08_T1_ 2385 tumor 90 2480959 95.38 5434 54.48 IonXpress_045   1995 1288 707 0.35 30 - 40 >50 Postmenopausal
217 35209 HE10/08 40939 BR8-051   YES TP53 YES NO other chr17 17p13.1 ex8-in8 7577120 AMPL706844244 7576996 7577170 61.6 1 2 SNV C 1 C/A   TP53 exonic missense CTT 8 p.Arg273Leu 818G>T c.818G>T NA   ############################################################################################################################################################################################################################################################### rs28934576 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 2,56 BR8-051T PRO-17-20140520_BR08_T1_ 1228 tumor 90 2480959 95.38 5434 54.48 IonXpress_045   1133 178 955 0.84 80 - 90 >50 Postmenopausal
218 35210 HE10/08 40863 BR8-052 1 YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR8-052T PRO-17-20140520_BR08_T1_ 1035 tumor 65 1463799 90.69 3526 76.03 IonXpress_046   999 225 774 0.77 70 - 80 <=50 Premenopausal
219 35221 HE10/08 40863 BR8-052   YES PIK3CA YES NO other chr03 3q26.3 ex21 178952103 AMPL392292511 178952020 178952194 36.3 3 2 INDEL CA 1 CA/C   PIK3CA exonic frameshiftDeletion TGG 21 p.Met1055Trp 3159_3159delA c.3159_3159delA NA       PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 2.89,2.33 BR8-052T PRO-17-20140520_BR08_T1_ 4627 tumor 65 1463799 90.69 3526 76.03 IonXpress_046   1766 178 1588 0.9 90 - 100 <=50 Premenopausal
220 35229 HE10/08 40863 BR8-052   YES TP53 YES NO other chr17 17p13.1 ex5-in5 7578406 AMPL1992796664 7578284 7578458 63.7 1 2 SNV C 1 C/T   TP53 exonic missense CAC 5 p.Arg175His 524G>A c.524G>A NA   ############################################################################################################################################################################################################################################################### rs28934578 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 2,7 BR8-052T PRO-17-20140520_BR08_T1_ 1206 tumor 65 1463799 90.69 3526 76.03 IonXpress_046   951 569 382 0.4 40 - 50 <=50 Premenopausal
221 35233 HE10/08 40947 BR8-056 1 YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR8-056T PRO-17-20140520_BR08_T1_ 2740 tumor 80 4315542 87.87 10493 76.86 IonXpress_049   1989 469 1520 0.76 70 - 80 >50 Postmenopausal
222 35234 HE10/08 40947 BR8-056   YES TP53 YES NO other chr17 17p13.1 ex5-in5 7578403 AMPL1992796664 7578284 7578458 63.7 1 2 SNV C 1 C/T   TP53 exonic missense TAC 5 p.Cys176Tyr 527G>A c.527G>A NA   HER-positive_carcinoma:lymphoid_neoplasm:hepatocellular_carcinoma:Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour:intestil_adenocarcinoma:yolk_sac_tumour:undifferentiated_adenocarcinoma:Bowen_disease:mucinous_carcinoma:adrel_cortical_carcin   P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,47 BR8-056T PRO-17-20140520_BR08_T1_ 5860 tumor 80 4315542 87.87 10493 76.86 IonXpress_049   1994 889 1105 0.55 50 - 60 >50 Postmenopausal
223 35251 HE10/08 40947 BR8-056   YES PIK3CA YES NO other chr03 3q26.3 ex 10 178936091 AMPL393459515 178935994 178936131 38.6 3 2 SNV G 1 G/A   PIK3CA exonic missense AAG 10 p.Glu545Lys 1633G>A c.1633G>A NA 946 HER-positive_carcinoma:intestil_adenocarcinoma:Merkel_cell_carcinoma:lobular_carcinoma:endometrioid_carcinoma:carcinoid-endocrine_tumour:mucinous_carcinoma:adenoid_cystic_carcinoma:serrated_carcinoma:adenoma:sopharyngeal_carcinoma:basal_cell_carcinoma rs104886003 PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 2,72 BR8-056T PRO-17-20140520_BR08_T1_ 28231 tumor 80 4315542 87.87 10493 76.86 IonXpress_049   1999 1457 542 0.27 20 - 30 >50 Postmenopausal
224 35260 HE10/08 40846 BR8-062 1 YES TP53 YES NO other chr17 17p13.1 ex5-in5 7578404 AMPL1992796664 7578284 7578458 63.7 1 2 SNV A 1 A/G   TP53 exonic missense CGC 5 p.Cys176Arg 526T>C c.526T>C NA 1 ###############################################################################################################################################################################################################################################################   P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 2,26 BR8-062T PRO-17-20140520_BR08_T1_ 342 tumor 40 216821 85.42 491.3 76.12 IonXpress_055   303 235 68 0.22 20 - 30 >50 Postmenopausal
225 35277 HE10/08 40846 BR8-062   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 ex7-in7 7577407 AMPL3426752792 7577372 7577532 61 2 3 SNV A 1 A/C   TP53 intronic             NA     rs12951053 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif -1,68 BR8-062T PRO-17-20140520_BR08_T1_ 709 tumor 40 216821 85.42 491.3 76.12 IonXpress_055   657 370 287 0.44 40 - 50 >50 Postmenopausal
226 35278 HE10/08 40846 BR8-062   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 ex7-in7 7577427 AMPL3426752792 7577372 7577532 61 2 3 SNV G 1 G/A   TP53 intronic             NA     rs12947788 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 0,16 BR8-062T PRO-17-20140520_BR08_T1_ 709 tumor 40 216821 85.42 491.3 76.12 IonXpress_055   680 393 287 0.42 40 - 50 >50 Postmenopausal
227 35279 HE10/08 41224 BR8-064 1 NO   NO NO                                                                                             <=50 Premenopausal
228 35301 HE10/08 40207 BR8-065 1 YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR8-065T PRO-17-20140520_BR08_T1_ 230 tumor 65 669443 84.69 1460 77.94 IonXpress_057   224 71 153 0.68 60 - 70 >50 Postmenopausal
229 35323 HE10/08 40207 BR8-065   YES PIK3CA YES NO other chr03 3q26.3 ex21 178952103 AMPL392292511 178952020 178952194 36.3 3 2 INDEL CA 1 CA/C   PIK3CA exonic frameshiftDeletion TGG 21 p.Met1055Trp 3159_3159delA c.3159_3159delA NA       PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 2.89,2.33 BR8-065T PRO-17-20140520_BR08_T1_ 2233 tumor 65 669443 84.69 1460 77.94 IonXpress_057   761 169 592 0.78 70 - 80 >50 Postmenopausal
230 35330 HE10/08 40207 BR8-065   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 ex6-in6 7578210 AMPL4574207192 7578114 7578273 53.5 1 1 SNV T 1 T/C   TP53 exonic synonymous CGG 6 WT 639A>G c.639A>G NA   oligodendroglioma_Grade_II:adenocarcinoma:adenoma:carcinoma rs1800372 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif -0,16 BR8-065T PRO-17-20140520_BR08_T1_ 263 tumor 65 669443 84.69 1460 77.94 IonXpress_057   245 109 136 0.56 50 - 60 >50 Postmenopausal
231 35331 HE10/08 42257 BR8-066 1 YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR8-066ML PRO-17-20140520_BR08_T1_ 118 tumor 80 581890 77.9 1167 65.91 IonXpress_058   114 38 76 0.67 60 - 70 >50 Postmenopausal
232 35361 HE10/08 42257 BR8-066   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 in8-ex9-in9 7576852 AMPL1516620128 7576812 7576978 50 1 2 SNV C 1 C/T   TP53 splicesite_3             NA   adenocarcinoma:squamous_cell_carcinoma:adenoma:neoplasm:intestil_adenocarcinoma:basal_cell_carcinoma:malignt_fibrous_histiocytoma-pleomorphic_sarcoma:NS:small_cell_carcinoma:serous_carcinoma:carcinoma rs11575997 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 2,46 BR8-066ML PRO-17-20140520_BR08_T1_ 159 tumor 80 581890 77.9 1167 65.91 IonXpress_058   148 25 123 0.83 80 - 90 >50 Postmenopausal
233 35362 HE10/08 42257 BR8-066   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 ex7-in7 7577407 AMPL3426752792 7577372 7577532 61 2 3 SNV A 1 A/C   TP53 intronic             NA     rs12951053 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif -1,68 BR8-066ML PRO-17-20140520_BR08_T1_ 1756 tumor 80 581890 77.9 1167 65.91 IonXpress_058   1612 1330 282 0.17 10 - 20 >50 Postmenopausal
234 35363 HE10/08 42257 BR8-066   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 ex7-in7 7577427 AMPL3426752792 7577372 7577532 61 2 3 SNV G 1 G/A   TP53 intronic             NA     rs12947788 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 0,16 BR8-066ML PRO-17-20140520_BR08_T1_ 1756 tumor 80 581890 77.9 1167 65.91 IonXpress_058   1639 1361 278 0.17 10 - 20 >50 Postmenopausal
235 35364 HE10/08 42257 BR8-066   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 ex6-in6 7578158 AMPL4574207192 7578114 7578273 53.5 1 1 SNV C 1 C/T   TP53 intronic             NA       P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif -0,32 BR8-066ML PRO-17-20140520_BR08_T1_ 470 tumor 80 581890 77.9 1167 65.91 IonXpress_058 2.0E-5 447 401 46 0.1 10 - 20 >50 Postmenopausal
236 35382 HE10/08 42122 BR8-070   YES PIK3CA YES NO other chr03 3q26.3 ex 10 178936082 AMPL393459515 178935994 178936131 38.6 3 2 SNV G 1 G/A   PIK3CA exonic missense AAA 10 p.Glu542Lys 1624G>A c.1624G>A NA 998 HER-positive_carcinoma:liposarcoma:hepatocellular_carcinoma:intestil_adenocarcinoma:carcinosarcoma-malignt_mesodermal_mixed_tumour:undifferentiated_adenocarcinoma:Merkel_cell_carcinoma:lobular_carcinoma:endometrioid_carcinoma:mucinous_carcinoma:dysemb rs121913273 PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 2,72 BR8-070T PRO-17-20140520_BR08_T1_ 13733 tumor 65 957656 87.24 2246 49.87 IonXpress_062   1994 1411 583 0.29 20 - 30 <=50 Premenopausal
237 35390 HE10/08 42122 BR8-070   YES TP53 NO YES other chr17 17p13.1 in8-ex9-in9 7576841 AMPL1516620128 7576812 7576978 50 1 2 SNV A 1 A/G 0.017 TP53 intronic             NA     rs1800899 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif -1,12 BR8-070T   2187 tumor                     0.48 40 - 50 <=50 Premenopausal
238 35391 HE10/08 42122 BR8-070   YES TP53 NO YES other chr17 17p13.1 in3-ex4 7579579 AMPL6795075395 7579475 7579618 52 2 3 SNV C 1 C/T 0.012 TP53 exonic synonymous CCA 4 WT 108G>A c.108G>A NA   adenocarcinoma rs1800370 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif -1,05 BR8-070T PRO-17-20140520_BR08_T1_ 5648 tumor 65 957656 87.24 2246 49.87 IonXpress_062   1986 973 1013 0.51 50 - 60 <=50 Premenopausal
239 35392 HE10/08 41710 BR8-072 1 YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR8-072ML PRO-17-20140520_BR08_T1_ 1502 tumor 40 2731185 76.3 5445 80.52 IonXpress_063   1422 894 528 0.37 30 - 40 >50 Postmenopausal
240 35411 HE10/08 41710 BR8-072   YES PIK3CA NO NO nonMUTnonSNP chr03 3q26.3 in1 178866408 AMPL4347527835 178866384 178866543 78.2     SNV C 1 C/T   PIK3CA intronic             NA     rs2699887 PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 -0,07 BR8-072ML PRO-17-20140520_BR08_T1_ 216 tumor 40 2731185 76.3 5445 80.52 IonXpress_063   144 55 89 0.62 60 - 70 >50 Postmenopausal
241 35412 HE10/08 41710 BR8-072   YES PIK3CA YES NO other chr03 3q26.3 ex21 178952103 AMPL392292511 178952020 178952194 36.3 3 2 INDEL CA 1 CA/C   PIK3CA exonic frameshiftDeletion TGG 21 p.Met1055Trp 3159_3159delA c.3159_3159delA NA       PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 2.89,2.33 BR8-072ML PRO-17-20140520_BR08_T1_ 2894 tumor 40 2731185 76.3 5445 80.52 IonXpress_063   1190 188 1002 0.84 80 - 90 >50 Postmenopausal
242 35421 HE10/08 41154 BR8-073 1 YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR8-073T PRO-17-20140520_BR08_T1_ 191 tumor 60 345323 80.8 724.8 80.43 IonXpress_064   190 111 79 0.42 40 - 50 <=50 Premenopausal
243 35442 HE10/08 41154 BR8-073   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 ex7-in7 7577407 AMPL3426752792 7577372 7577532 61 2 3 SNV A 1 A/C   TP53 intronic             NA     rs12951053 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif -1,68 BR8-073T PRO-17-20140520_BR08_T1_ 804 tumor 60 345323 80.8 724.8 80.43 IonXpress_064   766 533 233 0.3 30 - 40 <=50 Premenopausal
244 35443 HE10/08 41154 BR8-073   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 ex7-in7 7577427 AMPL3426752792 7577372 7577532 61 2 3 SNV G 1 G/A   TP53 intronic             NA     rs12947788 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 0,16 BR8-073T PRO-17-20140520_BR08_T1_ 804 tumor 60 345323 80.8 724.8 80.43 IonXpress_064   778 544 234 0.3 30 - 40 <=50 Premenopausal
245 35444 HE10/08 41154 BR8-073   YES TP53 YES NO other chr17 17p13.1 in4-ex5 7578538 AMPL6326144323 7578407 7578581 61.7 1 3 SNV T 1 T/A   TP53 exonic missense ATC 5 p.Asn131Ile 392A>T c.392A>T NA   squamous_cell_carcinoma:hepatocellular_carcinoma:basal_(triple-negative)_carcinoma:ductal_carcinoma:astrocytoma:carcinoma   P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 2,21 BR8-073T PRO-17-20140520_BR08_T1_ 294 tumor 60 345323 80.8 724.8 80.43 IonXpress_064   283 207 76 0.27 20 - 30 <=50 Premenopausal
246 35450 HE10/08 40820 BR8-079 1 YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 ex7-in7 7577496 AMPL3426752792 7577372 7577532 61 2 3 SNV G 1 G/A   TP53 intronic             NA   hepatocellular_carcinoma   P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif -0,38 BR8-079aT PRO-17-20140520_BR08_T1_ 414 tumor 90 129671 68.88 227.4 55.96 IonXpress_068   413 360 53 0.13 10 - 20 >50 Postmenopausal
247 35475 HE10/08 40820 BR8-079   YES TP53 YES NO other chr17 17p13.1 in3-ex4 7579550 AMPL6795075395 7579475 7579618 52 2 3 SNV G 1 G/A   TP53 exonic missense TTC 4 p.Ser46Phe 137C>T c.137C>T NA   transitiol_cell_carcinoma:NK-T_cell_lymphoma   P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 0,42 BR8-079aT PRO-17-20140520_BR08_T1_ 483 tumor 90 129671 68.88 227.4 55.96 IonXpress_068   479 418 61 0.13 10 - 20 >50 Postmenopausal
248 35477 HE10/08 41406 BR8-081 1 YES TP53 YES NO other chr17 17p13.1 in4-ex5 7578455 AMPL6326144323 7578407 7578581 61.7 1 3 INDEL CGCGGACGCGG 10 CGCGGACGCGG/C   TP53 exonic frameshiftDeletion   5 p.Arg156Pro 465_474delCCGCGTCCGC c.465_474delCCGCGTCCGC NA   lymphoid_neoplasm:hepatocellular_carcinoma:synovial_sarcoma:aplastic_carcinoma:large_cell_carcinoma:small_cell_carcinoma:serous_carcinoma:carcinoid-endocrine_tumour:acute_lymphoblastic_leukaemia:dysplasia:adenocarcinoma:squamous_cell_carcinoma:tubular_a rs139200646:rs121912654 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 0.33,-1.52,1.51,0.82,0.06,2.21,0.39,-4.12,0.78,0.07,0.31 BR8-081bT PRO-25-20140718_BR08_rest_ 3064 tumor 40 3593003 79.34 7206 80.11 IonXpress_064   1872 1415 457 0.24 20 - 30 <=50 Premenopausal
249 35504 HE10/08 41406 BR8-081   YES TP53 NO YES nonMUTnonSNP chr17 17p13.1 ex10-in10 7573897 AMPL1481481122 7573824 7573997 62.3 1 1 SNV T 1 T/A 0.003 TP53 intronic             NA   squamous_cell_carcinoma rs17880847 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif -0,75 BR8-081bT PRO-25-20140718_BR08_rest_ 316 tumor 40 3593003 79.34 7206 80.11 IonXpress_064   247 150 97 0.39 30 - 40 <=50 Premenopausal
250 35506 HE10/08 41406 BR8-081   YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR8-081bT PRO-25-20140718_BR08_rest_ 1098 tumor 40 3593003 79.34 7206 80.11 IonXpress_064   998 586 412 0.41 40 - 50 <=50 Premenopausal
251 35521 HE10/08 40552 BR8-083   YES PIK3CA YES NO other chr03 3q26.3 ex 10 178936091 AMPL393459515 178935994 178936131 38.6 3 2 SNV G 1 G/A   PIK3CA exonic missense AAG 10 p.Glu545Lys 1633G>A c.1633G>A NA 946 ############################################################################################################################################################################################################################################################### rs104886003 PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 2,72 BR8-083bT PRO-17-20140520_BR08_T1_ 1087 tumor 60 83837 84.57 180.3 66.61 IonXpress_070   1081 782 299 0.28 20 - 30 >50 Postmenopausal
252 35529 HE10/08 40229 BR8-084 1 NO   NO NO                                                                                             >50 Postmenopausal
253 35558 HE10/08 40928 BR8-086   YES PIK3CA NO NO nonMUTnonSNP chr03 3q26.3 ex2 178916557 AMPL1566372753 178916552 178916726 43 2 1 SNV C 1 C/G   PIK3CA utr_5             NA       PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 0,24 BR8-086T PRO-17-20140520_BR08_T1_ 4373 tumor 90 2588259 89.02 6447 81.34 IonXpress_072   464 240 224 0.48 40 - 50 <=50 Postmenopausal
254 35569 HE10/08 40928 BR8-086   YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR8-086T PRO-17-20140520_BR08_T1_ 1719 tumor 90 2588259 89.02 6447 81.34 IonXpress_072   1591 1359 232 0.15 10 - 20 <=50 Postmenopausal
255 35571 HE10/08 41054 BR8-087 1 NO   NO NO                                                                                             <=50 Premenopausal
256 35580 HE10/08 40816 BR8-088 1 YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR8-088aT PRO-17-20140520_BR08_T1_ 2503 tumor 70 2060070 85.51 4686 81.99 IonXpress_074   1991 588 1403 0.7 70 - 80 >50 Postmenopausal
257 35594 HE10/08 40816 BR8-088   YES PIK3CA YES NO other chr03 3q26.3 ex21 178952085 AMPL392292511 178952020 178952194 36.3 3 2 SNV A 1 A/G   PIK3CA exonic missense CGT 21 p.His1047Arg 3140A>G c.3140A>G NA 926 ############################################################################################################################################################################################################################################################### rs121913279 PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 2,33 BR8-088aT PRO-17-20140520_BR08_T1_ 4672 tumor 70 2060070 85.51 4686 81.99 IonXpress_074   1866 1062 804 0.43 40 - 50 >50 Postmenopausal
258 35605 HE10/08 41407 BR8-090 1 YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR8-090aT PRO-17-20140520_BR08_T1_ 538 tumor 65 195919 88.67 472.7 60.7 IonXpress_077   513 105 408 0.8 80 - 90 <=50 Premenopausal
259 35626 HE10/08 41222 BR8-092 1 NO   NO NO                                                                                             >50 Postmenopausal
260 35651 HE10/08 41163 BR8-094 1 YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR8-094T PRO-17-20140520_BR08_T1_ 545 tumor 60 239831 88.2 567.4 67.02 IonXpress_081   524 247 277 0.53 50 - 60 >50 Postmenopausal
261 35668 HE10/08 41163 BR8-094   YES PIK3CA YES NO other chr03 3q26.3 ex 10 178936082 AMPL393459515 178935994 178936131 38.6 3 2 SNV G 1 G/A   PIK3CA exonic missense AAA 10 p.Glu542Lys 1624G>A c.1624G>A NA 998 ############################################################################################################################################################################################################################################################### rs121913273 PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 2,72 BR8-094T PRO-17-20140520_BR08_T1_ 538 tumor 60 239831 88.2 567.4 67.02 IonXpress_081   533 311 222 0.42 40 - 50 >50 Postmenopausal
262 35674 HE10/08 41163 BR8-094   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 ex7-in7 7577407 AMPL3426752792 7577372 7577532 61 2 3 SNV A 1 A/C   TP53 intronic             NA     rs12951053 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif -1,68 BR8-094T PRO-17-20140520_BR08_T1_ 303 tumor 60 239831 88.2 567.4 67.02 IonXpress_081   222 139 83 0.37 30 - 40 >50 Postmenopausal
263 35675 HE10/08 41163 BR8-094   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 ex7-in7 7577427 AMPL3426752792 7577372 7577532 61 2 3 SNV G 1 G/A   TP53 intronic             NA     rs12947788 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 0,16 BR8-094T PRO-17-20140520_BR08_T1_ 303 tumor 60 239831 88.2 567.4 67.02 IonXpress_081   232 148 84 0.36 30 - 40 >50 Postmenopausal
264 35676 HE10/08 41038 BR8-095 1 YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR8-095T PRO-17-20140520_BR08_T1_ 805 tumor 80 1007816 88.22 2364 82.47 IonXpress_082   776 189 587 0.76 70 - 80 <=50 Premenopausal
265 35692 HE10/08 41038 BR8-095   YES PIK3CA YES NO other chr03 3q26.3 ex21 178952103 AMPL392292511 178952020 178952194 36.3 3 2 INDEL CA 1 CA/C   PIK3CA exonic frameshiftDeletion TGG 21 p.Met1055Trp 3159_3159delA c.3159_3159delA NA       PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 2.89,2.33 BR8-095T PRO-17-20140520_BR08_T1_ 3554 tumor 80 1007816 88.22 2364 82.47 IonXpress_082   1389 467 922 0.66 60 - 70 <=50 Premenopausal
266 35700 HE10/08 41038 BR8-095   YES TP53 YES NO other chr17 17p13.1 in6-ex7-in7 7577539 AMPL4981177402 7577472 7577638 53.4 2 3 SNV G 1 G/A   TP53 exonic missense TGG 7 p.Arg248Trp 742C>T c.742C>T NA 1 ############################################################################################################################################################################################################################################################### rs121912651 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 0,64 BR8-095T PRO-17-20140520_BR08_T1_ 1820 tumor 80 1007816 88.22 2364 82.47 IonXpress_082   1701 1170 531 0.31 30 - 40 <=50 Premenopausal
267 35701 HE10/08 40603 BR8-096 1 YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR8-096T PRO-17-20140520_BR08_T1_ 1236 tumor 70 923539 89.31 2247 55.68 IonXpress_083   1187 308 879 0.74 70 - 80 <=50 Premenopausal
268 35719 HE10/08 40603 BR8-096   YES PIK3CA YES NO other chr03 3q26.3 ex21 178952085 AMPL392292511 178952020 178952194 36.3 3 2 SNV A 1 A/G   PIK3CA exonic missense CGT 21 p.His1047Arg 3140A>G c.3140A>G NA 926 ############################################################################################################################################################################################################################################################### rs121913279 PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 2,33 BR8-096T PRO-17-20140520_BR08_T1_ 7239 tumor 70 923539 89.31 2247 55.68 IonXpress_083   1999 1247 752 0.38 30 - 40 <=50 Premenopausal
269 35736 HE10/08 40616 BR8-099 1 YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR8-099T PRO-17-20140520_BR08_T1_ 1338 tumor 50 570853 87.2 1352 53.02 IonXpress_086   1269 300 969 0.76 70 - 80 <=50 Premenopausal
270 35750 HE10/08 40616 BR8-099   YES TP53 YES NO other chr17 17p13.1 in5-ex6 7578265 AMPL4392179183 7578209 7578382 58.3 1 2 SNV A 1 A/G   TP53 exonic missense ACC 6 p.Ile195Thr 584T>C c.584T>C NA   ###############################################################################################################################################################################################################################################################   P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 0,46 BR8-099T PRO-17-20140520_BR08_T1_ 661 tumor 50 570853 87.2 1352 53.02 IonXpress_086   624 503 121 0.19 10 - 20 <=50 Premenopausal
271 35754 HE10/08 41123 BR8-103 1 YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR8-103T PRO-17-20140520_BR08_T1_ 542 tumor 75 869430 82.59 1863 81.62 IonXpress_088   522 123 399 0.76 70 - 80 >50 Postmenopausal
272 35767 HE10/08 41123 BR8-103   YES PIK3CA YES NO other chr03 3q26.3 ex21 178952103 AMPL392292511 178952020 178952194 36.3 3 2 INDEL CA 1 CA/C   PIK3CA exonic frameshiftDeletion TGG 21 p.Met1055Trp 3159_3159delA c.3159_3159delA NA       PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 2.89,2.33 BR8-103T PRO-17-20140520_BR08_T1_ 2100 tumor 75 869430 82.59 1863 81.62 IonXpress_088   719 134 585 0.81 80 - 90 >50 Postmenopausal
273 35775 HE10/08 41123 BR8-103   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 ex6-in6 7578210 AMPL4574207192 7578114 7578273 53.5 1 1 SNV T 1 T/C   TP53 exonic synonymous CGG 6 WT 639A>G c.639A>G NA   oligodendroglioma_Grade_II:adenocarcinoma:adenoma:carcinoma rs1800372 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif -0,16 BR8-103T PRO-17-20140520_BR08_T1_ 507 tumor 75 869430 82.59 1863 81.62 IonXpress_088   494 261 233 0.47 40 - 50 >50 Postmenopausal
274 35798 HE10/08 40609 BR8-104   YES PIK3CA YES NO other chr03 3q26.3 ex21 178952103 AMPL392292511 178952020 178952194 36.3 3 2 INDEL CA 1 CA/C   PIK3CA exonic frameshiftDeletion TGG 21 p.Met1055Trp 3159_3159delA c.3159_3159delA NA       PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 2.89,2.33 BR8-104T PRO-17-20140520_BR08_T1_ 998 tumor 55 280556 82.79 585.6 67.18 IonXpress_089   396 142 254 0.64 60 - 70 <=50 Premenopausal
275 35806 HE10/08 40609 BR8-104   YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR8-104T PRO-17-20140520_BR08_T1_ 126 tumor 55 280556 82.79 585.6 67.18 IonXpress_089   122 32 90 0.74 70 - 80 <=50 Premenopausal
276 35810 HE10/08 41135 BR8-106 1 YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR8-106T PRO-17-20140520_BR08_T1_ 5110 tumor 70 8978542 81.82 19216 83.79 IonXpress_091   1986 1105 881 0.44 40 - 50 <=50 Premenopausal
277 35831 HE10/08 41135 BR8-106   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 ex7-in7 7577429 AMPL3426752792 7577372 7577532 61 2 3 SNV C 1 C/T   TP53 intronic             NA       P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif -0,74 BR8-106T   12587 tumor                     0.11 10 - 20 <=50 Premenopausal
278 35832 HE10/08 41135 BR8-106   YES TP53 YES NO other chr17 17p13.1 in4-ex5 7578550 AMPL6326144323 7578407 7578581 61.7 1 3 SNV G 1 G/T   TP53 exonic missense TAC 5 p.Ser127Tyr 380C>A c.380C>A NA   hamartoma:malignt_melanoma:astrocytoma_Grade_II:hepatocellular_carcinoma:intestil_adenocarcinoma:NS:oligoastrocytoma_Grade_II:endometrioid_carcinoma:serous_carcinoma:in_situ_epithelial_neoplasm:transitiol_cell_carcinoma:diffuse_large_B_cell_lymphoma   P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,45 BR8-106T PRO-17-20140520_BR08_T1_ 9470 tumor 70 8978542 81.82 19216 83.79 IonXpress_091   1984 1448 536 0.27 20 - 30 <=50 Premenopausal
279 35833 HE10/08 41080 BR8-107 1 YES TP53 YES NO other chr17 17p13.1 ex8-in8 7577106 AMPL706844244 7576996 7577170 61.6 1 2 SNV G 1 G/A   TP53 exonic missense TCT 8 p.Pro278Ser 832C>T c.832C>T NA 1 ############################################################################################################################################################################################################################################################### rs17849781 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 2,67 BR8-107T PRO-17-20140520_BR08_T1_ 2412 tumor 30 2174791 79.69 4482 83 IonXpress_092   1999 1752 247 0.12 10 - 20 >50 Premenopausal
280 35847 HE10/08 41080 BR8-107   YES PIK3CA NO NO nonMUTnonSNP chr03 3q26.3 in1 178866408 AMPL4347527835 178866384 178866543 78.2     SNV C 1 C/T   PIK3CA intronic             NA     rs2699887 PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 -0,07 BR8-107T PRO-17-20140520_BR08_T1_ 163 tumor 30 2174791 79.69 4482 83 IonXpress_092   112 62 50 0.45 40 - 50 >50 Premenopausal
281 35858 HE10/08 40995 BR8-108 1 YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR8-108T PRO-17-20140520_BR08_T1_ 1302 tumor 5 1457004 82.14 3128 81.45 IonXpress_093   1247 267 980 0.79 70 - 80 >50 Premenopausal
282 35875 HE10/08 40995 BR8-108   YES PIK3CA YES NO other chr03 3q26.3 ex 10 178936095 AMPL393459515 178935994 178936131 38.6 3 2 SNV A 1 A/G   PIK3CA exonic missense CGG 10 p.Gln546Arg 1637A>G c.1637A>G NA 996 adenocarcinoma:squamous_cell_carcinoma:ER-PR-positive_carcinoma:oligodendroglioma_Grade_III:clear_cell_carcinoma:ductal_carcinoma:serous_carcinoma:carcinoma:astrocytoma_Grade_III:endometrioid_carcinoma   PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 2,2 BR8-108T PRO-17-20140520_BR08_T1_ 9677 tumor 5 1457004 82.14 3128 81.45 IonXpress_093   1994 1627 367 0.18 10 - 20 >50 Premenopausal
283 35876 HE10/08 40995 BR8-108   YES PIK3CA YES NO other chr03 3q26.3 ex21 178952103 AMPL392292511 178952020 178952194 36.3 3 2 INDEL CA 1 CA/C   PIK3CA exonic frameshiftDeletion TGG 21 p.Met1055Trp 3159_3159delA c.3159_3159delA NA       PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 2.89,2.33 BR8-108T PRO-17-20140520_BR08_T1_ 3912 tumor 5 1457004 82.14 3128 81.45 IonXpress_093   1421 256 1165 0.82 80 - 90 >50 Premenopausal
284 35891 HE10/08 40995 BR8-108   YES TP53 YES NO other chr17 17p13.1 in3-ex4 7579589 AMPL6795075395 7579475 7579618 52 2 3 INDEL G 1 G/GA   TP53 exonic frameshiftInsertion   9 p.Ser33Phe 96_97insT c.96_97insT NA   adenocarcinoma:squamous_cell_carcinoma   P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif -0,13 BR8-108T PRO-17-20140520_BR08_T1_ 4216 tumor 5 1457004 82.14 3128 81.45 IonXpress_093   1982 1653 329 0.17 10 - 20 >50 Premenopausal
285 35892 HE10/08 41146 BR8-109 1 YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 ex10-in10 7573897 AMPL1481481122 7573824 7573997 62.3 1 1 SNV T 1 T/A   TP53 intronic             NA   squamous_cell_carcinoma rs17880847 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif -0,75 BR8-109aT PRO-17-20140520_BR08_T1_ 119 tumor 80 271479 80.17 563.7 60.4 IonXpress_094   111 54 57 0.51 50 - 60 >50 Postmenopausal
286 35904 HE10/08 41146 BR8-109   YES PIK3CA YES NO other chr03 3q26.3 ex21 178952103 AMPL392292511 178952020 178952194 36.3 3 2 INDEL CA 1 CA/C   PIK3CA exonic frameshiftDeletion TGG 21 p.Met1055Trp 3159_3159delA c.3159_3159delA NA       PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 2.89,2.33 BR8-109aT PRO-17-20140520_BR08_T1_ 682 tumor 80 271479 80.17 563.7 60.4 IonXpress_094   138 45 93 0.67 60 - 70 >50 Postmenopausal
287 35908 HE10/08 41146 BR8-109   YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR8-109aT PRO-17-20140520_BR08_T1_ 426 tumor 80 271479 80.17 563.7 60.4 IonXpress_094   407 119 288 0.71 70 - 80 >50 Postmenopausal
288 35932 HE10/08 40893 BR8-110   YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR8-110T PRO-17-20140520_BR08_T1_ 3726 tumor 90 7142907 87.44 15715 77.19 IonXpress_095   1996 493 1503 0.75 70 - 80 <=50 Premenopausal
289 35933 HE10/08 40728 BR8-111 1 YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR8-111T PRO-17-20140520_BR08_T1_ 7007 tumor 65 7888011 84.82 17472 85.15 IonXpress_096   1992 552 1440 0.72 70 - 80 <=50 Premenopausal
290 35961 HE10/08 40361 BR8-112 1 YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR8-112T PRO-18-20140522_BR08_T2_ 2326 tumor 80 6217293 83.2 13642 80.49 IonXpress_001 1.0E-5 1996 736 1260 0.63 60 - 70 >50 Premenopausal
291 35979 HE10/08 40361 BR8-112   YES PIK3CA NO NO nonMUTnonSNP chr03 3q26.3 off target 115118900 AMPL6795279620 115118832 115118979 44.9 2 1 SNV C 1 C/T                   NA     rs9821873   -2,3 BR8-112T PRO-18-20140522_BR08_T2_ 22058 tumor 80 6217293 83.2 13642 80.49 IonXpress_001 1.0E-5 1996 958 1038 0.52 50 - 60 >50 Premenopausal
292 35994 HE10/08 40747 BR8-113 1 YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR8-113T PRO-18-20140522_BR08_T2_ 758 tumor 70 1325711 82.07 2885 81.63 IonXpress_002 1.0E-5 702 507 195 0.28 20 - 30 <=50 Premenopausal
293 36015 HE10/08 40747 BR8-113   YES TP53 YES NO other chr17 17p13.1 in4-ex5 7578435 AMPL6326144323 7578407 7578581 61.7 1 3 INDEL C 1 C/CT   TP53 exonic frameshiftInsertion   5 p.Ser166Val 493_494insA c.493_494insA NA   adenocarcinoma:squamous_cell_carcinoma:astrocytoma:carcinoma   P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 0,13 BR8-113T PRO-18-20140522_BR08_T2_ 1313 tumor 70 1325711 82.07 2885 81.63 IonXpress_002 1.0E-5 1872 1231 641 0.34 30 - 40 <=50 Premenopausal
294 36016 HE10/08 40842 BR8-114 1 YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR8-114T PRO-18-20140522_BR08_T2_ 206 tumor 65 493305 51.31 632.7 79.64 IonXpress_003 1.0E-5 196 54 142 0.72 70 - 80 <=50 Premenopausal
295 36037 HE10/08 40842 BR8-114   YES PIK3CA NO NO nonMUTnonSNP chr03 3q26.3 off target 115118838 AMPL6795277223 115118748 115118874 48.8 3 3 SNV T 1 T/C                   NA     rs191214851   0,44 BR8-114T PRO-18-20140522_BR08_T2_ 3153 tumor 65 493305 51.31 632.7 79.64 IonXpress_003 1.0E-5 1986 1162 824 0.41 40 - 50 <=50 Premenopausal
296 36049 HE10/08 40842 BR8-114   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 ex7-in7 7577407 AMPL3426752792 7577372 7577532 61 2 3 SNV A 1 A/C   TP53 intronic             NA     rs12951053 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif -1,68 BR8-114T PRO-18-20140522_BR08_T2_ 870 tumor 65 493305 51.31 632.7 79.64 IonXpress_003 1.0E-5 791 446 345 0.44 40 - 50 <=50 Premenopausal
297 36050 HE10/08 40842 BR8-114   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 ex7-in7 7577427 AMPL3426752792 7577372 7577532 61 2 3 SNV G 1 G/A   TP53 intronic             NA     rs12947788 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 0,16 BR8-114T PRO-18-20140522_BR08_T2_ 870 tumor 65 493305 51.31 632.7 79.64 IonXpress_003 1.0E-5 804 461 343 0.43 40 - 50 <=50 Premenopausal
298 36052 HE10/08 40842 BR8-114   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 ex6-in6 7578210 AMPL4574207192 7578114 7578273 53.5 1 1 SNV T 1 T/C   TP53 exonic synonymous CGG 6 WT 639A>G c.639A>G NA   oligodendroglioma_Grade_II:adenocarcinoma:adenoma:carcinoma rs1800372 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif -0,16 BR8-114T PRO-18-20140522_BR08_T2_ 524 tumor 65 493305 51.31 632.7 79.64 IonXpress_003 1.0E-5 503 318 185 0.37 30 - 40 <=50 Premenopausal
299 36053 HE10/08 40553 BR8-115 1 YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR8-115T PRO-18-20140522_BR08_T2_ 789 tumor 65 2560210 85.99 5859 73.89 IonXpress_004 1.0E-5 726 533 193 0.27 20 - 30 <=50 Premenopausal
300 36072 HE10/08 40434 BR8-116 1 YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR8-116T PRO-18-20140522_BR08_T2_ 185 tumor 60 1216675 83.24 2637 66.1 IonXpress_005 1.0E-5 170 31 139 0.82 80 - 90 <=50 Premenopausal
301 36088 HE10/08 40434 BR8-116   YES PIK3CA YES NO other chr03 3q26.3 ex 10 178936091 AMPL393459515 178935994 178936131 38.6 3 2 SNV G 1 G/A   PIK3CA exonic missense AAG 10 p.Glu545Lys 1633G>A c.1633G>A NA 946 HER-positive_carcinoma:intestil_adenocarcinoma:Merkel_cell_carcinoma:lobular_carcinoma:endometrioid_carcinoma:carcinoid-endocrine_tumour:mucinous_carcinoma:adenoid_cystic_carcinoma:serrated_carcinoma:adenoma:sopharyngeal_carcinoma:basal_cell_carcinoma rs104886003 PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 2,72 BR8-116T PRO-18-20140522_BR08_T2_ 18358 tumor 60 1216675 83.24 2637 66.1 IonXpress_005 1.0E-5 2000 1411 589 0.29 20 - 30 <=50 Premenopausal
302 36101 HE10/08 40843 BR8-118 1 NO   NO NO                                                                                             >50 Postmenopausal
303 36109 HE10/08 41726 BR8-120 1 YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR8-120T PRO-18-20140522_BR08_T2_ 542 tumor 55 1404549 87.34 3265 77.84 IonXpress_009 1.0E-5 514 99 415 0.81 80 - 90 >50 Postmenopausal
304 36127 HE10/08 40622 BR8-121 1 YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR8-121aT PRO-18-20140522_BR08_T2_ 550 tumor 90 957280 70.23 1727 78.42 IonXpress_010 1.0E-5 506 254 252 0.5 50 - 60 >50 Postmenopausal
305 36156 HE10/08 40622 BR8-121   YES PIK3CA NO NO nonMUTnonSNP chr03 3q26.3 in 10-ex11 178937005 AMPL391535344 178936910 178937071 35.8 3 2 SNV C 1 C/T   PIK3CA exonic synonymous CCT 11 WT 1686C>T c.1686C>T NA     rs201815216 PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 -0,52 BR8-121aT PRO-18-20140522_BR08_T2_ 2089 tumor 90 957280 70.23 1727 78.42 IonXpress_010 1.0E-5 1999 915 1084 0.54 50 - 60 >50 Postmenopausal
306 36172 HE10/08 42186 BR8-122 1 NO   NO NO                                                                                             <=50 Premenopausal
307 36184 HE10/08 42152 BR8-123 1 YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 ex6-in6 7578210 AMPL4574207192 7578114 7578273 53.5 1 1 SNV T 1 T/C   TP53 exonic synonymous CGG 6 WT 639A>G c.639A>G NA   oligodendroglioma_Grade_II:adenocarcinoma:adenoma:carcinoma rs1800372 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif -0,16 BR8-123T PRO-18-20140522_BR08_T2_ 1053 tumor 75 682776 85.48 1554 47.03 IonXpress_013 1.0E-5 980 211 769 0.78 70 - 80 <=50 Premenopausal
308 36185 HE10/08 42152 BR8-123   YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR8-123T   2002 tumor                     0.9   <=50 Premenopausal
309 36218 HE10/08 40931 BR8-125   YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR8-125T   951 tumor                     0.87 80 - 90 <=50 Premenopausal
310 36263 HE10/08 40221 BR8-127   YES PIK3CA NO NO nonMUTnonSNP chr03 3q26.3 off target 115118900 AMPL6795279620 115118832 115118979 44.9 2 1 SNV C 1 C/T                   NA     rs9821873   -2,3 BR8-127T PRO-18-20140522_BR08_T2_ 461 tumor 75 207261 57.88 300.1 49.05 IonXpress_017 1.0E-5 446 231 215 0.48 40 - 50 >50 Postmenopausal
311 36282 HE10/08 41598 BR8-130 1 NO   NO NO                                                                                             <=50 Premenopausal
312 36294 HE10/08 41708 BR8-134   YES PIK3CA YES NO other chr03 3q26.3 ex 10 178936091 AMPL393459515 178935994 178936131 38.6 3 2 SNV G 1 G/A   PIK3CA exonic missense AAG 10 p.Glu545Lys 1633G>A c.1633G>A NA 946 HER-positive_carcinoma:intestil_adenocarcinoma:Merkel_cell_carcinoma:lobular_carcinoma:endometrioid_carcinoma:carcinoid-endocrine_tumour:mucinous_carcinoma:adenoid_cystic_carcinoma:serrated_carcinoma:adenoma:sopharyngeal_carcinoma:basal_cell_carcinoma rs104886003 PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 2,72 BR8-134ML PRO-18-20140522_BR08_T2_ 12342 tumor 60 604449 87.93 1429 48.05 IonXpress_024 1.0E-5 2000 1723 277 0.14 10 - 20 >50 Postmenopausal
313 36319 HE10/08 40817 BR8-135   YES PIK3CA YES NO other chr03 3q26.3 ex 10 178936091 AMPL393459515 178935994 178936131 38.6 3 2 SNV G 1 G/A   PIK3CA exonic missense AAG 10 p.Glu545Lys 1633G>A c.1633G>A NA 946 HER-positive_carcinoma:intestil_adenocarcinoma:Merkel_cell_carcinoma:lobular_carcinoma:endometrioid_carcinoma:carcinoid-endocrine_tumour:mucinous_carcinoma:adenoid_cystic_carcinoma:serrated_carcinoma:adenoma:sopharyngeal_carcinoma:basal_cell_carcinoma rs104886003 PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 2,72 BR8-135T PRO-18-20140522_BR08_T2_ 1739 tumor 75 150682 52.96 200.6 49.31 IonXpress_025 1.0E-5 1721 1337 384 0.22 20 - 30 <=50 Premenopausal
314 36323 HE10/08 40845 BR8-136 1 NO   NO NO                                                                                             >50 Postmenopausal
315 36337 HE10/08 42034 BR8-137 1 NO   NO NO                                                                                             >50 Postmenopausal
316 36356 HE10/08 41142 BR8-143 1 YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR8-143T PRO-18-20140522_BR08_T2_ 3189 tumor 80 2338016 74.66 4444 60.51 IonXpress_031   1987 1206 781 0.39 30 - 40 <=50 Premenopausal
317 36379 HE10/08 41142 BR8-143   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 ex7-in7 7577429 AMPL3426752792 7577372 7577532 61 2 3 SNV C 1 C/T   TP53 intronic             NA       P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif -0,74 BR8-143T PRO-18-20140522_BR08_T2_ 1996 tumor 80 2338016 74.66 4444 60.51 IonXpress_031 2.0E-5 1656 1485 171 0.1 10 - 20 <=50 Premenopausal
318 36380 HE10/08 41142 BR8-143   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 in5-ex6 7578210 AMPL4392179183 7578209 7578382 58.3 1 2 SNV T 1 T/C   TP53 exonic synonymous CGG 6 WT 639A>G c.639A>G NA   oligodendroglioma_Grade_II:adenocarcinoma:adenoma:carcinoma rs1800372 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif -0,16 BR8-143T PRO-18-20140522_BR08_T2_ 947 tumor 80 2338016 74.66 4444 60.51 IonXpress_031   606 290 316 0.52 50 - 60 <=50 Premenopausal
319 36396 HE10/08 41037 BR8-145   YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR8-145T PRO-18-20140522_BR08_T2_ 301 tumor 30 366513 81.16 795.7 50.53 IonXpress_033 1.0E-5 287 123 164 0.57 50 - 60 >50 Postmenopausal
320 36412 HE10/08 41143 BR8-154 1 YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR8-154IS PRO-25-20140718_BR08_rest_ 153 tumor n/a 148447 80.54 302.7 52.64 IonXpress_028   143 43 100 0.7 70 - 80 <=50 Premenopausal
321 36422 HE10/08 41143 BR8-154   YES PIK3CA YES NO other chr03 3q26.3 ex21 178952085 AMPL392292511 178952020 178952194 36.3 3 2 SNV A 1 A/G   PIK3CA exonic missense CGT 21 p.His1047Arg 3140A>G c.3140A>G NA 926 HER-positive_carcinoma:ductal_epithelial_hyperplasia-hyperplasia_of_usual_type:hepatocellular_carcinoma:SHH_subtype:Merkel_cell_carcinoma:lobular_carcinoma:mixed_endometrioid_and_clear_cell_carcinoma:sopharyngeal_carcinoma:endometriosis:papilloma:mixed_ rs121913279 PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 2,33 BR8-154IS PRO-25-20140718_BR08_rest_ 711 tumor n/a 148447 80.54 302.7 52.64 IonXpress_028   549 365 184 0.34 30 - 40 <=50 Premenopausal
322 36423 HE10/08 41741 BR8-155 1 NO   NO NO                                                                                             <=50 Perimenopausal (<=2 years without menses)
323 36440 HE10/08 40147 BR8-156 1 NO   NO NO                                                                                             <=50 Premenopausal
324 36457 HE10/08 40325 BR8-157 1 YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR8-157T PRO-18-20140522_BR08_T2_ 1720 tumor 60 1561310 83.23 3436 78.51 IonXpress_043 1.0E-5 1613 909 704 0.44 40 - 50 <=50 Premenopausal
325 36467 HE10/08 40325 BR8-157   YES PIK3CA YES NO other chr03 3q26.3 ex 10 178936082 AMPL393459515 178935994 178936131 38.6 3 2 SNV G 1 G/A   PIK3CA exonic missense AAA 10 p.Glu542Lys 1624G>A c.1624G>A NA 998 HER-positive_carcinoma:liposarcoma:hepatocellular_carcinoma:intestil_adenocarcinoma:carcinosarcoma-malignt_mesodermal_mixed_tumour:undifferentiated_adenocarcinoma:Merkel_cell_carcinoma:lobular_carcinoma:endometrioid_carcinoma:mucinous_carcinoma:dysemb rs121913273 PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 2,72 BR8-157T PRO-18-20140522_BR08_T2_ 8537 tumor 60 1561310 83.23 3436 78.51 IonXpress_043 1.0E-5 1997 1701 296 0.15 10 - 20 <=50 Premenopausal
326 36478 HE10/08 40615 BR8-162 1 YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR8-162aT PRO-18-20140522_BR08_T2_ 249 tumor 85 162420 72.56 292.4 61.41 IonXpress_046 1.0E-5 92 21 71 0.77 70 - 80 >50 Postmenopausal
327 36498 HE10/08 40850 BR8-164 1 YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 ex7-in7 7577407 AMPL3426752792 7577372 7577532 61 2 3 SNV A 1 A/C   TP53 intronic             NA     rs12951053 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif -1,68 BR8-164bT   2476 tumor                     0.46 40 - 50 >50 Postmenopausal
328 36512 HE10/08 40850 BR8-164   YES PIK3CA YES NO other chr03 3q26.3 ex 10 178936082 AMPL393459515 178935994 178936131 38.6 3 2 SNV G 1 G/A   PIK3CA exonic missense AAA 10 p.Glu542Lys 1624G>A c.1624G>A NA 998 HER-positive_carcinoma:liposarcoma:hepatocellular_carcinoma:intestil_adenocarcinoma:carcinosarcoma-malignt_mesodermal_mixed_tumour:undifferentiated_adenocarcinoma:Merkel_cell_carcinoma:lobular_carcinoma:endometrioid_carcinoma:mucinous_carcinoma:dysemb rs121913273 PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 2,72 BR8-164bT   7694 tumor                     0.09 <10 >50 Postmenopausal
329 36521 HE10/08 40850 BR8-164   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 ex7-in7 7577427 AMPL3426752792 7577372 7577532 61 2 3 SNV G 1 G/A   TP53 intronic             NA     rs12947788 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 0,16 BR8-164bT   2476 tumor                     0.46 40 - 50 >50 Postmenopausal
330 36524 HE10/08 40475 BR8-167 1 YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 ex6-in6 7578210 AMPL4574207192 7578114 7578273 53.5 1 1 SNV T 1 T/C   TP53 exonic synonymous CGG 6 WT 639A>G c.639A>G NA   oligodendroglioma_Grade_II:adenocarcinoma:adenoma:carcinoma rs1800372 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif -0,16 BR8-167T PRO-18-20140522_BR08_T2_ 876 tumor 75 989957 82.81 2150 52.54 IonXpress_051 1.0E-5 827 143 684 0.83 80 - 90 <=50 Premenopausal
331 36538 HE10/08 40475 BR8-167   YES PIK3CA NO NO nonMUTnonSNP chr03 3q26.3 in1 178866408 AMPL4347527835 178866384 178866543 78.2     SNV C 1 C/T   PIK3CA intronic             NA     rs2699887 PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 -0,07 BR8-167T PRO-18-20140522_BR08_T2_ 243 tumor 75 989957 82.81 2150 52.54 IonXpress_051 1.0E-5 137 42 95 0.69 60 - 70 <=50 Premenopausal
332 36545 HE10/08 40997 BR8-169 1 NO   NO NO                                                                                             >50 Postmenopausal
333 36557 HE10/08 40138 BR8-171 1 NO   NO NO                                                                                             >50 Postmenopausal
334 36568 HE10/08 41046 BR8-172 1 YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR8-172aIS PRO-25-20140718_BR08_rest_ 597 tumor n/a 745143 71 1382 83.41 IonXpress_032   537 477 60 0.11 10 - 20 <=50 Premenopausal
335 36601 HE10/08 40469 BR8-173   YES PIK3CA YES NO other chr03 3q26.3 ex 10 178936091 AMPL393459515 178935994 178936131 38.6 3 2 SNV G 1 G/A   PIK3CA exonic missense AAG 10 p.Glu545Lys 1633G>A c.1633G>A NA 946 HER-positive_carcinoma:intestil_adenocarcinoma:Merkel_cell_carcinoma:lobular_carcinoma:endometrioid_carcinoma:carcinoid-endocrine_tumour:mucinous_carcinoma:adenoid_cystic_carcinoma:serrated_carcinoma:adenoma:sopharyngeal_carcinoma:basal_cell_carcinoma rs104886003 PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 2,72 BR8-173T PRO-18-20140522_BR08_T2_ 6431 tumor 60 515658 76.94 1032 55.45 IonXpress_056 1.0E-5 1997 1186 811 0.41 40 - 50 <=50 Premenopausal
336 36610 HE10/08 41177 BR8-174 1 YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 ex7-in7 7577407 AMPL3426752792 7577372 7577532 61 2 3 SNV A 1 A/C   TP53 intronic             NA     rs12951053 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif -1,68 BR8-174T PRO-18-20140522_BR08_T2_ 2858 tumor 75 264860 88.86 608.6 46.37 IonXpress_057 1.0E-5 1999 1713 286 0.14 10 - 20 >50 Postmenopausal
337 36624 HE10/08 41177 BR8-174   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 in9-ex10 7574013 AMPL387899835 7573927 7574055 62.8 1 1 SNV G 1 G/A   TP53 exonic synonymous TTT 10 WT 1014C>T c.1014C>T NA   squamous_cell_carcinoma rs150293825 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif -1,36 BR8-174T PRO-18-20140522_BR08_T2_ 898 tumor 75 264860 88.86 608.6 46.37 IonXpress_057 1.0E-5 855 145 710 0.83 80 - 90 >50 Postmenopausal
338 36625 HE10/08 41177 BR8-174   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 ex7-in7 7577427 AMPL3426752792 7577372 7577532 61 2 3 SNV G 1 G/A   TP53 intronic             NA     rs12947788 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 0,16 BR8-174T PRO-18-20140522_BR08_T2_ 2858 tumor 75 264860 88.86 608.6 46.37 IonXpress_057 1.0E-5 1995 1718 277 0.14 10 - 20 >50 Postmenopausal
339 36641 HE10/08 41049 BR8-175   YES PIK3CA NO NO nonMUTnonSNP chr03 3q26.3 in1 178866408 AMPL4347527835 178866384 178866543 78.2     SNV C 1 C/T   PIK3CA intronic             NA     rs2699887 PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 -0,07 BR8-175T PRO-18-20140522_BR08_T2_ 473 tumor 70 1489995 87.55 3467 50.41 IonXpress_058 1.0E-5 189 103 86 0.46 40 - 50 <=50 Premenopausal
340 36642 HE10/08 41049 BR8-175   YES PIK3CA YES NO other chr03 3q26.3 ex 10 178936091 AMPL393459515 178935994 178936131 38.6 3 2 SNV G 1 G/A   PIK3CA exonic missense AAG 10 p.Glu545Lys 1633G>A c.1633G>A NA 946 HER-positive_carcinoma:intestil_adenocarcinoma:Merkel_cell_carcinoma:lobular_carcinoma:endometrioid_carcinoma:carcinoid-endocrine_tumour:mucinous_carcinoma:adenoid_cystic_carcinoma:serrated_carcinoma:adenoma:sopharyngeal_carcinoma:basal_cell_carcinoma rs104886003 PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 2,72 BR8-175T PRO-18-20140522_BR08_T2_ 21685 tumor 70 1489995 87.55 3467 50.41 IonXpress_058 1.0E-5 1999 1246 753 0.38 30 - 40 <=50 Premenopausal
341 36658 HE10/08 41057 BR8-177   YES PIK3CA NO NO nonMUTnonSNP chr03 3q26.3 in1 178866408 AMPL4347527835 178866384 178866543 78.2     SNV C 1 C/T   PIK3CA intronic             NA     rs2699887 PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 -0,07 BR8-177ML PRO-18-20140522_BR08_T2_ 556 tumor 85 1529787 83.02 3259 49.83 IonXpress_059 1.0E-5 303 97 206 0.68 60 - 70 >50 Postmenopausal
342 36662 HE10/08 41426 BR8-181 1 NO   NO NO                                                                                             >50 Postmenopausal
343 36669 HE10/08 41068 BR8-182 1 NO   NO NO                                                                                             >50 Postmenopausal
344 36673 HE10/08 41069 BR8-183 1 YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR8-183T PRO-18-20140522_BR08_T2_ 124 tumor 50 704241 86.27 1536 78.37 IonXpress_064 1.0E-5 115 47 68 0.59 50 - 60 >50 Postmenopausal
345 36691 HE10/08 41069 BR8-183   YES PIK3CA NO NO nonMUTnonSNP chr03 3q26.3 off target 115118900 AMPL6795279620 115118832 115118979 44.9 2 1 SNV C 1 C/T                   NA     rs9821873   -2,3 BR8-183T PRO-18-20140522_BR08_T2_ 1942 tumor 50 704241 86.27 1536 78.37 IonXpress_064 1.0E-5 1896 967 929 0.49 40 - 50 >50 Postmenopausal
346 36692 HE10/08 41069 BR8-183   YES PIK3CA YES NO other chr03 3q26.3 ex21 178952085 AMPL1497305257 178951918 178952092 38.1 3 3 SNV A 1 A/G   PIK3CA exonic missense CGT 21 p.His1047Arg 3140A>G c.3140A>G NA 926 HER-positive_carcinoma:ductal_epithelial_hyperplasia-hyperplasia_of_usual_type:hepatocellular_carcinoma:SHH_subtype:Merkel_cell_carcinoma:lobular_carcinoma:mixed_endometrioid_and_clear_cell_carcinoma:sopharyngeal_carcinoma:endometriosis:papilloma:mixed_ rs121913279 PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 2,33 BR8-183T PRO-18-20140522_BR08_T2_ 3256 tumor 50 704241 86.27 1536 78.37 IonXpress_064 1.0E-5 762 495 267 0.35 30 - 40 >50 Postmenopausal
347 36698 HE10/08 41413 BR8-184 1 YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR8-184ML PRO-18-20140522_BR08_T2_ 522 tumor 90 990627 82.08 2106 81.96 IonXpress_065 1.0E-5 489 191 298 0.61 60 - 70 >50 Postmenopausal
348 36714 HE10/08 41413 BR8-184   YES PIK3CA NO NO nonMUTnonSNP chr03 3q26.3 in3 178917844 AMPL2705185935 178917726 178917900 29.9 2 1 INDEL TA 1 TA/T   PIK3CA intronic             NA     rs146815076 PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 -0.63,1.03 BR8-184ML PRO-18-20140522_BR08_T2_ 2068 tumor 90 990627 82.08 2106 81.96 IonXpress_065 1.0E-5 1948 1087 861 0.44 40 - 50 >50 Postmenopausal
349 36722 HE10/08 41413 BR8-184   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 ex7-in7 7577407 AMPL3426752792 7577372 7577532 61 2 3 SNV A 1 A/C   TP53 intronic             NA     rs12951053 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif -1,68 BR8-184ML PRO-18-20140522_BR08_T2_ 1525 tumor 90 990627 82.08 2106 81.96 IonXpress_065 1.0E-5 1318 895 423 0.32 30 - 40 >50 Postmenopausal
350 36723 HE10/08 41413 BR8-184   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 ex7-in7 7577427 AMPL3426752792 7577372 7577532 61 2 3 SNV G 1 G/A   TP53 intronic             NA     rs12947788 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 0,16 BR8-184ML PRO-18-20140522_BR08_T2_ 1525 tumor 90 990627 82.08 2106 81.96 IonXpress_065 1.0E-5 1383 961 422 0.31 30 - 40 >50 Postmenopausal
351 36724 HE10/08 40210 BR8-185 1 NO   NO NO                                                                                             <=50 Premenopausal
352 36753 HE10/08 40175 BR8-191 1 YES TP53 NO YES other chr17 17p13.1 ex7-in7 7577407 AMPL3426752792 7577372 7577532 61 2 3 SNV A 1 A/C 0.163 TP53 intronic             NA     rs12951053 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif -1,68 BR8-191T PRO-25-20140718_BR08_rest_ 1711 tumor 50 254555 76.45 472.8 51.58 IonXpress_068   1407 767 640 0.45 40 - 50 >50 Postmenopausal
353 36771 HE10/08 40175 BR8-191   YES TP53 NO YES other chr17 17p13.1 ex7-in7 7577427 AMPL3426752792 7577372 7577532 61 2 3 SNV G 1 G/A 0.163 TP53 intronic             NA     rs12947788 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 0,16 BR8-191T PRO-25-20140718_BR08_rest_ 1711 tumor 50 254555 76.45 472.8 51.58 IonXpress_068   1468 823 645 0.44 40 - 50 >50 Postmenopausal
354 36778 HE10/08 40334 BR8-192   YES PIK3CA YES NO other chr03 3q26.3 ex 10 178936082 AMPL393459515 178935994 178936131 38.6 3 2 SNV G 1 G/A   PIK3CA exonic missense AAA 10 p.Glu542Lys 1624G>A c.1624G>A NA 998 HER-positive_carcinoma:liposarcoma:hepatocellular_carcinoma:intestil_adenocarcinoma:carcinosarcoma-malignt_mesodermal_mixed_tumour:undifferentiated_adenocarcinoma:Merkel_cell_carcinoma:lobular_carcinoma:endometrioid_carcinoma:mucinous_carcinoma:dysemb rs121913273 PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 2,72 BR8-192ML PRO-18-20140522_BR08_T2_ 938 tumor 75 35756 89.14 83.98 46.97 IonXpress_071 1.0E-5 929 736 166 0.18 10 - 20 <=50 Premenopausal
355 36782 HE10/08 40918 BR8-193 1 YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR8-193T PRO-18-20140522_BR08_T2_ 201 tumor 60 622601 85.51 1402 81.92 IonXpress_072 1.0E-5 187 135 52 0.28 20 - 30 >50 Postmenopausal
356 36806 HE10/08 40918 BR8-193   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 ex7-in7 7577407 AMPL3426752792 7577372 7577532 61 2 3 SNV A 1 A/C   TP53 intronic             NA     rs12951053 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif -1,68 BR8-193T PRO-18-20140522_BR08_T2_ 1351 tumor 60 622601 85.51 1402 81.92 IonXpress_072 1.0E-5 1236 379 857 0.69 60 - 70 >50 Postmenopausal
357 36807 HE10/08 40918 BR8-193   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 ex7-in7 7577427 AMPL3426752792 7577372 7577532 61 2 3 SNV G 1 G/A   TP53 intronic             NA     rs12947788 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 0,16 BR8-193T PRO-18-20140522_BR08_T2_ 1351 tumor 60 622601 85.51 1402 81.92 IonXpress_072 1.0E-5 1269 404 865 0.68 60 - 70 >50 Postmenopausal
358 36808 HE10/08 40918 BR8-193   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 ex4-in4 7579307 AMPL1481773781 7579257 7579411 56.1 2 3 SNV C 1 C/T   TP53 intronic             NA   serous_carcinoma rs68140816 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 2,4 BR8-193T PRO-18-20140522_BR08_T2_ 1622 tumor 60 622601 85.51 1402 81.92 IonXpress_072 1.0E-5 1596 980 616 0.39 30 - 40 >50 Postmenopausal
359 36821 HE10/08 40468 BR8-194   YES PIK3CA YES NO other chr03 3q26.3 ex 10 178936082 AMPL393459515 178935994 178936131 38.6 3 2 SNV G 1 G/A   PIK3CA exonic missense AAA 10 p.Glu542Lys 1624G>A c.1624G>A NA 998 HER-positive_carcinoma:liposarcoma:hepatocellular_carcinoma:intestil_adenocarcinoma:carcinosarcoma-malignt_mesodermal_mixed_tumour:undifferentiated_adenocarcinoma:Merkel_cell_carcinoma:lobular_carcinoma:endometrioid_carcinoma:mucinous_carcinoma:dysemb rs121913273 PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 2,72 BR8-194T PRO-18-20140522_BR08_T2_ 6956 tumor 75 235586 89.27 530 60.38 IonXpress_073 1.0E-5 1996 1255 741 0.37 30 - 40 >50 Postmenopausal
360 36847 HE10/08 41086 BR8-202 1 YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR8-202ML PRO-18-20140522_BR08_T2_ 2578 tumor 60 4137831 79.23 8622 85.78 IonXpress_080 1.0E-5 1989 467 1522 0.77 70 - 80 >50 Postmenopausal
361 36859 HE10/08 41086 BR8-202   YES PIK3CA NO NO nonMUTnonSNP chr03 3q26.3 in1 178866408 AMPL4347527835 178866384 178866543 78.2     SNV C 1 C/T   PIK3CA intronic             NA     rs2699887 PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 -0,07 BR8-202ML PRO-18-20140522_BR08_T2_ 699 tumor 60 4137831 79.23 8622 85.78 IonXpress_080 1.0E-5 641 275 366 0.57 50 - 60 >50 Postmenopausal
362 36866 HE10/08 41086 BR8-202   YES TP53 YES NO other chr17 17p13.1 ex8-in8 7577058 AMPL706844244 7576996 7577170 61.6 1 2 SNV C 1 C/T   TP53 exonic missense AAG 8 p.Glu294Lys 880G>A c.880G>A NA 18 HER-positive_carcinoma:hepatocellular_carcinoma:intestil_adenocarcinoma:large_cell_carcinoma:small_cell_carcinoma:Bowen_disease:serous_carcinoma:transitiol_cell_carcinoma:adenocarcinoma:diffuse_large_B_cell_lymphoma:squamous_cell_carcinoma:sarcoma:bas   P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,44 BR8-202ML PRO-18-20140522_BR08_T2_ 5422 tumor 60 4137831 79.23 8622 85.78 IonXpress_080 1.0E-5 1997 1631 366 0.18 10 - 20 >50 Postmenopausal
363 36867 HE10/08 41086 BR8-202   YES TP53 YES NO other chr17 17p13.1 ex8-in8 7577099 AMPL706844244 7576996 7577170 61.6 1 2 SNV C 1 C/G   TP53 exonic missense ACA 8 p.Arg280Thr 839G>C c.839G>C NA   pleomorphic_carcinoma:lymphoid_neoplasm:medullary_carcinoma:malignt_melanoma:intestil_adenocarcinoma:Burkitt_lymphoma:lobular_carcinoma:small_cell_carcinoma:Bowen_disease:serous_carcinoma:chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma:acute_ rs193920853:rs121912660 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 2,67 BR8-202ML PRO-18-20140522_BR08_T2_ 5422 tumor 60 4137831 79.23 8622 85.78 IonXpress_080 1.0E-5 1998 1619 379 0.19 10 - 20 >50 Postmenopausal
364 36883 HE10/08 40474 BR8-203   YES PIK3CA NO NO nonMUTnonSNP chr03 3q26.3 in3 178917831 AMPL2705185935 178917726 178917900 29.9 2 1 SNV G 1 G/A   PIK3CA intronic             NA       PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 -0,34 BR8-203T PRO-18-20140522_BR08_T2_ 496 tumor 65 199540 91.65 461.9 63.33 IonXpress_081 1.0E-5 475 306 169 0.36 30 - 40 >50 Postmenopausal
365 36885 HE10/08 40474 BR8-203   YES PIK3CA YES NO other chr03 3q26.3 ex21 178952085 AMPL392292511 178952020 178952194 36.3 3 2 SNV A 1 A/G   PIK3CA exonic missense CGT 21 p.His1047Arg 3140A>G c.3140A>G NA 926 HER-positive_carcinoma:ductal_epithelial_hyperplasia-hyperplasia_of_usual_type:hepatocellular_carcinoma:SHH_subtype:Merkel_cell_carcinoma:lobular_carcinoma:mixed_endometrioid_and_clear_cell_carcinoma:sopharyngeal_carcinoma:endometriosis:papilloma:mixed_ rs121913279 PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 2,33 BR8-203T PRO-18-20140522_BR08_T2_ 889 tumor 65 199540 91.65 461.9 63.33 IonXpress_081 1.0E-5 415 292 123 0.3 30 - 40 >50 Postmenopausal
366 36891 HE10/08 40994 BR8-204 1 YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR8-204T PRO-18-20140522_BR08_T2_ 2937 tumor 75 2989448 87.13 7092 83.99 IonXpress_082 1.0E-5 1998 793 1205 0.6 60 - 70 <=50 Premenopausal
367 36908 HE10/08 40994 BR8-204   YES PIK3CA NO NO nonMUTnonSNP chr03 3q26.3 in3 178917844 AMPL2705185935 178917726 178917900 29.9 2 1 INDEL TA 1 TA/T   PIK3CA intronic             NA     rs146815076 PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 -0.63,1.03 BR8-204T PRO-18-20140522_BR08_T2_ 5824 tumor 75 2989448 87.13 7092 83.99 IonXpress_082 1.0E-5 1978 925 1053 0.53 50 - 60 <=50 Premenopausal
368 36917 HE10/08 41078 BR8-206 1 YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR8-206T PRO-18-20140522_BR08_T2_ 1795 tumor 80 1598140 84.67 3572 81.06 IonXpress_083 1.0E-5 1667 720 947 0.57 50 - 60 >50 Postmenopausal
369 36943 HE10/08 41078 BR8-206   YES PIK3CA NO NO nonMUTnonSNP chr03 3q26.3 in1 178866408 AMPL4347527835 178866384 178866543 78.2     SNV C 1 C/T   PIK3CA intronic             NA     rs2699887 PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 -0,07 BR8-206T PRO-18-20140522_BR08_T2_ 446 tumor 80 1598140 84.67 3572 81.06 IonXpress_083 1.0E-5 508 200 308 0.61 60 - 70 >50 Postmenopausal
370 36944 HE10/08 41078 BR8-206   YES PIK3CA NO NO nonMUTnonSNP chr03 3q26.3 in 10-ex11 178936940 AMPL391535344 178936910 178937071 35.8 3 2 SNV C 1 C/A   PIK3CA intronic             NA     rs141589697 PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 0,89 BR8-206T PRO-18-20140522_BR08_T2_ 7058 tumor 80 1598140 84.67 3572 81.06 IonXpress_083 1.0E-5 1993 1190 803 0.4 40 - 50 >50 Postmenopausal
371 36952 HE10/08 40998 BR8-207 1 NO   NO NO                                                                                             >50 Postmenopausal
372 36968 HE10/08 41018 BR8-208 1 NO   NO NO                                                                                             >50 Postmenopausal
373 36975 HE10/08 41015 BR8-209 1 NO   NO NO                                                                                             <=50 Premenopausal
374 36976 HE10/08 41077 BR8-210 1 YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR8-210T PRO-18-20140522_BR08_T2_ 597 tumor 80 895660 82.97 2007 84.31 IonXpress_087 1.0E-5 562 98 464 0.83 80 - 90 >50 Postmenopausal
375 37000 HE10/08 41077 BR8-210   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 ex7-in7 7577407 AMPL3426752792 7577372 7577532 61 2 3 SNV A 1 A/C   TP53 intronic             NA     rs12951053 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif -1,68 BR8-210T PRO-18-20140522_BR08_T2_ 1651 tumor 80 895660 82.97 2007 84.31 IonXpress_087 1.0E-5 1486 1190 296 0.2 20 - 30 >50 Postmenopausal
376 37001 HE10/08 41077 BR8-210   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 ex7-in7 7577427 AMPL3426752792 7577372 7577532 61 2 3 SNV G 1 G/A   TP53 intronic             NA     rs12947788 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 0,16 BR8-210T PRO-18-20140522_BR08_T2_ 1651 tumor 80 895660 82.97 2007 84.31 IonXpress_087 1.0E-5 1561 1267 294 0.19 10 - 20 >50 Postmenopausal
377 37002 HE10/08 41147 BR8-211 1 YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR8-211T PRO-18-20140522_BR08_T2_ 2448 tumor 75 4252828 71.2 7811 84.02 IonXpress_088 1.0E-5 1991 437 1554 0.78 70 - 80 >50 Postmenopausal
378 37018 HE10/08 41147 BR8-211   YES PIK3CA NO NO nonMUTnonSNP chr03 3q26.3 ex1-in1 178866330 AMPL394912449 178866301 178866447 77.7     SNV C 1 C/T   PIK3CA utr_5             NA     rs149946088 PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 1,68 BR8-211T PRO-18-20140522_BR08_T2_ 175 tumor 75 4252828 71.2 7811 84.02 IonXpress_088 1.0E-5 119 55 64 0.54 50 - 60 >50 Postmenopausal
379 37020 HE10/08 41147 BR8-211   YES PIK3CA NO NO nonMUTnonSNP chr03 3q26.3 in1 178866408 AMPL4347527835 178866384 178866543 78.2     SNV C 1 T/T   PIK3CA intronic             NA     rs2699887 PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 -0,07 BR8-211T PRO-18-20140522_BR08_T2_ 597 tumor 75 4252828 71.2 7811 84.02 IonXpress_088 1.0E-5 444   444 1 90 - 100 >50 Postmenopausal
380 37026 HE10/08 41147 BR8-211   YES TP53 YES NO other chr17 17p13.1 ex5-in5 7578397 AMPL1992796664 7578284 7578458 63.7 1 2 INDEL T 1 T/TA   TP53 exonic frameshiftInsertion   5 p.His178Leu 531_532insT c.531_532insT NA   other:hepatocellular_carcinoma:aplastic_carcinoma:MALT_lymphoma:carcinosarcoma-malignt_mesodermal_mixed_tumour:serous_carcinoma:acute_myeloid_leukaemia:transitiol_cell_carcinoma:adenocarcinoma:squamous_cell_carcinoma:malignt_peripheral_nerve_sheat rs68130327 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,08 BR8-211T PRO-18-20140522_BR08_T2_ 4528 tumor 75 4252828 71.2 7811 84.02 IonXpress_088 1.0E-5 1946 815 1131 0.58 50 - 60 >50 Postmenopausal
381 37027 HE10/08 41162 BR8-212 1 YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR8-212T PRO-18-20140522_BR08_T2_ 1794 tumor 80 2684230 85.23 6062 83.33 IonXpress_089 1.0E-5 1694 374 1320 0.78 70 - 80 >50 Postmenopausal
382 37040 HE10/08 41162 BR8-212   YES PIK3CA YES NO other chr03 3q26.3 ex 10 178936092 AMPL393459515 178935994 178936131 38.6 3 2 SNV A 1 A/G   PIK3CA exonic missense GGG 10 p.Glu545Gly 1634A>G c.1634A>G NA 1 liposarcoma:hepatocellular_carcinoma:intestil_adenocarcinoma:synovial_sarcoma:NS:lobular_carcinoma:endometrioid_carcinoma:retinoblastoma:carcinoid-endocrine_tumour:blast_phase_chronic_myeloid_leukaemia:adenoma:adenoma-nodule-goitre:small_cell_carcinoma: rs121913274 PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 2,2 BR8-212T PRO-18-20140522_BR08_T2_ 21834 tumor 80 2684230 85.23 6062 83.33 IonXpress_089 1.0E-5 1998 1711 287 0.14 10 - 20 >50 Postmenopausal
383 37053 HE10/08 40223 BR8-213 1 NO   NO NO                                                                                             >50 Postmenopausal
384 37057 HE10/08 40996 BR8-214 1 YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR8-214T PRO-18-20140522_BR08_T2_ 2745 tumor 50 2566759 82.94 5650 83.64 IonXpress_091 1.0E-5 1988 1219 769 0.39 30 - 40 >50 Postmenopausal
385 37078 HE10/08 40996 BR8-214   YES PIK3CA NO NO nonMUTnonSNP chr03 3q26.3 in1 178866408 AMPL4347527835 178866384 178866543 78.2     SNV C 1 C/T   PIK3CA intronic             NA     rs2699887 PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 -0,07 BR8-214T PRO-18-20140522_BR08_T2_ 428 tumor 50 2566759 82.94 5650 83.64 IonXpress_091 1.0E-5 328 93 235 0.72 70 - 80 >50 Postmenopausal
386 37088 HE10/08 41411 BR8-215 1 YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR8-215ML PRO-18-20140522_BR08_T2_ 527 tumor 80 1457092 81.63 3158 81.35 IonXpress_092 1.0E-5 488 271 217 0.44 40 - 50 >50 Postmenopausal
387 37102 HE10/08 41411 BR8-215   YES PIK3CA YES NO other chr03 3q26.3 ex21 178952085 AMPL392292511 178952020 178952194 36.3 3 2 SNV A 1 A/G   PIK3CA exonic missense CGT 21 p.His1047Arg 3140A>G c.3140A>G NA 926 HER-positive_carcinoma:ductal_epithelial_hyperplasia-hyperplasia_of_usual_type:hepatocellular_carcinoma:SHH_subtype:Merkel_cell_carcinoma:lobular_carcinoma:mixed_endometrioid_and_clear_cell_carcinoma:sopharyngeal_carcinoma:endometriosis:papilloma:mixed_ rs121913279 PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 2,33 BR8-215ML PRO-18-20140522_BR08_T2_ 5406 tumor 80 1457092 81.63 3158 81.35 IonXpress_092 1.0E-5 1996 1553 443 0.22 20 - 30 >50 Postmenopausal
388 37127 HE10/08 41416 BR8-216   YES PIK3CA YES NO other chr03 3q26.3 ex 10 178936095 AMPL393459515 178935994 178936131 38.6 3 2 SNV A 1 A/G   PIK3CA exonic missense CGG 10 p.Gln546Arg 1637A>G c.1637A>G NA 996 adenocarcinoma:squamous_cell_carcinoma:ER-PR-positive_carcinoma:oligodendroglioma_Grade_III:clear_cell_carcinoma:ductal_carcinoma:serous_carcinoma:carcinoma:astrocytoma_Grade_III:endometrioid_carcinoma   PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 2,2 BR8-216T PRO-18-20140522_BR08_T2_ 693 tumor 65 91509 84.3 207.1 82.9 IonXpress_093 1.0E-5 687 607 80 0.12 10 - 20 >50 Postmenopausal
389 37142 HE10/08 41055 BR8-217 1 YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR8-217T PRO-18-20140522_BR08_T2_ 1108 tumor 70 1531729 86.6 3658 82.54 IonXpress_094 1.0E-5 1044 757 287 0.27 20 - 30 >50 Postmenopausal
390 37165 HE10/08 41055 BR8-217   YES PIK3CA YES NO other chr03 3q26.3 ex 10 178936082 AMPL393459515 178935994 178936131 38.6 3 2 SNV G 1 G/A   PIK3CA exonic missense AAA 10 p.Glu542Lys 1624G>A c.1624G>A NA 998 HER-positive_carcinoma:liposarcoma:hepatocellular_carcinoma:intestil_adenocarcinoma:carcinosarcoma-malignt_mesodermal_mixed_tumour:undifferentiated_adenocarcinoma:Merkel_cell_carcinoma:lobular_carcinoma:endometrioid_carcinoma:mucinous_carcinoma:dysemb rs121913273 PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 2,72 BR8-217T PRO-18-20140522_BR08_T2_ 10316 tumor 70 1531729 86.6 3658 82.54 IonXpress_094 1.0E-5 1992 1418 574 0.29 20 - 30 >50 Postmenopausal
391 37175 HE10/08 41055 BR8-217   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 in9-ex10 7574013 AMPL387899835 7573927 7574055 62.8 1 1 SNV G 1 G/A   TP53 exonic synonymous TTT 10 WT 1014C>T c.1014C>T NA   squamous_cell_carcinoma rs150293825 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif -1,36 BR8-217T PRO-18-20140522_BR08_T2_ 595 tumor 70 1531729 86.6 3658 82.54 IonXpress_094 1.0E-5 585 436 149 0.25 20 - 30 >50 Postmenopausal
392 37176 HE10/08 41005 BR8-218 1 YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR8-218T PRO-18-20140522_BR08_T2_ 5290 tumor 55 9562744 79.34 19622 80.61 IonXpress_095 1.0E-5 1991 383 1608 0.81 80 - 90 <=50 Premenopausal
393 37193 HE10/08 41005 BR8-218   YES PIK3CA NO NO nonMUTnonSNP chr03 3q26.3 in1 178866408 AMPL4347527835 178866384 178866543 78.2     SNV C 1 C/T   PIK3CA intronic             NA     rs2699887 PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 -0,07 BR8-218T PRO-18-20140522_BR08_T2_ 772 tumor 55 9562744 79.34 19622 80.61 IonXpress_095 1.0E-5 715 312 403 0.56 50 - 60 <=50 Premenopausal
394 37202 HE10/08 41425 BR8-219 1 NO   NO NO                                                                                             >50 Postmenopausal
395 37226 HE10/08 41588 BR8-220 1 YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 in3-ex4 7579579 AMPL6795075395 7579475 7579618 52 2 3 SNV C 1 C/T   TP53 exonic synonymous CCA 4 WT 108G>A c.108G>A NA   adenocarcinoma rs1800370 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif -1,05 BR8-220T PRO-19-20140523_BR08_T3_ 773 tumor 80 294797 79.51 616.5 83.79 IonXpress_001   753 221 532 0.71 70 - 80 >50 Postmenopausal
396 37249 HE10/08 41588 BR8-220   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 in8-ex9-in9 7576841 AMPL1516620128 7576812 7576978 50 1 2 SNV A 1 A/G   TP53 intronic             NA     rs1800899 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif -1,12 BR8-220T PRO-19-20140523_BR08_T3_ 295 tumor 80 294797 79.51 616.5 83.79 IonXpress_001   272 83 189 0.69 60 - 70 >50 Postmenopausal
397 37250 HE10/08 41588 BR8-220   YES TP53 YES NO other chr17 17p13.1 in4-ex5 7578461 AMPL6326144323 7578407 7578581 61.7 1 3 SNV C 1 C/A   TP53 exonic missense TTC 5 p.Val157Phe 469G>T c.469G>T NA 998 hepatocellular_carcinoma:intestil_adenocarcinoma:undifferentiated_adenocarcinoma:endometrioid_carcinoma:adrel_cortical_carcinoma:adenoid_cystic_carcinoma:acute_lymphoblastic_B_cell_leukaemia:non_small_cell_carcinoma:chondrosarcoma:chromophobe_rel_ce rs121912654 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 0,39 BR8-220T PRO-19-20140523_BR08_T3_ 237 tumor 80 294797 79.51 616.5 83.79 IonXpress_001   223 107 116 0.52 50 - 60 >50 Postmenopausal
398 37278 HE10/08 40483 BR8-221   YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR8-221T PRO-19-20140523_BR08_T3_ 566 tumor 60 182712 74.84 363.6 84.09 IonXpress_002   86 54 32 0.37 30 - 40 >50 Postmenopausal
399 37280 HE10/08 40522 BR8-222 1 NO   NO NO                                                                                             >50 Postmenopausal
400 37297 HE10/08 40855 BR8-223 1 YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR8-223T PRO-19-20140523_BR08_T3_ 412 tumor 80 1249093 82.56 2647 79.67 IonXpress_004   380 60 320 0.84 80 - 90 >50 Postmenopausal
401 37321 HE10/08 40855 BR8-223   YES PIK3CA YES NO other chr03 3q26.3 ex21 178952085 AMPL1497305257 178951918 178952092 38.1 3 3 SNV A 1 A/G   PIK3CA exonic missense CGT 21 p.His1047Arg 3140A>G c.3140A>G NA 926 HER-positive_carcinoma:ductal_epithelial_hyperplasia-hyperplasia_of_usual_type:hepatocellular_carcinoma:SHH_subtype:Merkel_cell_carcinoma:lobular_carcinoma:mixed_endometrioid_and_clear_cell_carcinoma:sopharyngeal_carcinoma:endometriosis:papilloma:mixed_ rs121913279 PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 2,33 BR8-223T PRO-19-20140523_BR08_T3_ 5087 tumor 80 1249093 82.56 2647 79.67 IonXpress_004   360 74 286 0.79 70 - 80 >50 Postmenopausal
402 37334 HE10/08 40855 BR8-223   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 in9-ex10 7574013 AMPL387899835 7573927 7574055 62.8 1 1 SNV G 1 G/A   TP53 exonic synonymous TTT 10 WT 1014C>T c.1014C>T NA   squamous_cell_carcinoma rs150293825 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif -1,36 BR8-223T PRO-19-20140523_BR08_T3_ 1172 tumor 80 1249093 82.56 2647 79.67 IonXpress_004   1152 379 773 0.67 60 - 70 >50 Postmenopausal
403 37336 HE10/08 40855 BR8-223   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 ex6-in6 7578210 AMPL4574207192 7578114 7578273 53.5 1 1 SNV T 1 T/C   TP53 exonic synonymous CGG 6 WT 639A>G c.639A>G NA   oligodendroglioma_Grade_II:adenocarcinoma:adenoma:carcinoma rs1800372 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif -0,16 BR8-223T PRO-19-20140523_BR08_T3_ 736 tumor 80 1249093 82.56 2647 79.67 IonXpress_004   715 449 266 0.37 30 - 40 >50 Postmenopausal
404 37346 HE10/08 41348 BR8-225   YES PIK3CA YES NO other chr03 3q26.3 ex 10 178936091 AMPL393459515 178935994 178936131 38.6 3 2 SNV G 1 G/A   PIK3CA exonic missense AAG 10 p.Glu545Lys 1633G>A c.1633G>A NA 946 HER-positive_carcinoma:intestil_adenocarcinoma:Merkel_cell_carcinoma:lobular_carcinoma:endometrioid_carcinoma:carcinoid-endocrine_tumour:mucinous_carcinoma:adenoid_cystic_carcinoma:serrated_carcinoma:adenoma:sopharyngeal_carcinoma:basal_cell_carcinoma rs104886003 PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 2,72 BR8-225T PRO-19-20140523_BR08_T3_ 1518 tumor 65 97678 84.57 218.1 49.29 IonXpress_006   1509 999 510 0.34 30 - 40 >50 Postmenopausal
405 37351 HE10/08 41126 BR8-226 1 NO   NO NO                                                                                             >50 Postmenopausal
406 37373 HE10/08 41127 BR8-227 1 NO   NO NO                                                                                             <=50 Premenopausal
407 37382 HE10/08 41414 BR8-228 1 NO   NO NO                                                                                             >50 Postmenopausal
408 37402 HE10/08 40697 BR8-229 1 NO   NO NO                                                                                             >50 Postmenopausal
409 37417 HE10/08 40208 BR8-231 1 YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 ex6-in6 7578210 AMPL4574207192 7578114 7578273 53.5 1 1 SNV T 1 T/C   TP53 exonic synonymous CGG 6 WT 639A>G c.639A>G NA   oligodendroglioma_Grade_II:adenocarcinoma:adenoma:carcinoma rs1800372 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif -0,16 BR8-231T PRO-19-20140523_BR08_T3_ 692 tumor 75 571962 88.54 1330 49.59 IonXpress_011   667 514 153 0.23 20 - 30 >50 Postmenopausal
410 37428 HE10/08 41007 BR8-232 1 NO   NO NO                                                                                             <=50 Premenopausal
411 37456 HE10/08 41428 BR8-235   YES PIK3CA YES NO other chr03 3q26.3 ex 10 178936082 AMPL393459515 178935994 178936131 38.6 3 2 SNV G 1 G/A   PIK3CA exonic missense AAA 10 p.Glu542Lys 1624G>A c.1624G>A NA 998 HER-positive_carcinoma:liposarcoma:hepatocellular_carcinoma:intestil_adenocarcinoma:carcinosarcoma-malignt_mesodermal_mixed_tumour:undifferentiated_adenocarcinoma:Merkel_cell_carcinoma:lobular_carcinoma:endometrioid_carcinoma:mucinous_carcinoma:dysemb rs121913273 PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 2,72 BR8-235T PRO-19-20140523_BR08_T3_ 641 tumor 75 35978 78.61 73.27 48.69 IonXpress_014   628 444 184 0.29 20 - 30 >50 Postmenopausal
412 37478 HE10/08 40308 BR8-236   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 ex6-in6 7578210 AMPL4574207192 7578114 7578273 53.5 1 1 SNV T 1 T/C   TP53 exonic synonymous CGG 6 WT 639A>G c.639A>G NA   oligodendroglioma_Grade_II:adenocarcinoma:adenoma:carcinoma rs1800372 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif -0,16 BR8-236T PRO-19-20140523_BR08_T3_ 465 tumor 80 533863 85.62 1210 72.3 IonXpress_015   446 339 107 0.24 20 - 30 >50 Premenopausal
413 37492 HE10/08 41001 BR8-237   YES PIK3CA YES NO other chr03 3q26.3 ex 10 178936091 AMPL393459515 178935994 178936131 38.6 3 2 SNV G 1 G/A   PIK3CA exonic missense AAG 10 p.Glu545Lys 1633G>A c.1633G>A NA 946 HER-positive_carcinoma:intestil_adenocarcinoma:Merkel_cell_carcinoma:lobular_carcinoma:endometrioid_carcinoma:carcinoid-endocrine_tumour:mucinous_carcinoma:adenoid_cystic_carcinoma:serrated_carcinoma:adenoma:sopharyngeal_carcinoma:basal_cell_carcinoma rs104886003 PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 2,72 BR8-237T PRO-19-20140523_BR08_T3_ 1198 tumor 70 163742 83.32 362.9 83.59 IonXpress_016   1188 1067 121 0.1 10 - 20 >50 Postmenopausal
414 37501 HE10/08 41001 BR8-237   YES TP53 NO NO nonMUTnonSNP chr17 17p13.1 ex4-in4 7579307 AMPL1481773781 7579257 7579411 56.1 2 3 INDEL CT 1 CT/C   TP53 intronic             NA   serous_carcinoma rs68140816 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 2.4,1.95 BR8-237T PRO-19-20140523_BR08_T3_ 337 tumor 70 163742 83.32 362.9 83.59 IonXpress_016   323 278 45 0.14 10 - 20 >50 Postmenopausal
415 37503 HE10/08 40218 BR8-238 1 YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR8-238T PRO-19-20140523_BR08_T3_ 414 tumor 55 551487 84.08 1239 84.11 IonXpress_017   384 242 142 0.37 30 - 40 >50 Postmenopausal
416 37517 HE10/08 40218 BR8-238   YES PIK3CA YES NO other chr03 3q26.3 ex21 178952103 AMPL392292511 178952020 178952194 36.3 3 2 INDEL CAA 1 CAA/CA   PIK3CA exonic frameshiftDeletion TGG 21 p.Met1055Trp 3159_3159delA c.3159_3159delA NA       PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 2.89,2.33,2.33 BR8-238T PRO-19-20140523_BR08_T3_ 1289 tumor 55 551487 84.08 1239 84.11 IonXpress_017   176 102 63 0.36 30 - 40 >50 Postmenopausal
417 37520 HE10/08 40218 BR8-238   YES TP53 YES NO other chr17 17p13.1 in6-ex7-in7 7577548 AMPL4981177402 7577472 7577638 53.4 2 3 SNV C 1 C/T   TP53 exonic missense AGC 7 p.Gly245Ser 733G>A c.733G>A NA 1 HER-positive_carcinoma:hepatocellular_carcinoma:follicular_lymphoma:chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma:glioma:spindle_cell_carcinoma:basal_cell_carcinoma:osteosarcoma:pleomorphic_carcinoma:astrocytoma_Grade_II:serous_carcinoma:rhabdo rs28934575 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 2,56 BR8-238T PRO-19-20140523_BR08_T3_ 805 tumor 55 551487 84.08 1239 84.11 IonXpress_017   733 564 169 0.23 20 - 30 >50 Postmenopausal
418 37521 HE10/08 40942 BR8-239 1 YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR8-239T PRO-19-20140523_BR08_T3_ 269 tumor 80 1089207 81.79 2294 76.55 IonXpress_018   247 42 205 0.83 80 - 90 >50 Postmenopausal
419 37548 HE10/08 41131 BR8-241   YES PIK3CA NO NO nonMUTnonSNP chr03 3q26.3 off target 115118900 AMPL6795279620 115118832 115118979 44.9 2 1 SNV C 1 C/T                   NA     rs9821873   -2,3 BR8-241T PRO-19-20140523_BR08_T3_ 776 tumor 80 238045 77.22 473 49.23 IonXpress_020   745 395 350 0.47 40 - 50 <=50 Premenopausal
420 37556 HE10/08 40211 BR8-243 1 YES TP53 NO YES other chr17 17p13.1 ex4 (intraexonic) 7579472 AMPL6794971662 7579363 7579535 66.4 1 2 SNV G 1 G/C 0.397 TP53 exonic missense CGC 4 p.Pro72Arg 215C>G c.215C>G NA   astrocytoma_Grade_IV:carcinoma rs1042522 P53 D-binding domain:P53 transactivation motif:P53 tetramerisation motif 1,36 BR8-243T   571 tumor                     0.91   <=50 Premenopausal
421 37569 HE10/08 40211 BR8-243   YES PIK3CA NO YES other chr03 3q26.3 in3 178917844 AMPL2705185935 178917726 178917900 29.9 2 1 INDEL TA 1 TA/T 0.013 PIK3CA intronic             NA     rs146815076 PI3-kise family:Phosphatidylinositol 3- and 4-kise:Phosphoinositide 3-kise family:Phosphoinositide 3-kise C2 -0.63,1.03 BR8-243T   1215 tumor                     0.49 40 - 50 <=50 Premenopausal
422 37579 HE10/08 41071 BR8-246 1 NO   NO NO                                                                                             <=50 Premenopausal
423 37582 HE10/08 40982 BR8-248 1 NO   NO NO