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  A B C D E F G H I J K L M N O P Q R S T U V W X Y Z AA AB AC AD AE AF AG AH AI AJ AK AL AM AN AO AP AQ AR AS AT AU AV AW AX AY AZ BA BB BC BD
1                                                                                                                
2   Table S4: Associations between EGFR related parameters with standard clinicopathological characteristics and with p53 IHC                                                                                                  
3                                                                                                                
4     EGFR FISH   EGFR copies (continuous)   CEN7 copies (continuous)   EGFR mutations   EGFR mRNA (75% cut-off)   EGFR IHC   p53 IHC   Basal   Lymphocytic infiltrates     Ki67 (continuous)   p53/EGFR IHC (4 scale)   p53/EGFR (binary)
5     Negative (N=259) Positive (N=11) p-value   N Median Range p-value   N Median Range p-value   Mutant (N=12) Non-mutant (N=258) p-value   Low (N=133) High (N=44) P-value   Negative (N=161) Positive (N=185) p-value   Negative (N=126) Positive (N=182) p-value   No (N=64) Yes (N=283) p-value   0 (≤1) 1 (>1-25) 2 (>25-75) 3 (>75) p-value   N Median Range p-value   Both negative Both positive p53 negative and EGFR positive p53 positive and EGFR negative p-value   Both negative or both positive One negative and one positive p-value
6     N (%) N (%)                         N (%) N (%)     N (%) N (%)     N (%) N (%)     N (%) N (%)     N (%) N (%)     N (%) N (%) N (%) N (%)               N (%) N (%) N (%) N (%)     N (%) N (%)  
7   Age (median cut off)                                                                                                            
8   <53.2 137 (52.9) 2 (18.2) 0.031   139 2.6 (1.1-8.0) 0.002   139 2.7 (1.2-5.8) 0.003   7 (58.3) 130 (50.4) 0.77   74 (55.6) 18 (40.9) 0.12   85 (52.8) 87 (47.0) 0.33   57 (45.6) 94 (51.6) 0.35   30 (46.9) 142 (50.2) 0.68   68 (45.9) 48 (55.2) 32 (54.2) 19 (46.3) 0.47   158 59.5 (0.0-100.0) 0.001   32 (50.0) 57 (51.8) 25 (41.0) 37 (52.1) 0.53   89 (51.1) 62 (47.0) 0.49
9   ≥53.2 122 (47.1) 9 (81.8)     131 3.1 (1.1-24.6)     131 3.0 (1.4-19.9)     5 (41.7) 128 (49.6)     59 (44.4) 26 (59.1)     76 (47.2) 98 (53.0)     68 (54.4) 88 (48.4)     34 (53.1) 141 (49.8)     80 (54.1) 39 (44.8) 27 (45.8) 22 (53.7)     159 37.5 (0.0-100.0)     32 (50.0) 53 (48.2) 36 (59.0) 34 (47.9)     85 (48.9) 70 (53.0)  
10   Histological type                                                                                                            
11   Apocrine 10 (3.9) 0 (0.0) 0.71   10 3.0 (1.9-4.9) 0.91   10 3.4 (1.9-4.7) 0.59   0 (0.0) 9 (3.5) 0.37   6 (4.5) 0 (0.0) 0.40   2 (1.2) 10 (5.4) 0.002   5 (4.0) 4 (2.2) 0.005   2 (3.1) 10 (3.5) <0.001   6 (4.1) 5 (5.7) 0 (0) 1 (2.4) <0.001   9 36.0 (1.0-100.0) 0.001   0 (0.0) 2 (1.8) 5 (8.2) 2 (2.8) 0.001   2 (1.1) 7 (5.3) 0.22
12   Lobular 7 (2.7) 0 (0.0)     7 2.5 (1.6-6.0)     7 2.1 (1.6-6.0)     1 (8.3) 10 (3.9)     2 (1.5) 2 (4.5)     13 (8.1) 3 (1.6)     10 (8.0) 3 (1.6)     12 (18.8) 4 (1.4)     11 (7.4) 2 (2.3) 2 (3.4) 0 (0)     12 5.5 (0.0-55.0)     7 (10.9) 0 (0.0) 3 (4.9) 3 (4.2)     7 (4.0) 6 (4.5)  
13   Medullar 14 (5.4) 0 (0.0)     14 2.8 (2.0-3.6)     14 2.9 (1.9-3.6)     1 (8.3) 16 (6.2)     6 (4.5) 3 (6.8)     10 (6.2) 12 (6.5)     11 (8.8) 10 (5.5)     2 (3.1) 20 (7.1)     0 (0) 4 (4.6) 5 (8.5) 13 (31.7)     22 69.0 (0.0-99.5)     7 (10.9) 8 (7.3) 4 (6.6) 2 (2.8)     15 (8.6) 6 (4.5)  
14   Metaplastic 15 (5.8) 1 (9.1)     16 3.0 (2.1-8.0)     16 2.9 (1.9-5.8)     1 (8.3) 14 (5.4)     5 (3.8) 3 (6.8)     3 (1.9) 14 (7.6)     10 (8.0) 7 (3.8)     1 (1.6) 16 (5.7)     8 (5.4) 2 (2.3) 6 (10.2) 1 (2.4)     17 65.3 (0.0-95.0)     2 (3.1) 6 (5.5) 8 (13.1) 1 (1.4)     8 (4.6) 9 (6.8)  
15   NST 203 (78.4) 9 (81.8)     212 2.8 (1.1-24.6)     212 2.8 (1.2-19.9)     8 (66.7) 201 (77.9)     109 (82.0) 34 (77.3)     129 (80.1) 139 (75.1)     88 (70.4) 149 (81.9)     45 (70.3) 224 (79.2)     116 (78.4) 70 (80.5) 46 (78.0) 26 (63.4)     246 46.5 (0.0-100.0)     48 (75.0) 88 (80.0) 40 (65.6) 60 (84.5)     136 (78.2) 100 (75.8)  
16   Other 10 (3.9) 1 (9.1)     11 2.6 (1.8-18.5)     11 3.4 (1.7-5.8)     1 (8.3) 8 (3.1)     5 (3.8) 2 (4.5)     4 (2.5) 7 (3.8)     1 (0.8) 9 (4.9)     2 (3.1) 9 (3.2)     7 (4.7) 4 (4.6) 0 (0) 0 (0)     11 25.0 (5.0-93.0)       6 (5.5) 1 (1.6) 3 (4.2)     6 (3.4) 4 (3.0)  
17   Histological grade                                                                                                            
18   I-II 2 (18.2) 1,000     45 2.6 (1.2-18.5) 0.17   45 2.5 (1.7-6.0) 0.047   2 (16.7) 40 (15.6) >0.999   21 (15.9) 6 (13.6) 0.81   37 (23.3) 26 (14.1) 0.036   24 (19.4) 28 (15.5) 0.44   21 (33.9) 42 (14.9) 0.001   31 (21.2) 18 (20.9) 7 (11.9) 4 (9.8) 0.18   54 15.5 (0.0-100.0) <0.001   14 (21.9) 11 (10.0) 10 (16.7) 17 (24.3) 0.058   25 (14.4) 27 (20.8) 0.17
19   III 9 (81.8)       223 2.9 (1.1-24.6)     223 2.9 (1.2-19.9)     10 (83.3) 216 (84.4)     111 (84.1) 38 (86.4)     122 (76.7) 158 (85.9)     100 (80.6) 153 (84.5)     41 (66.1) 240 (85.1)     115 (78.8) 68 (79.1) 52 (88.1) 37 (90.2)     261 55.0 (0.0-100.0)     50 (78.1) 99 (90.0) 50 (83.3) 53 (75.7)     149 (85.6) 103 (79.2)  
20   Menopausal status                                                                                                            
21   Premenopausal 119 (46.9) 2 (18.2) 0.071   121 2.7 (1.2-8.0) 0.037   121 2.7 (1.2-5.8) 0.006   6 (50.0) 113 (44.8) 0.77   64 (49.2) 17 (40.5) 0.38   71 (44.1) 75 (42.1) 0.74   44 (36.4) 87 (48.6) 0.044   23 (35.9) 124 (44.9) 0.21   61 (42.1) 42 (50.0) 25 (42.4) 15 (37.5) 0.536   137 60.5 (0.0-100.0) 0.003   26 (40.6) 53 (49.5) 18 (31.6) 33 (46.5) 0.15   79 (46.2) 51 (39.8) 0.29
22   Postmenopausal 135 (53.1) 9 (81.8)     144 2.9 (1.1-24.6)     144 2.9 (1.4-19.9)     6 (50.0) 139 (55.2)     66 (50.8) 25 (59.5)     90 (55.9) 103 (57.9)     77 (63.6) 92 (51.4)     41 (64.1) 152 (55.1)     84 (57.9) 42 (50.0) 34 (57.6) 25 (62.5)     173 39.3 (0.0-100.0)     38 (59.4) 54 (50.5) 39 (68.4) 38 (53.5)     92 (53.8) 77 (60.2)  
23   Number of positive nodes                                                                                                            
24     89 (35.2) 2 (18.2) 0.34   91 2.7 (1.1-19.8) 0.26   91 2.8 (1.6-6.4) 0.60   3 (25.0) 87 (34.7) 0.81   44 (34.1) 14 (33.3) >0.999   51 (32.7) 62 (34.4) 0.12   45 (36.6) 57 (32.2) 0.53   14 (22.6) 100 (36.4) 0.006   54 (38.0) 27 (31.4) 17 (29.8) 16 (40.0) 0.18   104 43.3 (0.0-100.0) 0.67   23 (36.5) 35 (32.7) 22 (36.7) 21 (30.4) 0.57   58 (34.1) 43 (33.3) 0.34
25   1-3 87 (34.4) 6 (54.5)     93 2.9 (1.2-18.5)     93 2.9 (1.6-6.6)     5 (41.7) 91 (36.3)     45 (34.9) 15 (35.7)     48 (30.8) 70 (38.9)     39 (31.7) 67 (37.9)     18 (29.0) 100 (36.4)     42 (29.6) 37 (43.0) 26 (45.6) 10 (25.0)     110 50.0 (0.0-100.0)     20 (31.7) 45 (42.1) 19 (31.7) 22 (31.9)     65 (38.2) 41 (31.8)  
26   ≥4 77 (30.4) 3 (27.3)     80 2.8 (1.2-24.6)     80 2.8 (1.2-19.9)     4 (33.3) 73 (29.1)     40 (31.0) 13 (31.0)     57 (36.5) 48 (26.7)     39 (31.7) 53 (29.9)     30 (48.4) 75 (27.3)     46 (32.4) 22 (25.6) 14 (24.6) 14 (35.0)     95 43.3 (0.0-100.0)     20 (31.7) 27 (25.2) 19 (31.7) 26 (37.7)     47 (27.6) 45 (34.9)  
27   Tumor size                                                                                                            
28   ≤2cm 84 (32.8) 6 (54.5)     90 2.8 (1.1-24.6) 0.10   90 2.8 (1.2-19.9) 0.20   2 (16.7) 95 (37.3) 0.16   41 (31.5) 12 (27.3) 0.005   59 (37.3) 65 (35.7) 0.83   46 (37.1) 61 (34.1) 0.77   21 (33.3) 103 (37.1) 0.44   40 (27.4) 28 (33.3) 29 (49.2) 22 (55.0) 0.009   109 38.5 (0.0-100.0) 0.69   27 (42.2) 40 (37.0) 19 (31.7) 21 (30.0) 0.67   67 (39.0) 40 (30.8) 0.20
29   2-5cm 152 (59.4) 3 (27.3) 0.047   155 2.7 (1.1-18.5)     155 2.8 (1.4-6.4)     10 (83.3) 137 (53.7)     81 (62.3) 21 (47.7)     84 (53.2) 102 (56.0)     66 (53.2) 103 (57.5)     34 (54.0) 153 (55.0)     91 (62.3) 47 (56.0) 27 (45.8) 17 (42.5)     2-5cm 176 46.5 (0.0-100.0)   32 (50.0) 61 (56.5) 34 (56.7) 41 (58.6)     93 (54.1) 75 (57.7)  
30   >5cm 20 (7.8) 2 (18.2)     22 3.4 (1.2-11.1)     22 3.3 (1.6-6.0)       23 (9.0)     8 (6.2) 11 (25.0)     15 (9.5) 15 (8.2)     12 (9.7) 15 (8.4)     8 (12.7) 22 (7.9)     15 (10.3) 9 (10.7) 3 (5.1) 1 (2.5)     27 59.0 (0.0-95.0)     5 (7.8) 7 (6.5) 7 (11.7) 8 (11.4)     12 (7.0) 15 (11.5)  
31   Multifocality                                                                                                            
32   No 243 (93.8) 11 (100.0) >0.999   254 2.8 (1.1-24.6) 0.63   254 2.8 (1.2-19.9) 0.46   11 (91.7) 242 (93.8) 0.55   124 (93.2) 42 (95.5) 0.73   152 (94.4) 173 (93.5) 0.82   117 (93.6) 171 (94.0) >0.999   57 (89.1) 269 (95.1) 0.082   138 (93.2) 80 (92.0) 57 (96.6) 38 (92.7) 0.72   298 43.7 (0.0-100.0) 0.26   60 (93.8) 103 (93.6) 57 (93.4) 67 (94.4) 0.99   163 (93.7) 124 (93.9) >0.999
33   Yes 16 (6.2)       16 3.0 (1.8-5.8)     16 2.9 (1.4-5.8)     1 (8.3) 16 (6.2)     9 (6.8) 2 (4.5)     9 (5.6) 12 (6.5)     8 (6.4) 11 (6.0)     7 (10.9) 14 (4.9)     10 (6.8) 7 (8.0) 2 (3.4) 3 (7.3)     19 65.0 (1.3-99.0)     4 (6.3) 7 (6.4) 4 (6.6) 4 (5.6)     0 (0.0) 0 (0.0)  
34   Basal                                                                                                            
35   No 32 (12.4%) 1 (10.0%) >0.999   33 2.7 (1.7-6.0) 0.84   33 2.4 (1.7-6.0) 0.12   5 (41.7) 38 (15.0) 0.029   16 (12.1) 1 (2.3) 0.075   63 (39.1) 0 (0.0) <0.001   27 (21.6) 20 (11.0) 0.015   - -     31 (21.1) 16 (18.8) 8 (13.8) 4 (9.8) 0.31   49 11.0 (0.0-100.0) <0.001   27 (42.2) 0 (0.0) 0 (0.0) 19 (26.8) <0.001   27 (15.5) 19 (14.4) 0.87
36   Yes 226 (87.6%) 9 (90.0%)     235 2.8 (1.1-24.6)     235 2.9 (1.2-19.9)     7 (58.3) 216 (85.0)     116 (87.9) 42 (97.7)     98 (60.9) 185 (100.0)     98 (78.4) 162 (89.0)     - - -   116 (78.9) 69 (81.2) 50 (86.2) 37 (90.2)     268 52.3 (0.0-100.0)     37 (57.8) 110 (100.0) 61 (100.0) 52 (73.2)     147 (84.5) 113 (85.6)  
37   Lymphocytic infiltrations                                                                                                            
38   0 (≤1%) 111 (44.9%) 3 (27.3%) 0.21   114 2.8 (1.1-19.8) 0.73   114 2.9 (1.4-6.0) 0.87   6 (50.0) 102 (41.3) 0.88   50 (38.2) 22 (53.7) 0.42   72 (47.1) 74 (41.8) 0.56   53 (45.3) 74 (42.3) 0.72   31 (52.5) 116 (42.6) 0.33   - - - - -   135 36.5 (0.0-99.0) 0.008   33 (55.0) 44 (41.5) 20 (35.1) 29 (42.7) 0.23   77 (46.4) 49 (39.2) 0.11
39   1 (>1-25%) 59 (23.9%) 6 (54.5%)     65 2.7 (1.2-18.5)     65 2.8 (1.2-7.9)     4 (33.3) 67 (27.1)     40 (30.5) 9 (22.0)     39 (25.5) 46 (26.0)     25 (21.4) 47 (26.9)     16 (27.1) 69 (25.4)     - - - -     74 42.9 (1.0-100.0)     8 (13.3) 26 (24.5) 17 (29.8) 21 (30.9)     34 (20.5) 38 (30.4)  
40   2 (>25-75%) 45 (18.2%) 1 (9.1%)     46 2.6 (1.1-8.4)     46 2.8 (1.4-6.6)     1 (8.3) 45 (18.2)     24 (18.3) 6 (14.6)     27 (17.6) 31 (17.5)     22 (18.8) 33 (18.9)     8 (13.6) 50 (18.4)     - - - -     55 52.5 (0.0-100.0)     10 (16.7) 19 (17.9) 12 (21.1) 14 (20.6)     29 (17.5) 26 (20.8)  
41   3 (>75%) 32 (13.0%) 1 (9.1%)     33 2.7 (1.9-24.6)     33 2.9 (1.9-19.9)     1 (8.3) 33 (13.4)     17 (13.0) 4 (9.8)     15 (9.8) 26 (14.7)     17 (14.5) 21 (12.0)     4 (6.8) 37 (13.6)     - - - -     38 67.5 (0.0-100.0)     9 (15.0) 17 (16.1) 8 (14.0) 4 (5.9)     26 (15.7) 12 (9.6)  
42   Ki-67 (continuous)                                                                                                            
43   N 252 9 0.41   - - - -   - - - -   11 243 0.27   128 42 0.46   142 174 0.001   123 181 0.001   49 268 <0.001   135 74 55 38 0.008   - - - -   62 110 61 70 <0.001   172 131 0.31
44   Median 50.0 46.5     - - -     - - -     40.0 50.0     60.8 58.0     35.0 52.3     28.5 52.5     11 52.3     36.5 42.9 52.5 67.5     - - -     28.5 65.0 42.5 38.4     50.0 42.0  
45   Range (0.0-100.0) (2.0-95.0)     - - -     - - -     (0.0-93.0) (0.0-100.0)     (1.3-100.0) (1.5-99.5)     (0.0-100.0) (1.3-100.0)     (0.0-100.0) (0.0-100.0)     (0.0-100.0) (0.0-100.0)     (0.0-99.0) (1.0-100.0) (0.0-100.0) (0.0-100.0)     - - -     (0.0-100.0) (2.5-100.0) (1.3-100.0) (1.0-100.0)     (0.0-100.0) (1.0-100.0)  
46   p53 IHC                                                                                                            
47   Negative 97 (39.8) 4 (44.4) >0.999   101 2.5 (1.1-11.5) 0.033   101 2.5 (1.4-6.6) 0.006   3 (30.0) 99 (41.3) 0.53   50 (39.4) 13 (31.7) 0.46   64 (47.4) 61 (35.7) 0.046   - - -   27 (57.4) 98 (37.7) 0.015   53 (41.7) 25 (34.7) 22 (40.0) 17 (44.7) 0.72   123 38.5 (0.0-100.0) 0.001   64 (100.0) 0 (0.0) 61 (100.0) 0 (0.0) <0.001   64 (36.8) 61 (46.2) 0.10
48   Positive 147 (60.2) 5 (55.6)     152 2.9 (1.1-24.6)     152 2.9 (1.2-19.9)     7 (70.0) 141 (58.8)     77 (60.6) 28 (68.3)     71 (52.6) 110 (64.3)     - - -   20 (42.6) 162 (62.3)     74 (58.3) 47 (65.3) 33 (60.0) 21 (55.3)     181 52.5 (0.0-100.0)     0 (0.0) 110 (100.0) 0 (0.0) 71 (100.0)     110 (63.2) 71 (53.8)  
49 N, number; NST, non-specific type