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1          
2   Table S5: Association of EGFR positivity at any molecular level (positive by IHC/FISH or mRNA overexpression or mutant) with clinicopathological parameters
3  
4          
5     EGFR negative (N=152) EGFR positive (N=199) p-value*
6     N (%) N (%)  
7   Age (median cut off)      
8   <53.2 80 (52.6) 94 (47.2) 0.33
9   ≥53.2 72 (47.4) 105 (52.8)  
10   Histological type      
11   Apocrine 2 (1.3) 10 (5.0) 0.009
12   Lobular 12 (7.9) 4 (2.0)  
13   Medullar 9 (5.9) 13 (6.5)  
14   Metaplastic 3 (2.0) 14 (7.0)  
15   NOS 122 (80.3) 151 (75.9)  
16   Other 4 (2.6) 7 (3.5)  
17   Histological grade      
18   I-II 36 (24.0) 29 (14.6) 0.037
19   III 114 (76.0) 169 (85.4)  
20   Menopausal status      
21   Postmenopausal 84 (55.3) 111 (55.8) 0.047
22   Premenopausal 68 (44.7) 81 (40.7)  
23   Unknown 0 (0.0) 7 (3.5)  
24   Multifocality      
25   No 142 (93.4) 187 (94.0) 0.83
26   Yes 10 (6.6) 12 (6.0)  
27   Number of positive nodes      
28     48 (32.7) 67 (34.5) 0.20
29   1-3 46 (31.3) 74 (38.1)  
30   ≥4 53 (36.1) 53 (27.3)  
31   Tumor size      
32   ≤2cm 77 (51.7) 111 (56.6) 0.64
33   2-5cm 58 (38.9) 69 (35.2)  
34   >5cm 14 (9.4) 16 (8.2)  
35   Basal      
36   No 57 (38.3) 7 (3.5) <0.001
37   Yes 92 (61.7) 191 (96.5)  
38   Lymphocytic infiltrations      
39   0 (≤1%) 65 (45.1) 83 (43.5) 0.61
40   1 (>1-25%) 37 (25.7) 50 (26.2)  
41   2 (>25-75%) 28 (19.4) 31 (16.2)  
42   3 (>75%) 14 (9.7) 27 (14.1)  
43   Ki67 mean      
44   N 131 186 0.003^
45   Median 35 51.9  
46   Range 0-100 0-100  
47   p53 IHC      
48   Negative 61 (48.8) 64 (35.2) 0.018
49   Positive 64 (51.2) 118 (64.8)  
50   N, number; NOS, non-specific
51   * Fisher's exact test; ^ Wilcoxon rank sum test