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2   Table S6: Univariate Cox regression analysis for all study variables with respect to DFS      
3              
4   Variables / Categories N of patients N of events HR 95% CI Wald's p
5   EGFR, any molecular level
6   Yes vs. No 197 vs. 152 60 vs.48 1.05 0.72-1.53 0.81
7   EGFR copies; cut off at 2.6*          
8   High vs. Low 149 vs. 120 43 vs. 45 0.7 0.46-1.07 0.098
9   CEN7 copies; cut off at 2.6*          
10   High vs. Low 153 vs. 116 45 vs.43 0.71 0.47-1.08 0.11
11   EGFR mRNA#          
12   Low vs. High 132 vs. 44 44 vs.13 1.17 0.63-2.18 0.62
13   EGFR FISH^          
14   Positive vs. Negative 11 vs. 258 0 vs.88 - - -
15   EGFR IHC          
16   Positive vs. Negative 183 vs. 161 54 vs.52 0.98 0.67-1.44 0.92
17   EGFR mutations          
18   Non-mutant vs. mutant 257 vs. 12 80 vs.5 0.63 0.26-1.56 0.32
19   p53 (positive ≥10%)          
20   Positive vs. Negative 180 vs. 125 56 vs.36 1.12 0.74-1.70 0.60
21   p53/EGFR IHC (4 scale)          
22   Both positive vs. Both negative 108 vs. 64 29 vs.15 1.28 0.69-2.39 0.44
23   p53 negative and EGFR positive vs. Both negative 61 vs. 64 21 vs.15 1.78 0.92-3.46 0.088
24   p53 positive and EGFR negative vs. Both negative 71 vs. 64 27 vs.15 1.89 1.01-3.56 0.048
25   p53/EGFR IHC (binary)          
26   One negative and one positive vs. Both negative or both positive 132 vs. 172 48 vs.44 1.58 1.05-2.38 0.029
27   Age (median cutoff)          
28   ≥53.2 vs. <53.2 178 vs. 174 50 vs. 58 0.81 0.55-1.18 0.27
29   Age (categorical)         0.24
30   <35 vs. 35-50 24 vs. 121 4 vs.43 0.44 0.16-1.22 0.12
31   ≥50 vs. 35-50 204 vs. 121 61 vs.43 0.83 0.56-1.22 0.34
32   Adjuvant HT          
33   Yes vs. No 70 vs. 279 32 vs.76 1.55 1.02-2.37 0.040
34   Adjuvant RT          
35   Yes vs. No 258 vs. 91 78 vs.30 0.88 0.58-1.34 0.55
36   Breast surgery          
37   Breast conserving surgery vs. MRM 177 vs. 163 47 vs.57 0.78 0.53-1.15 0.21
38   Basal          
39   Yes vs. No 281 vs. 64 87 vs.19 1.19 0.72-1.96 0.51
40   CK5          
41   Positive vs. Negative 236 vs. 93 71 vs.28 1.03 0.66-1.59 0.90
42   ER/PgR (IHC local pathology)          
43   Positive vs. Negative 46 vs. 273 22 vs. 80 1.59 0.98-2.58 0.058
44   HER2 overexpression (IHC local pathology)          
45   Yes vs. No 20 vs. 301 9 vs.89 1.42 0.72-2.83 0.31
46   Histological type          
47   Lobular vs. Apocrine 16 vs. 12 8 vs.5 1.06 0.35-3.24 0.92
48   Medullar vs. Apocrine 22 vs. 12 1 vs.5 0.08 0.01-0.66 0.020
49   Metaplastic vs. Apocrine 17 vs. 12 4 vs.5 0.49 0.13-1.83 0.29
50   NOS vs. Apocrine 272 vs. 12 88 vs.5 0.67 0.27-1.65 0.39
51   Other vs. Apocrine 10 vs. 12 2 vs.5 0.47 0.09-2.40 0.36
52   Histological grade          
53   III vs. I-II 281 vs. 65 88 vs.20 1.09 0.67-1.78 0.72
54   Ki-67 (10% increments)     0.99 0.93-1.05 0.66
55   Lymphocytic infiltrates** (4 scale)          
56   1 vs. 0 86 vs. 147 24 vs.48 0.79 0.48-1.28 0.34
57   2 vs. 0 59 vs. 147 20 vs.48 0.93 0.55-1.57 0.78
58   3 vs. 0 41 vs. 147 7 vs.48 0.43 0.19-0.95 0.038
59   Menopausal status          
60   Postmenopausal vs. premenopausal 195 vs. 149 59 vs.47 0.96 0.65-1.40 0.82
61   Multifocal          
62   Yes vs. No 21 vs. 328 7 vs.101 1.12 0.52-2.41 0.77
63   Number of positive nodes          
64   0 vs. ≥4 114 vs. 106 21 vs. 57 0.3 0.18-0.49 <0.001
65   1-3 vs. ≥4 120 vs. 106 25 vs. 57 0.32 0.20-0.51 <0.001
66   Tumor size          
67   2-5 vs. ≤2cm 188 vs. 126 57 vs. 31 1.35 0.87-2.09 0.18
68   >5 vs. ≤2cm 30 vs. 126 18 vs. 31 3.02 1.69-5.42 <0.001
69   N, number; NOS, non-specific          
70   #: 75% cutoff; *: 3y-ROC cutoff coinciding with median value; ^: EGFR/CEN7 ratio≥2.0 or ratio<2 and copies > 6; **: evaluated on whole sections