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  A B C D E F G H I
1                  
2   Table S7: Univariate Cox regression analysis for all study variables with respect to OS      
3                  
4   Variable / Categories N of patients N of events HR 95% CI Wald's p    
5   EGFR any molecular level        
6   Yes vs. No 197 vs. 152 49 vs.39 1.07 0.70-1.64 0.74    
7   EGFR copies; cut off at 2.6*              
8   High vs. Low 149 vs. 120 35 vs. 37 0.66 0.42-1.06 0.087    
9   CEN7 copies; cut off at 2.6*              
10   High vs. Low 153 vs. 116 35 vs.37 0.61 0.38-0.97 0.039    
11   EGFR mRNA#              
12   Low vs. High 132 vs. 44 32 vs.12 0.89 0.46-1.72 0.72    
13   EGFR FISH^              
14   Positive vs. Negative 11 vs. 258 0 vs.72          
15   EGFR IHC              
16   Positive vs. Negative 183 vs. 161 45 vs.41 1.07 0.70-1.64 0.75    
17   EGFR mutations              
18   Non-mutant vs. mutant 257 vs. 12 64 vs.4 0.66 0.24-1.83 0.43    
19   p53 (positive ≥10%)              
20   Positive vs. Negative 180 vs. 125 45 vs.31 1.05 0.66-1.66 0.84    
21   p53/EGFR IHC (4 scale)              
22   Both positive vs. Both negative 108 vs. 64 24 vs.14 1.14 0.59-2.20 0.70    
23   p53 negative and EGFR positive vs. Both negative 61 vs. 64 17 vs.14 1.53 0.75-3.10 0.24    
24   p53 positive and EGFR negative vs. Both negative 71 vs. 64 21 vs.14 1.57 0.80-3.09 0.19    
25   p53/EGFR IHC (binary)              
26   One negative and one positive vs. Both negative or both positive 132 vs. 172 38 vs.38 1.43 0.91-2.25 0.12    
27   Age (median cutoff)              
28   ≥53.2 vs. <53.2 178 vs. 174 42 vs.45 0.95 0.62-1.44 0.80    
29   Adjuvant HT              
30   Yes vs. No 70 vs. 279 29 vs.59 1.64 1.04-2.59 0.032    
31   Adjuvant RT              
32   Yes vs. No 258 vs. 91 63 vs.25 0.83 0.52-1.31 0.42    
33   Age (categorical)              
34   <35 vs. 35-50 24 vs. 121 3 vs.33 0.48 0.15-1.55 0.22    
35   ≥50 vs. 35-50 204 vs. 121 52 vs.33 0.99 0.64-1.54 0.97    
36   Breast surgery              
37   Breast conserving surgery vs. MRM 177 vs. 163 36 vs.48 0.73 0.47-1.12 0.15    
38   Basal              
39   Yes vs. No 281 vs. 64 70 vs.16 1.19 0.69-2.08 0.53    
40   CK5              
41   Positive vs. Negative 236 vs. 93 56 vs.25 0.92 0.57-1.47 0.71    
42   ER/PR (IHC local pathology)              
43   Positive vs. Negative 46 vs. 273 20 vs. 63 1.74 1.05-2.91 0.032    
44   HER2 overexpression (IHC local pathology)              
45   Yes vs. No 20 vs. 301 7 vs.71 1.29 0.59-2.81 0.53    
46   Histological type              
47   Lobular vs. Apocrine 16 vs. 12 8 vs.4 1.34 0.40-4.45 0.64    
48   Medullar vs. Apocrine 22 vs. 12 1 vs.4 0.10 0.01-0.91 0.041    
49   Metaplastic vs. Apocrine 17 vs. 12 4 vs.4 0.67 0.17-2.66 0.56    
50   NOS vs. Apocrine 272 vs. 12 70 vs.4 0.66 0.24-1.82 0.43    
51   Other vs. Apocrine 10 vs. 12 1 vs.4 0.33 0.04-2.97 0.32    
52   Histological grade              
53   III vs. I-II 281 vs. 65 70 vs.18 0.94 0.56-1.58 0.82    
54   Ki-67 (10% increments)     0.99 0.92-1.06 0.70    
55   Lymphocytic infiltrates** (4 scale)         0.22    
56   1 vs. 0 86 vs. 147 19 vs.41 0.70 0.40-1.21 0.20    
57   2 vs. 0 59 vs. 147 14 vs.41 0.75 0.41-1.37 0.35    
58   3 vs. 0 41 vs. 147 6 vs.41 0.44 0.19-1.04 0.063    
59   Menopausal status              
60   Postmenopausal vs. premenopausal 195 vs. 149 51 vs.35 1.18 0.77-1.82 0.44    
61   Multifocal              
62   Yes vs. No 21 vs. 328 7 vs.81 1.59 0.73-3.44 0.24    
63   Number of positive nodes              
64   0 vs. ≥4 114 vs. 106 13 vs 51 0.23 0.12-0.42 <0.001    
65   1-3 vs. ≥4 120 vs. 106 19 vs. 51 0.29 0.17-0.48 <0.001    
66   Tumor size              
67   2-5 vs. ≤2cm 188 vs. 126 49 vs. 22 1.64 0.99-2.71 0.055    
68   >5 vs. ≤2cm 30 vs. 126 16 vs. 22 3.64 1.91-6.95 <0.001    
69   N, number; NOS, non-specific              
70   #: 75% cutoff; *: 3y-ROC cutoff coinciding with median value; ^: EGFR/CEN7 ratio>=2.0 or ratio<2 and copies > 6; **: evaluated on whole sections