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1   Table S8: Multivariate analysis for EGFR related parameters (backwards selection models), models including separately IHC and FISH data  
2    
3                
4   Parameter / Categories N of patients N of events HR 95% CI p-value  
5   A. DISEASE-FREE SURVIVAL            
6   MODEL 1; N=289            
7   Age (median cutoff)            
8   ≥53.2 vs. <53.2 146 vs. 143 37 vs. 48 0.66 0.42-1.02 0.063  
9   Number of positive nodes            
10   0 vs. ≥4 97 vs. 88 18 vs. 46 0.28 0.16-0.50 <0.001  
11   1-3 vs. ≥4 104 vs. 88 21 vs. 46 0.28 0.16-0.47 <0.001  
12   Histological grade            
13   III vs. I-II 241 vs. 48 76 vs. 9 2.2 1.06-4.56 0.033  
14   Adjuvant HT            
15   Yes vs. No 54 vs. 235 24 vs. 61 1.8 1.09-2.98 0.021  
16   Adjuvant RT            
17   Yes vs. No 217 vs. 72 61 vs. 24 0.51 0.31-0.85 0.009  
18   p53/EGFR IHC (4 scale)            
19   Both positive vs. Both negative 104 vs. 61 26 vs. 14 1.29 0.67-2.49 0.44  
20   p53 negative and EGFR positive vs. Both negative 57 vs. 61 20 vs. 14 1.93 0.97-3.84 0.063  
21   p53 positive and EGFR negative vs. Both negative 67 vs. 61 25 vs. 14 2.11 1.09-4.10 0.027  
22   MODEL 2; N=289            
23   Age (median cutoff)            
24   ≥53.2 vs. <53.2 146 vs. 143 37 vs. 48 0.66 0.43-1.03 0.066  
25   Number of positive nodes            
26   1-3 vs. 0 97 vs. 88 18 vs. 46 0.28 0.16-0.50 <0.001  
27   ≥4 vs. <0 104 vs. 88 21 vs. 46 0.28 0.17-0.48 <0.001  
28   Histological grade            
29   III vs. I-II 241 vs. 48 76 vs. 9 2.24 1.09-4.61 0.028  
30   Adjuvant HT            
31   Yes vs. No 54 vs. 235 24 vs. 61 1.77 1.08-2.90 0.023  
32   Adjuvant RT            
33   Yes vs. No 217 vs. 72 61 vs. 24 0.52 0.31-0.86 0.010  
34   p53/EGFR IHC (binary)            
35   One negative and one positive vs. Both negative or both positive 124 vs. 165 45 vs. 40 1.73 1.12-2.67 0.013  
36   MODEL 3; N=251            
37   Number of positive nodes            
38   0 vs. ≥4 86 vs. 75 17 vs. 43 0.29 0.16-0.52 <0.001  
39   1-3 vs. ≥4 90 vs. 75 21 vs. 43 0.3 0.17-0.51 <0.001  
40   Histological grade            
41   III vs. I-II 211 vs. 40 71 vs. 10 1.89 0.96-3.74 0.066  
42   Adjuvant HT            
43   Yes vs. No 46 vs. 205 23 vs. 58 1.83 1.10-3.03 0.019  
44   Adjuvant RT            
45   Yes vs. No 189 vs. 62 57 vs. 24 0.47 0.28-0.78 0.003  
46   EGFR copies; cut off at 2.6*            
47   High vs. Low 139 vs. 112 39 vs. 42 0.66 0.42-1.03 0.066  
48   B. OVERALL SURVIVAL            
49   MODEL 2; N=289            
50   Age (median cutoff)            
51   ≥53.2 vs. <53.2 146 vs. 143 31 vs. 39 0.4 0.18-0.89 0.024  
52   Menopausal status            
53   postmenopausal vs. premenopausal 161 vs. 128 38 vs. 32 1.95 0.87-4.40 0.11  
54   Number of positive nodes            
55   0 vs. ≥4 97 vs. 88 13 vs. 41 0.25 0.13-0.49 <0.001  
56   1-3 vs. ≥4 104 vs. 88 16 vs. 41 0.26 0.14-0.47 <0.001  
57   Histological grade            
58   III vs. I-II 241 vs. 48 61 vs. 9 1.88 0.90-3.89 0.091  
59   Adjuvant HT            
60   Yes vs. No 54 vs. 235 22 vs. 48 1.93 1.13-3.29 0.016  
61   Adjuvant RT            
62   Yes vs. No 217 vs. 72 50 vs. 20 0.48 0.27-0.85 0.011  
63   p53/EGFR IHC (binary)            
64   One negative and one positive vs. Both negative or both positive 124 vs. 165 35 vs. 35 1.5 0.93-2.44 0.098  
65   MODEL 3; N=251            
66   Number of positive nodes            
67   0 vs. ≥4 86 vs. 75 12 vs. 38 0.26 0.13-0.51 <0.001  
68   1-3 vs. ≥4 90 vs. 75 16 vs.38 0.28 0.15-0.51 <0.001  
69   Adjuvant HT            
70   Yes vs. No 46 vs. 205 21 vs. 45 1.84 1.07-3.18 0.028  
71   Adjuvant RT            
72   Yes vs. No 189 vs. 62 46 vs. 20 0.41 0.24-0.73 0.002  
73   CEN7 copies; cut off at 2.6*            
74   High vs. Low 141 vs. 110 30 vs. 36 0.57 0.34-0.93 0.025  
75   N, number            
76   *: 3y-ROC cutoff coinciding with median value; HR: hazard ratio