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  A B C D E F G H I J K L M N O P Q
1 Table S1. Associations between standard clinicopathological characteristics and Notch2, Notch3 and Jag1 protein expression.                        
2                                  
3     Notch2 cyto (binary) Notch3 cyto (binary) Notch3 memb (binary) Jag1 cyto (binary) Jag1 nucl (binary)
4     Negative (0-4) Positive (5-9) p-value Negative (0-4) Positive (5-9) p-value Negative (0-4) Positive (5-9) p-value Negative (0-4) Positive (5-9) p-value Negative (0-4) Positive (5-9) p-value
5                                  
6     N (%) N (%)   N (%) N (%)   N (%) N (%)              
7                    
8 Adjuvant hormonal therapy No 158 (82.3) 84 (80.0) 0.64 92 (85.2) 151 (80.7) 0.43 189 (83.3) 54 (79.4) 0.47 140 (83.3) 98 (78.4) 0.29 201 (82.7) 37 (74.0) 0.16
9   Yes 34 (17.7) 21 (20.0)   16 (14.8) 36 (19.3)   38 (16.7) 14 (20.6)   28 (16.7) 27 (21.6)   42 (17.3) 13 (26.0)  
10                    
11 Adjuvant radiotherapy No 55 (28.6) 21 (20.0) 0.13 33 (30.6) 44 (23.5) 0.22 62 (27.3) 15 (22.1) 0.43 44 (26.2) 33 (26.4) >0.999 70 (28.8) 7 (14.0) 0.034
12   Yes 137 (71.4) 84 (80.0)   75 (69.4) 143 (76.5)   165 (72.7) 53 (77.9)   124 (73.8) 92 (73.6)   173 (71.2) 43 (86.0)  
13                    
14 Age (median cutoff) <53.2 93 (48.4) 51 (48.6) >0.999 44 (40.7) 103 (55.1) 0.022 107 (47.1) 40 (58.8) 0.099 89 (53.0) 56 (44.8) 0.19 121 (49.8) 24 (48.0) 0.88
15   ≥53.2 99 (51.6) 54 (51.4)   64 (59.3) 84 (44.9)   120 (52.9) 28 (41.2)   79 (47.0) 69 (55.2)   122 (50.2) 26 (52.0)  
16                    
17 Basal-like phenotype No 24 (12.5) 23 (21.9) 0.045 28 (25.9) 15 (8.1) <0.001 40 (17.6) 3 (4.5) 0.006 20 (11.9) 23 (18.7) 0.13 43 (17.8) 0 (0) <0.001
18   Yes 168 (87.5) 82 (78.1)   80 (74.1) 171 (91.9)   187 (82.4) 64 (95.5)   148 (88.1) 100 (81.3)   198 (82.2) 50 (100.0)  
19                    
20 Breast surgery Biopsy only 3 (1.6) 1 (1.0) 0.92 2 (1.9) 3 (1.6) 0.41 5 (2.2)   0.17 1 (0.6) 3 (2.5) 0.30 3 (1.3) 1 (2.0) 0.29
21   Breast conserving surgery 102 (53.7) 54 (52.4)   51 (47.2) 100 (54.9)   111 (49.3) 40 (61.5)   84 (50.9) 67 (54.9)   121 (50.8) 30 (61.2)  
22   Modified radical mastectomy 85 (44.7) 48 (46.6)   55 (50.9) 79 (43.4)   109 (48.4) 25 (38.5)   80 (48.5) 52 (42.6)   114 (47.9) 18 (36.7)  
23                    
24 Histological type Apocrine 7 (3.6) 2 (1.9) 0.40 6 (5.6) 2 (1.1) 0.001 8 (3.5) 0 (0) 0.032 3 (1.8) 4 (3.2) 0.67 6 (2.5) 1 (2.0) 0.26
25   Lobular 8 (4.2) 6 (5.7)   9 (8.3) 2 (1.1)   11 (4.8) 0 (0)   7 (4.2) 8 (6.4)   14 (5.8) 1 (2.0)  
26   Medullar 9 (4.7) 10 (9.5)   5 (4.6) 14 (7.5)   11 (4.8) 8 (11.8)   11 (6.5) 7 (5.6)   18 (7.4) 0 (0)  
27   Metaplastic 9 (4.7) 8 (7.6)   5 (4.6) 11 (5.9)   10 (4.4) 6 (8.8)   12 (7.1) 5 (4.0)   14 (5.8) 3 (6.0)  
28   Non-specific 151 (78.6) 76 (72.4)   76 (70.4) 154 (82.4)   179 (78.9) 51 (75.0)   128 (76.2) 98 (78.4)   182 (74.9) 44 (88.0)  
29   Other 8 (4.2) 3 (2.9)   7 (6.5) 4 (2.1)   8 (3.5) 3 (4.4)   7 (4.2) 3 (2.4)   9 (3.7) 1 (2.0)  
30                                  
31 Histological grade I-II 34 (17.9) 17 (16.2) 0.75 24 (22.4) 27 (14.5) 0.11 40 (17.8) 11 (16.2) 0.86 21 (12.6) 28 (22.8) 0.026 39 (16.2) 10 (20.4) 0.53
32   III 156 (82.1) 88 (83.8)   83 (77.6) 159 (85.5)   185 (82.2) 57 (83.8)   146 (87.4) 95 (77.2)   202 (83.8) 39 (79.6)  
33                    
34 Lymphocytic infiltrates (Low vs. High) Low 162 (89.5) 82 (81.2)   88 (88.0) 156 (86.2)   190 (88.8) 54 (80.6)   138 (86.3) 105 (88.2)   200 (86.2) 43 (91.5)  
35   High (>75%) 19 (10.5) 19 (18.8) 0.068 12 (12.0) 25 (13.8) 0.72 24 (11.2) 13 (19.4) 0.098 22 (13.8) 14 (11.8) 0.72 32 (13.8) 4 (8.5) 0.47
36                                  
37 Lymphocytic infiltrates (whole sections) 0 (≤1%) 84 (46.4) 40 (39.6) 0.072 47 (47.0) 76 (42.0) 0.76 102 (47.7) 21 (31.3) 0.078 69 (43.1) 57 (47.9) 0.57 107 (46.1) 19 (40.4) 0.49
38   1 (>1-25%) 41 (22.7) 29 (28.7)   26 (26.0) 45 (24.9)   51 (23.8) 20 (29.9)   37 (23.1) 31 (26.1)   55 (23.7) 13 (27.7)  
39   2 (>25-75%) 37 (20.4) 13 (12.9)   15 (15.0) 35 (19.3)   37 (17.3) 13 (19.4)   32 (20.0) 17 (14.3)   38 (16.4) 11 (23.4)  
40   3 (>75%) 19 (10.5) 19 (18.8)   12 (12.0) 25 (13.8)   24 (11.2) 13 (19.4)   22 (13.8) 14 (11.8)   32 (13.8) 4 (8.5)  
41                    
42 Menopausal status Premenopausal 82 (43.6) 45 (43.7) >0.999 41 (38.3) 89 (48.9) 0.088 96 (43.0) 34 (51.5) 0.26 84 (51.5) 43 (35.2) 0.008 105 (44.5) 22 (44.9) >0.999
43   Postmenopausal 106 (56.4) 58 (56.3)   66 (61.7) 93 (51.1)   127 (57.0) 32 (48.5)   79 (48.5) 79 (64.8)   131 (55.5) 27 (55.1)  
44                    
45 Multifocal No 183 (95.3) 98 (93.3) 0.59 100 (92.6) 180 (96.3) 0.18 216 (95.2) 64 (94.1) 0.75 159 (94.6) 116 (92.8) 0.62 229 (94.2) 46 (92.0) 0.52
46   Yes 9 (4.7) 7 (6.7)   8 (7.4) 7 (3.7)   11 (4.8) 4 (5.9)   9 (5.4) 9 (7.2)   14 (5.8) 4 (8.0)  
47                    
48 Number of positive nodes   63 (33.9) 37 (35.6) 0.40 35 (33.0) 65 (35.7) 0.43 67 (30.3) 33 (49.3) 0.017 58 (35.2) 37 (30.8) 0.20 83 (35.2) 12 (24.5) 0.33
49   1-3 71 (38.2) 32 (30.8)   34 (32.1) 67 (36.8)   81 (36.7) 20 (29.9)   63 (38.2) 39 (32.5)   83 (35.2) 19 (38.8)  
50   ≥4 52 (28.0) 35 (33.7)   37 (34.9) 50 (27.5)   73 (33.0) 14 (20.9)   44 (26.7) 44 (36.7)   70 (29.7) 18 (36.7)  
51                    
52 Tumor size ≤2 cm 67 (35.4) 33 (31.7) 0.49 36 (33.6) 65 (35.3) 0.96 79 (35.1) 22 (33.3) 0.37 51 (30.7) 46 (37.7) 0.065 80 (33.5) 17 (34.7) >0.999
53   2-5 cm 109 (57.7) 60 (57.7)   62 (57.9) 103 (56.0)   124 (55.1) 41 (62.1)   104 (62.7) 61 (50.0)   137 (57.3) 28 (57.1)  
54   >5 cm 13 (6.9) 11 (10.6)   9 (8.4) 16 (8.7)   22 (9.8) 3 (4.5)   11 (6.6) 15 (12.3)   22 (9.2) 4 (8.2)  
55                                  
56 Ki67 labeling N 191 101 0.57 106 186 <0.001 225 67 <0.001 166 123 <0.001 239 50 0.001
57   Median 46.5 47.3   27.5 63.8   40.0 77.5   62.3 29.0   41.5 67.5  
58   Range (0.0-100.0) (0.0-100.0)   (0.0-100.0) (0.5-100.0)   (0.0-100.0) (1.5-100.0)   (0.0-100.0) (0.0-100.0)   (0.0-100.0) (4.5-100.0)  
59 N, number.
60 Significant p-values are shown in bold.                                
61                                  
62                                  
63