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1 Table S2. Associations between standard clinicopathological characteristics and E-cadherin. P-cadherin and p53 protein expression.          
2                      
3     E-cadherin membranous P-cadherin membranous p53 nuclear
4     Negative (<10%) Positive (≥10%) p-value Negative (<10%) Positive (≥10%) p-value Negative (<10%) Positive (≥10%) p-value
5                      
6     N (%) N (%)   N (%) N (%)   N (%) N (%)  
7                      
8 Adjuvant hormonal therapy No 66 (77.6) 176 (83.4) 0.25 38 (73.1) 214 (83.3) 0.12 100 (79.4) 152 (83.5) 0.37
9   Yes 19 (22.4) 35 (16.6)   14 (26.9) 43 (16.7)   26 (20.6) 30 (16.5)  
10                      
11 Adjuvant radiotherapy No 23 (27.1) 52 (24.6) 0.66 16 (30.8) 66 (25.7) 0.49 34 (27.0) 49 (26.9) >0.999
12   Yes 62 (72.9) 159 (75.4)   36 (69.2) 191 (74.3)   92 (73.0) 133 (73.1)  
13                      
14 Age (median cutoff) <53.2 37 (43.5) 109 (51.7) 0.25 18 (34.6) 134 (52.1) 0.023 57 (45.2) 94 (51.6) 0.30
15   ≥53.2 48 (56.5) 102 (48.3)   34 (65.4) 123 (47.9)   69 (54.8) 88 (48.4)  
16                      
17 Basal-like phenotype No 26 (31.3) 17 (8.1) <0.001 23 (45.1) 25 (9.9) <0.001 27 (21.6) 20 (11.0) 0.015
18   Yes 57 (68.7) 192 (91.9)   28 (54.9) 228 (90.1)   98 (78.4) 162 (89.0)  
19                      
20 Breast Surgery Biopsy only 1 (1.2) 3 (1.4) 0.038   3 (1.2) 0.025 1 (0.8) 3 (1.7) 0.87
21   Breast conserving surgery 36 (42.9) 121 (58.2)   19 (37.3) 143 (56.7)   66 (53.7) 93 (52.2)  
22   Modified radical mastectomy 47 (56.0) 84 (40.4)   32 (62.7) 106 (42.1)   56 (45.5) 82 (46.1)  
23                      
24 Histological type Apocrine 2 (2.4) 6 (2.8) 0.005 2 (3.8) 7 (2.7) <0.001 5 (4.0) 4 (2.2) 0.003
25   Lobular 9 (10.6) 2 (0.9)   10 (19.2) 3 (1.2)   11 (8.7) 3 (1.6)  
26   Medullar 8 (9.4) 12 (5.7)   4 (7.7) 17 (6.6)   11 (8.7) 10 (5.5)  
27   Metaplastic 5 (5.9) 12 (5.7)   1 (1.9) 14 (5.4)   10 (7.9) 7 (3.8)  
28   Non-specific 59 (69.4) 171 (81.0)   33 (63.5) 207 (80.5)   88 (69.8) 149 (81.9)  
29   Other 2 (2.4) 8 (3.8)   2 (3.8) 9 (3.5)   1 (0.8) 9 (4.9)  
30                      
31 Histological grade I-II 18 (21.4) 33 (15.7) 0.24 20 (39.2) 36 (14.1) <0.001 25 (20.0) 28 (15.5) 0.36
32   III 66 (78.6) 177 (84.3)   31 (60.8) 220 (85.9)   100 (80.0) 153 (84.5)  
33                      
34 Lymphocytic infiltrates (whole sections) 0 (≤1%) 32 (40.0) 89 (44.3) 0.81 24 (50.0) 105 (42.7) 0.50 54 (45.8) 74 (42.3) 0.70
35   1 (>1-25%) 23 (28.8) 48 (23.9)   14 (29.2) 61 (24.8)   25 (21.2) 47 (26.9)  
36   2 (>25-75%) 15 (18.8) 35 (17.4)   6 (12.5) 47 (19.1)   22 (18.6) 33 (18.9)  
37   3 (>75%) 10 (12.5) 29 (14.4)   4 (8.3) 33 (13.4)   17 (14.4) 21 (12.0)  
38                      
39 Lymphocytic infiltrates (Low vs. High) Low 70 (87.5) 172 (85.6) 0.85 44 (91.7) 213 (86.6) 0.48 101 (85.6) 154 (88.0) 0.60
40   High (>75%) 10 (12.5) 29 (14.4)   4 (8.3) 33 (13.4)   17 (14.4) 21 (12.0)  
41                      
42 Menopausal status Premenopausal 34 (40.5) 91 (44.2) 0.60 17 (33.3) 114 (45.4) 0.12 44 (36.4) 87 (48.6) 0.044
43   Postmenopausal 50 (59.5) 115 (55.8)   34 (66.7) 137 (54.6)   77 (63.6) 92 (51.4)  
44                      
45 Multifocal No 81 (95.3) 199 (94.3) >0.999 50 (96.2) 240 (93.4) 0.75 118 (93.7) 171 (94.0) >0.999
46   Yes 4 (4.7) 12 (5.7)   2 (3.8) 17 (6.6)   8 (6.3) 11 (6.0)  
47                      
48 Number of positive nodes   23 (27.4) 74 (35.7) 0.22 17 (33.3) 86 (34.3) 0.41 45 (36.6) 57 (32.2) 0.53
49   1-3 29 (34.5) 74 (35.7)   15 (29.4) 94 (37.5)   39 (31.7) 67 (37.9)  
50   ≥4 32 (38.1) 59 (28.5)   19 (37.3) 71 (28.3)   39 (31.7) 53 (29.9)  
51                      
52 Tumor size ≤2 cm 23 (27.7) 78 (37.1) 0.19 16 (32.0) 94 (37.0) 0.80 46 (37.1) 61 (34.1) 0.77
53   2-5 cm 55 (66.3) 114 (54.3)   30 (60.0) 142 (55.9)   66 (53.2) 103 (57.5)  
54   >5 cm 5 (6.0) 18 (8.6)   4 (8.0) 18 (7.1)   12 (9.7) 15 (8.4)  
55                      
56 Ki67 labeling N 80 209 0.001 51 249 <0.001 124 181 <0.001
57   Median 31.7 50.0   9.0 50.0   38.0 52.5  
58   Range (0.0-100.0) (0.5-100.0)   (0.0-100.0) (0.0-100.0)   (0.0-100.0) (0.0-100.0)  
59  
60 N. number.                    
61 Significant p-values are shown in bold.