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  A B C D E F G H I J K L
1                        
2                        
3   Table S3. Significant correlations between study IHC parameters (continuous measurements).          
4                  
5   Variable 1 Variable 2 Spearman's rho p-value              
6   P-cadherin (memb) E-cadherin (memb) 0.6213 <.0001              
7   Notch3 (cyto) Ki67 labeling 0.364 <0.001              
8   Notch3 (memb) Notch3 (cyto) 0.321 <0.001              
9   p53 (nucl) Ki67 labeling 0.278 <0.001              
10   Notch3 (cyto) p53 (nucl) 0.270 <0.001              
11   Notch3 (memb) Ki67 labeling 0.264 <0.001              
12   Jag1 (nucl) Ki67 labeling 0.251 <0.001              
13   Notch2 (cyto) Jag1 (cyto) 0.245 <0.001              
14   P-cadherin (memb) Ki67 labeling 0.238 <0.001              
15   Notch3 (cyto) E-cadherin (memb) 0.233 <0.001              
16   Jag1 (cyto) Ki67 labeling -0.340 <0.001              
17   Jag1 (nucl) Jag1 (cyto) -0.362 <0.001              
18                
19   Variable 1 Variable 2 Pearson's r Lower 95% Upper 95%            
20   P-cadherin (memb) E-cadherin (memb) 0.615 0.537 0.682            
21   Notch3 (cyto) Ki67 labeling 0.383 0.281 0.477            
22   Notch3 (memb) Notch3 (cyto) 0.335 0.230 0.433            
23   Notch3 (memb) Ki67 labeling 0.265 0.155 0.369            
24   p53 (nucl) Ki67 labeling 0.265 0.157 0.366            
25   Notch2 (cyto) Jag1 (cyto) 0.256 0.144 0.363            
26   Notch3 (cyto) p53 (nucl) 0.252 0.140 0.358            
27   Notch3 (cyto) Jag1 (nucl) 0.251 0.138 0.358            
28   Notch3 (cyto) P-cadherin (memb) 0.244 0.130 0.351            
29   P-cadherin (memb) Ki67 labeling 0.225 0.114 0.330            
30   Notch2 (cyto) P-cadherin (memb) 0.216 0.102 0.325            
31   Notch3 (cyto) E-cadherin (memb) 0.215 0.100 0.325            
32   Jag1 (nucl) Ki67 labeling 0.214 0.101 0.321            
33   Jag1 (nucl) Jag1 (cyto) -0.278 -0.381 -0.169            
34   Jag1 (cyto) Ki67 labeling -0.307 -0.408 -0.199