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  A B C D E F G H I J K L M
1 Table S4. Associations between standard clinicopathological characteristics and the two sets of hierarchical clusters, as indicated.              
2    
3     All Jag/Notch clusters Jag1 (nucl)/Notch3 (memb)/Ki67 clusters  
4     Cluster 1 Cluster 2 Cluster 3 Cluster 4 p-value Cluster A Cluster B Cluster C Cluster D p-value  
5    
6     N (%) N (%) N (%) N (%)   N (%) N (%) N (%) N (%)    
7                          
8 Adjuvant hormonal therapy No 56 (78.9) 58 (80.6) 68 (85.0) 42 (84.0) 0.75 55 (77.5) 87 (82.9) 44 (83.0) 41 (83.7) 0.77  
9   Yes 15 (21.1) 14 (19.4) 12 (15.0) 8 (16.0)   16 (22.5) 18 (17.1) 9 (17.0) 8 (16.3)    
10                          
11 Adjuvant radiotherapy No 15 (21.1) 21 (29.2) 20 (25.0) 14 (28.0) 0.71 14 (19.7) 33 (31.4) 14 (26.4) 11 (22.4) 0.33  
12   Yes 56 (78.9) 51 (70.8) 60 (75.0) 36 (72.0)   57 (80.3) 72 (68.6) 39 (73.6) 38 (77.6)    
13                          
14 Age (median cutoff) <53.2 37 (52.1) 27 (37.5) 42 (52.5) 28 (56.0) 0.14 37 (52.1) 42 (40.0) 29 (54.7) 30 (61.2) 0.064  
15   ≥53.2 34 (47.9) 45 (62.5) 38 (47.5) 22 (44.0)   34 (47.9) 63 (60.0) 24 (45.3) 19 (38.8)    
16                          
17                          
18 Basal-like phenotype No 2 (2.8) 24 (33.3) 11 (13.8) 3 (6.0) <0.001 1 (1.4) 31 (29.5) 5 (9.4) 2 (4.1) <0.001  
19   Yes 69 (97.2) 48 (66.7) 69 (86.3) 47 (94.0)   70 (98.6) 74 (70.5) 48 (90.6) 47 (95.9)    
20                          
21 Breast Surgery Biopsy only 2 (2.9) 1 (1.4) 1 (1.3) 0 (0) 0.68 2 (2.9) 2 (1.9) 0 (0) 0 (0) 0.45  
22   Breast-conserving surgery 39 (56.5) 33 (45.8) 42 (53.2) 28 (57.1)   39 (56.5) 48 (45.7) 29 (55.8) 28 (58.3)    
23   Modified radical mastectomy 28 (40.6) 38 (52.8) 36 (45.6) 21 (42.9)   28 (40.6) 55 (52.4) 23 (44.2) 20 (41.7)    
24                          
25 Histological type Apocrine 1 (1.4) 4 (5.6) 1 (1.3) 1 (2.0) 0.001 1 (1.4) 3 (2.9) 2 (3.8) 1 (2.0) 0.019  
26   Lobular   9 (12.5) 2 (2.5)     1 (1.4) 9 (8.6)        
27   Medullar 1 (1.4) 3 (4.2) 4 (5.0) 9 (18.0)   1 (1.4) 3 (2.9) 5 (9.4) 8 (16.3)    
28   Metaplastic 4 (5.6) 3 (4.2) 6 (7.5) 3 (6.0)   5 (7.0) 4 (3.8) 4 (7.5) 3 (6.1)    
29   Non-specific 62 (87.3) 50 (69.4) 65 (81.3) 35 (70.0)   60 (84.5) 82 (78.1) 40 (75.5) 36 (73.5)    
30   Other 3 (4.2) 3 (4.2) 2 (2.5) 2 (4.0)   3 (4.2) 4 (3.8) 2 (3.8) 1 (2.0)    
31                          
32 Histological grade I-II 13 (18.6) 18 (25.4) 7 (8.8) 7 (14.0) 0.048 14 (20.0) 21 (20.2) 2 (3.8) 7 (14.3) 0.042  
33   III 57 (81.4) 53 (74.6) 73 (91.3) 43 (86.0)   56 (80.0) 83 (79.8) 51 (96.2) 42 (85.7)    
34                          
35 Lymphocytic infiltrates (whole sections) Low 61 (88.4) 61 (93.8) 66 (88.0) 36 (72.0) 0.006 60 (88.2) 91 (93.8) 41 (82.0) 37 (75.5) 0.013  
36   High (>75%) 8 (11.6) 4 (6.2) 9 (12.0) 14 (28.0)   8 (11.8) 6 (6.2) 9 (18.0) 12 (24.5)    
37                          
38 Lymphocytic infiltrates (Low vs. High) 0 (≤1%) 31 (44.9) 34 (52.3) 34 (45.3) 13 (26.0) 0.073 31 (45.6) 53 (54.6) 18 (36.0) 14 (28.6) 0.031  
39   1 (>1-25%) 17 (24.6) 16 (24.6) 19 (25.3) 13 (26.0)   17 (25.0) 21 (21.6) 16 (32.0) 11 (22.4)    
40   2 (>25-75%) 13 (18.8) 11 (16.9) 13 (17.3) 10 (20.0)   12 (17.6) 17 (17.5) 7 (14.0) 12 (24.5)    
41   3 (>75%) 8 (11.6) 4 (6.2) 9 (12.0) 14 (28.0)   8 (11.8) 6 (6.2) 9 (18.0) 12 (24.5)    
42                          
43 Menopausal status Premenopausal 32 (47.8) 24 (33.8) 37 (46.3) 23 (46.9) 0.30 32 (47.1) 41 (39.4) 23 (44.2) 24 (50.0) 0.61  
44   Postmenopausal 35 (52.2) 47 (66.2) 43 (53.8) 26 (53.1)   36 (52.9) 63 (60.6) 29 (55.8) 24 (50.0)    
45                          
46 Multifocal No 68 (95.8) 66 (91.7) 77 (96.3) 49 (98.0) 0.38 67 (94.4) 101 (96.2) 48 (90.6) 48 (98.0) 0.33  
47   Yes 3 (4.2) 6 (8.3) 3 (3.8) 1 (2.0)   4 (5.6) 4 (3.8) 5 (9.4) 1 (2.0)    
48                          
49 Number of positive nodes   19 (27.5) 19 (26.8) 28 (35.9) 24 (49.0) 0.065 20 (29.0) 31 (30.1) 17 (32.7) 23 (47.9) 0.15  
50   1-3 24 (34.8) 24 (33.8) 29 (37.2) 17 (34.7)   21 (30.4) 40 (38.8) 22 (42.3) 13 (27.1)    
51   ≥4 26 (37.7) 28 (39.4) 21 (26.9) 8 (16.3)   28 (40.6) 32 (31.1) 13 (25.0) 12 (25.0)    
52                          
53 Tumor size ≤2cm 21 (30.0) 24 (33.3) 30 (38.0) 16 (32.7) 0.91 21 (30.0) 38 (36.5) 19 (35.8) 15 (31.3) 0.91  
54   2-5cm 43 (61.4) 41 (56.9) 41 (51.9) 30 (61.2)   42 (60.0) 57 (54.8) 28 (52.8) 30 (62.5)    
55   >5cm 6 (8.6) 7 (9.7) 8 (10.1) 3 (6.1)   7 (10.0) 9 (8.7) 6 (11.3) 3 (6.3)    
56                          
57 Ki67 labeling N 71 71 80 50 <0.001 71 105 53 49 <0.001  
58   Median 61.0 13.0 54.3 60.3   65.0 13.5 82.0 65.0    
59   Range (4.5-100.0) (0.0-100.0) (0.5-100.0) (1.5-100.0)   (4.5-100.0) (0.0-56.0) (58.5-100.0) (1.5-99.5)    
60    
61 N, number.                        
62 Significant p-values are shown in bold.