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1 Table S5. Univariate Cox regression analysis for standard clinicopathological characteristics and study parameters on patient DFS.    
2  
3   N of patients N of events HR 95% CI Wald's p
4              
5 Adjuvant hormonal therapy Yes vs. No 64 vs. 266 27 vs.71 1.50 0.96-2.34 0.076
6              
7 Adjuvant radiotherapy Yes vs. No 244 vs. 86 71 vs.27 0.90 0.57-1.39 0.62
8              
9 Age (median cutoff) ≥53.2 vs. <53.2 165 vs. 165 44 vs. 54 0.75 0.51-1.12 0.16
10              
11 Basal-like phenotype Yes vs. No 269 vs. 55 82 vs.15 1.22 0.71-2.13 0.47
12              
13 Breast Surgery Breast-conserving surgery vs. Biopsy only 169 vs. 5 43 vs.3 0.33 0.10-1.07 0.065
14   Modified radical mastectomy vs. Biopsy only 152 vs. 5 51 vs.3 0.43 0.13-1.39 0.16
15              
16 Histological type Apocrine vs. Other 9 vs. 10 4 vs.2 2.37 0.43-12.93 0.32
17   Lobular vs. Other 17 vs. 10 8 vs.2 2.09 0.44-9.89 0.35
18   Medullar vs. Other 21 vs. 10 1 vs.2 0.18 0.02-1.96 0.16
19   Metaplastic vs. Other 17 vs. 10 4 vs.2 1.06 0.19-5.78 0.95
20   Non-specific vs. Other 256 vs. 10 79 vs.2 1.39 0.34-5.67 0.64
21              
22 Histological grade III vs. I-II 269 vs. 58 84 vs.14 1.38 0.79-2.44 0.26
23              
24 Lymphocytic infiltrates (whole sections) 1 (>1-25%) vs. 0 (≤1%) 81 vs. 139 21 vs.44 0.77 0.46-1.30 0.34
25   2 (26-75%) vs. 0 (≤1%) 56 vs. 139 18 vs.44 0.95 0.55-1.64 0.85
26   3 (>75%) vs. 0 (≤1%) 39 vs. 139 7 vs.44 0.47 0.21-1.05 0.067
27              
28 Lymphocytic infiltrates (Low vs. High) High (>75%) vs. Low 39 vs. 276 7 vs. 83 0.52 0.24-1.12 0.093
29              
30 Menopausal status Postmenopausal vs. Premenopausal 181 vs. 144 51 vs.45 0.89 0.60-1.33 0.58
31              
32 Multifocal Yes vs. No 19 vs. 311 6 vs.92 1.10 0.48-2.52 0.81
33              
34 Number of positive nodes 0 vs. ≥4 106 vs. 101 20 vs. 53 0.32 0.19-0.53 <0.001
35   1-3 vs. ≥4 116 vs. 101 22 vs. 53 0.29 0.18-0.48 <0.001
36              
37 Tumor size 2-5 cm vs. ≤2 cm 184 vs. 114 53 vs.27 1.32 0.83-2.10 0.24
38   >5cm vs. ≤2 cm 28 vs. 114 17 vs.27 3.30 1.80-6.07 <0.001
39              
40 Ki67 labeling       0.999 0.99-1.01 0.67
41              
42 Notch2 cytoplasmic (binary) 5-9 vs. 0-4 104 vs. 192 27 vs.62 0.70 0.45-1.10 0.12
43              
44 Notch3 cytoplasmic (binary) 5-9 vs. 0-4 186 vs. 108 58 vs.33 1.05 0.69-1.61 0.82
45              
46 Notch3 mebranous (binary) 5-9 vs. 0-4 67 vs. 227 15 vs.76 0.61 0.35-1.06 0.082
47              
48 Jag1 cytoplasmic (binary) 5-9 vs. 0-4 123 vs. 167 40 vs.49 1.06 0.70-1.61 0.78
49              
50 Jag1 nuclear (binary) 5-9 vs. 0-4 50 vs. 240 19 vs.70 1.41 0.85-2.35 0.18
51              
52 E-cadherin Positive (≥10%) vs. Negative 210 vs. 85 63 vs.25 1.05 0.66-1.66 0.85
53              
54 P-cadherin Positive (≥10%) vs. Negative 255 vs. 52 78 vs.14 1.19 0.68-2.11 0.54
55              
56 p53 Positive (≥10%) vs. Negative 180 vs. 125 56 vs.36 1.12 0.74-1.70 0.60
57              
58 All Jag/Notch clusters Cluster 1 vs. Cluster 4 71 vs. 50 25 vs. 7 3.14 1.36-7.25 0.008
59   Cluster 2 vs. Cluster 4 72 vs. 50 27 vs. 7 3.10 1.35-7.11 0.008
60   Cluster 3 vs. Cluster 4 80 vs. 50 27 vs. 7 2.91 1.27-6.69 0.012
61              
62 Jag1/Notch3/Ki67 clusters Cluster A vs. Cluster D 71 vs. 49 26 vs. 8 2.73 1.24-6.04 0.013
63   Cluster B vs. Cluster D 105 vs. 49 37 vs. 8 2.35 1.09-5.05 0.028
64   Cluster C vs. Cluster D 53 vs. 49 18 vs. 8 2.31 1.00-5.31 0.049
65  
66 N, number; HR, hazard ratio; CI, confidence interval.            
67 Significant p-values are shown in bold.