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1 Table S6. Univariate Cox regression analysis for standard clinicopathological characteristics and study parameters on patient OS.      
2    
3   N of patients N of events HR 95% CI Wald's p  
4                
5 Adjuvant hormonal therapy Yes vs. No 64 vs. 266 24 vs.56 1.53 0.94-2.49 0.089  
6                
7 Adjuvant radiotherapy Yes vs. No 244 vs. 86 57 vs.23 0.80 0.49-1.30 0.37  
8                
9 Age (median cutoff) ≥53.2 vs. <53.2 165 vs. 165 38 vs. 42 0.87 0.56-1.35 0.54  
10                
11 Basal-like phenotype Yes vs. No 269 vs. 55 66 vs.13 1.16 0.64-2.11 0.62  
12                
13 Breast Surgery Breast-conserving surgery vs. Biopsy only 169 vs. 5 33 vs.3 0.26 0.08-0.84 0.025  
14   Modified radical mastectomy vs. Biopsy only 152 vs. 5 43 vs.3 0.36 0.11-1.18 0.091  
15                
16 Histological type Apocrine vs. Other 9 vs. 10 3 vs.1 3.11 0.32-29.92 0.33  
17   Lobular vs. Other 17 vs. 10 8 vs.1 3.68 0.46-29.48 0.22  
18   Medullar vs. Other 21 vs. 10 1 vs.1 0.33 0.02-5.25 0.43  
19   Metaplastic vs. Other 17 vs. 10 4 vs.1 2.03 0.23-18.16 0.53  
20   Non-specific vs. Other 256 vs. 10 63 vs.1 1.95 0.27-14.11 0.51  
21                
22 Histological grade III vs. I-II 269 vs. 58 67 vs.13 1.16 0.64-2.10 0.63  
23                
24 Lymphocytic infiltrates (whole sections) 1 (>1-25%) vs. 0 (≤1%) 81 vs. 139 18 vs.37 0.78 0.44-1.37 0.39  
25   2 (26-75%) vs. 0 (≤1%) 56 vs. 139 12 vs.37 0.74 0.39-1.42 0.36  
26   3 (>75%) vs. 0 (≤1%) 39 vs. 139 6 vs.37 0.49 0.21-1.17 0.11  
27                
28 Lymphocytic infiltrates (Low vs. High) High (>75%) vs. Low 39 vs. 276 7 vs. 67 0.56 0.24-1.30 0.18  
29                
30 Menopausal status Postmenopausal vs. Premenopausal 181 vs. 144 44 vs.34 1.09 0.70-1.71 0.71  
31                
32 Multifocal Yes vs. No 19 vs. 311 6 vs.74 1.55 0.67-3.57 0.30  
33                
34 Number of positive nodes 0 vs. ≥4 106 vs. 101 13 vs. 48 0.25 0.14-0.47 <0.001  
35   1-3 vs. ≥4 116 vs. 101 16 vs. 48 0.25 0.14-0.43 <0.001  
36                
37 Tumor size 2-5 cm vs. ≤2 cm 184 vs. 114 46 vs.19 1.63 0.96-2.79 0.073  
38   >5cm vs. ≤2 cm 28 vs. 114 15 vs.19 3.89 1.97-7.67 <0.001  
39                
40 Ki67 labeling       0.999 0.99-1.01 0.71  
41                
42 Notch2 cytoplasmic (binary) 5-9 vs. 0-4 104 vs. 192 20 vs.51 0.64 0.38-1.07 0.089  
43                
44 Notch3 cytoplasmic (binary) 5-9 vs. 0-4 186 vs. 108 47 vs.27 1.05 0.65-1.68 0.85  
45                
46 Notch3 mebranous (binary) 5-9 vs. 0-4 67 vs. 227 13 vs.61 0.68 0.37-1.23 0.20  
47                
48 Jag1 cytoplasmic (binary) 5-9 vs. 0-4 123 vs. 167 33 vs.40 1.08 0.68-1.71 0.75  
49                
50 Jag1 nuclear (binary) 5-9 vs. 0-4 50 vs. 240 16 vs.57 1.41 0.80-2.47 0.23  
51                
52 E-cadherin Positive (≥10%) vs. Negative 210 vs. 85 52 vs.20 1.07 0.64-1.79 0.80  
53                
54 P-cadherin Positive (≥10%) vs. Negative 255 vs. 52 63 vs.12 1.14 0.62-2.12 0.67  
55                
56 p53 Positive (≥10%) vs. Negative 180 vs. 125 45 vs.31 1.05 0.66-1.66 0.84  
57                
58 All Jag/Notch clusters Cluster 1 vs. Cluster 4 71 vs. 50 21 vs. 5 3.37 1.27-8.96 0.015  
59   Cluster 2 vs. Cluster 4 72 vs. 50 22 vs. 5 3.32 1.26-8.77 0.015  
60   Cluster 3 vs. Cluster 4 80 vs. 50 22 vs. 5 3.07 1.16-8.12 0.024  
61                
62 Jag1/Notch3/Ki67 clusters Cluster A vs. Cluster D 71 vs. 49 23 vs. 7 2.59 1.11-6.05 0.028  
63   Cluster B vs. Cluster D 105 vs. 49 29 vs. 7 1.98 0.87-4.53 0.10  
64   Cluster C vs. Cluster D 53 vs. 49 14 vs. 7 1.90 0.77-4.72 0.16  
65    
66 N, number; HR, hazard ratio; CI, confidence interval.              
67 Significant p-values are shown in bold.